RU2017105845A - Устройство для назальной доставки лекарственных средств - Google Patents

Устройство для назальной доставки лекарственных средств Download PDF

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RU2017105845A
RU2017105845A RU2017105845A RU2017105845A RU2017105845A RU 2017105845 A RU2017105845 A RU 2017105845A RU 2017105845 A RU2017105845 A RU 2017105845A RU 2017105845 A RU2017105845 A RU 2017105845A RU 2017105845 A RU2017105845 A RU 2017105845A
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diffuser
composition
chamber
item
drug
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RU2017105845A
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RU2728583C2 (ru
RU2017105845A3 (ru
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Д. ХОКМАН Джон
Майкл ХАЙТ
Алан БРУНЕЛЛ
Джоэл РЕЛЕТФОРД
Родни Дж. Й. ХО
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Импел Ньюрофарма Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A61M16/201—Controlled valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/27—General characteristics of the apparatus preventing use
    • A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8218—Gas operated
    • A61M2205/8225—Gas operated using incorporated gas cartridges for the driving gas

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (35)

1. Устройство для доставки композиции в обонятельную область назальной полости, содержащее:
корпусной элемент, вмещающий контейнер для пропеллента под давлением, выпускной клапанный узел и соединительный канал в сообщении с выпускным клапанным узлом,
диффузор,
камеру для лекарственного средства, сообщающуюся с диффузором, при этом камера для лекарственного средства способна вмещать композицию,
сопло, сообщающееся с камерой для лекарственного средства, и
направляющий элемент, содержащий направляющую штангу, ручку направляющей штанги и ручку вращения, причем ручка направляющей штанги расположена смежно направляющей штанге и выполнена за одно целое с ручкой вращения, связанной с корпусным элементом.
2. Устройство по п.1, в котором диффузор является неоднородно пористым или однородно пористым.
3. Устройство по п.1, в котором диффузор представляет собой пористую фритту, выполненную в виде дисковидного элемента, содержащего по меньше мере один элемент конической формы, имеющий дистальное отверстие.
4. Устройство по п.1, в котором композиция является лекарством или диагностическим средством.
5. Устройство по п.4, в котором лекарство является оксимом.
6. Устройство по п.4, в котором диагностическое средство является агентом визуализации.
7. Устройство по п.1, дополнительно содержащее направляющий элемент.
8. Устройство по п.1, дополнительно содержащее отверстие для введения, сообщающееся с камерой для лекарственного средства и выполненное с возможностью приема введения композиции снаружи устройства в камеру для лекарственного средства.
9. Устройство по п.1, в котором диффузор продолжается в композицию в камере для лекарственного средства.
10. Устройство по п.1, в котором диффузор находится в сообщении с контейнером, способным вмещать пропеллент, причем диффузор выполнен с возможностью превращения пропеллента из жидкости в газ.
11. Устройство по п.1, в котором диффузор находится в сообщении с контейнером для пропеллента под давлением, способным вмещать пропеллент, причем диффузор представляет собой односторонний запорный клапан.
12. Устройство для доставки композиции в обонятельную область назальной полости, содержащее:
контейнер, способный вмещать пропеллент,
диффузор, сообщающийся с контейнером,
камеру для композиции, сообщающуюся с диффузором, при этом, камера для композиции способна вмещать композицию, и
диффузионную трубку, обеспечивающую канал между контейнером и пустым пространством в камере для композиции в обход композиции в камере для композиции, и
сопло, сообщающееся с камерой для композиции,
причем, устройство способно доставлять композицию в обонятельную область назальной полости.
13. Устройство по п.12, в котором диффузор находится в сообщении с диффузионной трубкой для действия в виде одностороннего запорного клапана.
14. Устройство по п.12, дополнительно содержащее:
корпусной элемент, и
направляющий элемент, содержащий направляющую штангу, ручку направляющей штанги и ручку вращения, причем ручка направляющей штанги расположена смежно направляющей штанге и выполнена за одно целое с ручкой вращения, связанной с корпусным элементом
15. Устройство по п.12, в котором диффузор является неоднородно пористым или однородно пористым.
16. Устройство по п.12, в котором диффузор представляет собой пористую фритту, выполненную в виде дисковидного элемента, содержащего по меньше мере один элемент конической формы, имеющий дистальное отверстие.
17. Устройство по п.12, в котором композиция является лекарством или диагностическим средством.
18. Устройство по п.17, в котором лекарство является оксимом.
19. Устройство по п.12, дополнительно содержащее направляющий элемент.
20. Устройство по п.12, дополнительно содержащее отверстие для введения, сообщающееся с камерой для лекарственного средства и выполненное с возможностью приема введения композиции снаружи устройства в камеру для лекарственного средства.
21. Устройство по п.12, в котором диффузор продолжается в композицию в камере для лекарственного средства.
22. Устройство по п.12, в котором диффузор находится в сообщении с контейнером, способным вмещать пропеллент, причем диффузор выполнен с возможностью превращения пропеллента из жидкости в газ.
RU2017105845A 2011-03-03 2012-03-05 Устройство для назальной доставки лекарственных средств RU2728583C2 (ru)

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US201161449008P 2011-03-03 2011-03-03
US61/449,008 2011-03-03
US201161451935P 2011-03-11 2011-03-11
US61/451,935 2011-03-11
US201161484025P 2011-05-09 2011-05-09
US61/498,025 2011-05-09
US201161498974P 2011-06-20 2011-06-20
US61/498,974 2011-06-20

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EP (3) EP4088769A1 (ru)
JP (1) JP6339371B2 (ru)
CN (1) CN103917265B (ru)
AU (3) AU2012223160B2 (ru)
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Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2728583C2 (ru) 2011-03-03 2020-07-30 Импел Ньюрофарма Инк. Устройство для назальной доставки лекарственных средств
RU2618084C2 (ru) 2011-05-09 2017-05-02 Импел Ньюрофарма Инк. Наконечники для назальной доставки лекарственных средств
US10537692B2 (en) 2013-04-28 2020-01-21 Impel Neuropharma, Inc. Medical unit dose container
GB201401659D0 (en) * 2014-01-31 2014-03-19 3M Innovative Properties Co Actuator for an inhaler
ES2721006T3 (es) * 2014-05-19 2019-07-26 Inhaletech Llc Dispositivo para administrar medicamentos al cerebro por vía nasal
US11559483B2 (en) * 2015-07-10 2023-01-24 Sanjay Gupta Nasal foam via cribriform plate for medication delivery to the brain and/or body and for nasal moisturization and hygiene
CA2998182A1 (en) 2015-09-10 2017-03-16 Impel Neuropharma, Inc. In-line nasal delivery device
EP3162404B1 (de) 2015-10-29 2018-02-14 W & H Dentalwerk Bürmoos GmbH Dentalmedizinische vorrichtung zur abgabe eines pulverförmigen mediums
EP3377089B1 (en) 2015-11-18 2020-04-08 Herantis Pharma Plc Compositions comprising cdnf for use in the intranasal treatment of central nervous system diseases
US10940274B2 (en) 2015-12-01 2021-03-09 Cipla Limited Nasal spray assembly
FR3046553B1 (fr) * 2016-01-07 2018-02-16 Aptar France Sas Ensemble de distribution nasale de produit fluide.
KR101978554B1 (ko) 2016-05-17 2019-05-16 한양대학교 산학협력단 비강-뇌 약물전달장치
WO2017205610A1 (en) * 2016-05-25 2017-11-30 University Of Florida Research Foundation, Inc. Use of angiotensin ii receptor agonists in the treatment and prevention of stroke
GB201619637D0 (en) 2016-11-21 2017-01-04 Pekna Marcela And Pekny Milos And Stokowska Anna C3a receptor agonists
CA3066361A1 (en) 2017-06-07 2018-12-13 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11559640B2 (en) 2017-09-15 2023-01-24 Shin Nippon Biomedical Laboratories, Ltd. Medicine storage cartridge with nozzle, sprayer therefor, and powdered medicine dispensing device for nasal cavity
US10368502B2 (en) 2017-09-25 2019-08-06 Multiple Energy Technologies Llc Bioceramic and carbon-based hydroponic systems, methods and devices
CN111556763B (zh) 2017-11-13 2023-09-01 施菲姆德控股有限责任公司 血管内流体运动装置、系统
KR102168749B1 (ko) * 2017-11-17 2020-10-22 한양대학교 산학협력단 비강을 통한 뇌 약물 전달 장치 및 비강을 통한 뇌 약물 전달 방법
CA3081680A1 (en) * 2017-11-21 2019-05-31 Impel Neuropharma, Inc. Intranasal device with inlet interface
US10391269B2 (en) * 2017-11-29 2019-08-27 Meshil A. M. O. H. Al-Jarba Nasal sprayer with multiple applicators
US11918646B2 (en) * 2017-12-11 2024-03-05 Board Of Regents, The University Of Texas System Dry adjuvanted immune stimulating compositions and use thereof for mucosal administration
CA3087698A1 (en) * 2018-01-05 2019-07-11 Impel Neuropharma, Inc. Intranasal delivery of olanzapine by precision olfactory device
CN111801141A (zh) * 2018-01-05 2020-10-20 英倍尔药业股份有限公司 通过精密鼻装置的左旋多巴粉末的鼻内递送
EP3735244B1 (en) * 2018-01-05 2022-11-23 Impel Pharmaceuticals Inc. Intranasal delivery of dihydroergotamine by precision olfactory device
EP3746149A4 (en) 2018-02-01 2021-10-27 Shifamed Holdings, LLC INTRAVASCULAR BLOOD PUMPS AND METHODS OF USE AND METHODS OF MANUFACTURING
MX2020010706A (es) * 2018-04-12 2021-01-20 Rocket Science Health Corp Proceso, sistema y dispositivo de entrega intranasal de medicamentos.
KR20210034047A (ko) 2018-07-19 2021-03-29 임펠 뉴로파마 인코포레이티드 파킨슨 병 치료를 위한 레보도파 및 도파 데카르복실라아제 저해제의 기도 전달
KR20210109007A (ko) * 2019-01-03 2021-09-03 임펠 뉴로파마 인코포레이티드 비강 약물 전달 장치
US11433063B1 (en) 2019-03-12 2022-09-06 Belhaven Biopharma, Inc. Intranasal composition of pharmaceutical countermeasures for chemical warfare nerve agents and accidental exposure to organophosphate pesticides
WO2021003467A1 (en) * 2019-07-04 2021-01-07 Sw Holdings, Inc. Metered dosing compositions and methods of use of psychedelic compounds
WO2021011473A1 (en) 2019-07-12 2021-01-21 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use
WO2021016372A1 (en) 2019-07-22 2021-01-28 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
CA3163594A1 (en) * 2020-01-22 2021-07-29 Worth LONGEST Air-jet dry powder inhaler for rapid delivery of pharmaceutical aerosols to infants
WO2021185343A1 (zh) * 2020-03-20 2021-09-23 江苏恒瑞医药股份有限公司 格列本脲脂质体组合物及其制备方法
WO2021191904A1 (en) * 2020-03-26 2021-09-30 Tree Of Life Pharma Ltd. Methods for preventing and treating viral infection
RU2745231C9 (ru) * 2020-06-08 2021-04-27 Акционерное общество "Столетика" Спрей-ингалятор с функцией приготовления и хранения лекарственных форм
GB202011729D0 (en) 2020-07-29 2020-09-09 Kindeva Drug Delivery Lp Device for delivery of a compound to a region of the nasal cavity
WO2022049077A1 (en) * 2020-09-01 2022-03-10 Janssen Pharmaceutica Nv Drug delivery device with a spinning nozzle
FR3120534B1 (fr) * 2021-03-09 2023-06-30 Aptar France Sas Tête de distribution nasale de produit fluide et dispositif comportant une telle tête
CN113491608B (zh) * 2021-05-18 2023-05-30 李富财 一种鼻整形术后定型用气动撑塞
US12005185B2 (en) 2021-12-17 2024-06-11 Belhaven BioPharma Inc. Medical counter measures including dry powder formulations and associated methods

Family Cites Families (211)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2574339A (en) * 1945-02-03 1951-11-06 Marshall L Lockhart Hypodermic syringe
GB806284A (en) 1955-11-14 1958-12-23 Chi Ah Lai A new or improved nasal inhaler
US3425414A (en) * 1965-05-28 1969-02-04 William J La Roche Inhalant dispenser
US3888253A (en) 1972-08-04 1975-06-10 Beecham Group Ltd Device for administration of medicines
FR2224175B1 (ru) 1973-04-04 1978-04-14 Isf Spa
GB1479283A (en) 1973-07-23 1977-07-13 Bespak Industries Ltd Inhaler for powdered medicament
US3971377A (en) 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
US3908654A (en) 1974-08-02 1975-09-30 Rit Rech Ind Therapeut Dispensing package for a dry biological and a liquid diluent
YU41046B (en) * 1974-08-22 1986-10-31 Schering Ag Medicine inholating device
US3998226A (en) 1975-09-22 1976-12-21 Edward G. Gomez Inhalation device for encapsulated concentrates
ZA758010B (en) 1975-11-14 1977-08-31 Syntex Inc Nasal spray adapter
SE408265B (sv) 1975-12-12 1979-06-05 Draco Ab Anordning for koldioxiddriven endosaerosol, avsedd for inhalering
US4095596A (en) 1976-11-26 1978-06-20 Smithkline Corporation Nasal inhaler
US4154309A (en) * 1977-11-14 1979-05-15 J & D Tool and Supply, Inc. Housing for fluid actuated hand tool
US4227522A (en) 1978-09-05 1980-10-14 Syntex Puerto Rico, Inc. Inhalation device
US4187985A (en) 1978-12-08 1980-02-12 The Continental Group, Inc. Aerosol valve for barrier type packages
IT1116047B (it) 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma
BR8007911A (pt) 1979-12-06 1981-06-16 Glaxo Group Ltd Inalador aperfeicoado
US4412573A (en) 1981-12-28 1983-11-01 Baxter Travenol Laboratories, Inc. Injection site
US4446990A (en) 1982-04-03 1984-05-08 David J. Stevenson Self-defense spray device
US4620670A (en) 1983-11-28 1986-11-04 Vortran Corporation Gas-powered nebulizer
WO1985002345A1 (en) 1983-11-28 1985-06-06 Vortran Corporation Single inlet prepackaged inhaler
EP0194258A1 (en) 1984-09-18 1986-09-17 Vortran Corporation All purpose nebulizer
DE3779310D1 (de) * 1987-08-12 1992-06-25 Brugger Stephan Transportables inhalationsgeraet.
US4896832A (en) 1987-09-07 1990-01-30 Bespak Plc Dispensing apparatus for metered quantities of pressurised fluid
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
US5624898A (en) 1989-12-05 1997-04-29 Ramsey Foundation Method for administering neurologic agents to the brain
SG45171A1 (en) * 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
IL98441A (en) 1990-06-14 1995-12-31 Rhone Poulenc Rorer Ltd Powder inhaler
DE4038049C2 (de) 1990-11-29 1994-12-01 Anschuetz & Co Gmbh Implantierbare Infusionspumpe
US5331954A (en) 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
IT1249600B (it) 1991-02-21 1995-03-09 Elettro Plastica Spa Erogatore nasale di sostanze farmaceutiche nebulizzate
US6681767B1 (en) 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
IT1250691B (it) 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
GB9125699D0 (en) 1991-12-03 1992-01-29 Glaxo Group Ltd Device
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
DE4239402A1 (de) * 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
US5899201A (en) * 1993-05-26 1999-05-04 Minnesota Mining And Manufacturing Company Aerosol actuator
GB9311892D0 (en) 1993-06-09 1993-07-28 Glaxo Wellcome Australia Ltd Device
US5349947A (en) 1993-07-15 1994-09-27 Newhouse Michael T Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow
US5516006A (en) 1993-07-30 1996-05-14 Meshberg; Philip Nasal dispenser
US5398850A (en) 1993-08-06 1995-03-21 River Medical, Inc. Gas delivery apparatus for infusion
IT1266794B1 (it) 1993-11-09 1997-01-21 Faustino Ballini Dispositivo a doccia micronizzata per il lavaggio delle cavita' nasali e limitrofe
DE4342174C1 (de) 1993-12-10 1995-05-11 Lohmann Therapie Syst Lts Transdermales therapeutisches System sowie ein Verfahren zur Herstellung eines transdermalen therapeutischen Systems zur kombinierten transdermalen Anwendung von Physostigmin und Scopolamin für die Prophylaxe und zur Vorbehandlung einer Vergiftung durch hochtoxische phosphororganische Nervengifte, insbesondere Soman und seine Verwendung
EP0759744B1 (en) 1994-05-13 2001-10-17 Aradigm Corporation Narcotic containing aerosol formulation
US5435282A (en) 1994-05-19 1995-07-25 Habley Medical Technology Corporation Nebulizer
JP3372105B2 (ja) 1994-05-26 2003-01-27 株式会社日立ユニシアオートモティブ 吸入式投薬器
US5901703A (en) 1995-02-06 1999-05-11 Unisia Jecs Corporation Medicine administering device for nasal cavities
DE19518580A1 (de) 1995-05-20 1996-11-21 Thomas Ossinger Lötbadtiegel
JPH08322934A (ja) 1995-05-29 1996-12-10 Unisia Jecs Corp 鼻腔用投薬器
DE19523516C1 (de) 1995-06-30 1996-10-31 Asta Medica Ag Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen
US5823183A (en) 1995-08-02 1998-10-20 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
GB9516984D0 (en) 1995-08-18 1995-10-18 Pharmasol Ltd Spray applicator
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5711488A (en) 1995-10-13 1998-01-27 The Procter & Gamble Company High pressure swirl atomizer
US6678553B2 (en) 1995-11-21 2004-01-13 Intraabrain International Nv Device for enhanced delivery of biologically active substances and compounds in an organism
US5797390A (en) 1996-03-06 1998-08-25 Mcsoley; Thomas E. Nasal inhaler having a directed spray pattern
US5875776A (en) 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
AUPN976496A0 (en) 1996-05-10 1996-05-30 Glaxo Wellcome Australia Ltd Unit dose dispensing device
US6595202B2 (en) 1996-05-13 2003-07-22 Universidad De Sevilla Device and method for creating aerosols for drug delivery
DE19622124A1 (de) 1996-06-01 1997-12-04 Alfred Von Schuckmann Gerät zum Aufbringen von Flüssigkeiten
US6158676A (en) 1996-06-21 2000-12-12 Hughes Technology Group, L.L.C. Micro-atomizing device
US5906198A (en) 1996-07-16 1999-05-25 Flickinger; William J. Nasal nebulizer
US6410046B1 (en) 1996-11-19 2002-06-25 Intrabrain International Nv Administering pharmaceuticals to the mammalian central nervous system
US7033598B2 (en) 1996-11-19 2006-04-25 Intrabrain International N.V. Methods and apparatus for enhanced and controlled delivery of a biologically active agent into the central nervous system of a mammal
US5824684A (en) * 1997-02-21 1998-10-20 Synapse Pharmaceuticals International, Inc. Method for treating drug and alcohol addiction
DE19704849B4 (de) 1997-02-08 2011-02-17 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für Medien
IS4516A (is) 1997-07-01 1999-01-02 Gizurarson Sveinbjörn Nýtt lyfjaform
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US6200293B1 (en) * 1997-08-27 2001-03-13 Science Incorporated Fluid delivery device with temperature controlled energy source
GB9719775D0 (en) 1997-09-18 1997-11-19 Glaxo Group Ltd Device
US6703374B1 (en) * 1997-10-30 2004-03-09 The United States Of America As Represented By The Department Of Health And Human Services Nucleosides for imaging and treatment applications
US5954696A (en) 1997-12-15 1999-09-21 B. Braun Medical, Inc. Pressure infusion pump
US7335186B2 (en) 1998-03-13 2008-02-26 Alexander George Brian O'Neil Patient controlled drug delivery device
US6113078A (en) 1998-03-18 2000-09-05 Lytesyde, Llc Fluid processing method
GB9805938D0 (en) * 1998-03-19 1998-05-13 Glaxo Group Ltd Valve for aerosol container
US6062213A (en) 1998-06-16 2000-05-16 Fuisz Technologies Ltd. Single unit dose inhalation therapy device
DE59911149D1 (de) 1998-07-24 2004-12-30 Jago Res Ag Muttenz Medizinische aerosolformulierungen
FR2782024B1 (fr) 1998-08-04 2000-10-13 Valois Sa Tete de distribution et dispositif de distribution de produit fluide comportant une telle tete
GB2345010B (en) 1998-12-17 2002-12-31 Electrosols Ltd A delivery device
US6294153B1 (en) 1998-12-21 2001-09-25 Generex Pharmaceuticals, Inc. Aerosol pharmaceutical formulation for pulmonary and nasal delivery
WO2000044432A1 (en) 1999-01-27 2000-08-03 Levin Bruce H Compositions, kits, apparatus, and methods for inhibiting cerebral neurovascular disorders and muscular headaches
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
GB0114272D0 (en) * 2001-06-12 2001-08-01 Optinose As Nasal delivery device
GB0121568D0 (en) 2001-09-06 2001-10-24 Optinose As Nasal delivery device
BR0008650B1 (pt) 1999-03-03 2010-12-28 dispositivo de transmissão via nasal.
JP2002538959A (ja) 1999-03-12 2002-11-19 グラクソ グループ リミテッド 計量弁
CO5241299A1 (es) 1999-03-17 2003-01-31 Emsar Inc Aparato y metodo para administrar una pulverizacion medicinal
WO2000057851A2 (en) 1999-03-26 2000-10-05 Pozen Inc. High potency dihydroergotamine compositions
DE19944209A1 (de) 1999-09-15 2001-03-22 Pfeiffer Erich Gmbh & Co Kg Spender zum ggf. zerstäubten Ausbringen eines insbesondere flüssigen Mediums aus einem Behältnis
US6211230B1 (en) * 1999-09-27 2001-04-03 The United States Of America As Represented By The Secretary Of The Army Method of reducing brain damage resulting from seizures
US6382204B1 (en) 1999-10-14 2002-05-07 Becton Dickinson And Company Drug delivery system including holder and drug container
DK1092447T3 (da) 1999-10-14 2004-05-10 Becton Dickinson Co Nasalafgivelsesindretning indbefattende en spröjtedyse
US6367471B1 (en) 1999-11-01 2002-04-09 Sheffield Pharmaceuticals, Inc. Internal vortex mechanism for inhaler device
CA2393688A1 (en) 1999-12-09 2001-06-14 Chiron Corporation Method for administering a cytokine to the central nervous system and the lymphatic system
US6810872B1 (en) 1999-12-10 2004-11-02 Unisia Jecs Corporation Inhalant medicator
US6302101B1 (en) 1999-12-14 2001-10-16 Daniel Py System and method for application of medicament into the nasal passage
US6734162B2 (en) 2000-01-24 2004-05-11 Minimed Inc. Mixed buffer system for stabilizing polypeptide formulations
US6585957B1 (en) 2000-01-25 2003-07-01 Aeropharm Technology Incorporated Medicinal aerosol formulation
US6540983B1 (en) 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
US6644305B2 (en) 2000-04-14 2003-11-11 Trudell Medical International Nasal inhaler
JP4684461B2 (ja) 2000-04-28 2011-05-18 パナソニック株式会社 磁性素子の製造方法
GB0015309D0 (en) 2000-06-21 2000-08-16 Djupesland Per G Apparatus
IT1317998B1 (it) 2000-06-26 2003-07-21 Medical Internat Licensing N V Valvola erogatrice per spray nasale.
IT1318646B1 (it) 2000-07-26 2003-08-27 Medical Internat Licensing N V Ugello pr somministrazioni e lavaggi nasali.
