CN105408320B - 用于治疗癌症的作为癌症干细胞途径激酶抑制剂的3-(芳基或杂芳基)甲基吲哚-2-酮衍生物 - Google Patents

用于治疗癌症的作为癌症干细胞途径激酶抑制剂的3-(芳基或杂芳基)甲基吲哚-2-酮衍生物 Download PDF

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CN105408320B
CN105408320B CN201480026333.XA CN201480026333A CN105408320B CN 105408320 B CN105408320 B CN 105408320B CN 201480026333 A CN201480026333 A CN 201480026333A CN 105408320 B CN105408320 B CN 105408320B
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substituted
compound
aryl
heterocycle
hydrogen
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CN105408320A (zh
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李嘉强
刘继峰
W·李
A·古比奥
H·罗格夫
K·坪井
Y·高梨
S·东条
T·儿玉
K·久保田
T·卡奈
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1Globe Biomedical Co Ltd
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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CN201480026333.XA 2013-03-13 2014-03-13 用于治疗癌症的作为癌症干细胞途径激酶抑制剂的3-(芳基或杂芳基)甲基吲哚-2-酮衍生物 Active CN105408320B (zh)

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US201361780263P 2013-03-13 2013-03-13
US201361780248P 2013-03-13 2013-03-13
US61/780,248 2013-03-13
US61/780,263 2013-03-13
PCT/US2014/026498 WO2014160401A1 (en) 2013-03-13 2014-03-13 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer

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CN105408320B true CN105408320B (zh) 2019-08-13

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US (2) US20160031888A1 (https=)
EP (1) EP2970206A1 (https=)
JP (2) JP6378308B2 (https=)
KR (1) KR20150127249A (https=)
CN (1) CN105408320B (https=)
AU (2) AU2014243869A1 (https=)
BR (1) BR112015022431A2 (https=)
CA (1) CA2904152A1 (https=)
HK (1) HK1220184A1 (https=)
IL (1) IL240960A0 (https=)
MX (1) MX2015011456A (https=)
RU (2) RU2015143526A (https=)
SG (2) SG10201806965XA (https=)
WO (1) WO2014160401A1 (https=)

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Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors;Nan-Horng Lin, et al.;《Bioorganic & Medicinal Chemistry Letters》;20051018;第16卷;第421-426页 *

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HK1220184A1 (zh) 2017-04-28
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WO2014160401A1 (en) 2014-10-02
CN105408320A (zh) 2016-03-16
CA2904152A1 (en) 2014-10-02
AU2014243869A1 (en) 2015-09-24
US20160031888A1 (en) 2016-02-04
IL240960A0 (en) 2015-11-30
SG10201806965XA (en) 2018-09-27
EP2970206A1 (en) 2016-01-20
BR112015022431A2 (pt) 2017-05-09
RU2019104092A (ru) 2019-03-20
JP2016513656A (ja) 2016-05-16
RU2015143526A (ru) 2017-04-19
US20190241569A1 (en) 2019-08-08
JP2018168187A (ja) 2018-11-01
AU2018233033A1 (en) 2018-10-11
KR20150127249A (ko) 2015-11-16
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