RU2015118217A - Способ кристаллизации трициклических индольных производных - Google Patents
Способ кристаллизации трициклических индольных производных Download PDFInfo
- Publication number
- RU2015118217A RU2015118217A RU2015118217A RU2015118217A RU2015118217A RU 2015118217 A RU2015118217 A RU 2015118217A RU 2015118217 A RU2015118217 A RU 2015118217A RU 2015118217 A RU2015118217 A RU 2015118217A RU 2015118217 A RU2015118217 A RU 2015118217A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- composition according
- alkyl
- composition
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 6
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- YCKRFDGAMUMZLT-BJUDXGSMSA-N fluorine-18 atom Chemical compound [18F] YCKRFDGAMUMZLT-BJUDXGSMSA-N 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 238000000968 medical method and process Methods 0.000 claims 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical group CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 2
- -1 [ 18 F] fluoro Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 230000008025 crystallization Effects 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 150000007530 organic bases Chemical class 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- 238000007363 ring formation reaction Methods 0.000 claims 2
- SPXOTSHWBDUUMT-UHFFFAOYSA-M 4-nitrobenzenesulfonate Chemical compound [O-][N+](=O)C1=CC=C(S([O-])(=O)=O)C=C1 SPXOTSHWBDUUMT-UHFFFAOYSA-M 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 150000008052 alkyl sulfonates Chemical class 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 238000011503 in vivo imaging Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3689DE2012 | 2012-11-30 | ||
| IN3689/DEL/2012 | 2012-11-30 | ||
| GB1300647.3 | 2013-01-15 | ||
| GBGB1300647.3A GB201300647D0 (en) | 2013-01-15 | 2013-01-15 | Crystallization |
| PCT/EP2013/074986 WO2014083113A1 (en) | 2012-11-30 | 2013-11-28 | Crystallization process of tricyclic indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015118217A true RU2015118217A (ru) | 2017-01-11 |
Family
ID=54266915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015118217A RU2015118217A (ru) | 2012-11-30 | 2013-11-28 | Способ кристаллизации трициклических индольных производных |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10709798B2 (https=) |
| EP (1) | EP2943195A1 (https=) |
| JP (1) | JP6280560B2 (https=) |
| KR (1) | KR20150088802A (https=) |
| CN (2) | CN111362863A (https=) |
| AU (1) | AU2013351152A1 (https=) |
| BR (1) | BR112015012138A2 (https=) |
| CA (1) | CA2892485A1 (https=) |
| IN (1) | IN2015DN03978A (https=) |
| MX (1) | MX2015006871A (https=) |
| RU (1) | RU2015118217A (https=) |
| WO (1) | WO2014083113A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150088802A (ko) | 2012-11-30 | 2015-08-03 | 지이 헬쓰케어 리미티드 | 트리시클릭 인돌 유도체의 결정화 방법 |
| US20160144477A1 (en) * | 2014-11-21 | 2016-05-26 | Diane Scott | Coated compressive subpad for chemical mechanical polishing |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177440B1 (en) * | 1996-10-30 | 2001-01-23 | Eli Lilly And Company | Substituted tricyclics |
| CA2310250A1 (en) | 1997-11-14 | 1999-05-27 | August Masaru Watanabe | Treatment for alzheimer's disease |
| DZ2769A1 (fr) | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Composés tricycliques substitués. |
| US7160909B2 (en) | 2001-08-09 | 2007-01-09 | Eli Lilly And Company | Cyclopenta[b]indole derivatives as sPLA2 inhibitors |
| ATE312817T1 (de) | 2001-08-09 | 2005-12-15 | Lilly Co Eli | Cyclohept'bö indolderivate als spla2-inhibitoren |
| GB0905328D0 (en) | 2009-03-27 | 2009-05-13 | Ge Healthcare Ltd | Indole derivatives |
| JP5830519B2 (ja) | 2010-03-26 | 2015-12-09 | ジーイー・ヘルスケア・リミテッド | Ｐｂｒリガンドとしての三環式インドール誘導体 |
| GB201016038D0 (en) | 2010-09-24 | 2010-11-10 | Ge Healthcare Ltd | In vivo imaging method |
| GB201016411D0 (en) | 2010-09-30 | 2010-11-10 | Ge Healthcare Ltd | In vivo imaging method for cancer |
| GB201021263D0 (en) | 2010-12-15 | 2011-01-26 | Ge Healthcare Ltd | Solid phase extraction method |
| US9220795B2 (en) * | 2011-09-22 | 2015-12-29 | Ge Healthcare Limited | Indole derivatives |
| KR20150088802A (ko) | 2012-11-30 | 2015-08-03 | 지이 헬쓰케어 리미티드 | 트리시클릭 인돌 유도체의 결정화 방법 |
-
2013
- 2013-11-28 KR KR1020157013974A patent/KR20150088802A/ko not_active Withdrawn
- 2013-11-28 WO PCT/EP2013/074986 patent/WO2014083113A1/en not_active Ceased
- 2013-11-28 BR BR112015012138A patent/BR112015012138A2/pt not_active IP Right Cessation
- 2013-11-28 CA CA2892485A patent/CA2892485A1/en not_active Abandoned
- 2013-11-28 MX MX2015006871A patent/MX2015006871A/es unknown
- 2013-11-28 AU AU2013351152A patent/AU2013351152A1/en not_active Abandoned
- 2013-11-28 JP JP2015544462A patent/JP6280560B2/ja active Active
- 2013-11-28 CN CN202010090283.9A patent/CN111362863A/zh active Pending
- 2013-11-28 IN IN3978DEN2015 patent/IN2015DN03978A/en unknown
- 2013-11-28 EP EP13796090.2A patent/EP2943195A1/en not_active Withdrawn
- 2013-11-28 RU RU2015118217A patent/RU2015118217A/ru not_active Application Discontinuation
- 2013-11-28 US US14/648,353 patent/US10709798B2/en active Active
- 2013-11-28 CN CN201380062872.4A patent/CN104837489A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014083113A1 (en) | 2014-06-05 |
| US10709798B2 (en) | 2020-07-14 |
| JP2016507477A (ja) | 2016-03-10 |
| JP6280560B2 (ja) | 2018-02-14 |
| KR20150088802A (ko) | 2015-08-03 |
| CA2892485A1 (en) | 2014-06-05 |
| CN111362863A (zh) | 2020-07-03 |
| AU2013351152A1 (en) | 2015-05-21 |
| BR112015012138A2 (pt) | 2017-07-11 |
| IN2015DN03978A (https=) | 2015-10-02 |
| CN104837489A (zh) | 2015-08-12 |
| US20150335766A1 (en) | 2015-11-26 |
| EP2943195A1 (en) | 2015-11-18 |
| MX2015006871A (es) | 2015-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20161129 |