RU2016151316A3 - - Google Patents

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RU2016151316A3
RU2016151316A3 RU2016151316A RU2016151316A RU2016151316A3 RU 2016151316 A3 RU2016151316 A3 RU 2016151316A3 RU 2016151316 A RU2016151316 A RU 2016151316A RU 2016151316 A RU2016151316 A RU 2016151316A RU 2016151316 A3 RU2016151316 A3 RU 2016151316A3
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Russia
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RU2016151316A
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RU2694327C2 (ru
RU2016151316A (ru
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062General methods for three-dimensional culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0037Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/28Constructional details, e.g. recesses, hinges disposable or single use
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/58Reaction vessels connected in series or in parallel
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16Vibrating; Shaking; Tilting
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10Perfusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0031Serum-free culture media
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0681Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2511/00Cells for large scale production

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
RU2016151316A 2014-06-09 2015-06-08 Способ культивирования в системе посевных ферментеров (варианты) RU2694327C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462009553P 2014-06-09 2014-06-09
US62/009,553 2014-06-09
PCT/US2015/034709 WO2015191462A1 (en) 2014-06-09 2015-06-08 Seed train processes and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2019119708A Division RU2786997C2 (ru) 2014-06-09 2015-06-08 Процессы культивирования в системе посевных ферментеров и способы их применения

Publications (3)

Publication Number Publication Date
RU2016151316A RU2016151316A (ru) 2018-07-10
RU2016151316A3 true RU2016151316A3 (enExample) 2018-11-15
RU2694327C2 RU2694327C2 (ru) 2019-07-11

Family

ID=53477008

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016151316A RU2694327C2 (ru) 2014-06-09 2015-06-08 Способ культивирования в системе посевных ферментеров (варианты)

Country Status (18)

Country Link
US (2) US10570367B2 (enExample)
EP (3) EP3858983B1 (enExample)
JP (3) JP6784600B2 (enExample)
KR (2) KR102416402B1 (enExample)
CN (2) CN106574249B (enExample)
AU (3) AU2015274897B2 (enExample)
BR (1) BR112016028891B1 (enExample)
CA (1) CA2951551C (enExample)
CY (1) CY1122803T1 (enExample)
DK (1) DK3152299T3 (enExample)
ES (2) ES3043610T3 (enExample)
HU (1) HUE047683T2 (enExample)
IL (3) IL290096B2 (enExample)
MX (2) MX373323B (enExample)
RU (1) RU2694327C2 (enExample)
SG (1) SG11201610216UA (enExample)
TW (3) TWI776235B (enExample)
WO (1) WO2015191462A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2958988A2 (en) 2013-02-22 2015-12-30 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
HUE042094T2 (hu) 2013-02-22 2019-06-28 Genzyme Corp Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TWI776235B (zh) 2014-06-09 2022-09-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
CA2971861C (en) 2014-12-22 2024-02-13 Genzyme Corporation Methods of culturing a mammalian cell
EP3368176A2 (en) * 2015-10-26 2018-09-05 Lonza Limited A manufacturing facility for the production of biopharmaceuticals
WO2018116967A1 (ja) * 2016-12-22 2018-06-28 東亞合成株式会社 接着剤組成物並びにこれを用いたカバーレイフィルム、ボンディングシート、銅張積層板及び電磁波シールド材
US20200255785A1 (en) * 2017-09-15 2020-08-13 Bristol-Myers Squibb Company Online biomass capacitance monitoring during large scale production of polypeptides of interest
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
US12071607B2 (en) * 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
EP3650528A1 (en) 2018-11-08 2020-05-13 Aglaris Ltd Cell culture system and method
JP7365419B2 (ja) * 2019-01-25 2023-10-19 エンゼン・バイオサイエンシズ・リミテッド 治療用タンパク質を生産するための自動化統合連続システム及びバイオプロセス
SG11202107441RA (en) * 2019-02-15 2021-08-30 Just Evotec Biologics Inc Automated biomanufacturing systems, facilities, and processes
EP3976762A1 (en) * 2019-05-24 2022-04-06 Rubius Therapeutics, Inc. Methods of generating enucleated erythroid cells
GB201908612D0 (en) * 2019-06-17 2019-07-31 Ge Healthcare Bio Sciences Ab A method for separating biomolecules
US11713442B2 (en) * 2019-06-17 2023-08-01 Deka Products Limited Partnership System and method for cell and tissue preparation
CN114127260A (zh) * 2019-07-16 2022-03-01 信达生物制药(苏州)有限公司 高密度连续接种的细胞培养方法及其应用
EP3831924A1 (en) * 2019-12-03 2021-06-09 Sartorius Stedim Data Analytics AB Adapting control of a cell culture in a production scale vessel with regard to a starting medium
TW202405159A (zh) * 2022-06-28 2024-02-01 美商安進公司 用於治療性產品製造的靈活的設施配置
JP2025527931A (ja) * 2022-09-06 2025-08-22 アムジェン インコーポレイテッド 大規模バイオリアクタシステム及び方法
IL322954A (en) * 2023-03-13 2025-10-01 Amgen Inc Systems and methods for optimizing seed crops

