CN111655713A - Iap抑制剂及其在药物中的应用 - Google Patents

Iap抑制剂及其在药物中的应用 Download PDF

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Publication number
CN111655713A
CN111655713A CN201980008153.1A CN201980008153A CN111655713A CN 111655713 A CN111655713 A CN 111655713A CN 201980008153 A CN201980008153 A CN 201980008153A CN 111655713 A CN111655713 A CN 111655713A
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compound
membered
alkyl
aryl
independently
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CN111655713B (zh
Inventor
谢洪明
寇玉辉
蒋海港
黄仕海
张英俊
张健存
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Guangdong HEC Pharmaceutical
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Sunshine Lake Pharma Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

一种抑制IAP的新化合物及其用途。具体涉及一种可作为IAP抑制剂的化合物，或其立体异构体、互变异构体、氮氧化物、水合物、溶剂化物、代谢产物、药学上可接受的盐或前药。还涉及所述化合物和其药物组合物在制备用于治疗或预防IAP紊乱所致疾病的药物中的用途，尤其是在制备用于治疗或预防癌症或者乙型肝炎病毒感染的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN201980008153.1A 2018-02-09 2019-01-21 Iap抑制剂及其在药物中的应用 Active CN111655713B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018101327894 2018-02-09
CN201810132789 2018-02-09
PCT/CN2019/072531 WO2019154053A1 (zh) 2018-02-09 2019-01-21 Iap抑制剂及其在药物中的应用

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CN111655713A true CN111655713A (zh) 2020-09-11
CN111655713B CN111655713B (zh) 2023-06-27

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CN (1) CN111655713B (zh)
WO (1) WO2019154053A1 (zh)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101035802A (zh) * 2004-07-02 2007-09-12 健泰科生物技术公司 Iap抑制剂
CN101128425A (zh) * 2005-02-25 2008-02-20 泰特拉洛吉克药业公司 Iap二聚体抑制剂
CN101516904A (zh) * 2006-07-24 2009-08-26 泰特拉洛吉克药业公司 二聚的iap拮抗剂
CN102471275A (zh) * 2009-07-02 2012-05-23 泰特拉洛吉克药业公司 Smac模拟物
CN108440507A (zh) * 2017-02-16 2018-08-24 南京圣和药业股份有限公司 作为细胞凋亡蛋白抑制剂的化合物及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103261186A (zh) * 2010-12-13 2013-08-21 诺瓦提斯公司 二聚化iap抑制剂

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101035802A (zh) * 2004-07-02 2007-09-12 健泰科生物技术公司 Iap抑制剂
CN101128425A (zh) * 2005-02-25 2008-02-20 泰特拉洛吉克药业公司 Iap二聚体抑制剂
CN101516904A (zh) * 2006-07-24 2009-08-26 泰特拉洛吉克药业公司 二聚的iap拮抗剂
CN102471275A (zh) * 2009-07-02 2012-05-23 泰特拉洛吉克药业公司 Smac模拟物
CN108440507A (zh) * 2017-02-16 2018-08-24 南京圣和药业股份有限公司 作为细胞凋亡蛋白抑制剂的化合物及其应用

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WO2019154053A1 (zh) 2019-08-15
CN111655713B (zh) 2023-06-27

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Address after: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province

Patentee after: Guangdong Dongyangguang Pharmaceutical Co.,Ltd.

Address before: 523808 No. 1 Industrial North Road, Songshan Industrial Park, Songshan, Guangdong, Dongguan, Hubei

Patentee before: SUNSHINE LAKE PHARMA Co.,Ltd.