ES2773630T3 - Procesos encadenados de inóculo y usos de los mismos - Google Patents

Procesos encadenados de inóculo y usos de los mismos Download PDF

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Publication number
ES2773630T3
ES2773630T3 ES15730933T ES15730933T ES2773630T3 ES 2773630 T3 ES2773630 T3 ES 2773630T3 ES 15730933 T ES15730933 T ES 15730933T ES 15730933 T ES15730933 T ES 15730933T ES 2773630 T3 ES2773630 T3 ES 2773630T3
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Prior art keywords
cells
approximately
days
cell
culture medium
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English (en)
Spanish (es)
Inventor
Michael Bruninghaus
Konstantin Konstantinov
Benjamin Wright
Weichang Zhou
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Genzyme Corp
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Genzyme Corp
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10Perfusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/28Constructional details, e.g. recesses, hinges disposable or single use
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/58Reaction vessels connected in series or in parallel
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16Vibrating; Shaking; Tilting
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0031Serum-free culture media
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0037Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062General methods for three-dimensional culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0681Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00Cells for large scale production

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES15730933T 2014-06-09 2015-06-08 Procesos encadenados de inóculo y usos de los mismos Active ES2773630T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462009553P 2014-06-09 2014-06-09
PCT/US2015/034709 WO2015191462A1 (en) 2014-06-09 2015-06-08 Seed train processes and uses thereof

Publications (1)

Publication Number Publication Date
ES2773630T3 true ES2773630T3 (es) 2020-07-13

Family

ID=53477008

Family Applications (2)

Application Number Title Priority Date Filing Date
ES15730933T Active ES2773630T3 (es) 2014-06-09 2015-06-08 Procesos encadenados de inóculo y usos de los mismos
ES21161811T Active ES3043610T3 (en) 2014-06-09 2015-06-08 Seed train processes and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES21161811T Active ES3043610T3 (en) 2014-06-09 2015-06-08 Seed train processes and uses thereof

Country Status (18)

Country Link
US (2) US10570367B2 (enExample)
EP (3) EP3858983B1 (enExample)
JP (3) JP6784600B2 (enExample)
KR (2) KR102584375B1 (enExample)
CN (2) CN111575225B (enExample)
AU (3) AU2015274897B2 (enExample)
BR (1) BR112016028891B1 (enExample)
CA (1) CA2951551C (enExample)
CY (1) CY1122803T1 (enExample)
DK (1) DK3152299T3 (enExample)
ES (2) ES2773630T3 (enExample)
HU (1) HUE047683T2 (enExample)
IL (3) IL290096B2 (enExample)
MX (2) MX373323B (enExample)
RU (1) RU2694327C2 (enExample)
SG (1) SG11201610216UA (enExample)
TW (3) TWI707949B (enExample)
WO (1) WO2015191462A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201806083RA (en) 2013-02-22 2018-08-30 Genzyme Corp Microcarrier perfusion culturing methods and uses thereof
HUE042094T2 (hu) 2013-02-22 2019-06-28 Genzyme Corp Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TWI707949B (zh) 2014-06-09 2020-10-21 美商健臻公司 種子罐培養法(seed train processes)及其用途
SG10202001034PA (en) 2014-12-22 2020-04-29 Genzyme Corp Methods of culturing a mammalian cell
EP3368176A2 (en) * 2015-10-26 2018-09-05 Lonza Limited A manufacturing facility for the production of biopharmaceuticals
US11624009B2 (en) * 2016-12-22 2023-04-11 Toagosei Co., Ltd. Adhesive composition, and coverlay film, bonding sheet, copper-clad laminate and electromagnetic shielding material, each using said adhesive composition
JP2020533983A (ja) * 2017-09-15 2020-11-26 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 目的のポリペプチドのラージスケールの製造間のオンラインバイオマス静電容量モニタリング
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
US12071607B2 (en) * 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
EP3650528A1 (en) * 2018-11-08 2020-05-13 Aglaris Ltd Cell culture system and method
JP7365419B2 (ja) * 2019-01-25 2023-10-19 エンゼン・バイオサイエンシズ・リミテッド 治療用タンパク質を生産するための自動化統合連続システム及びバイオプロセス
JP2022520793A (ja) * 2019-02-15 2022-04-01 ジャスト-エヴォテック バイオロジックス、インコーポレイテッド 自動バイオ製造システム、施設、及びプロセス
CA3141315A1 (en) * 2019-05-24 2020-12-03 Rubius Therapeutics, Inc. Methods of generating enucleated erythroid cells
GB2629063B (en) * 2019-06-17 2025-02-12 Deka Products Lp System and method for cell and tissue preparation
GB201908612D0 (en) * 2019-06-17 2019-07-31 Ge Healthcare Bio Sciences Ab A method for separating biomolecules
JP7680418B2 (ja) * 2019-07-16 2025-05-20 イノベント バイオロジクス(スーチョウ)カンパニー,リミティド 高密度連続接種の細胞培養方法及びその応用
EP3831924A1 (en) * 2019-12-03 2021-06-09 Sartorius Stedim Data Analytics AB Adapting control of a cell culture in a production scale vessel with regard to a starting medium
IL316781A (en) * 2022-06-28 2025-01-01 Amgen Inc Flexible facility configurations for medical product manufacturing
AU2023338692A1 (en) * 2022-09-06 2025-02-20 Amgen Inc. Large scale bioreactor system and method
EP4680716A2 (en) * 2023-03-13 2026-01-21 Amgen Inc. Systems and methods for seed train optimization
WO2026033566A2 (en) 2024-08-09 2026-02-12 Omnibrx Biotechnologies Private Limited A multistage bioreactor system and method thereof
GB202414239D0 (en) * 2024-09-27 2024-11-13 St Andrews Pharmaceutical Tech Limited Method and/or apparatus for producing a cell inoculum for use in a biomanufacturing or cell culture process

