RU2015143526A - Производные 3-(арил или гетероарил)метилениндолин-2-она в качестве ингибиторов киназного пути раковых стволовых клеток для лечения рака - Google Patents
Производные 3-(арил или гетероарил)метилениндолин-2-она в качестве ингибиторов киназного пути раковых стволовых клеток для лечения рака Download PDFInfo
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- RU2015143526A RU2015143526A RU2015143526A RU2015143526A RU2015143526A RU 2015143526 A RU2015143526 A RU 2015143526A RU 2015143526 A RU2015143526 A RU 2015143526A RU 2015143526 A RU2015143526 A RU 2015143526A RU 2015143526 A RU2015143526 A RU 2015143526A
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- substituted
- heterocycle
- compound
- alkyl
- aryl
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- 125000003118 aryl group Chemical group 0.000 title claims 105
- 206010028980 Neoplasm Diseases 0.000 title claims 9
- 201000011510 cancer Diseases 0.000 title claims 9
- 210000000130 stem cell Anatomy 0.000 title claims 4
- 125000001072 heteroaryl group Chemical group 0.000 title claims 2
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000037361 pathway Effects 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 228
- 125000000623 heterocyclic group Chemical group 0.000 claims 211
- 125000000217 alkyl group Chemical group 0.000 claims 113
- 229910052739 hydrogen Inorganic materials 0.000 claims 107
- 239000001257 hydrogen Substances 0.000 claims 107
- 125000000547 substituted alkyl group Chemical group 0.000 claims 105
- 150000002431 hydrogen Chemical class 0.000 claims 92
- 125000003107 substituted aryl group Chemical group 0.000 claims 92
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 88
- 125000000753 cycloalkyl group Chemical group 0.000 claims 87
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 83
- 229910052799 carbon Inorganic materials 0.000 claims 60
- 229910052736 halogen Inorganic materials 0.000 claims 52
- 150000002367 halogens Chemical class 0.000 claims 52
- 125000004093 cyano group Chemical group *C#N 0.000 claims 47
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 46
- 229910052757 nitrogen Inorganic materials 0.000 claims 45
- 125000003342 alkenyl group Chemical group 0.000 claims 44
- 125000000304 alkynyl group Chemical group 0.000 claims 44
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 44
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 44
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 12
- -1 2- (di-ethylamino) ethyl Chemical group 0.000 claims 10
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 10
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- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
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- 102000001253 Protein Kinase Human genes 0.000 claims 7
- 125000003386 piperidinyl group Chemical group 0.000 claims 7
- 108060006633 protein kinase Proteins 0.000 claims 7
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- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 6
- 150000001721 carbon Chemical group 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 claims 6
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- 241000124008 Mammalia Species 0.000 claims 5
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 5
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 229930192474 thiophene Natural products 0.000 claims 5
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 4
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- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
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- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical compound C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
