RU2015139969A - Комбинация вакцинации и ингибирования пути pd-1 - Google Patents
Комбинация вакцинации и ингибирования пути pd-1 Download PDFInfo
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- 230000005764 inhibitory process Effects 0.000 title 1
- 238000002255 vaccination Methods 0.000 title 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 25
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 25
- 229940022005 RNA vaccine Drugs 0.000 claims 18
- 108700021021 mRNA Vaccine Proteins 0.000 claims 18
- 239000003112 inhibitor Substances 0.000 claims 17
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 13
- 230000037361 pathway Effects 0.000 claims 13
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 6
- 108700026244 Open Reading Frames Proteins 0.000 claims 6
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 6
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 6
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 5
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229960003301 nivolumab Drugs 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000003042 antagnostic effect Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000007327 Protamines Human genes 0.000 claims 1
- 108010007568 Protamines Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229950009791 durvalumab Drugs 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940048914 protamine Drugs 0.000 claims 1
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2039/53—DNA (RNA) vaccination
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (34)
1. Комбинация вакцина/ингибитор, содержащая:
(I) в качестве вакцины РНК-вакцину, содержащую по меньшей мере одну РНК, которая содержит по меньшей мере одну открытую рамку считывания (ОРС), кодирующую по меньшей мере один антиген, и
(II) в качестве ингибитора композицию, содержащую ингибитор PD-1-пути.
2. Комбинация по п. 1, в которой ингибитор PD-1-пути выбран из группы, состоящей из ингибиторов, направленных против PD-1, PD-L1 или PD-L2.
3. Комбинация по п. 1 или 2, в которой ингибитор PD-1-пути выбран из группы, состоящей из антагонистического антитела или нуклеиновой кислоты, кодирующей антагонистическое антитело, siPHK, антисмысловой РНК, белка, содержащего аминокислотную последовательность, которая обладает способностью связываться с PD-1, но препятствует передаче сигнала PD-1-путем, или нуклеиновой кислоты, кодирующей указанную аминокислотную последовательность, растворимого белка или нуклеиновой кислоты, кодирующей растворимый белок, который конкурирует с PD-1 за связывание с его лигандами PD-L1 и PD-L2, и низкомолекулярного ингибитора.
4. Комбинация по п. 3, в которой ингибитор PD-1-пути представляет собой антитело или нуклеиновую кислоту, кодирующую антитело, мишенью которого является PD-1 или лиганд PD-1.
5. Комбинация по п. 4, в которой антитело, мишенью которого является PD-1, представляет собой ниволумаб (BMS-936558/MDX1106), СТ-011 или MK-3475 (SCH 900475).
6. Комбинация по п. 4, в которой антитело, мишенью которого является PD-L1, представляет собой MDX-1105/BMS-936559, MPDL3280A/RG7446 или MEDI4736.
7. Комбинация по п. 3, в которой белок, содержащий аминокислотную последовательность, которая обладает способностью связываться с PD-1, но препятствует передаче сигнала PD-1-путем, или нуклеиновую кислоту, кодирующую указанную аминокислотную последовательность, представляет собой слитый белок фрагмента PD-L1 или лиганда PD-L2.
8. Комбинация по п. 7, в которой слитый белок представляет собой слитый белок внеклеточного домена PD-L1 или PD-L2, или его фрагмента, способного связываться с PD-1.
9. Комбинация по п. 8, в которой слитый белок представляет собой слитый белок внеклеточного домена PD-L2 и Fc-области иммуноглобулина.
10. Комбинация по п. 3, в которой растворимый белок представляет собой растворимый рецептор PD-1, который конкурирует со связанным с мембраной PD-1 за связывание с PD-L1 и/или PD-L2.
11. Комбинация по одному из пп. 1, 2 и 4-10, в которой по меньшей мере одна РНК, входящая в РНК-вакцину, представляет собой выделенную РНК.
12. Комбинация по одному из пп. 1, 2 и 4-10, в которой по меньшей мере одна РНК, входящая в РНК-вакцину, представляет собой стабилизированную РНК.
13. Комбинация по одному из пп. 1, 2 и 4-10, в которой по меньшей мере одна РНК, входящая в РНК-вакцину, является по меньшей мере частично G/C-модифицированной, в которой предпочтительно содержание G/C по меньшей мере в одной открытой рамке считывания по меньшей мере одной РНК, входящей в РНК-вакцину, увеличено по сравнению с открытой рамкой считывания дикого типа.
14. Комбинация по одному из пп. 1, 2 и 4-10, в которой по меньшей мере одна РНК, входящая в РНК-вакцину, содержит область с оптимизированными кодонами, предпочтительно в которой по меньшей мере одна открытая рамка считывания по меньшей мере одной РНК, входящей в РНК-вакцину, имеет оптимизированные кодоны.
15. Комбинация по одному из пп. 1, 2 и 4-10, в которой по меньшей мере одна РНК, входящая в РНК-вакцину, представляет собой мРНК.
16. Комбинация по одному из пп. 1, 2 и 4-10, в которой по меньшей мере одна РНК, входящая в РНК-вакцину, включена в комплекс с носителем.
