AR072538A1 - Derivados de indolinonas, composiciones farmacéuticas y usos - Google Patents
Derivados de indolinonas, composiciones farmacéuticas y usosInfo
- Publication number
- AR072538A1 AR072538A1 ARP090102874A ARP090102874A AR072538A1 AR 072538 A1 AR072538 A1 AR 072538A1 AR P090102874 A ARP090102874 A AR P090102874A AR P090102874 A ARP090102874 A AR P090102874A AR 072538 A1 AR072538 A1 AR 072538A1
- Authority
- AR
- Argentina
- Prior art keywords
- nrcrc
- nrere
- membered
- nrg
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Abstract
Compuestos de la formula general (1), uso de estos compuestos en el tratamiento de enfermedades caracterizadas por una proliferacion celular excesiva o anormal, así como su uso para preparar un medicamento. Reivindicacion 1: Compuestos caracterizados porque tienen la formula general (1) en la cual R1 es hidrogeno o un radical, eventualmente sustituido con uno o varios R5, seleccionado del grupo consistente en cicloalquilo C3-10, heterocicloalquilo de 3-8 miembros, arilo C6-15 y heteroarilo de 5-15 miembros; y R2 es un radical, eventualmente sustituido con uno o varios R5, seleccionado del grupo consistente en arilo C6-15 y heteroarilo de 5-15 miembros; y R3 es un radical, eventualmente sustituido con uno o varios R5, seleccionados del grupo consistente en alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo C6-15 y heteroarilo de 5-12 miembros, y R4 es hidrogeno, alquilo C1-6 o Rb, y R5 en cada caso independientemente uno de otro es un radical seleccionado del grupo consistente en Ra, Rb y Ra sustituido con uno o varios Rb y/o Rc, iguales o distintos; y cada Ra está seleccionado, independientemente uno de otro, del grupo consistente en alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-10, cicloalquil C4-10-alquilo, arilo C6-16, aril C7-16-alquilo, heteroalquilo de 2-6 miembros, heterocicloalquilo de 3-8 miembros, heterocicloalquilalquilo de 4-14 miembros, heteroarilo de 5-12 miembros y heteroarilalquilo de 6-18 miembros; cada Rb es un radical adecuado y. en cada caso independientemente uno de otro, se selecciona del grupo consistente en =O, -ORc, haloalquiloxi C1-3, -OCF3, =S, -SRc, =NRc, =NORc, =NNRcRc, =NN(Rg)C(O)NRcRc, -NRcRc, -ONRCRC, -N(ORc)Rc, -N(Rg)NRcRc, halogeno, -CF3, -CN, -NC, -OCN, -SCN, -NO, -NO2, =N2, -N3, -S(O)Rc, -S(O)ORc, -S(O)2Rc, -S(O)2ORc, -S(O)NRcRc, -S(O)2NRcRc, -OS(O)Rc, -OS(O)2Rc, -OS(O)2ORc, -OS(O)NRcRc, -OS(O)2NRcRc, -C(O)Rc, -C(O)ORc, -C(O)SRc, -C(O)NRcRc, -C(O)N(Rg)NRcRc, -C(O)N(Rg)ORc, -C(NRg)NRcRc, -C{NOH)Rc, -C(NOH)NRcRc, -OC(O)Rc -OC(O)ORc, -OC(O)SRc, -OC(O)NRcRc, -OC(NRg)NRcRc, -SC(O)Rc, -SC(O)ORc, -SC(O)NRcRc, -SC(NRg)NRcRc, -N(Rg)C(O)Rc, -N[C(O)Rc]2, -N(ORg)C(O)Rc, -N(Rg)C(NRg)Rc, N(Rg)N(Rg)C(O)Rc, -N[C(O)Rc]NRcRc, -N(Rg)C(S)Rc, -N(Rg)S(O)Rc, -N(Rg)s(o)oRc, -N(Rg)S(O)2Rc, -N[S(O)2Rc]2, -N(Rg)S(O)2ORc, -N(Rg)s(o)2NRcRc, -N(Rg)[S(O)2]2Rc, -N(Rg)C(O)ORc, -N(Rg)C(O)SRc, -N(Rg)C(O)NRcRc, -N(Rg)C(O)NRgNRcRc, -N(Rg)N(Rg)C(O)NRcRc, -N(Rg)C(S)NRcRc, -[N(Rg)C(O)]2Rc, -N(Rg)[C(O)]2Rc, -N(Rg)[C(O)]2NRcRc, -N{[C(O)]2ORc}2, -N{[C(O)]2NRcRc}2, -N(Rg)[C(O)]2ORc, N(Rg)C(NRg)ORc, N(Rg)C(NOH)Rc, -N(Rg)C(NRg)SRc y -N(Rg)C(NRg)NRcRc, cada