RU2694327C2 - Способ культивирования в системе посевных ферментеров (варианты) - Google Patents
Способ культивирования в системе посевных ферментеров (варианты) Download PDFInfo
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- RU2694327C2 RU2694327C2 RU2016151316A RU2016151316A RU2694327C2 RU 2694327 C2 RU2694327 C2 RU 2694327C2 RU 2016151316 A RU2016151316 A RU 2016151316A RU 2016151316 A RU2016151316 A RU 2016151316A RU 2694327 C2 RU2694327 C2 RU 2694327C2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Cell Biology (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pretreatment Of Seeds And Plants (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009553P | 2014-06-09 | 2014-06-09 | |
| US62/009,553 | 2014-06-09 | ||
| PCT/US2015/034709 WO2015191462A1 (en) | 2014-06-09 | 2015-06-08 | Seed train processes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019119708A Division RU2786997C2 (ru) | 2014-06-09 | 2015-06-08 | Процессы культивирования в системе посевных ферментеров и способы их применения |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016151316A RU2016151316A (ru) | 2018-07-10 |
| RU2016151316A3 RU2016151316A3 (enExample) | 2018-11-15 |
| RU2694327C2 true RU2694327C2 (ru) | 2019-07-11 |
Family
ID=53477008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016151316A RU2694327C2 (ru) | 2014-06-09 | 2015-06-08 | Способ культивирования в системе посевных ферментеров (варианты) |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10570367B2 (enExample) |
| EP (3) | EP3858983B1 (enExample) |
| JP (3) | JP6784600B2 (enExample) |
| KR (2) | KR102416402B1 (enExample) |
| CN (2) | CN106574249B (enExample) |
| AU (3) | AU2015274897B2 (enExample) |
| BR (1) | BR112016028891B1 (enExample) |
| CA (1) | CA2951551C (enExample) |
| CY (1) | CY1122803T1 (enExample) |
| DK (1) | DK3152299T3 (enExample) |
| ES (2) | ES3043610T3 (enExample) |
| HU (1) | HUE047683T2 (enExample) |
| IL (3) | IL290096B2 (enExample) |
| MX (2) | MX373323B (enExample) |
| RU (1) | RU2694327C2 (enExample) |
| SG (1) | SG11201610216UA (enExample) |
| TW (3) | TWI776235B (enExample) |
| WO (1) | WO2015191462A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2958988A2 (en) | 2013-02-22 | 2015-12-30 | Genzyme Corporation | Microcarrier perfusion culturing methods and uses thereof |
| HUE042094T2 (hu) | 2013-02-22 | 2019-06-28 | Genzyme Corp | Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| CA2971861C (en) | 2014-12-22 | 2024-02-13 | Genzyme Corporation | Methods of culturing a mammalian cell |
| EP3368176A2 (en) * | 2015-10-26 | 2018-09-05 | Lonza Limited | A manufacturing facility for the production of biopharmaceuticals |
| WO2018116967A1 (ja) * | 2016-12-22 | 2018-06-28 | 東亞合成株式会社 | 接着剤組成物並びにこれを用いたカバーレイフィルム、ボンディングシート、銅張積層板及び電磁波シールド材 |
| US20200255785A1 (en) * | 2017-09-15 | 2020-08-13 | Bristol-Myers Squibb Company | Online biomass capacitance monitoring during large scale production of polypeptides of interest |
| TWI846694B (zh) * | 2018-05-04 | 2024-07-01 | 美商健臻公司 | 具有過濾系統的灌注式生物反應器 |
| US12071607B2 (en) * | 2018-06-01 | 2024-08-27 | Lonza Ltd. | Midscale model for organic growth and phasing |
| EP3650528A1 (en) | 2018-11-08 | 2020-05-13 | Aglaris Ltd | Cell culture system and method |
| JP7365419B2 (ja) * | 2019-01-25 | 2023-10-19 | エンゼン・バイオサイエンシズ・リミテッド | 治療用タンパク質を生産するための自動化統合連続システム及びバイオプロセス |
| SG11202107441RA (en) * | 2019-02-15 | 2021-08-30 | Just Evotec Biologics Inc | Automated biomanufacturing systems, facilities, and processes |
| EP3976762A1 (en) * | 2019-05-24 | 2022-04-06 | Rubius Therapeutics, Inc. | Methods of generating enucleated erythroid cells |
| GB201908612D0 (en) * | 2019-06-17 | 2019-07-31 | Ge Healthcare Bio Sciences Ab | A method for separating biomolecules |
| US11713442B2 (en) * | 2019-06-17 | 2023-08-01 | Deka Products Limited Partnership | System and method for cell and tissue preparation |
| CN114127260A (zh) * | 2019-07-16 | 2022-03-01 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