17. Комбинация по п. 16, в которой носитель представляет собой катионное или поликатионное соединение, или полимерный носитель, предпочтительно протамин.
18. Фармацевтическая композиция, содержащая:
(I) РНК-вакцину, содержащую по меньшей мере одну РНК, которая содержит по меньшей мере одну открытую рамку считывания, кодирующую по меньшей мере один антиген, по одному из предыдущих пунктов, и
(II) ингибитор PD-1-пути по одному из предыдущих пунктов.
19. Набор компонентов, содержащий:
(I) РНК-вакцину, содержащую по меньшей мере одну РНК, которая содержит по меньшей мере одну открытую рамку считывания, кодирующую по меньшей мере один антиген, по одному из предыдущих пунктов, и
(II) композицию, содержащую ингибитор PD-1-пути по одному из предыдущих пунктов.
20. Комбинация по одному из пп. 1, 2 и 4-10, фармацевтическая композиция по п. 18, набор компонентов по п. 19, предназначенные для медицинского применения.
21. Комбинация по одному из пп. 1, 2 и 4-10, фармацевтическая композиция по п. 18 или п. 20, набор компонентов по п. 19 или п. 20, предназначенные для применения в способе предупреждения или лечения опухолевого или ракового заболевания, или инфекционного заболевания.
22. Комбинация или набор компонентов по п. 21, где ингибитор PD-1-пути и РНК-вакцина предназначены для последовательного введения пациенту, нуждающемуся в этом.
23. Комбинация или набор компонентов по п. 21, где ингибитор PD-1-пути и РНК-вакцина предназначены для одновременного введения пациенту, нуждающемуся в этом.
24. Комбинация или набор компонентов по п. 21, где ингибитор PD-1-пути и РНК-вакцина предназначены для введения пациенту, нуждающемуся в этом, с помощью различных путей введения.
25. Применение ингибитора PD-1-пути согласно определению в любом из предыдущих пунктов, в терапии в комбинации с РНК-вакциной по одному из предыдущих пунктов.
26. Применение РНК-вакцины согласно определению в любом из предыдущих пунктов, предназначенная для применения в терапии в комбинации с ингибитором PD-1-пути по одному из предыдущих пунктов.
27. Способ лечения, включающий введение индивидууму, нуждающемуся в этом, в терапевтически эффективном количестве РНК-вакцины по одному из предыдущих пунктов в комбинации с ингибитором PD-1-пути по одному из предыдущих пунктов.
28. Способ лечения по п. 27, в котором РНК-вакцину и ингибитор PD-1-пути вводят последовательно и/или с помощью различных путей введения.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2013000526 | 2013-02-22 | ||
| EPPCT/EP2013/000526 | 2013-02-22 | ||
| PCT/EP2014/000461 WO2014127917A1 (en) | 2013-02-22 | 2014-02-21 | Combination of vaccination and inhibition of the pd-1 pathway |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015139969A true RU2015139969A (ru) | 2017-03-28 |
| RU2718988C2 RU2718988C2 (ru) | 2020-04-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2015139969A RU2718988C2 (ru) | 2013-02-22 | 2014-02-21 | Комбинация противораковой рнк-вакцины и ингибитора пути pd-1 и ее применение |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US9974845B2 (ru) |
| JP (2) | JP6456305B2 (ru) |
| KR (1) | KR102134056B1 (ru) |
| CN (2) | CN105073135A (ru) |
| AU (2) | AU2014220957A1 (ru) |
| BR (1) | BR112015018989B1 (ru) |
| CA (1) | CA2897858A1 (ru) |
| DK (1) | DK2958588T3 (ru) |
| ES (2) | ES2739913T3 (ru) |
| HK (1) | HK1250910A1 (ru) |
| MX (2) | MX2015010880A (ru) |
| RU (1) | RU2718988C2 (ru) |
| SG (3) | SG11201506052PA (ru) |
| WO (1) | WO2014127917A1 (ru) |
Families Citing this family (163)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2013120497A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein |
| WO2014127917A1 (en) * | 2013-02-22 | 2014-08-28 | Curevac Gmbh | Combination of vaccination and inhibition of the pd-1 pathway |
| RU2712743C2 (ru) | 2013-08-21 | 2020-01-30 | Куревак Аг | Вакцина против бешенства |
| WO2015024668A2 (en) | 2013-08-21 | 2015-02-26 | Curevac Gmbh | Respiratory syncytial virus (rsv) vaccine |
| CN105451779A (zh) | 2013-08-21 | 2016-03-30 | 库瑞瓦格股份公司 | 增加rna编码蛋白表达的方法 |
| AU2014310935B2 (en) | 2013-08-21 | 2019-11-21 | CureVac SE | Combination vaccine |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| AU2014329452B2 (en) | 2013-10-03 | 2019-06-20 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| WO2015062738A1 (en) | 2013-11-01 | 2015-05-07 | Curevac Gmbh | Modified rna with decreased immunostimulatory properties |
| SG11201604738TA (en) | 2013-12-12 | 2016-07-28 | Shanghai Hengrui Pharm Co Ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| JP6584414B2 (ja) | 2013-12-30 | 2019-10-02 | キュアバック アーゲー | 人工核酸分子 |
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2014
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