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- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- IJAPPYDYQCXOEF-UHFFFAOYSA-N phthalazin-1(2H)-one Chemical compound C1=CC=C2C(=O)NN=CC2=C1 IJAPPYDYQCXOEF-UHFFFAOYSA-N 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
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- 125000003373 pyrazinyl group Chemical group 0.000 claims 3
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 3
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims 3
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- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 2
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- 230000003247 decreasing effect Effects 0.000 claims 2
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- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
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- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
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- 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 claims 1
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- 125000003725 azepanyl group Chemical group 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Applications Claiming Priority (5)
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| US201361780248P | 2013-03-13 | 2013-03-13 | |
| US61/780,248 | 2013-03-13 | ||
| US61/780,263 | 2013-03-13 | ||
| PCT/US2014/026498 WO2014160401A1 (en) | 2013-03-13 | 2014-03-13 | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer |
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| CN104876928B (zh) * | 2015-05-07 | 2016-09-14 | 浙江司太立制药股份有限公司 | 7-氮杂吲哚啉-2-酮类化合物及其制备方法 |
| US10377749B2 (en) | 2015-08-10 | 2019-08-13 | Sumitomo Dainippon Pharma Co., Ltd. | Purification method for 5-(thiazol-4-yl)indolin-2-one derivative |
| EP3363799A4 (en) * | 2015-11-12 | 2018-12-05 | LG Chem, Ltd. | Pharmaceutical composition containing, as active ingredient, 7-azaindolin-2-one derivative or pharmaceutically acceptable salt thereof |
| CN105461705B (zh) * | 2015-11-30 | 2018-04-10 | 中国医科大学 | 二苯并氮杂卓二酮类抗肿瘤化合物及其制备方法 |
| JP2019519573A (ja) | 2016-06-28 | 2019-07-11 | ボストン バイオメディカル， インコーポレイテッド | がんを処置するための方法 |
| CN107698593A (zh) * | 2016-08-09 | 2018-02-16 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| CN106432228A (zh) * | 2016-09-06 | 2017-02-22 | 浙江司太立制药股份有限公司 | 含有4‑肟基‑1‑哌啶基片段的7‑氮杂吲哚啉‑2‑酮类化合物及其制备方法 |
| CN106397436A (zh) * | 2016-09-06 | 2017-02-15 | 浙江司太立制药股份有限公司 | 5‑溴‑7‑氮杂吲哚啉‑2‑酮类化合物及其制备方法 |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| WO2019002889A1 (en) * | 2017-06-30 | 2019-01-03 | Industrial Technology Research Institute | METHOD FOR TREATING AUTOIMMUNE NEUROLOGICAL DISEASE AND / OR NEURODEGENERATIVE DISEASE AND PHARMACEUTICAL FORMULAS FOR LIQUID GALENIC FORM AND CONTROLLED RELEASE GALENIC FORM |
| CN110357878B (zh) * | 2018-03-26 | 2022-04-12 | 武汉誉祥医药科技有限公司 | 1,3-二氢-2H-吡咯并[3,2-b]吡啶-2-酮衍生物及其医药用途 |
| CR20200553A (es) | 2018-04-18 | 2021-04-08 | Constellation Pharmaceuticals Inc | Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos |
| CN120097995A (zh) | 2018-05-21 | 2025-06-06 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
| CN117224541A (zh) * | 2018-09-18 | 2023-12-15 | 北京强新生物科技有限公司 | 肥胖症的治疗 |
| MX2021003156A (es) * | 2018-09-18 | 2021-05-14 | 1 Globe Biomedical Co Ltd | Tratamiento para la enfermedad del higado graso no alcoholico. |
| US12435059B2 (en) * | 2019-07-03 | 2025-10-07 | The Regents Of The University Of Colorado, A Body Corporate | AMP-activated protein kinase inhibitors and methods of making and using the same |
| WO2021016414A1 (en) | 2019-07-24 | 2021-01-28 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide |
| WO2021243040A2 (en) * | 2020-05-29 | 2021-12-02 | The Regents Of The University Of Michigan | Small molecule inhibitors of grk5 and grk5 subfamily members and uses thereof |
| CN111675647B (zh) * | 2020-06-26 | 2022-03-01 | 深圳技术大学 | 2-吲哚酮类pak1抑制剂及其在抗肿瘤治疗药物中的应用 |