| EP3831924A1 (en) * | 2019-12-03 | 2021-06-09 | Sartorius Stedim Data Analytics AB | Adapting control of a cell culture in a production scale vessel with regard to a starting medium |
| TW202405159A (zh) * | 2022-06-28 | 2024-02-01 | 美商安進公司 | 用於治療性產品製造的靈活的設施配置 |
| JP2025527931A (ja) * | 2022-09-06 | 2025-08-22 | アムジェン インコーポレイテッド | 大規模バイオリアクタシステム及び方法 |
| IL322954A (en) * | 2023-03-13 | 2025-10-01 | Amgen Inc | Systems and methods for optimizing seed crops |
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| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| EA039148B1 (ru) | 2014-06-04 | 2021-12-10 | Эмджен Инк. | Способ сбора рекомбинантного белка |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| CN104450597B (zh) | 2014-12-10 | 2020-07-28 | 青岛农业大学 | 一种石油降解菌固体菌剂的制备方法及由其制备的固体菌剂修复石油污染的土壤的方法 |
| CA2971861C (en) | 2014-12-22 | 2024-02-13 | Genzyme Corporation | Methods of culturing a mammalian cell |
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2015
- 2015-06-05 TW TW109131864A patent/TWI776235B/zh active
- 2015-06-05 TW TW104118240A patent/TWI707949B/zh active
- 2015-06-05 TW TW111129481A patent/TW202246486A/zh unknown
- 2015-06-08 ES ES21161811T patent/ES3043610T3/es active Active
- 2015-06-08 SG SG11201610216UA patent/SG11201610216UA/en unknown
- 2015-06-08 EP EP21161811.1A patent/EP3858983B1/en active Active
- 2015-06-08 AU AU2015274897A patent/AU2015274897B2/en active Active
- 2015-06-08 CN CN201580042488.7A patent/CN106574249B/zh active Active
- 2015-06-08 IL IL290096A patent/IL290096B2/en unknown
- 2015-06-08 CA CA2951551A patent/CA2951551C/en active Active
- 2015-06-08 BR BR112016028891-2A patent/BR112016028891B1/pt active IP Right Grant
- 2015-06-08 HU HUE15730933A patent/HUE047683T2/hu unknown
- 2015-06-08 US US14/733,630 patent/US10570367B2/en active Active
- 2015-06-08 EP EP15730933.7A patent/EP3152299B1/en not_active Revoked
- 2015-06-08 CN CN202010299662.9A patent/CN111575225B/zh active Active
- 2015-06-08 KR KR1020177000249A patent/KR102416402B1/ko active Active
- 2015-06-08 DK DK15730933.7T patent/DK3152299T3/da active
- 2015-06-08 EP EP19209942.2A patent/EP3628730A1/en active Pending
- 2015-06-08 WO PCT/US2015/034709 patent/WO2015191462A1/en not_active Ceased
- 2015-06-08 JP JP2016572251A patent/JP6784600B2/ja active Active
- 2015-06-08 ES ES15730933T patent/ES2773630T3/es active Active
- 2015-06-08 RU RU2016151316A patent/RU2694327C2/ru active
- 2015-06-08 KR KR1020227022305A patent/KR102584375B1/ko active Active
- 2015-06-08 MX MX2016016301A patent/MX373323B/es active IP Right Grant
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2016
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2020
- 2020-02-19 CY CY20201100157T patent/CY1122803T1/el unknown
- 2020-02-24 US US16/799,592 patent/US20200377850A1/en not_active Abandoned
- 2020-10-22 JP JP2020177043A patent/JP7089000B2/ja active Active
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2021
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2022
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2023
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2058992C1 (ru) * | 1993-07-14 | 1996-04-27 | Антипин Георгий Васильевич | Способ получения кормового белка и устройство для его осуществления |
| RU2215748C2 (ru) * | 1999-04-09 | 2003-11-10 | Сентро Де Инмунология Молекулар | Способ получения рекомбинантного эритропоэтина человека и полученный эритропоэтин, фармацевтическая композиция |
| WO2002050251A2 (en) * | 2000-12-20 | 2002-06-27 | Bayer Pharmaceuticals Corporation | A device and method for seed-train expansion of mammalian cells |
| US20090042253A1 (en) * | 2007-08-09 | 2009-02-12 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
| US20130260419A1 (en) * | 2010-12-06 | 2013-10-03 | Thomas C. Ransohoff | Continuous processing methods for biological products |
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