RU2017138468A - Антитела против человеческого her3, имеющие низкое содержание фукозы, и области их применения - Google Patents

Антитела против человеческого her3, имеющие низкое содержание фукозы, и области их применения Download PDF

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Publication number
RU2017138468A
RU2017138468A RU2017138468A RU2017138468A RU2017138468A RU 2017138468 A RU2017138468 A RU 2017138468A RU 2017138468 A RU2017138468 A RU 2017138468A RU 2017138468 A RU2017138468 A RU 2017138468A RU 2017138468 A RU2017138468 A RU 2017138468A
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Russia
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antibody
cancer
seq
neuregulin
immunoconjugate
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RU2017138468A
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English (en)
Russian (ru)
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RU2017138468A3 (cg-RX-API-DMAC10.html
Inventor
Тьерри ШАРДЕС
Оливье ДЮБРЕЙ
Андре ПЕЛЕГРЕН
Кристель Ларбуре
Жан-Франсуа ПРОСТ
Жан-Марк БАРРЕ
Стефан ДЕГОВ
Original Assignee
Гамама Фарма
Институт Насьональ Де Ла Санте Э Де Ла Решерш Медикаль (Инсерм)
Юниверсите Де Монпелье
Институт Режиональ Дю Кансер Де Монпелье
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Application filed by Гамама Фарма, Институт Насьональ Де Ла Санте Э Де Ла Решерш Медикаль (Инсерм), Юниверсите Де Монпелье, Институт Режиональ Дю Кансер Де Монпелье filed Critical Гамама Фарма
Publication of RU2017138468A publication Critical patent/RU2017138468A/ru
Publication of RU2017138468A3 publication Critical patent/RU2017138468A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
RU2017138468A 2015-05-06 2016-05-02 Антитела против человеческого her3, имеющие низкое содержание фукозы, и области их применения RU2017138468A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15305695.7A EP3091033A1 (en) 2015-05-06 2015-05-06 Anti-human-her3 antibodies and uses thereof
EP15305695.7 2015-05-06
PCT/EP2016/059739 WO2016177664A1 (en) 2015-05-06 2016-05-02 Anti-human-her3 antibodies and uses thereof

Publications (2)

Publication Number Publication Date
RU2017138468A true RU2017138468A (ru) 2019-06-06
RU2017138468A3 RU2017138468A3 (cg-RX-API-DMAC10.html) 2019-09-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017138468A RU2017138468A (ru) 2015-05-06 2016-05-02 Антитела против человеческого her3, имеющие низкое содержание фукозы, и области их применения

Country Status (12)

Country Link
US (1) US11001634B2 (cg-RX-API-DMAC10.html)
EP (2) EP3091033A1 (cg-RX-API-DMAC10.html)
JP (1) JP6987742B2 (cg-RX-API-DMAC10.html)
CN (1) CN107771183A (cg-RX-API-DMAC10.html)
BR (1) BR112017023874A2 (cg-RX-API-DMAC10.html)
CA (1) CA2985143C (cg-RX-API-DMAC10.html)
ES (1) ES2905531T3 (cg-RX-API-DMAC10.html)
PL (1) PL3292154T3 (cg-RX-API-DMAC10.html)
PT (1) PT3292154T (cg-RX-API-DMAC10.html)
RS (1) RS62912B1 (cg-RX-API-DMAC10.html)
RU (1) RU2017138468A (cg-RX-API-DMAC10.html)
WO (1) WO2016177664A1 (cg-RX-API-DMAC10.html)

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CN110724194B (zh) * 2018-07-17 2021-03-19 上海生物制品研究所有限责任公司 抗her3人源化单克隆抗体及其制剂
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GB201913079D0 (en) * 2019-09-11 2019-10-23 Hummingbird Bioscience Holdings Pte Ltd Treatment and prevention of cancer using her3 antigen-binding molecules
CN113135995B (zh) * 2020-01-17 2022-08-12 上海生物制品研究所有限责任公司 抗her3单克隆抗体及其应用
JP7454110B2 (ja) * 2020-12-04 2024-03-21 シャンハイ フダン－チャンジャン バイオ－ファーマシューティカル カンパニー リミテッド 抗体薬物複合体、その中間体、製造方法及び使用
EP4355787A4 (en) * 2021-06-15 2025-04-30 Beijing Sinotau Bio-Pharmaceuticals Technology Co., Ltd. Anti-her3 antibody, antibody drug conjugate containing the same, and use thereof
KR20240137076A (ko) * 2022-01-25 2024-09-19 메디링크 테라퓨틱스 (쑤저우) 컴퍼니, 리미티드 Her3에 대한 항체, 접합체 및 이의 용도
CN115724979B (zh) * 2022-10-13 2025-09-30 深圳市百士通科技开发有限公司 一种多功能重组抗体及其制备方法和应用
CN116444672B (zh) * 2023-06-13 2023-11-03 上海偌妥生物科技有限公司 人表皮生长因子3的抗体、其制备方法及其应用
WO2025248097A2 (en) * 2024-05-31 2025-12-04 Gamamabs Pharma Humanized anti-human her3 antibodies and uses thereof

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Also Published As

Publication number Publication date
EP3091033A1 (en) 2016-11-09
EP3292154B1 (en) 2021-11-03
US20180155433A1 (en) 2018-06-07
RS62912B1 (sr) 2022-03-31
ES2905531T3 (es) 2022-04-11
EP3292154A1 (en) 2018-03-14
PT3292154T (pt) 2022-01-26
RU2017138468A3 (cg-RX-API-DMAC10.html) 2019-09-03
WO2016177664A1 (en) 2016-11-10
US11001634B2 (en) 2021-05-11
CA2985143C (en) 2023-10-17
CN107771183A (zh) 2018-03-06
JP2018515137A (ja) 2018-06-14
CA2985143A1 (en) 2016-11-10
BR112017023874A2 (pt) 2018-07-24
JP6987742B2 (ja) 2022-01-05
PL3292154T3 (pl) 2022-04-19

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Effective date: 20210220