RU2015101761A - Способ производства микроносителей - Google Patents

Способ производства микроносителей Download PDF

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RU2015101761A
RU2015101761A RU2015101761A RU2015101761A RU2015101761A RU 2015101761 A RU2015101761 A RU 2015101761A RU 2015101761 A RU2015101761 A RU 2015101761A RU 2015101761 A RU2015101761 A RU 2015101761A RU 2015101761 A RU2015101761 A RU 2015101761A
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microcarriers
active layer
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Рафаел ТОРНЭЙ
Николас ДЕМАЙЕРРИ
Стефан ГАМПЕР
Филипп РЕНАУД
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МАЙКАРТИС ЭнВи
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    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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Abstract

1. Способ изготовления микроносителей (19, 20), включающий в себя следующие шаги:(a) получение пластины (6), имеющей структуру сэндвича, состоящего из нижнего слоя (7), верхнего слоя (8) и изолирующего слоя (9), расположенного между упомянутым нижним и верхним слоями (7, 8),(b) стравливание верхнего слоя (8) с целью разграничения боковых стенок (12) тел (11) микроносителей (19, 20),(c) нанесение первого активного слоя (13) как минимум на верхнюю поверхность (14) тел (11),(d) нанесение сплошного полимерного слоя (16, 22) поверх первого активного слоя (13),(e) стравливание нижнего слоя (7) и изолирующего слоя (9),(f) удаление полимерного слоя (16, 22) для освобождения микроносителей (19, 20).2. Способ по п. 1, в котором шаг (е) осуществляется путем первого травления для селективного травления нижнего слоя (7), например, путем использования травильной ванны и путем второго травления для селективного травления изолирующего слоя (9), например, путем сухого травления.3. Способ по п. 1, в котором полимерный слой (16) удаляется путем сухого травления.4. Способ по п. 1, в котором отличительная метка, например код (2, 3), гравируется на микроносителях (19, 20), например, между шагами (b) и (с).5. Способ по п. 1, в котором в состав нижнего слоя (7) и/или верхнего слоя (8) входит монокристаллический кремний.6. Способ по п. 1, в котором в состав изолирующего слоя (9) входит диоксид кремния.7. Способ по п. 1, в котором в состав полимерного слоя (16) входит дипараксилен.8. Способ по п. 1, в котором полимерный слой представляет собой слой клея (22), который связывает подложку (21), например пластину, изготавливаемую из кремния, кварца или стекла, с пластиной (6).9. Способ по п. 1, в котором второй активный слой (17) наносится как минимум на нижнюю поверхность (18) тел (11) микроносителей (19), например, между шагами (e) и (f).10. Способ по п. 1, в котором в состав первого

Claims (12)

1. Способ изготовления микроносителей (19, 20), включающий в себя следующие шаги:
(a) получение пластины (6), имеющей структуру сэндвича, состоящего из нижнего слоя (7), верхнего слоя (8) и изолирующего слоя (9), расположенного между упомянутым нижним и верхним слоями (7, 8),
(b) стравливание верхнего слоя (8) с целью разграничения боковых стенок (12) тел (11) микроносителей (19, 20),
(c) нанесение первого активного слоя (13) как минимум на верхнюю поверхность (14) тел (11),
(d) нанесение сплошного полимерного слоя (16, 22) поверх первого активного слоя (13),
(e) стравливание нижнего слоя (7) и изолирующего слоя (9),
(f) удаление полимерного слоя (16, 22) для освобождения микроносителей (19, 20).
2. Способ по п. 1, в котором шаг (е) осуществляется путем первого травления для селективного травления нижнего слоя (7), например, путем использования травильной ванны и путем второго травления для селективного травления изолирующего слоя (9), например, путем сухого травления.
3. Способ по п. 1, в котором полимерный слой (16) удаляется путем сухого травления.
4. Способ по п. 1, в котором отличительная метка, например код (2, 3), гравируется на микроносителях (19, 20), например, между шагами (b) и (с).
5. Способ по п. 1, в котором в состав нижнего слоя (7) и/или верхнего слоя (8) входит монокристаллический кремний.
6. Способ по п. 1, в котором в состав изолирующего слоя (9) входит диоксид кремния.
7. Способ по п. 1, в котором в состав полимерного слоя (16) входит дипараксилен.
8. Способ по п. 1, в котором полимерный слой представляет собой слой клея (22), который связывает подложку (21), например пластину, изготавливаемую из кремния, кварца или стекла, с пластиной (6).
9. Способ по п. 1, в котором второй активный слой (17) наносится как минимум на нижнюю поверхность (18) тел (11) микроносителей (19), например, между шагами (e) и (f).
10. Способ по п. 1, в котором в состав первого активного слоя (13) и/или второго активного слоя (17) входит материал, обладающий оптическими или магнитными свойствами, поликристаллический кремний и/или политетрафторэтилен или слой металла с высоким коэффициентом отражения.
11. Способ по п. 1, в котором в состав первого активного слоя (13) и/или второго активного слоя (17) входит оксид или нитрид, например диоксид кремния, или слой металла.
12. Микроноситель (19), изготавливаемый способом по п. 9, включающий в себя тело (11), имеющее верхнюю поверхность (14), покрытую первым активным слоем (13), и нижнюю поверхность (18), покрытую вторым активным слоем (17).
RU2015101761A 2012-07-24 2013-07-22 Способ производства микроносителей RU2631526C2 (ru)

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EP12177718.9A EP2690059A1 (en) 2012-07-24 2012-07-24 Method for producing microcarriers
EP12177718.9 2012-07-24
PCT/EP2013/065442 WO2014016262A1 (en) 2012-07-24 2013-07-22 Method for producing microcarriers

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CN110484129B (zh) * 2019-07-02 2022-01-25 昆山联滔电子有限公司 带有防护涂层的产品及其制备方法

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US9349545B2 (en) 2016-05-24
KR20150040939A (ko) 2015-04-15
IN2015DN00439A (ru) 2015-06-19
EP2690059A1 (en) 2014-01-29
BR112015001463A2 (pt) 2017-07-04
AU2013295081A1 (en) 2015-02-05
EP2877423A1 (en) 2015-06-03
RU2631526C2 (ru) 2017-09-25
ES2787857T3 (es) 2020-10-19
CN104736470A (zh) 2015-06-24
US20150162141A1 (en) 2015-06-11
AU2013295081B2 (en) 2016-10-06
JP2015531691A (ja) 2015-11-05
CA2879150C (en) 2020-07-14
CN104736470B (zh) 2016-08-17
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ZA201500438B (en) 2017-11-29

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