BR112017023874A2 - anticorpos anti-her3 humanos com baixa fucose e seus usos - Google Patents

anticorpos anti-her3 humanos com baixa fucose e seus usos

Info

Publication number
BR112017023874A2
BR112017023874A2 BR112017023874A BR112017023874A BR112017023874A2 BR 112017023874 A2 BR112017023874 A2 BR 112017023874A2 BR 112017023874 A BR112017023874 A BR 112017023874A BR 112017023874 A BR112017023874 A BR 112017023874A BR 112017023874 A2 BR112017023874 A2 BR 112017023874A2
Authority
BR
Brazil
Prior art keywords
human anti
antibody
her3 antibodies
low fucose
human
Prior art date
Application number
BR112017023874A
Other languages
English (en)
Inventor
Chardès Thierry
Dubreuil Olivier
Pelegrin André
Larbouret Christel
Prost Jean-François
Marc Barret Jean-
Degove Stéphane
Original Assignee
Gamamabs Pharma
Institut National De La Santé Et De La Recherche Médicale (Inserm)
Universite De Montpellier
Institut Regional Du Cancer De Montpellier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gamamabs Pharma, Institut National De La Santé Et De La Recherche Médicale (Inserm), Universite De Montpellier, Institut Regional Du Cancer De Montpellier filed Critical Gamamabs Pharma
Publication of BR112017023874A2 publication Critical patent/BR112017023874A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente divulgação se refere a um anticorpo her3 anti-humano alostérico não competitivo de neuregulina que tem uma região humana constante; e menos de 65% das estruturas de glicano carregadas pelo sítio de glicosilação do anticorpo compreendem uma molécula de fucose. o anticorpo é caracterizado por suas sequências variáveis.
BR112017023874A 2015-05-06 2016-05-02 anticorpos anti-her3 humanos com baixa fucose e seus usos BR112017023874A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15305695.7A EP3091033A1 (en) 2015-05-06 2015-05-06 Anti-human-her3 antibodies and uses thereof
PCT/EP2016/059739 WO2016177664A1 (en) 2015-05-06 2016-05-02 Anti-human-her3 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
BR112017023874A2 true BR112017023874A2 (pt) 2018-07-24

Family

ID=53059029

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017023874A BR112017023874A2 (pt) 2015-05-06 2016-05-02 anticorpos anti-her3 humanos com baixa fucose e seus usos

Country Status (12)

Country Link
US (1) US11001634B2 (pt)
EP (2) EP3091033A1 (pt)
JP (1) JP6987742B2 (pt)
CN (1) CN107771183A (pt)
BR (1) BR112017023874A2 (pt)
CA (1) CA2985143C (pt)
ES (1) ES2905531T3 (pt)
PL (1) PL3292154T3 (pt)
PT (1) PT3292154T (pt)
RS (1) RS62912B1 (pt)
RU (1) RU2017138468A (pt)
WO (1) WO2016177664A1 (pt)

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US11326182B2 (en) 2016-04-29 2022-05-10 Voyager Therapeutics, Inc. Compositions for the treatment of disease
WO2017189964A2 (en) 2016-04-29 2017-11-02 Voyager Therapeutics, Inc. Compositions for the treatment of disease
CN110724194B (zh) * 2018-07-17 2021-03-19 上海生物制品研究所有限责任公司 抗her3人源化单克隆抗体及其制剂
GB201913079D0 (en) * 2019-09-11 2019-10-23 Hummingbird Bioscience Holdings Pte Ltd Treatment and prevention of cancer using her3 antigen-binding molecules
CN113135995B (zh) * 2020-01-17 2022-08-12 上海生物制品研究所有限责任公司 抗her3单克隆抗体及其应用
US20240016949A1 (en) * 2020-12-04 2024-01-18 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Antibody-drug conjugate, and intermediate thereof, preparation method therefor, and application thereof
CN117500832A (zh) * 2021-06-15 2024-02-02 北京先通生物医药技术有限公司 抗her3抗体、含有该抗体的抗体药物缀合物及其用途
WO2023143263A1 (zh) * 2022-01-25 2023-08-03 苏州宜联生物医药有限公司 一种针对Her3的抗体，偶联物及其用途
CN115724979A (zh) * 2022-10-13 2023-03-03 深圳市百士通科技开发有限公司 一种多功能重组抗体及其制备方法和应用

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Also Published As

Publication number Publication date
EP3091033A1 (en) 2016-11-09
WO2016177664A1 (en) 2016-11-10
ES2905531T3 (es) 2022-04-11
JP6987742B2 (ja) 2022-01-05
US20180155433A1 (en) 2018-06-07
US11001634B2 (en) 2021-05-11
RS62912B1 (sr) 2022-03-31
JP2018515137A (ja) 2018-06-14
PT3292154T (pt) 2022-01-26
CN107771183A (zh) 2018-03-06
EP3292154A1 (en) 2018-03-14
CA2985143A1 (en) 2016-11-10
RU2017138468A3 (pt) 2019-09-03
RU2017138468A (ru) 2019-06-06
PL3292154T3 (pl) 2022-04-19
CA2985143C (en) 2023-10-17
EP3292154B1 (en) 2021-11-03

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements