JP6339371B2 - 経鼻薬物送達デバイス - Google Patents
経鼻薬物送達デバイス Download PDFInfo
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- JP6339371B2 JP6339371B2 JP2013556677A JP2013556677A JP6339371B2 JP 6339371 B2 JP6339371 B2 JP 6339371B2 JP 2013556677 A JP2013556677 A JP 2013556677A JP 2013556677 A JP2013556677 A JP 2013556677A JP 6339371 B2 JP6339371 B2 JP 6339371B2
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- diffuser
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- propellant
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/073—Syringe, piston type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/27—General characteristics of the apparatus preventing use
- A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8218—Gas operated
- A61M2205/8225—Gas operated using incorporated gas cartridges for the driving gas
Description
本出願は、2011年3月3日に出願の米国特許出願第61/449,008号、2011年3月11日に出願の米国特許出願第61/451,935号、2011年5月9日に出願の米国特許出願第61/484,025号、および2011年6月20日に出願の米国特許出願第61/498,974号に対する優先権を主張するものであり、参照によりそれらの内容全体が本明細書に組み込まれる。
本発明は、米国陸軍のSBIR助成金第W81XWH−10−C−0238号に従い、米国政府の支援によって成されたものである。政府は、本発明において特定の権利を有し得る。
Claims (14)
- 鼻腔の嗅上皮に化合物を送達するためのデバイスであって、
推進剤を収容することができる容器であって、前記推進剤は加圧液体である、該容器と、
前記容器と連通している拡散器であって、前記拡散器は、多孔質であり、および前記加圧液体の前記推進剤をガスに変換する、該拡散器と、
前記拡散器と連通している化合物チャンバであって、前記化合物を収容することができる、化合物チャンバと、
前記化合物チャンバと連通しているノズルと、を備え、
前記鼻腔の前記嗅上皮に前記化合物を送達することができることを特徴とするデバイス。 - 前記化合物は、オキシムであることを特徴とする請求項1に記載のデバイス。
- 前記拡散器は、多孔質部材またはフィルタであることを特徴とする請求項1に記載のデバイス。
- 前記推進剤は前記加圧液体のヒドロフルオロアルカンであって、
前記加圧液体のヒドロフルオロアルカンは、前記デバイスが作動すると、前記容器から放出され、前記拡散器と連通し、それによって、前記加圧液体のヒドロフルオロアルカンはガス状ヒドロフルオロアルカンに変換されることを特徴とする請求項1に記載のデバイス。 - 前記加圧液体のヒドロフルオロアルカンの一部はガス状ヒドロフルオロアルカンに変換されることを特徴とする請求項4に記載のデバイス。
- 前記加圧液体のヒドロフルオロアルカンの大部分はガス状ヒドロフルオロアルカンに変換されることを特徴とする請求項4に記載のデバイス。
- 前記容器は、シリンジ、シレット、またはバレルであることを特徴とする請求項1に記載のデバイス。
- 照準ガイドをさらに備えたことを特徴とする請求項1に記載のデバイス。
- 前記化合物チャンバと連通している挿入ポートをさらに備え、前記挿入ポートは、前記デバイスの外側から前記化合物チャンバに、化合物が挿入されるように構成されたことを特徴とする請求項1に記載のデバイス。
- 前記拡散器は、不均一に多孔質であることを特徴とする請求項1に記載のデバイス。
- 前記拡散器は、均一に多孔質であることを特徴とする請求項1に記載のデバイス。
- 前記拡散器は、前記化合物チャンバの中の前記化合物の中へ延在したことを特徴とする請求項1に記載のデバイス。
- 前記拡散器は、遠位開口を有する円錐形部材を含む、円板形部材であることを特徴とする請求項1に記載のデバイス。
- 前記オキシムは、2−ピリジンアルドキシムメチルクロリド、1,1−メチレンビス[4-[(ヒドロキシイミノ)メチル)]−ピリジニウム]ジメタンスルホナート、1−(2−ヒドロ ヒドロキシイミノメチルピリジニウム)−3−(4−カルバモイルピリジニウム)−2−オキサプロパン ジクロリド、トリメドキシムの中の少なくとも一つまたは、Hlo7であることを特徴とする請求項2に記載のデバイス。
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161449008P | 2011-03-03 | 2011-03-03 | |
US61/449,008 | 2011-03-03 | ||
US201161451935P | 2011-03-11 | 2011-03-11 | |
US61/451,935 | 2011-03-11 | ||
US201161484025P | 2011-05-09 | 2011-05-09 | |
US61/484,025 | 2011-05-09 | ||
US201161498974P | 2011-06-20 | 2011-06-20 | |
US61/498,974 | 2011-06-20 | ||
PCT/US2012/027754 WO2012119153A2 (en) | 2011-03-03 | 2012-03-05 | Nasal drug delivery device |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2014530637A JP2014530637A (ja) | 2014-11-20 |
JP2014530637A5 JP2014530637A5 (ja) | 2015-04-02 |
JP6339371B2 true JP6339371B2 (ja) | 2018-06-06 |
Family
ID=46758525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013556677A Active JP6339371B2 (ja) | 2011-03-03 | 2012-03-05 | 経鼻薬物送達デバイス |
Country Status (9)
Country | Link |
---|---|
US (3) | US9550036B2 (ja) |
EP (3) | EP3679971B1 (ja) |
JP (1) | JP6339371B2 (ja) |
CN (1) | CN103917265B (ja) |
AU (3) | AU2012223160B2 (ja) |
BR (2) | BR122021002471B8 (ja) |
CA (2) | CA2828884C (ja) |
RU (2) | RU2728583C2 (ja) |
WO (1) | WO2012119153A2 (ja) |
Cited By (5)
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US10722631B2 (en) | 2018-02-01 | 2020-07-28 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
US11185677B2 (en) | 2017-06-07 | 2021-11-30 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
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