RU2017118971A - Композиция на основе аминокислот для восстановления фиброэластина в дермальных соединительных тканях - Google Patents
Композиция на основе аминокислот для восстановления фиброэластина в дермальных соединительных тканях Download PDFInfo
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- RU2017118971A RU2017118971A RU2017118971A RU2017118971A RU2017118971A RU 2017118971 A RU2017118971 A RU 2017118971A RU 2017118971 A RU2017118971 A RU 2017118971A RU 2017118971 A RU2017118971 A RU 2017118971A RU 2017118971 A RU2017118971 A RU 2017118971A
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- composition
- valine
- proline
- leucine
- alanine
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims 15
- 150000001413 amino acids Chemical class 0.000 title claims 7
- 210000002808 connective tissue Anatomy 0.000 title 1
- 230000002500 effect on skin Effects 0.000 title 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 10
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 10
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 10
- 229940024606 amino acid Drugs 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 6
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 5
- 239000004471 Glycine Substances 0.000 claims 5
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 5
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 5
- 235000019454 L-leucine Nutrition 0.000 claims 5
- 239000004395 L-leucine Substances 0.000 claims 5
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 claims 5
- 229930182821 L-proline Natural products 0.000 claims 5
- 229960003767 alanine Drugs 0.000 claims 5
- 229960003136 leucine Drugs 0.000 claims 5
- 229960002429 proline Drugs 0.000 claims 5
- 229960004295 valine Drugs 0.000 claims 5
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 206010002961 Aplasia Diseases 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 206010011985 Decubitus ulcer Diseases 0.000 claims 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 1
- 235000013878 L-cysteine Nutrition 0.000 claims 1
- 239000004201 L-cysteine Substances 0.000 claims 1
- 206010051246 Photodermatosis Diseases 0.000 claims 1
- 208000004210 Pressure Ulcer Diseases 0.000 claims 1
- 206010063562 Radiation skin injury Diseases 0.000 claims 1
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 229960002449 glycine Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 230000000642 iatrogenic effect Effects 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 230000008845 photoaging Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 206010040882 skin lesion Diseases 0.000 claims 1
- 231100000444 skin lesion Toxicity 0.000 claims 1
- 229940010747 sodium hyaluronate Drugs 0.000 claims 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000008174 sterile solution Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- -1 transdermal patches Substances 0.000 claims 1
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Claims (15)
1. Композиции, содержащие в качестве активного ингредиента смесь аминокислот, состоящую из глицина, L-пролина, L-аланина, L-валина, L-лейцина и гидрохлорида L-лизина в следующих массовых соотношениях:
2. Композиции по п. 1, дополнительно содержащие L-цистеин или N-ацетил-L-цистеин в количестве от 1 до 20% по массе от всей смеси аминокислот.
3. Композиции по п. 1 или 2 со следующими массовыми соотношениями аминокислот:
4. Композиции по п. 1 или 2 со следующими массовыми соотношениями аминокислот:
5. Композиции по п. 1 или 2 со следующими массовыми соотношениями аминокислот:
6. Композиции по любому из пп. 1-5 для перорального применения.
7. Композиции по п. 6 в форме растворов, гранул, диспергируемого порошка, таблеток или капсул.
8. Композиции по любому из пп. 1-5, дополнительно содержащие гиалуроновую кислоту или ее соли, в частности гиалуронат натрия, со средней молекулярной массой от 500000 до 3000000 Да в количестве от 0,01 до 3% по массе от общей массы композиции.
9. Композиции по п. 8 для местного или инъекционного применения.
10. Композиции по п. 9 в форме гелей, мазей, эмульсий, трансдермальных пластырей, стерильных растворов или стерильных порошков аминокислот, разработанных для восстановления в стерильных водных растворах гиалуронатов.