PL207845B1 (pl) 2000-07-31 2011-02-28 Nycomed Danmark As Spray donosowy do dostarczania kompozycji farmaceutycznej zawierającej fentanyl i zastosowanie soli fentanylu do wytwarzania środka leczniczego
US6596740B2 (en) 2000-10-24 2003-07-22 Richard L. Jones Nicotine mucosal spray
US6644309B2 (en) 2001-01-12 2003-11-11 Becton, Dickinson And Company Medicament respiratory delivery device and method
US6722364B2 (en) * 2001-01-12 2004-04-20 Becton, Dickinson And Company Medicament inhalation delivery devices and methods for using the same
WO2002056948A1 (en) * 2001-01-17 2002-07-25 Vectura Limited An inhaler device
ZA200306564B (en) 2001-02-26 2004-10-15 Optinose As Nasal devices.
WO2002074372A2 (en) * 2001-03-15 2002-09-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nebulizer having cooling chamber
GB0109002D0 (en) 2001-04-10 2001-05-30 Glaxo Group Ltd Dispenser
GB0109001D0 (en) 2001-04-10 2001-05-30 Glaxo Group Ltd Dispenser
EP1381417A4 (en) * 2001-04-26 2009-12-30 New England Pharm Inc DEVICE FOR RELEASING SATISFIED DOSHES OF LIQUID AND POWDERY MEDIUM
EP1392262A1 (en) 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
EP1279404A1 (en) 2001-07-26 2003-01-29 Istituto Superiore di Sanità Use of HIV-1 tat, fragments or derivatives thereof, to target or to activate antigen-presenting cells, to deliver cargo molecules for vaccination or to treat other diseases
US20030021775A1 (en) * 2001-07-27 2003-01-30 Ramot University Authority For Applied Research & Industrial Development Ltd. Device for and method of controlled enzymatic removal and retrieval of tissue
EP1450885B1 (en) 2001-09-28 2015-04-22 Kurve Technology, Inc. Nasal nebulizer
GB2380410B (en) 2001-10-05 2003-11-19 Alchemy Healthcare Ltd Apparatus for the nasal or oral delivery of a medicament
US7229593B1 (en) * 2001-10-25 2007-06-12 Sandia Corporation Portable vapor diffusion coefficient meter
US7021561B2 (en) 2001-12-18 2006-04-04 Becton, Dickinson And Company Spray device and method
GB2384190A (en) * 2002-01-22 2003-07-23 Bespak Plc Dispensing device for a powdered product
GB0204829D0 (en) 2002-03-01 2002-04-17 Glaxo Group Ltd A fluid dispensing device
US7666876B2 (en) 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
GB0207422D0 (en) 2002-03-28 2002-05-08 Optinose As Nasal devices
GB0209494D0 (en) 2002-04-25 2002-06-05 Optinose As Nasal devices
CA2485217C (en) 2002-05-06 2012-05-01 Thomas Jefferson University Insulin-associated peptides with effects on cerebral health
WO2003099359A1 (en) 2002-05-09 2003-12-04 Kurve Technology, Inc. Particle dispersion chamber for nasal nebulizer
US7220457B2 (en) 2002-06-06 2007-05-22 Anderson Steven R Air atomizing assembly and method and system of applying an air atomized material
GB0215270D0 (en) 2002-07-02 2002-08-14 Optinose As Nasal devices
GB0215904D0 (en) 2002-07-09 2002-08-21 Team Holdings Uk Ltd Drug delivery system and method
GB0217198D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicament dispenser
DE10241640A1 (de) * 2002-09-05 2004-03-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dosierinhalationsgerät, hierzu geeigneter Behälter, und System aus Dosierinhalationsgerät und Behälter
US6966990B2 (en) * 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
GB0309354D0 (en) 2003-04-24 2003-06-04 Glaxo Group Ltd Nozzle for a nasal inhaler
DE10321902A1 (de) 2003-05-06 2004-12-09 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für zumindest ein Medium
GB0313604D0 (en) * 2003-06-12 2003-07-16 Britannia Pharmaceuticals Ltd Delivery device for powdered medicament
GB0319119D0 (en) 2003-08-14 2003-09-17 Optinose As Delivery devices
GB0320171D0 (en) 2003-08-28 2003-10-01 Optinose As Delivery devices
WO2005023335A2 (en) 2003-09-05 2005-03-17 Kurve Technology, Inc. Integrated nebulizer and particle dispersing chamber for delivery of medicament
AU2004317954A1 (en) 2003-09-17 2005-10-13 Chiasma, Inc. Compositions capable of facilitating penetration across a biological barrier
GB0322284D0 (en) 2003-09-23 2003-10-22 Glaxo Group Ltd Medicament dispenser