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
RU2058992C1 (ru) * 1993-07-14 1996-04-27 Антипин Георгий Васильевич Способ получения кормового белка и устройство для его осуществления
DE19612966B4 (de) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
RU2215748C2 (ru) * 1999-04-09 2003-11-10 Сентро Де Инмунология Молекулар Способ получения рекомбинантного эритропоэтина человека и полученный эритропоэтин, фармацевтическая композиция
US6585971B1 (en) 1999-11-12 2003-07-01 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
ES2276853T3 (es) 2000-12-20 2007-07-01 Bayer Pharmaceuticals Corporation Dispositivo y procedimiento para expansion en serie de semillas de celulas de mamifero.
JP2005509406A (ja) 2001-05-09 2005-04-14 バイエル・フアーマシユーチカルズ・コーポレーシヨン 哺乳動物細胞株のための低温保存袋アセンブリー
AU2002333739B2 (en) 2001-08-31 2007-08-02 Bayer Intellectual Property Gmbh A unit and a process for carrying out high cell density fermentation
HUP0402158A2 (hu) 2001-10-02 2005-01-28 Novo Nordisk Health Care Ag Rekombináns fehérjék előállítási eljárása eukarióta sejtekben
AU2002348151A1 (en) 2001-11-05 2003-05-19 Genvec, Inc. Viral vector production methods and compositions
US6953692B2 (en) * 2001-12-18 2005-10-11 Bayer Pharmaceuticals Corporation Device and method for seed-train expansion of mammalian cells
US20050019914A1 (en) * 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
BE1016538A3 (fr) 2004-02-20 2007-01-09 Cesco Bioengineering Co Ltd Appareil et procede pour la preparation et la mise en culture de cellules.
TWI384069B (zh) * 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
EP1789528A4 (en) 2004-09-16 2011-07-20 Becton Dickinson Co BIOREACTOR FOR CULTIVATION OF CELLS UNDER PERFUSION
NZ588616A (en) 2004-09-30 2012-05-25 Bayer Healthcare Llc An apparatus for separating a protein of interest comprising a purification system integrated with a particle removal system
US20080199958A1 (en) 2005-06-15 2008-08-21 Amprotein Corporation Suspension Culture Vessels
WO2006138143A1 (en) 2005-06-15 2006-12-28 Amprotein Corporation Suspension culture vessels
WO2008024769A2 (en) 2006-08-21 2008-02-28 Raven Biotechnologies, Inc. Intensified perfusion production method
US20080207487A1 (en) 2006-11-02 2008-08-28 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
WO2008106515A1 (en) 2007-02-27 2008-09-04 The Board Of Trustees Of The University Of Illinois Insert device for multiwell plate
DK2126093T3 (da) * 2007-03-02 2013-01-07 Boehringer Ingelheim Pharma Forbedring af proteinfremstilling
CN101678244B (zh) 2007-04-17 2013-06-19 深度控股有限公司 用于连续膜吸附的方法和装置
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
EP2188371B1 (en) 2007-08-09 2017-12-20 Wyeth LLC Use of perfusion to enhance production of fed-batch cell culture in bioreactors
WO2009034186A2 (en) 2007-09-13 2009-03-19 Helmholtz-Zentrum für Infektionsforschung GmbH Process for cell cultivation
US20090233334A1 (en) 2008-03-11 2009-09-17 Excellgene Sa Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale
DE102008019691A1 (de) 2008-04-15 2009-10-29 Technische Universität Ilmenau Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion
US20100076380A1 (en) 2008-06-16 2010-03-25 Amprotein Corporation Bioreactors
US8728479B2 (en) 2009-03-31 2014-05-20 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
MX382080B (es) 2009-07-06 2025-03-13 Genentech Inc Método para cultivar células eucariónticas.
US20130260419A1 (en) * 2010-12-06 2013-10-03 Thomas C. Ransohoff Continuous processing methods for biological products
SG191745A1 (en) 2011-01-17 2013-08-30 Hoffmann La Roche Separation apparatus and use thereof
EP2707488B1 (en) 2011-05-12 2017-11-15 ProBioGen AG Enhancement of protein production yield mediated by a fast shuttling cdc42 gtpase
IL315908A (en) * 2011-07-01 2024-11-01 Amgen Inc Mammalian cell culture
AR089231A1 (es) * 2011-12-15 2014-08-06 Amgen Inc Metodo de floculacion
WO2013116449A1 (en) 2012-02-02 2013-08-08 Corning Incorporated Automatic continuous perfusion cell culture microplate consumables
SG10201607963SA (en) 2012-04-01 2016-11-29 Emd Millipore Corp Cell culture and gradient migration assay method and devices
CN104903436B (zh) 2012-10-23 2018-03-30 建新公司 灌注培养方法及其用途
HUE042094T2 (hu) 2013-02-22 2019-06-28 Genzyme Corp Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk
EP2958988A2 (en) 2013-02-22 2015-12-30 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
CN118388581A (zh) 2013-03-08 2024-07-26 建新公司 治疗性蛋白药物物质的整合连续制造
US10188099B2 (en) 2013-03-15 2019-01-29 Genzyme Corporation High density cell banking methods
BR122021001466B1 (pt) 2013-09-16 2021-10-13 Genzyme Corporation Sistema de filtração de circuito aberto
JP2017500017A (ja) * 2013-12-20 2017-01-05 バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
EA039148B1 (ru) 2014-06-04 2021-12-10 Эмджен Инк. Способ сбора рекомбинантного белка
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TWI776235B (zh) 2014-06-09 2022-09-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
CN104450597B (zh) 2014-12-10 2020-07-28 青岛农业大学 一种石油降解菌固体菌剂的制备方法及由其制备的固体菌剂修复石油污染的土壤的方法
CA2971861C (en) 2014-12-22 2024-02-13 Genzyme Corporation Methods of culturing a mammalian cell

