HRP20201050T1 - Derivati diarilmetiliden-piperidina i njihova primjena kao agonista delta opioidnih receptora - Google Patents
Derivati diarilmetiliden-piperidina i njihova primjena kao agonista delta opioidnih receptora Download PDFInfo
- Publication number
- HRP20201050T1 HRP20201050T1 HRP20201050TT HRP20201050T HRP20201050T1 HR P20201050 T1 HRP20201050 T1 HR P20201050T1 HR P20201050T T HRP20201050T T HR P20201050TT HR P20201050 T HRP20201050 T HR P20201050T HR P20201050 T1 HRP20201050 T1 HR P20201050T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- formula
- receptor agonists
- opioid receptor
- piperidine derivatives
- Prior art date
Links
- 101100244562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprD gene Proteins 0.000 title 1
- 108700023159 delta Opioid Receptors Proteins 0.000 title 1
- 102000048124 delta Opioid Receptors Human genes 0.000 title 1
- 150000003053 piperidines Chemical class 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 6
- 208000002193 Pain Diseases 0.000 claims 3
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Claims (6)
1. Spoj formule I
[image]
2. Spoj formule I prema točki 1 zahtjeva za primjenu u bolnim stanjima.
3. Spoj formule I prema točki 2 zahtjeva pri čemu su bolna stanja vezana uz akutnu bol.
4. Spoj formule I prema točki 2 zahtjeva pri čemu su bolna stanja vezana uz kroničnu bol.
5. Spoj formule I prema točki 4 zahtjeva pri čemu su stanja vezana uz kroničnu boli u zglobovima, kao što su bolna stanja uzrokovana osteoartritisom ili fibromijalgijom.
6. Farmaceutski sastav koji kao aktivni sastojak sadrži barem spoj formule I u skladu s točkom 1 zahtjeva ili njezinu fiziološki prihvatljivu sol zajedno s farmaceutski prihvatljivim nosačem.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1451616 | 2014-12-19 | ||
| EP15870465.0A EP3233825B1 (en) | 2014-12-19 | 2015-12-17 | Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists |
| PCT/SE2015/051363 WO2016099393A1 (en) | 2014-12-19 | 2015-12-17 | Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201050T1 true HRP20201050T1 (hr) | 2020-10-30 |
Family
ID=56127081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201050TT HRP20201050T1 (hr) | 2014-12-19 | 2020-07-03 | Derivati diarilmetiliden-piperidina i njihova primjena kao agonista delta opioidnih receptora |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10118921B2 (hr) |
| EP (1) | EP3233825B1 (hr) |
| JP (1) | JP6691135B2 (hr) |
| CN (1) | CN107531670B (hr) |
| AU (1) | AU2015363757B2 (hr) |
| CA (1) | CA2970256C (hr) |
| DK (1) | DK3233825T3 (hr) |
| ES (1) | ES2808667T3 (hr) |
| HR (1) | HRP20201050T1 (hr) |
| HU (1) | HUE050241T2 (hr) |
| LT (1) | LT3233825T (hr) |
| PL (1) | PL3233825T3 (hr) |
| PT (1) | PT3233825T (hr) |
| RS (1) | RS60744B1 (hr) |
| SI (1) | SI3233825T1 (hr) |
| WO (1) | WO2016099393A1 (hr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022013153A1 (en) | 2020-07-17 | 2022-01-20 | Pharmnovo Ab | Polymorphs of a hydrochloride salt of pn6047 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0101771D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101768D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0103313D0 (sv) | 2001-10-03 | 2001-10-03 | Astrazeneca Ab | Novel compounds |
| SE0300987D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
-
2015
- 2015-12-17 CN CN201580073559.XA patent/CN107531670B/zh active Active
- 2015-12-17 RS RS20200908A patent/RS60744B1/sr unknown
- 2015-12-17 SI SI201531296T patent/SI3233825T1/sl unknown
- 2015-12-17 LT LTEP15870465.0T patent/LT3233825T/lt unknown
- 2015-12-17 EP EP15870465.0A patent/EP3233825B1/en active Active
- 2015-12-17 CA CA2970256A patent/CA2970256C/en active Active
- 2015-12-17 AU AU2015363757A patent/AU2015363757B2/en active Active
- 2015-12-17 US US15/535,464 patent/US10118921B2/en active Active
- 2015-12-17 PL PL15870465T patent/PL3233825T3/pl unknown
- 2015-12-17 HU HUE15870465A patent/HUE050241T2/hu unknown
- 2015-12-17 DK DK15870465.0T patent/DK3233825T3/da active
- 2015-12-17 WO PCT/SE2015/051363 patent/WO2016099393A1/en active Application Filing
- 2015-12-17 PT PT158704650T patent/PT3233825T/pt unknown
- 2015-12-17 JP JP2017551989A patent/JP6691135B2/ja active Active
- 2015-12-17 ES ES15870465T patent/ES2808667T3/es active Active
-
2020
- 2020-07-03 HR HRP20201050TT patent/HRP20201050T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016099393A1 (en) | 2016-06-23 |
| EP3233825A1 (en) | 2017-10-25 |
| US10118921B2 (en) | 2018-11-06 |
| PL3233825T3 (pl) | 2020-11-02 |
| RS60744B1 (sr) | 2020-10-30 |
| AU2015363757B2 (en) | 2019-11-14 |
| DK3233825T3 (da) | 2020-06-29 |
| JP2018501314A (ja) | 2018-01-18 |
| CA2970256C (en) | 2022-03-29 |
| LT3233825T (lt) | 2020-08-10 |
| JP6691135B2 (ja) | 2020-04-28 |
| US20170327491A1 (en) | 2017-11-16 |
| CA2970256A1 (en) | 2016-06-23 |
| AU2015363757A1 (en) | 2017-08-03 |
| SI3233825T1 (sl) | 2020-10-30 |
| ES2808667T3 (es) | 2021-03-01 |
| PT3233825T (pt) | 2020-07-15 |
| EP3233825A4 (en) | 2018-08-15 |
| CN107531670B (zh) | 2020-12-15 |
| HUE050241T2 (hu) | 2020-11-30 |
| EP3233825B1 (en) | 2020-04-29 |
| CN107531670A (zh) | 2018-01-02 |
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