ATE483488T1 (de) * 2004-04-02 2010-10-15 Us Gov Health & Human Serv Aerosolabgabesysteme
US7654997B2 (en) * 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat
WO2006004646A1 (en) 2004-06-28 2006-01-12 Nektar Therapeutics Aerosol formulation comprising nicotine salt
WO2006037636A2 (en) 2004-10-06 2006-04-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing powder
US7832394B2 (en) 2004-12-22 2010-11-16 Schechter Alan M Apparatus for dispensing pressurized contents
GB0503738D0 (en) 2005-02-23 2005-03-30 Optinose As Powder delivery devices
US20060198940A1 (en) 2005-03-04 2006-09-07 Mcmorrow David Method of producing particles utilizing a vibrating mesh nebulizer for coating a medical appliance, a system for producing particles, and a medical appliance
CN103462894A (zh) * 2005-03-16 2013-12-25 霍尼韦尔国际公司 药物递送制剂、装置和方法
US7638558B2 (en) 2005-04-01 2009-12-29 Intezyne Technologies, Inc. Polymeric micelles for drug delivery
US20060260606A1 (en) * 2005-05-18 2006-11-23 Coifman Robert E Inhalable formulations of amphotericin B and methods and devices for delivery thereof
GB0515592D0 (en) 2005-07-28 2005-09-07 Glaxo Group Ltd Nozzle for a nasal inhaler
US20070074722A1 (en) 2005-09-21 2007-04-05 Kurve Technology, Inc. Medicament delivery control, monitoring, and reporting system and method
JP4765526B2 (ja) * 2005-10-04 2011-09-07 オムロンヘルスケア株式会社 吸入器および吸入器用マウスピース
CN101466397A (zh) 2005-11-11 2009-06-24 奥罗根公司 给予胰岛素治疗与组织皱缩或萎缩有关的成人中枢神经系统疾病或病症的方法
WO2007064657A1 (en) 2005-11-29 2007-06-07 Alza Corporation Nasal delivery device for the delivery of a substance to the olfactory region
EP1792660A1 (en) * 2005-12-02 2007-06-06 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device
DE102006001113B3 (de) * 2006-01-09 2007-06-28 Pari GmbH Spezialisten für effektive Inhalation Aerosoltherapievorrichtung
US20070202051A1 (en) 2006-02-10 2007-08-30 Pari Gmbh Aerosols for sinunasal drug delivery
US8171929B2 (en) 2006-02-14 2012-05-08 Optinose As Delivery device and method
GB0604444D0 (en) 2006-03-06 2006-04-12 Optinose As Nasal devices
GB0605799D0 (en) 2006-03-23 2006-05-03 Optinose As Nasal delivery devices
US7841338B2 (en) * 2006-04-13 2010-11-30 Boehringer Ingelheim International Gmbh Dispensing device
GB2440316A (en) 2006-07-25 2008-01-30 Optinose As Nasal inhaler with scrubber
WO2008028092A2 (en) 2006-08-30 2008-03-06 Kurve Technology, Inc. Aerosol generating and delivery device
JP2010502388A (ja) 2006-09-06 2010-01-28 アボツト・レスピラトリー・エル・エル・シー 可変投与量のエアロゾル薬用キャニスター
US20080066739A1 (en) * 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
US8042536B1 (en) * 2006-10-18 2011-10-25 Care 2 Medical Nebulizer apparatus
EP1915986A1 (en) 2006-10-23 2008-04-30 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Lipid growth factor formulations
FR2908753B1 (fr) 2006-11-16 2011-11-11 Becton Dickinson France Dispositif pour delivrer automatiquement des doses successives de produit
WO2008067254A2 (en) 2006-11-27 2008-06-05 Abbott Respiratory Llc Nasal drug delivery device and method
GB0623728D0 (en) 2006-11-28 2007-01-10 Optinose As Delivery devices
GB0623732D0 (en) 2006-11-28 2007-01-10 Optinose As Powder delivery devices
US20100143503A1 (en) * 2006-12-22 2010-06-10 Ikaria, Inc. Combinations of nitric oxide and sulfide and methods of use and manufacture thereof
US8664364B2 (en) * 2007-01-24 2014-03-04 Carnegie Mellon University Optical biosensors
CA2677838C (en) 2007-02-11 2017-08-01 Map Pharmaceuticals, Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
US7845359B2 (en) * 2007-03-22 2010-12-07 Pierre Denain Artificial smoke cigarette
GB2448193A (en) 2007-04-05 2008-10-08 Optinose As Nasal delivery device
US8530463B2 (en) 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
JP2011504163A (ja) 2007-06-08 2011-02-03 ヘルスパートナーズ リサーチ ファウンデーション 中枢神経系への治療化合物の標的化を高めるための薬学的組成物および方法
US20090151722A1 (en) * 2007-07-06 2009-06-18 Vectura Delivery Devices Limited Inhaler
EP2030644A1 (en) * 2007-08-31 2009-03-04 PARI Pharma GmbH Aerosols for sinunasal drug delivery