Rc es, independientemente uno de otro, hidrogeno o un radical eventualmente sustituido con uno o varios Rd y/o Re iguales o distintos. seleccionado del grupo consistente en alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-10, cicloalquil C4-11-alquilo, arilo C6-10, aril C7-16-alquilo, heteroalquilo de 2-6 miembros, heterocicloalquilo de 3-8 miembros, heterocicloalquilalquilo de 4-14 miembros, heteroarilo de 5-12 miembros y heteroarilalquilo de 6-18 miembros; cada Rd es un radical adecuado y, en cada caso independientemente uno de otro, se selecciona del grupo consistente en =O, -ORe, haloalquiloxi C1-3, -OCF3, =S, -SRe, =NRe, =NORe, =NNReRe, =NN(Rg)C(O)NReRe, -ONReRe, -N(Rg)NReRe, halogeno, -CF3, -CN, -NC, -OCN, -SCN, -NO, -NO2, =N2, -N3, -S(O)Re, -S(O)ORe, -S(O)2Re, -s(o)2oRe, -S(O)NReRe, -S(O)2NReRe, -OS(O)Re, -OS(O)2Re, -OS(O)2ORe, -os(o)NReRe, -os(O)2NReRe, -C(O)Re, -C(O)ORe, -C(O)SRe, -C(O)NReRe, -C(O)N(Rg)NReRe, -C(O)N(Rg)ORe, -C(NRg)NReRe, -C(NOH)Re, -C(NOH)NReRe, -OC(O)Re, -OC(O)ORe, -OC(O)SRe, -oc(o)NReRe, -OC(NRg)NReRe, -SC(O)Re, -SC(O)ORe, -SC(O)NReRe, -sc(NRg)NReRe, -N(Rg)C(O)Re, -N[C(O)Re]2, -N(ORg)C(O)Re, -N(Rg)C(NRg)Re, -N(Rg)N(Rg)C(O)Re, -N[c(o)Rg]NReRe, -N(Rg)C(S)Re, -N(Rg)S(O)Re, N(Rg)s(o)oRe, -N(Rg)S(O)2Re, -N[S(O)2Re]2, -N(Rg)S(O)2ORe, -N(Rg)s(o)2NReRe, -N(Rg)[S(O)2]2Re, -N(Rg)C(O)ORe, -N(Rg)C(O)SRe, -N(Rg)C(O)ORe, -N(Rg)C(O)NReRe, -N(Rg)C(O)NRgNReRe, -N(Rg)N(Rg)C(O)NReRe, -N(Rg)C(S)NReRe, -[N(Rg)C(O)]2Re, -N(Rg)[C(O)]2Re, -N{[C(O)]2Re}2, -N(Rg)[C(O)]2ORe, N(Rg)[C(O)]2NReRe, -N{[C(O)]2ORe}2, -N{[C(O)]2NReRe}2, -[N(Rg)C(O)]2ORe, -N(Rg)C(NRg)ORe, -N(Rg)C(NOH)Re, -N(Rg)C(NRg)SRe, y -N(Rg)C(NRg)NReRe; cada Re es, independientemente uno de otro, hidrogeno o un radical eventualmente sustituido con uno o varios Rf y/o Rg iguales o distintos, seleccionado del grupo consistente en alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, cicloalquil C4-11-alquilo. arilo C6-10, aril C7-16-alquilo, heteroalquilo de 2-6 miembros, heterocicloalquilo de 3-8 miembros, heterocicloalquilalquilo de 4-14 miembros, heteroarilo de 5-12 miembros y heteroarilalquilo de 6-18 miembros; cada Rf es un radical adecuado y, en cada caso independientemente uno de otro, se selecciona del grupo consistente en halogeno, -CF3 y -NRgRg; y cada Rg es, independientemente uno de otro, hidrogeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, cicloalquil C4-11-alquilo, arilo C6-10, aril C7-16-alquilo, heteroalquilo de 2-6 miembros, heterocicloalquilo de 3-8 miembros, heterocicloalquilo de 4-14 miembros, heteroarilo de 5-12 miembros o heteroarilalquilo de 6-18 miembros; eventualmente en forma de sus profármacos, sus tautomeros, sus racematos, sus enantiomeros, sus diastereoisomeros y sus mezclas, así como, eventualmente, sus sales por adicion de ácidos farmacologicamente inocuas, con la condicion de que, para el caso de que R3 sea fenilo, éste está sustituido al menos con un Rb y con la condicion de que no estén incluidos 3-(Z)-{1-[4-(piperidin-1-il-metil-anilino]-1-fenil-metiliden}-6-(pirrol-1-il)-2-indolinona y 3-(Z)-{1-[4-(piperidin-1-il-metil)-anilino]-1-fenil-metiliden}-6-(pirrolidin-1-il)-2-indolinona.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08161381 | 2008-07-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR072538A1 true AR072538A1 (es) | 2010-09-01 |