11. Композиции по пп. 1-10 для применения в лечении эластоза и дермоэпидермальной атрофии в результате фотостарения, кожных расстройств дермоатрофической и ятрогенной этиологии, ожогов, лучевых ожогов, поражений кожи, пролежней, аплазии кожи, вызванной применением лекарственных средств, поражений сухожилий и суставов.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2014A002084 | 2014-12-04 | ||
| ITMI20142084 | 2014-12-04 | ||
| PCT/IB2015/059330 WO2016088078A1 (en) | 2014-12-04 | 2015-12-03 | Aminoacid-based composition for fibroelastin recovery in dermal connective tissues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017118971A true RU2017118971A (ru) | 2019-01-10 |
| RU2017118971A3 RU2017118971A3 (ru) | 2019-05-31 |
| RU2704032C2 RU2704032C2 (ru) | 2019-10-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017118971A RU2704032C2 (ru) | 2014-12-04 | 2015-12-03 | Композиция на основе аминокислот для восстановления фиброэластина в дермальных соединительных тканях |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10272059B2 (ru) |
| EP (1) | EP3226854B1 (ru) |
| JP (1) | JP6726182B2 (ru) |
| KR (1) | KR102429451B1 (ru) |
| CN (1) | CN106999390A (ru) |
| AU (1) | AU2015356587B2 (ru) |
| BR (1) | BR112017011476B1 (ru) |
| CA (1) | CA2969383C (ru) |
| CY (1) | CY1123040T1 (ru) |
| DK (1) | DK3226854T3 (ru) |
| ES (1) | ES2777775T3 (ru) |
| LT (1) | LT3226854T (ru) |
| MX (1) | MX368900B (ru) |
| MY (1) | MY185991A (ru) |
| PH (1) | PH12017501003B1 (ru) |
| PL (1) | PL3226854T3 (ru) |
| RS (1) | RS60268B1 (ru) |
| RU (1) | RU2704032C2 (ru) |
| SA (1) | SA517381725B1 (ru) |
| SG (1) | SG11201704423SA (ru) |
| UA (1) | UA120627C2 (ru) |
| WO (1) | WO2016088078A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| IT201700075026A1 (it) * | 2017-07-04 | 2019-01-04 | Professional Derma Sa | Composizioni iniettabili per filler dermico |
| EP3668499A1 (en) | 2017-08-14 | 2020-06-24 | Axcella Health Inc. | Amino acid compositions for the treatment of liver disease |
| EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
| KR102226810B1 (ko) * | 2020-09-02 | 2021-03-15 | 주식회사 엘라스틱랩 | 연결 조직 중 엘라스틴 및 콜라겐 생합성 증진용 조성물 |
| US20230148647A1 (en) * | 2020-09-02 | 2023-05-18 | Elastic Lab Inc. | Composition for promoting biosynthesis of elastin and collagen in connective tissue |
| IT202100023903A1 (it) * | 2021-09-16 | 2023-03-16 | Professional Derma Sa | Composizione ad uso cosmetico |
| CN115670969B (zh) * | 2022-11-08 | 2023-11-07 | 瑞玞生物医学(深圳)有限公司 | 一种刺激弹性蛋白形成的组合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2185646T3 (es) * | 1992-12-22 | 2003-05-01 | Baxter Int | Soluciones de aminoacido mejoradas para el tratamiento de pacientes de dialisis peritoneal. |
| JP3553992B2 (ja) * | 1993-05-28 | 2004-08-11 | 独立行政法人理化学研究所 | 代謝調節剤 |
| US6159485A (en) * | 1999-01-08 | 2000-12-12 | Yugenic Limited Partnership | N-acetyl aldosamines, n-acetylamino acids and related n-acetyl compounds and their topical use |
| CN1126541C (zh) * | 1999-12-03 | 2003-11-05 | 中国人民解放军军事医学科学院放射医学研究所 | 新型复合氨基酸组合物 |
| JP2004123564A (ja) * | 2002-09-30 | 2004-04-22 | Inst Of Physical & Chemical Res | 中枢機能改善用アミノ酸組成物 |