GB0719299D0 (en) 2007-10-03 2007-11-14 Optinose As Nasal delivery devices
US20110053859A1 (en) 2007-10-10 2011-03-03 The U. S. Government Respresented by the Department of Veterans Affairs Methods to reduce the effects of sleep deprivation
WO2009100383A2 (en) * 2008-02-07 2009-08-13 University Of Washington Circumferential aerosol device
CA2715302A1 (en) 2008-02-15 2009-08-20 Timothy Sean Immel Aerosol therapy device with high frequency delivery
US8517026B2 (en) 2008-02-25 2013-08-27 Adva Beck Amon Nasal inserts
GB0803551D0 (en) 2008-02-26 2008-04-02 Microsharp Corp Ltd Prismatic lenses
JP2011518155A (ja) * 2008-04-15 2011-06-23 サーコード コーポレイション 免疫関連障害の局所治療に使用するためのエアゾール化ｌｆａ−１アンタゴニスト
NO329804B1 (no) 2009-02-09 2010-12-20 Fmc Kongsberg Subsea As Kobling for bruk i et stigeror, stigeror med en slik kobling og fremgangsmate for a oke operasjonsvinduet til et stigeror
EP2429495A4 (en) 2009-05-15 2014-01-22 Shin Nippon Biomedical Lab Ltd INTRANASAL PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PHARMACOKINETICS
US8839790B2 (en) 2009-07-29 2014-09-23 Adva Beck Arnon Nasal inserts
WO2011013003A2 (en) * 2009-07-31 2011-02-03 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
US8408427B2 (en) 2009-09-07 2013-04-02 Mk International Pty Ltd Single dose nasal spray pump
US8162921B2 (en) * 2009-12-08 2012-04-24 Medinvent, Llc Method and device for nasal irrigation and drug delivery
US8925544B2 (en) 2009-12-08 2015-01-06 Medinvent, Llc Portable nebulizer device
US20130142868A1 (en) 2010-08-20 2013-06-06 University Of Washington Circumferential Aerosol Device for Delivering Drugs to Olfactory Epithelium and Brain
JP5887355B2 (ja) 2010-11-29 2016-03-16 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 吸入器用の薬用モジュール
RU2728583C2 (ru) * 2011-03-03 2020-07-30 Импел Ньюрофарма Инк. Устройство для назальной доставки лекарственных средств
RU2618084C2 (ru) 2011-05-09 2017-05-02 Импел Ньюрофарма Инк. Наконечники для назальной доставки лекарственных средств
US8987199B2 (en) 2011-06-15 2015-03-24 Nerve Access, Inc. Pharmaceutical compositions for intranasal administration for the treatment of neurodegenerative disorders
DE102012201178B3 (de) 2012-01-27 2013-02-14 Aptar Radolfzell Gmbh Düseneinheit und Spender mit einer solchen
US20150216993A1 (en) * 2012-04-18 2015-08-06 The Regents Of The University Of Michigan Multifunctional small molecules
US20140056990A1 (en) 2012-08-24 2014-02-27 Vr1, Inc. Composition for the treatment of migraine headaches and methods thereof
DE102013100473A1 (de) 2013-01-17 2014-07-17 Seho Systemtechnik Gmbh Verfahren und Vorrichtung zum Reinigen einer Lötdüse
US10537692B2 (en) 2013-04-28 2020-01-21 Impel Neuropharma, Inc. Medical unit dose container
EP3049059B1 (en) 2013-09-24 2021-11-03 Satsuma Pharmaceuticals, Inc. Intranasal dhe formulation for the treatment of headache
US9603905B2 (en) 2014-03-13 2017-03-28 The Research Foundation For Mental Hygiene, Inc Intranasal insulin administration for the minimization of anesthesia-induced memory loss

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CA2828884A1 (en) 2012-09-07
AU2012223160A1 (en) 2013-09-12
RU2728583C2 (ru) 2020-07-30
CA2828884C (en) 2021-04-27
AU2016256665A1 (en) 2016-11-24
CA3111516C (en) 2023-05-23
RU2612506C2 (ru) 2017-03-09
AU2016256665B2 (en) 2018-11-08
BR112013022249B8 (pt) 2022-10-25
US10507295B2 (en) 2019-12-17
WO2012119153A2 (en) 2012-09-07
EP4088769A1 (en) 2022-11-16
EP2680913B1 (en) 2020-05-06
JP2014530637A (ja) 2014-11-20
EP3679971A1 (en) 2020-07-15
RU2017105845A3 (ru) 2020-05-25
CN103917265A (zh) 2014-07-09
AU2012223160A2 (en) 2013-12-05
US20200078544A1 (en) 2020-03-12
AU2012223160B2 (en) 2016-08-18
US20170043109A1 (en) 2017-02-16
US9550036B2 (en) 2017-01-24
RU2013144395A (ru) 2015-04-10
BR122021002471B1 (pt) 2022-06-14
CA3111516A1 (en) 2012-09-07
BR112013022249B1 (pt) 2022-04-12
JP6339371B2 (ja) 2018-06-06
US11730903B2 (en) 2023-08-22
AU2016256665B9 (en) 2018-11-22
BR112013022249A2 (pt) 2020-04-28
CN103917265B (zh) 2017-02-15

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