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Publication number Publication date
US20200377850A1 (en) 2020-12-03
MX373323B (es) 2020-05-04
TW201610148A (zh) 2016-03-16
CN111575225A (zh) 2020-08-25
KR20170015472A (ko) 2017-02-08
RU2019119708A (ru) 2019-07-03
JP7360504B2 (ja) 2023-10-12
ES2773630T3 (es) 2020-07-13
ES3043610T3 (en) 2025-11-25
AU2021245116B2 (en) 2023-07-27
IL290096B1 (en) 2023-12-01
BR112016028891A2 (pt) 2017-08-22
AU2023203734A1 (en) 2023-07-06
RU2694327C2 (ru) 2019-07-11
WO2015191462A1 (en) 2015-12-17
MX2020004073A (es) 2020-07-29
CN106574249B (zh) 2020-05-08
EP3628730A1 (en) 2020-04-01
IL290096B2 (en) 2024-04-01
TW202102658A (zh) 2021-01-16
CN106574249A (zh) 2017-04-19
JP7089000B2 (ja) 2022-06-21
BR112016028891B1 (pt) 2023-04-11
EP3858983B1 (en) 2025-07-16
IL281626A (en) 2021-05-31
CA2951551A1 (en) 2015-12-17
AU2015274897B2 (en) 2021-11-04
KR102416402B1 (ko) 2022-07-04
JP2022120031A (ja) 2022-08-17
AU2015274897A1 (en) 2017-01-12
US20150353896A1 (en) 2015-12-10
MX2016016301A (es) 2017-04-06
CY1122803T1 (el) 2021-05-05
JP2017521057A (ja) 2017-08-03
IL249452B (en) 2021-04-29
HUE047683T2 (hu) 2020-05-28
TWI776235B (zh) 2022-09-01
JP2021019621A (ja) 2021-02-18
CA2951551C (en) 2023-02-28
EP3152299B1 (en) 2019-11-20
IL281626B (en) 2022-03-01
IL249452A0 (en) 2017-02-28
JP6784600B2 (ja) 2020-11-11
CN111575225B (zh) 2023-09-08
US10570367B2 (en) 2020-02-25
EP3858983C0 (en) 2025-07-16
DK3152299T3 (da) 2020-02-24
RU2016151316A (ru) 2018-07-10
KR102584375B1 (ko) 2023-09-27
EP3858983A1 (en) 2021-08-04
AU2021245116A1 (en) 2021-10-28
KR20220098051A (ko) 2022-07-08
TWI707949B (zh) 2020-10-21
EP3152299A1 (en) 2017-04-12
TW202246486A (zh) 2022-12-01
SG11201610216UA (en) 2017-01-27
IL290096A (en) 2022-03-01

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