Family
ID=39951549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090102874A AR072538A1 (es) | 2008-07-29 | 2009-07-28 | Derivados de indolinonas, composiciones farmacéuticas y usos |
Country Status (22)
Country | Link |
---|---|
US (1) | US8853420B2 (es) |
EP (2) | EP2324012A1 (es) |
JP (1) | JP5651110B2 (es) |
KR (1) | KR20110039474A (es) |
CN (1) | CN102112468A (es) |
AR (1) | AR072538A1 (es) |
AU (1) | AU2009275964A1 (es) |
BR (1) | BRPI0916432A2 (es) |
CA (1) | CA2731919A1 (es) |
CL (1) | CL2011000165A1 (es) |
CO (1) | CO6331434A2 (es) |
EA (1) | EA201100254A1 (es) |
EC (1) | ECSP11010816A (es) |
IL (1) | IL210344A0 (es) |
MA (1) | MA32506B1 (es) |
MX (1) | MX2011000730A (es) |
NZ (1) | NZ590560A (es) |
PE (1) | PE20110213A1 (es) |
SG (1) | SG193154A1 (es) |
TW (1) | TW201011002A (es) |
UY (1) | UY32010A (es) |
WO (1) | WO2010012747A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120107304A1 (en) | 2010-04-27 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
US20130004481A1 (en) * | 2011-01-12 | 2013-01-03 | Boehringer Ingelheim International Gmbh | Anticancer therapy |
WO2013060872A1 (en) | 2011-10-27 | 2013-05-02 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
CN103130775B (zh) * | 2011-11-22 | 2015-09-30 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的吲哚满酮衍生物 |
US20150005353A1 (en) * | 2012-02-10 | 2015-01-01 | Virginia Commonwealth University | 3-(2-amino-ethyl)-alkylidene)-thiazolidine-2,4-dione and 1-(2-amino-ethyl)-alkylidene-1,3-dihydro-indol-2-one derivatives as selective sphingosine kinase 2 inhibitors |
WO2014009319A1 (en) | 2012-07-11 | 2014-01-16 | Boehringer Ingelheim International Gmbh | Indolinone derivatives anticancer compounds |
WO2014009318A1 (en) | 2012-07-11 | 2014-01-16 | Boehringer Ingelheim International Gmbh | 3-{3-[1 -(4-dimethylaminomethyl-phenylamino)-1 -phenyl-meth-(z)-ylidene]-2-oxo-2,3-dihydro-1 h-indol-6-yll-propynoic acid ethylamide and its use in the treatment of cancer |
TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
EP3495359A1 (en) * | 2013-02-04 | 2019-06-12 | Janssen Pharmaceutica NV | Flap modulators |
RU2015143526A (ru) * | 2013-03-13 | 2017-04-19 | Бостон Байомедикал, Инк. | Производные 3-(арил или гетероарил)метилениндолин-2-она в качестве ингибиторов киназного пути раковых стволовых клеток для лечения рака |
WO2024112705A1 (en) * | 2022-11-21 | 2024-05-30 | Elima Therapeutics, Inc. | Boronic acid and boronate compositions and methods |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1115704B1 (de) | 1998-09-25 | 2003-06-18 | Boehringer Ingelheim Pharma GmbH & Co.KG | Neue substituierte indolinone mit einer inhibierenden wirkung auf verschiedene kinasen und cyclin/cdk-komplexe |
DE19924401A1 (de) | 1999-05-27 | 2000-11-30 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
AU6998000A (en) * | 1999-08-27 | 2001-03-26 | Boehringer Ingelheim Pharma Kg | Substituted indolinones as tyrosine kinase inhibitors |
UA75054C2 (uk) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