| EP4178958A4 (en) * | 2020-07-10 | 2024-12-11 | Blossomhill Therapeutics, Inc. | MACROCYCLES AND THEIR USE |
| AU2023204770A1 (en) * | 2022-01-05 | 2024-07-18 | Blossomhill Therapeutics, Inc. | Macrocyclic compounds and use as kinase inhibitors |
| CN114213396B (zh) * | 2022-01-27 | 2023-03-24 | 深圳市乐土生物医药有限公司 | 一种吲哚-2-酮类化合物及其制备方法与用途 |
| CN117624014A (zh) * | 2022-11-02 | 2024-03-01 | 徐诺药业(南京)有限公司 | 3-(吲哚氨基)亚甲基吲哚啉类衍生物及其制备方法和应用 |
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| US3492397A (en) | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
| US4060598A (en) | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
| US3538214A (en) | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| US4173626A (en) | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| AU7284096A (en) * | 1995-10-09 | 1997-04-30 | Dieter Binder | Heterocyclically-substituted 1-indole carboxamides as cyclo-oxygenase-2 inhibitors |
| GB9716557D0 (en) * | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| EP1149093A1 (en) * | 1998-12-17 | 2001-10-31 | F. Hoffmann-La Roche Ag | 4-aryloxindoles as inhibitors of jnk protein kinases |
| WO2001046196A1 (en) * | 1999-12-21 | 2001-06-28 | Sugen, Inc. | 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors |
| SI1255752T1 (sl) * | 2000-02-15 | 2007-12-31 | Pharmacia & Upjohn Co Llc | S pirolom substituirani zaviralci 2-indolinon protein kinaza |
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| JP2007509173A (ja) * | 2003-10-24 | 2007-04-12 | シエーリング アクチエンゲゼルシャフト | インドリノン誘導体類及び疾病状態、例えば癌の処理へのそれらの使用 |
| JP2008524165A (ja) * | 2004-12-17 | 2008-07-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | インドリノン及びその抗増殖薬としての使用 |
| WO2007005644A2 (en) | 2005-07-01 | 2007-01-11 | Concert Pharmaceuticals Inc. | Novel aryloxypropanamines |
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| CN101007801A (zh) * | 2006-01-27 | 2007-08-01 | 上海恒瑞医药有限公司 | 吡咯取代的2－二氢吲哚酮衍生物、其制法与医药上的用途 |
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| EP3037419B1 (en) * | 2007-09-06 | 2019-09-04 | Boston Biomedical, Inc. | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
| WO2009140128A2 (en) * | 2008-05-13 | 2009-11-19 | Irm Llc | Compounds and compositions as kinase inhibitors |
| NZ590560A (en) * | 2008-07-29 | 2012-12-21 | Boehringer Ingelheim Int | Indolinone Inhibitors of cell cycle kinases |
| US9187454B2 (en) * | 2013-03-13 | 2015-11-17 | Boston Biomedical, Inc. | Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof |
| US9227962B2 (en) * | 2013-03-13 | 2016-01-05 | Boston Biomedical, Inc. | Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative |
| RU2016128396A (ru) * | 2014-01-27 | 2018-03-02 | Бостон Биомедикал, Инк. | Новые способы лечения рака |
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- 2014-03-13 CN CN201480026333.XA patent/CN105408320B/zh active Active
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- 2014-03-13 RU RU2015143526A patent/RU2015143526A/ru not_active Application Discontinuation
- 2014-03-13 BR BR112015022431A patent/BR112015022431A2/pt not_active Application Discontinuation
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| HK1220184A1 (zh) | 2017-04-28 |
| JP6378308B2 (ja) | 2018-08-22 |
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| CN105408320A (zh) | 2016-03-16 |
| CA2904152A1 (en) | 2014-10-02 |
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| US20160031888A1 (en) | 2016-02-04 |
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| SG10201806965XA (en) | 2018-09-27 |
| EP2970206A1 (en) | 2016-01-20 |
| BR112015022431A2 (pt) | 2017-05-09 |
| RU2019104092A (ru) | 2019-03-20 |
| JP2016513656A (ja) | 2016-05-16 |
| US20190241569A1 (en) | 2019-08-08 |
| JP2018168187A (ja) | 2018-11-01 |
| AU2018233033A1 (en) | 2018-10-11 |
| KR20150127249A (ko) | 2015-11-16 |
| MX2015011456A (es) | 2016-05-31 |
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