| FR2849383B1 (fr) | 2002-12-26 | 2005-09-30 | Jean Noel Thorel | Composition trophique en milieu aqueux, et ses applications, notamment en ophtalmologie |
| DE10313200A1 (de) | 2003-03-19 | 2004-10-07 | Ami-Agrolinz Melamine International Gmbh | Prepregs für Faserverbunde hoher Festigkeit und Elastizität |
| ITMI20052035A1 (it) | 2005-10-26 | 2007-04-27 | Professional Dietetics Srl | Composizioni farmaceutiche cicatrizzanti sotto forma di crema a base di amminoacidi e sodio ialuronato |
| US20080102107A1 (en) * | 2005-12-16 | 2008-05-01 | Valex Pharmaceuticals, Llc | Compositions and methods for transdermal joint pain therapy |
| EP2033689A1 (en) | 2007-08-22 | 2009-03-11 | Italfarmacia S.r.l. | Injectable dermatological composition for treatment of the wrinkles |
| CN102131492B (zh) * | 2008-08-27 | 2013-04-24 | 株式会社太平洋 | 含胶原肽的皮肤美容用组合物 |
| FR2948286B1 (fr) * | 2009-07-27 | 2011-08-26 | Jean-Noel Thorel | Composition injectable associant un agent de comblement et un milieu de croissance des fibroblastes |
| IT1396935B1 (it) | 2009-11-26 | 2012-12-20 | Solartium Entpr Ltd | Uso di una combinazione per il trattamento delle mucositi indotte da radiazioni o da chemioterapici |
| EA015078B1 (ru) * | 2010-07-29 | 2011-04-29 | Елена Михайловна Хороших | Препарат и способ профилактики и коррекции патологических состояний животных |
| CN104013619A (zh) * | 2014-05-27 | 2014-09-03 | 刘力 | 复方氨基酸注射液18aa-v的药物组合物和用途 |
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- 2015-12-03 ES ES15825820T patent/ES2777775T3/es active Active
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- 2015-12-03 LT LTEP15825820.2T patent/LT3226854T/lt unknown
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- 2015-12-03 EP EP15825820.2A patent/EP3226854B1/en active Active
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| KR20170088868A (ko) | 2017-08-02 |
| BR112017011476A2 (pt) | 2018-02-27 |
| PL3226854T3 (pl) | 2020-08-24 |
| RU2017118971A3 (ru) | 2019-05-31 |
| JP6726182B2 (ja) | 2020-07-22 |
| PH12017501003A1 (en) | 2017-12-18 |
| MX2017007184A (es) | 2017-12-04 |
| RU2704032C2 (ru) | 2019-10-23 |
| SG11201704423SA (en) | 2017-06-29 |
| JP2017536388A (ja) | 2017-12-07 |
| ES2777775T3 (es) | 2020-08-06 |
| RS60268B1 (sr) | 2020-06-30 |
| NZ732377A (en) | 2023-12-22 |
| PH12017501003B1 (en) | 2017-12-18 |
| BR112017011476B1 (pt) | 2023-02-23 |
| DK3226854T3 (da) | 2020-03-23 |
| AU2015356587B2 (en) | 2020-04-09 |
| CN106999390A (zh) | 2017-08-01 |
| CA2969383C (en) | 2023-05-09 |
| WO2016088078A1 (en) | 2016-06-09 |
| SA517381725B1 (ar) | 2021-04-12 |
| KR102429451B1 (ko) | 2022-08-04 |
| AU2015356587A1 (en) | 2017-06-29 |
| CY1123040T1 (el) | 2021-10-29 |
| MY185991A (en) | 2021-06-14 |
| CA2969383A1 (en) | 2016-06-09 |
| MX368900B (es) | 2019-10-21 |
| US20170326089A1 (en) | 2017-11-16 |
| LT3226854T (lt) | 2020-04-27 |
| EP3226854A1 (en) | 2017-10-11 |
| EP3226854B1 (en) | 2020-02-26 |
| US10272059B2 (en) | 2019-04-30 |
| UA120627C2 (uk) | 2020-01-10 |
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