DE10117204A1 (de) * | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
PE20040701A1 (es) | 2002-07-23 | 2004-11-30 | Boehringer Ingelheim Pharma | Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos |
US7148249B2 (en) | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
US20060154939A1 (en) | 2004-12-24 | 2006-07-13 | Boehringer Ingelheim International Gmbh | Medicaments for the Treatment or Prevention of Fibrotic Diseases |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
WO2007057397A1 (en) | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer |
JP2009533480A (ja) | 2006-04-24 | 2009-09-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 3−(アミノメチリデン)2−インドリノン誘導体及びその細胞増殖抑制薬としての使用 |
EP1870400A1 (en) * | 2006-06-08 | 2007-12-26 | Boehringer Ingelheim Pharma GmbH & Co. KG | Salts and crystalline salt forms of an 2-indolinone derivative |
UY31984A (es) * | 2008-07-16 | 2010-02-26 | Boehringer Ingelheim Int | DERIVADOS DE 1-(3,4-difluorobencil)-6-oxo-1,6-dihidropirimidin-5-carboxamidas N-sustituidas y de 2-(3,4-difluorobencil)-3-oxo-2,3-dihidro-1H-pirazol-4-carboxamidas N-sustituidas. |
UY31982A (es) * | 2008-07-16 | 2010-02-26 | Boehringer Ingelheim Int | Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas |
AU2009276757A1 (en) | 2008-07-29 | 2010-02-04 | Amgen Inc. | Asymmetric process for making substituted 2-amino-thiazolones |
DK2323992T3 (en) | 2008-07-29 | 2016-10-31 | Boehringer Ingelheim Int | 5-alkynyl pyrimidines |
-
2009
- 2009-07-28 EP EP09802511A patent/EP2324012A1/en not_active Withdrawn
- 2009-07-28 MX MX2011000730A patent/MX2011000730A/es not_active Application Discontinuation
- 2009-07-28 JP JP2011520494A patent/JP5651110B2/ja not_active Expired - Fee Related
- 2009-07-28 BR BRPI0916432A patent/BRPI0916432A2/pt not_active IP Right Cessation
- 2009-07-28 KR KR1020117004476A patent/KR20110039474A/ko not_active Application Discontinuation
- 2009-07-28 PE PE2011000099A patent/PE20110213A1/es not_active Application Discontinuation
- 2009-07-28 NZ NZ590560A patent/NZ590560A/xx not_active IP Right Cessation
- 2009-07-28 CA CA2731919A patent/CA2731919A1/en not_active Abandoned
- 2009-07-28 WO PCT/EP2009/059770 patent/WO2010012747A1/en active Application Filing
- 2009-07-28 AU AU2009275964A patent/AU2009275964A1/en not_active Abandoned
- 2009-07-28 EA EA201100254A patent/EA201100254A1/ru unknown
- 2009-07-28 AR ARP090102874A patent/AR072538A1/es unknown
- 2009-07-28 EP EP12160987A patent/EP2471787A1/en not_active Ceased
- 2009-07-28 CN CN2009801301747A patent/CN102112468A/zh active Pending
- 2009-07-28 UY UY0001032010A patent/UY32010A/es not_active Application Discontinuation
- 2009-07-28 TW TW098125418A patent/TW201011002A/zh unknown
- 2009-07-28 US US13/125,841 patent/US8853420B2/en active Active
- 2009-07-28 SG SG2013057252A patent/SG193154A1/en unknown
-
2010
- 2010-12-29 IL IL210344A patent/IL210344A0/en unknown
-
2011
- 2011-01-26 CL CL2011000165A patent/CL2011000165A1/es unknown
- 2011-01-26 MA MA33561A patent/MA32506B1/fr unknown
- 2011-01-27 CO CO11009250A patent/CO6331434A2/es active IP Right Grant
- 2011-02-09 EC EC2011010816A patent/ECSP11010816A/es unknown
