CN111362863A - 三环吲哚衍生物的结晶方法 - Google Patents

三环吲哚衍生物的结晶方法 Download PDF

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Publication number
CN111362863A
CN111362863A CN202010090283.9A CN202010090283A CN111362863A CN 111362863 A CN111362863 A CN 111362863A CN 202010090283 A CN202010090283 A CN 202010090283A CN 111362863 A CN111362863 A CN 111362863A
Authority
CN
China
Prior art keywords
group
composition
compound
formula
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010090283.9A
Other languages
English (en)
Chinese (zh)
Inventor
S.尼尔森
S.B.A.P.巴拉吉
U.P.莫卡帕蒂
A.M.卡达维帕兰普穆罕默德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1300647.3A external-priority patent/GB201300647D0/en
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN111362863A publication Critical patent/CN111362863A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
CN202010090283.9A 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法 Pending CN111362863A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN3689DE2012 2012-11-30
IN3689/DEL/2012 2012-11-30
GB1300647.3 2013-01-15
GBGB1300647.3A GB201300647D0 (en) 2013-01-15 2013-01-15 Crystallization
CN201380062872.4A CN104837489A (zh) 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380062872.4A Division CN104837489A (zh) 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法

Publications (1)

Publication Number Publication Date
CN111362863A true CN111362863A (zh) 2020-07-03

Family

ID=54266915

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202010090283.9A Pending CN111362863A (zh) 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法
CN201380062872.4A Pending CN104837489A (zh) 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201380062872.4A Pending CN104837489A (zh) 2012-11-30 2013-11-28 三环吲哚衍生物的结晶方法

Country Status (12)

Country Link
US (1) US10709798B2 (https=)
EP (1) EP2943195A1 (https=)
JP (1) JP6280560B2 (https=)
KR (1) KR20150088802A (https=)
CN (2) CN111362863A (https=)
AU (1) AU2013351152A1 (https=)
BR (1) BR112015012138A2 (https=)
CA (1) CA2892485A1 (https=)
IN (1) IN2015DN03978A (https=)
MX (1) MX2015006871A (https=)
RU (1) RU2015118217A (https=)
WO (1) WO2014083113A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150088802A (ko) 2012-11-30 2015-08-03 지이 헬쓰케어 리미티드 트리시클릭 인돌 유도체의 결정화 방법
US20160144477A1 (en) * 2014-11-21 2016-05-26 Diane Scott Coated compressive subpad for chemical mechanical polishing

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102448933A (zh) * 2009-03-27 2012-05-09 通用电气健康护理有限公司 作为pbr配体的吲哚衍生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177440B1 (en) * 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
CA2310250A1 (en) 1997-11-14 1999-05-27 August Masaru Watanabe Treatment for alzheimer's disease
DZ2769A1 (fr) 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
US7160909B2 (en) 2001-08-09 2007-01-09 Eli Lilly And Company Cyclopenta[b]indole derivatives as sPLA2 inhibitors
ATE312817T1 (de) 2001-08-09 2005-12-15 Lilly Co Eli Cyclohept'bö indolderivate als spla2-inhibitoren
JP5830519B2 (ja) 2010-03-26 2015-12-09 ジーイー・ヘルスケア・リミテッド Ｐｂｒリガンドとしての三環式インドール誘導体
GB201016038D0 (en) 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
GB201021263D0 (en) 2010-12-15 2011-01-26 Ge Healthcare Ltd Solid phase extraction method
US9220795B2 (en) * 2011-09-22 2015-12-29 Ge Healthcare Limited Indole derivatives
KR20150088802A (ko) 2012-11-30 2015-08-03 지이 헬쓰케어 리미티드 트리시클릭 인돌 유도체의 결정화 방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102448933A (zh) * 2009-03-27 2012-05-09 通用电气健康护理有限公司 作为pbr配体的吲哚衍生物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HARRY WADSWORTH等: "[18F]GE-180: A novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO)", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *

Also Published As

Publication number Publication date
WO2014083113A1 (en) 2014-06-05
US10709798B2 (en) 2020-07-14
JP2016507477A (ja) 2016-03-10
JP6280560B2 (ja) 2018-02-14
KR20150088802A (ko) 2015-08-03
CA2892485A1 (en) 2014-06-05
AU2013351152A1 (en) 2015-05-21
RU2015118217A (ru) 2017-01-11
BR112015012138A2 (pt) 2017-07-11
IN2015DN03978A (https=) 2015-10-02
CN104837489A (zh) 2015-08-12
US20150335766A1 (en) 2015-11-26
EP2943195A1 (en) 2015-11-18
MX2015006871A (es) 2015-09-16

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Application publication date: 20200703