RU2016101363A - Способ лечения заболеваний, связанных с глюкокортикоидной нечувствительностью - Google Patents

Способ лечения заболеваний, связанных с глюкокортикоидной нечувствительностью Download PDF

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RU2016101363A
RU2016101363A RU2016101363A RU2016101363A RU2016101363A RU 2016101363 A RU2016101363 A RU 2016101363A RU 2016101363 A RU2016101363 A RU 2016101363A RU 2016101363 A RU2016101363 A RU 2016101363A RU 2016101363 A RU2016101363 A RU 2016101363A
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derivatives
refractory
metabolites
pharmaceutical composition
glucocorticoid
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RU2016101363A3 (enExample
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Тао Том ДУ
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Прэари Фармасьютикалз, Ллк
Тао Том ДУ
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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RU2016101363A 2010-02-08 2011-02-07 Способ лечения заболеваний, связанных с глюкокортикоидной нечувствительностью RU2016101363A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30232510P 2010-02-08 2010-02-08
US61/302,325 2010-02-08
US13/021,950 2011-02-07
US13/021,950 US10231976B2 (en) 2010-02-08 2011-02-07 Methods for the use of progestogen as a glucocorticoid sensitizer

Related Parent Applications (1)

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RU2012135985/15A Division RU2575824C2 (ru) 2010-02-08 2011-02-07 Способы применения прогестогена в качестве глюкокортикоидного сенсибилизатора

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RU2016101363A true RU2016101363A (ru) 2018-11-21
RU2016101363A3 RU2016101363A3 (enExample) 2018-11-21