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
RU2058992C1 (ru) * 1993-07-14 1996-04-27 Антипин Георгий Васильевич Способ получения кормового белка и устройство для его осуществления
DE19612966B4 (de) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
RU2215748C2 (ru) 1999-04-09 2003-11-10 Сентро Де Инмунология Молекулар Способ получения рекомбинантного эритропоэтина человека и полученный эритропоэтин, фармацевтическая композиция
US6585971B1 (en) 1999-11-12 2003-07-01 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
JP4176472B2 (ja) * 2000-12-20 2008-11-05 バイエル・フアーマシユーチカルズ・コーポレーシヨン 哺乳動物細胞の種連続増殖(seed−trainexpansion)のための装置及び方法
JP2005509406A (ja) * 2001-05-09 2005-04-14 バイエル・フアーマシユーチカルズ・コーポレーシヨン 哺乳動物細胞株のための低温保存袋アセンブリー
DK1451290T3 (da) 2001-08-31 2011-04-26 Bayer Schering Pharma Ag Indretning og fremgangsmåde til udførelse af fermentering af høj celledensitet
EP1434857B1 (en) 2001-10-02 2007-08-01 Novo Nordisk Health Care AG Method for production of recombinant proteins in eukaryote cells
AU2002348151A1 (en) 2001-11-05 2003-05-19 Genvec, Inc. Viral vector production methods and compositions
US6953692B2 (en) * 2001-12-18 2005-10-11 Bayer Pharmaceuticals Corporation Device and method for seed-train expansion of mammalian cells
US20050019914A1 (en) 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
GB2411178B8 (en) 2004-02-20 2008-07-11 Cesco Bioengineering Co Ltd Apparatus and method for preparing and culturing cells
TWI384069B (zh) * 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
CA2579680A1 (en) 2004-09-16 2006-03-30 Becton, Dickinson And Company Perfusion bioreactor for culturing cells
PL1807101T3 (pl) 2004-09-30 2016-11-30 Urządzenia i sposoby do zintegrowanego wytwarzania cząsteczek biologicznych w sposób ciągły
ES2662589T3 (es) 2005-06-15 2018-04-09 Zhejiang Jinyishengshi Bioengineering Co., Ltd. Recipientes para cultivo en suspensión
WO2006138143A1 (en) 2005-06-15 2006-12-28 Amprotein Corporation Suspension culture vessels
US20080206819A1 (en) 2006-08-21 2008-08-28 Mary Tsao Intensified Perfusion Production Method
US20080207487A1 (en) 2006-11-02 2008-08-28 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
US8501462B2 (en) 2007-02-27 2013-08-06 The Board Of Trustees Of The University Of Illinois Insert device for multiwell plate
NZ580043A (en) * 2007-03-02 2012-04-27 Boehringer Ingelheim Pharma Improvement of protein production through increased expression of mutated start domain protein cert
JP5140721B2 (ja) 2007-04-17 2013-02-13 イクスエンド、ホールディング、ベスローテン、フェンノートシャップ 連続メンブレン吸着方法および装置
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
ES2657055T3 (es) 2007-08-09 2018-03-01 Wyeth Llc Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores
WO2009034186A2 (en) 2007-09-13 2009-03-19 Helmholtz-Zentrum für Infektionsforschung GmbH Process for cell cultivation
US20090233334A1 (en) 2008-03-11 2009-09-17 Excellgene Sa Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale
DE102008019691A1 (de) 2008-04-15 2009-10-29 Technische Universität Ilmenau Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion
WO2010005746A1 (en) 2008-06-16 2010-01-14 Amprotein Corporation Bioreactors
WO2010120514A2 (en) 2009-03-31 2010-10-21 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
BR112012000242B1 (pt) * 2009-07-06 2019-07-09 Genentech Inc Métodos para cultivo em batelada de células eucariontes
JP2013544524A (ja) * 2010-12-06 2013-12-19 ターポン バイオシステムズ,インコーポレイテッド 生物学的生成物の連続プロセス法
EP4036207B1 (en) 2011-01-17 2025-10-22 F. Hoffmann-La Roche AG Use of a separation apparatus in a seed train
EP2707488B1 (en) 2011-05-12 2017-11-15 ProBioGen AG Enhancement of protein production yield mediated by a fast shuttling cdc42 gtpase
PT2837680T (pt) * 2011-07-01 2020-04-17 Amgen Inc Cultura celular de mamífero
AR089231A1 (es) * 2011-12-15 2014-08-06 Amgen Inc Metodo de floculacion
US20150004686A1 (en) 2012-02-02 2015-01-01 Corning Incorporated Automatic continuous perfusion cell culture microplate consumables
JP2015517804A (ja) 2012-04-01 2015-06-25 イー・エム・デイー・ミリポア・コーポレイシヨン 細胞培養及び傾斜移動アッセイ方法及び装置
AU2013334602B2 (en) 2012-10-23 2018-05-31 Genzyme Corporation Perfusion culturing methods and uses thereof
HUE042094T2 (hu) 2013-02-22 2019-06-28 Genzyme Corp Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk
SG10201806083RA (en) 2013-02-22 2018-08-30 Genzyme Corp Microcarrier perfusion culturing methods and uses thereof
AU2014226126B2 (en) 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
HUE056073T2 (hu) 2013-03-15 2022-01-28 Genzyme Corp Magas denzitású sejtbanki tárolási eljárások
BR112016005545B1 (pt) 2013-09-16 2021-06-01 Genzyme Corporation Método de processamento de uma cultura de células de mamífero
WO2015095809A1 (en) 2013-12-20 2015-06-25 Biogen Idec Ma Inc. Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
AU2015269365A1 (en) 2014-06-04 2016-12-15 Amgen Inc. Methods for harvesting mammalian cell cultures
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TWI707949B (zh) 2014-06-09 2020-10-21 美商健臻公司 種子罐培養法(seed train processes)及其用途
CN104450597B (zh) 2014-12-10 2020-07-28 青岛农业大学 一种石油降解菌固体菌剂的制备方法及由其制备的固体菌剂修复石油污染的土壤的方法
SG10202001034PA (en) 2014-12-22 2020-04-29 Genzyme Corp Methods of culturing a mammalian cell

