RU2016114306A3 - - Google Patents
Download PDFInfo
- Publication number
- RU2016114306A3 RU2016114306A3 RU2016114306A RU2016114306A RU2016114306A3 RU 2016114306 A3 RU2016114306 A3 RU 2016114306A3 RU 2016114306 A RU2016114306 A RU 2016114306A RU 2016114306 A RU2016114306 A RU 2016114306A RU 2016114306 A3 RU2016114306 A3 RU 2016114306A3
- Authority
- RU
- Russia
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/030,424 | 2013-09-18 | ||
| US14/030,424 US20140013456A1 (en) | 2012-03-16 | 2013-09-18 | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| PCT/US2014/056285 WO2015042250A1 (en) | 2013-09-18 | 2014-09-18 | Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019121863A Division RU2019121863A (ru) | 2013-09-18 | 2014-09-18 | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016114306A RU2016114306A (ru) | 2017-10-23 |
| RU2016114306A3 true RU2016114306A3 (ru) | 2018-04-26 |
| RU2694728C2 RU2694728C2 (ru) | 2019-07-16 |
Family
ID=51663490
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016114306A RU2694728C2 (ru) | 2013-09-18 | 2014-09-18 | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения |
| RU2019121863A RU2019121863A (ru) | 2013-09-18 | 2014-09-18 | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019121863A RU2019121863A (ru) | 2013-09-18 | 2014-09-18 | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения |
Country Status (25)
| Country | Link |
|---|---|
| EP (2) | EP3046412B1 (ru) |
| JP (3) | JP6621750B2 (ru) |
| KR (2) | KR20200103882A (ru) |
| CN (2) | CN111019953A (ru) |
| AU (2) | AU2014323527B2 (ru) |
| BR (1) | BR112016005912A2 (ru) |
| CA (1) | CA2922892C (ru) |
| CY (1) | CY1121798T1 (ru) |
| DK (1) | DK3046412T3 (ru) |
| ES (2) | ES2738679T3 (ru) |
| HK (1) | HK1225913A1 (ru) |
| HR (1) | HRP20191233T1 (ru) |
| HU (1) | HUE044747T2 (ru) |
| IL (2) | IL244226B (ru) |
| LT (1) | LT3046412T (ru) |
| MX (1) | MX362904B (ru) |
| MY (1) | MY191512A (ru) |
| PL (1) | PL3046412T3 (ru) |
| PT (1) | PT3046412T (ru) |
| RS (1) | RS59003B1 (ru) |
| RU (2) | RU2694728C2 (ru) |
| SG (2) | SG11201601272YA (ru) |
| SI (1) | SI3046412T1 (ru) |
| TR (1) | TR201909967T4 (ru) |
| WO (1) | WO2015042250A1 (ru) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG192945A1 (en) | 2011-02-25 | 2013-09-30 | Chugai Pharmaceutical Co Ltd | Fcgriib-specific fc antibody |
| EP3939996A1 (en) | 2011-09-30 | 2022-01-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
| RU2739792C1 (ru) | 2011-11-30 | 2020-12-28 | Чугаи Сейяку Кабусики Кайся | Содержащий лекарственное средство переносчик в клетку для формирования иммунного комплекса |
| DK2889377T3 (da) | 2012-08-24 | 2020-03-30 | Chugai Pharmaceutical Co Ltd | Fc?RIIb-Specifik Fc-regionsvariant |
| US10766960B2 (en) | 2012-12-27 | 2020-09-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| WO2014163101A1 (ja) | 2013-04-02 | 2014-10-09 | 中外製薬株式会社 | Ｆｃ領域改変体 |
| CR20170326A (es) | 2014-12-19 | 2017-08-22 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipéptidos que contienen regiones fc variantes, y métodos de uso |
| WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| KR20230079499A (ko) | 2016-08-05 | 2023-06-07 | 추가이 세이야쿠 가부시키가이샤 | Il-8 관련 질환의 치료용 또는 예방용 조성물 |
| US20220090125A1 (en) * | 2018-12-21 | 2022-03-24 | Compass Therapeutics Llc | Transgenic mouse expressing common human light chain |
| EP4075965A1 (en) * | 2019-12-18 | 2022-10-26 | Bristol-Myers Squibb Company | Bcr transgenic mice with a common leader sequence |
| WO2022056276A1 (en) | 2020-09-11 | 2022-03-17 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| KR20230147048A (ko) | 2020-12-16 | 2023-10-20 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 Fc 알파 수용체를 발현하는 마우스 |
| CN114568343B (zh) * | 2022-03-11 | 2023-04-07 | 成都合拓创展生物科技有限公司 | 制备眼病模型的头具及其应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| JP5514539B2 (ja) * | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
| CA2652976C (en) | 2006-06-02 | 2015-08-11 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human il-6 receptor |
| SG189775A1 (en) * | 2008-04-11 | 2013-05-31 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| JP2012508022A (ja) * | 2008-11-06 | 2012-04-05 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 減少した免疫原性を有する操作された抗体および作製方法 |
| MY164121A (en) | 2009-06-26 | 2017-11-30 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
| CA2767957C (en) | 2009-07-16 | 2020-08-25 | Wageningen Universiteit | Regulation of zinc deficiency and tolerance in plants |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| BR112012018163A2 (pt) * | 2010-01-21 | 2019-09-24 | Oxyrane Uk Ltd | métodos e composições para exibição de um polipeptídeo sobre a superfície de uma célula de levredura |
| US20130185821A1 (en) | 2010-02-08 | 2013-07-18 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| LT3095871T (lt) | 2010-02-08 | 2019-05-27 | Regeneron Pharmaceuticals, Inc. | Bendros lengvosios grandinės pelė |
| CN102844332B (zh) * | 2010-03-11 | 2015-08-19 | 瑞纳神经科学公司 | 呈pH依赖性抗原结合的抗体 |
| BR112012033248A2 (pt) * | 2010-06-22 | 2017-11-28 | Regeneron Pharma | camundongos expressando uma cadeia leve com variável de lâmbda humana e regiões constantes de camundongo |
| MX353795B (es) * | 2010-11-19 | 2018-01-30 | Morphosys Ag | Coleccion y metodos para su uso. |
| KR102528622B1 (ko) * | 2011-09-30 | 2023-05-04 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존성 결합 분자 라이브러리 |
| US20140013456A1 (en) * | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| TR201810255T4 (tr) * | 2013-02-20 | 2018-08-27 | Regeneron Pharma | Modifiye edilmiş immunoglobulin ağır zincir sekanslarına sahip olan insan olmayan hayvanlar. |
-
2014
- 2014-09-18 CN CN201911266988.5A patent/CN111019953A/zh active Pending
- 2014-09-18 EP EP14781761.3A patent/EP3046412B1/en active Active
- 2014-09-18 KR KR1020207024599A patent/KR20200103882A/ko not_active Application Discontinuation
- 2014-09-18 BR BR112016005912A patent/BR112016005912A2/pt not_active IP Right Cessation
- 2014-09-18 ES ES14781761T patent/ES2738679T3/es active Active
- 2014-09-18 HU HUE14781761 patent/HUE044747T2/hu unknown
- 2014-09-18 SI SI201431271T patent/SI3046412T1/sl unknown
- 2014-09-18 JP JP2016543984A patent/JP6621750B2/ja active Active
- 2014-09-18 ES ES19159475T patent/ES2962489T3/es active Active
- 2014-09-18 RS RS20190873A patent/RS59003B1/sr unknown
- 2014-09-18 EP EP19159475.3A patent/EP3549437B1/en active Active
- 2014-09-18 TR TR2019/09967T patent/TR201909967T4/tr unknown
- 2014-09-18 AU AU2014323527A patent/AU2014323527B2/en active Active
- 2014-09-18 SG SG11201601272YA patent/SG11201601272YA/en unknown
- 2014-09-18 RU RU2016114306A patent/RU2694728C2/ru active
- 2014-09-18 LT LTEP14781761.3T patent/LT3046412T/lt unknown
- 2014-09-18 MX MX2016003638A patent/MX362904B/es active IP Right Grant
- 2014-09-18 DK DK14781761.3T patent/DK3046412T3/da active
- 2014-09-18 SG SG10201810825YA patent/SG10201810825YA/en unknown
- 2014-09-18 WO PCT/US2014/056285 patent/WO2015042250A1/en active Application Filing
- 2014-09-18 RU RU2019121863A patent/RU2019121863A/ru unknown
- 2014-09-18 PT PT14781761T patent/PT3046412T/pt unknown
- 2014-09-18 KR KR1020167009721A patent/KR102150414B1/ko active IP Right Grant
- 2014-09-18 CA CA2922892A patent/CA2922892C/en active Active
- 2014-09-18 CN CN201480061443.XA patent/CN105722387B/zh active Active
- 2014-09-18 PL PL14781761T patent/PL3046412T3/pl unknown
- 2014-09-18 MY MYPI2016700599A patent/MY191512A/en unknown
-
2016
- 2016-02-22 IL IL244226A patent/IL244226B/en active IP Right Grant
- 2016-12-16 HK HK16114363A patent/HK1225913A1/zh unknown
-
2019
- 2019-01-16 JP JP2019004905A patent/JP2019068850A/ja not_active Withdrawn
- 2019-01-21 IL IL264358A patent/IL264358A/en unknown
- 2019-07-10 HR HRP20191233TT patent/HRP20191233T1/hr unknown
- 2019-07-10 CY CY20191100728T patent/CY1121798T1/el unknown
-
2020
- 2020-03-03 JP JP2020035905A patent/JP2020078350A/ja not_active Withdrawn
-
2021
- 2021-01-15 AU AU2021200228A patent/AU2021200228A1/en active Pending