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US (1) US10231976B2 (enExample)
EP (2) EP2533799B8 (enExample)
JP (1) JP5913136B2 (enExample)
CN (1) CN102811730B (enExample)
BR (1) BR112012019725A2 (enExample)
ES (1) ES2773079T3 (enExample)
RU (1) RU2016101363A (enExample)
WO (1) WO2011097571A2 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110262502A1 (en) * 2010-02-08 2011-10-27 Prairie Pharmaceuticals LLC Pulmonary delivery of 17-hydroxyprogesterone caproate (17-hpc)
US10987361B2 (en) * 2010-02-08 2021-04-27 Shenzhen Evergreen Therapeutics Co., Ltd. Treating auto-immune and auto-inflammatory diseases
US10231976B2 (en) 2010-02-08 2019-03-19 Prairie Pharmaceuticals LLC Methods for the use of progestogen as a glucocorticoid sensitizer
US10993879B2 (en) * 2010-02-08 2021-05-04 Shenzhen Evergreen Therapeutics Co., Ltd. Pulmonary delivery of progestogen
EP2782584B1 (en) 2011-11-23 2021-06-09 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
AR100562A1 (es) 2014-05-22 2016-10-12 Therapeuticsmd Inc Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal
US20160008376A1 (en) * 2014-07-10 2016-01-14 Biocopea Limited Compositions, Methods and Uses for Treating Gender-Biased Immune Disorders
US9624998B2 (en) 2014-07-30 2017-04-18 Tenneco Automotive Operating Company Inc. Electromagnetic flywheel damper and method therefor
RS60450B1 (sr) * 2014-09-03 2020-07-31 Rhizen Pharmaceuticals Sa Postupak za tretiranje i kompozicije koje sadrže dvojni inhibitor pi3k delta-gama kinaze i kortikosteroid
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
JP2018529767A (ja) * 2015-09-21 2018-10-11 プレーリー ファーマシューティカルズ エルエルシー 自己免疫疾患及び自己炎症疾患の治療方法
CN106994128A (zh) * 2016-01-26 2017-08-01 上海普瑞得生物技术有限公司 17-α羟孕酮化合物在预防和治疗中性粒细胞炎症疾病中的应用
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
CN106310280A (zh) * 2016-08-18 2017-01-11 滨州医学院 地瑞那韦增强糖皮质激素抗炎作用的医药新用途
EP3548035A4 (en) * 2016-11-30 2020-07-22 Case Western Reserve University COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES
CN110573154A (zh) 2017-02-06 2019-12-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
CN108272804A (zh) * 2018-02-09 2018-07-13 上海礼璞生物医药科技有限公司 孕激素在制备糖原合成酶激酶-3β抑制剂药物中的应用及糖原合成酶激酶-3β抑制剂
CN108159056A (zh) * 2018-02-09 2018-06-15 上海礼璞生物医药科技有限公司 孕激素在制备组蛋白去乙酰化酶抑制剂和气道周围胶原沉积抑制剂药物中的应用及抑制剂
CN108159057A (zh) * 2018-02-09 2018-06-15 上海礼璞生物医药科技有限公司 黄体酮及其药学上可接受的衍生物在制备抑制α平滑肌肌动蛋白表达的药物中的用途
WO2020106998A1 (en) 2018-11-21 2020-05-28 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
KR102490714B1 (ko) 2018-12-28 2023-01-26 재단법인 아산사회복지재단 Pibf 단백질을 유효성분으로 함유하는 염증성 질환 예방 또는 치료용 약학 조성물
AU2021224268A1 (en) 2020-02-21 2022-09-15 Case Western Reserve University Compositions and methods for treating renal injury
US11918570B2 (en) 2020-04-13 2024-03-05 The Research Foundation For The State University Of New York Method of treatment for prevention of glucocorticoid toxicity and/or enhancement of muscle regeneration via neutrophil elastase inhibition
CN113559107B (zh) * 2020-04-28 2023-01-06 深圳埃格林医药有限公司 孕激素在制备抑制细胞因子风暴的药物中的应用
CN113616660A (zh) * 2020-05-07 2021-11-09 深圳埃格林医药有限公司 孕激素制剂及其用途
CN114569623A (zh) * 2020-12-01 2022-06-03 深圳埃格林医药有限公司 己酸羟孕酮在制备治疗间质性肺炎的药物中的用途
EP4209219A1 (en) * 2022-01-07 2023-07-12 MetrioPharm AG Combination of budesonide and 5-amino-2,3-dihydro-1,4-phtalazinedione
CN115501236B (zh) * 2022-11-09 2024-01-23 复旦大学附属肿瘤医院 一种醋酸烯诺孕酮在制备降低肺部炎症性疾病的药物中的应用
CN115885925B (zh) * 2022-12-29 2026-06-26 孙良丹 一种压力加重银屑病小鼠模型的构建方法及应用
CN118924767B (zh) * 2024-07-25 2025-11-11 中南大学湘雅医院 孕烯醇酮作为活性成分在制备银屑病或特应性皮炎的治疗药物中的应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
US4720489A (en) * 1984-10-15 1988-01-19 Douglas Shander Hair growth modification with ornithine decarboxylase inhibitors
AU763307B2 (en) * 1998-02-04 2003-07-17 Charlotte-Mecklenburg Hospital Authority Androsterone derivatives for inhibiting DNA binding of AP-1 and airway smooth muscle proliferation
US6562370B2 (en) * 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers
US20010034340A1 (en) * 2000-03-20 2001-10-25 American Home Products Corporation Hormone replacement therapy
EP1591121B1 (en) * 2000-12-14 2009-06-24 Ortho-McNeil-Janssen Pharmaceuticals, Inc. Process for preparing steroid hormone products comprising a stabilizing agent in non-crystalline form
FR2821555B1 (fr) * 2001-03-01 2003-05-16 Besins Int Lab Progestatif co-micronise avec un tensioactif, composition pharmaceutique le comprenant, leurs procedes de fabrication et leurs utilisations
MXPA04005277A (es) 2001-12-05 2005-03-31 Nupharmx Llc DISPOSITIVO MEDICO Y METODO PARA LA INHALACION DE UN FáRMACO EN AEROSOL CON HELIOX.
KR20040101545A (ko) * 2002-04-26 2004-12-02 화이자 헬스 에이비 대사증후군 치료
US20060216231A1 (en) * 2002-09-23 2006-09-28 Shelley Carl S Methods for diagnosing and treating tumors and suppressing cd promoters
DE10251028A1 (de) * 2002-11-01 2004-05-19 Jenapharm Gmbh & Co. Kg Verwendung von Progesteron oder einem Progesteronrezeptor-Agonisten zur Hemmung der Steroidsynthese
FR2851918B1 (fr) * 2003-03-06 2006-06-16 Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication
JP4898431B2 (ja) * 2003-04-29 2012-03-14 ザ ジェネラル ホスピタル コーポレイション 複数薬物の持続放出のための方法およびデバイス
US20050042268A1 (en) * 2003-07-16 2005-02-24 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
JP2007533697A (ja) * 2004-04-22 2007-11-22 デュオコート エービー グルココルチコイド救急治療用の医薬組成物
US20060052306A1 (en) 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. GRAS composition for enhanced mucosal delivery of parathyroid hormone
AR049707A1 (es) * 2004-07-07 2006-08-30 Wyeth Corp Regimenes y kits de progestina ciclica
GB0425266D0 (en) 2004-11-16 2004-12-15 Norton Healthcare Ltd Pharmaceutical manufacturing process
ATE499104T1 (de) 2005-03-24 2011-03-15 Univ Emory Progesterone dosierungsanweisung in der behandlung einer traumatischen verletzung des gehirns
EP1893182B8 (en) * 2005-05-26 2012-04-04 Teva Women's Health, Inc. Oral dosage forms comprising progesterone and method of making and using the same
TW200711649A (en) * 2005-06-17 2007-04-01 Combinatorx Inc Combination therapy for the treatment of immunoinflammatory disorders
US20070178166A1 (en) 2005-12-15 2007-08-02 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
GB0908129D0 (en) * 2009-05-12 2009-06-24 Innovata Ltd Composition
US10987361B2 (en) 2010-02-08 2021-04-27 Shenzhen Evergreen Therapeutics Co., Ltd. Treating auto-immune and auto-inflammatory diseases
US20110262502A1 (en) 2010-02-08 2011-10-27 Prairie Pharmaceuticals LLC Pulmonary delivery of 17-hydroxyprogesterone caproate (17-hpc)
US10231976B2 (en) 2010-02-08 2019-03-19 Prairie Pharmaceuticals LLC Methods for the use of progestogen as a glucocorticoid sensitizer
PT105058B (pt) 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos

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BR112012019725A2 (pt) 2020-11-10
CN102811730B (zh) 2014-07-09
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EP2533799B8 (en) 2019-12-25
EP3689364A1 (en) 2020-08-05
EP2533799A4 (en) 2013-07-31
RU2012135985A (ru) 2014-03-20
US10231976B2 (en) 2019-03-19
US20110195031A1 (en) 2011-08-11
JP5913136B2 (ja) 2016-04-27
WO2011097571A3 (en) 2011-12-29
ES2773079T3 (es) 2020-07-09
CN102811730A (zh) 2012-12-05
RU2016101363A3 (enExample) 2018-11-21
JP2013518908A (ja) 2013-05-23
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