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Publication number Publication date
TWI776235B (zh) 2022-09-01
AU2015274897A1 (en) 2017-01-12
KR20220098051A (ko) 2022-07-08
KR102584375B1 (ko) 2023-09-27
RU2016151316A (ru) 2018-07-10
JP7089000B2 (ja) 2022-06-21
IL281626A (en) 2021-05-31
IL249452B (en) 2021-04-29
EP3858983A1 (en) 2021-08-04
CN106574249B (zh) 2020-05-08
TW202246486A (zh) 2022-12-01
EP3858983B1 (en) 2025-07-16
JP2017521057A (ja) 2017-08-03
DK3152299T3 (da) 2020-02-24
US10570367B2 (en) 2020-02-25
CN111575225B (zh) 2023-09-08
ES3043610T3 (en) 2025-11-25
TW202102658A (zh) 2021-01-16
TW201610148A (zh) 2016-03-16
IL290096A (en) 2022-03-01
IL290096B2 (en) 2024-04-01
MX2016016301A (es) 2017-04-06
JP2022120031A (ja) 2022-08-17
KR102416402B1 (ko) 2022-07-04
MX373323B (es) 2020-05-04
EP3858983C0 (en) 2025-07-16
CN106574249A (zh) 2017-04-19
IL249452A0 (en) 2017-02-28
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