Also Published As
Publication number | Publication date |
---|---|
SG193154A1 (en) | 2013-09-30 |
NZ590560A (en) | 2012-12-21 |
AU2009275964A1 (en) | 2010-02-04 |
CL2011000165A1 (es) | 2011-06-17 |
TW201011002A (en) | 2010-03-16 |
EP2471787A1 (en) | 2012-07-04 |
JP5651110B2 (ja) | 2015-01-07 |
WO2010012747A1 (en) | 2010-02-04 |
IL210344A0 (en) | 2011-03-31 |
CO6331434A2 (es) | 2011-10-20 |
MX2011000730A (es) | 2011-03-15 |
US8853420B2 (en) | 2014-10-07 |
ECSP11010816A (es) | 2011-03-31 |
CN102112468A (zh) | 2011-06-29 |
EA201100254A1 (ru) | 2011-08-30 |
EP2324012A1 (en) | 2011-05-25 |
MA32506B1 (fr) | 2011-07-03 |
PE20110213A1 (es) | 2011-04-16 |
KR20110039474A (ko) | 2011-04-18 |
UY32010A (es) | 2010-02-26 |
JP2011529470A (ja) | 2011-12-08 |
US20110263565A1 (en) | 2011-10-27 |
BRPI0916432A2 (pt) | 2016-02-16 |
CA2731919A1 (en) | 2010-02-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR072538A1 (es) | Derivados de indolinonas, composiciones farmacéuticas y usos | |
AR076134A1 (es) | Derivados de 2,4 diaminopirimidinas | |
AR066963A1 (es) | Derivados de indolinona, preparaciones farmaceuticas que los contienen y usos de los mismos para el tratamiento y/o prevencion de cancer y enfermedades inflamatorias y autoinmunes. | |
AR078513A1 (es) | Pirimidinas y composiciones farmaceuticas que las comprenden | |
AR074210A1 (es) | Derivados de pirimidina como inhibidores de ptk2-quinasa | |
AR074209A1 (es) | Derivados de pirimidina utiles para el tratamiento del cancer | |
AR074127A1 (es) | 2,4 diaminopirimidinas y uso para la preparacion de un medicamento para el tratamiento de cancer, infecciones y enfermedades inflamatorias y autoinmunes | |
AR051743A1 (es) | Tiazolil - dihidro- indazoles | |
AR072845A1 (es) | 5-alquil-pirimidinas y su uso en el tratamiento de enfermedades mediadas por la actividad de quinasas. | |
AR076620A1 (es) | 2,4 DIAMINOPIRIMIDINAS, COMPOSICIONES FARMACEUTICAS, PROCESOS DE PREPARACIoN Y SU USO COMO MEDICAMENTO. | |
EA201891861A1 (ru) | 2-(морфолин-4-ил)-1,7-нафтиридины | |
EA201200794A1 (ru) | Триазолопиридины | |
EA201301181A1 (ru) | Триазолопиридины | |
EA201001126A1 (ru) | Пирролопиримидины и пирролопиридины | |
CY1116958T1 (el) | Υποκατεστημενες τριαζολοπυριδινες και η χρηση τους ως ττκ αναστολεις | |
CO7400867A2 (es) | Modificador del sabor dulce | |
PE20160501A1 (es) | Derivados de quinolizina sustituidos utiles como inhibidores de integrasa del vih | |
ECSP10010434A (es) | Inhibidores de hsp90 | |
NI201400043A (es) | 4 - fenil - piridinas sustituidas para el tratamiento de enfermedades relacionadas con el receptor de nk1 | |
AR086828A1 (es) | Compuestos heterociclicos fusionados como moduladores del canal ionico | |
AR082850A1 (es) | Aminopirazoloquinazolinas | |
AR060890A1 (es) | Compuestos derivados de pirimidina y composicion farmaceutica en base a ellos | |
PE20181197A1 (es) | 2,4-dihidroxi-nicotinamidas como agonistas del receptor de apelina (apj) | |
PE20170947A1 (es) | 2-amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de bace1 | |
PE20161405A1 (es) | Analogos de cortistatina y sintesis y usos de los mismos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |