RU2014151992A - Лечение воспалительных заболеваний глаз с применением лахинимода - Google Patents
Лечение воспалительных заболеваний глаз с применением лахинимода Download PDFInfo
- Publication number
- RU2014151992A RU2014151992A RU2014151992A RU2014151992A RU2014151992A RU 2014151992 A RU2014151992 A RU 2014151992A RU 2014151992 A RU2014151992 A RU 2014151992A RU 2014151992 A RU2014151992 A RU 2014151992A RU 2014151992 A RU2014151992 A RU 2014151992A
- Authority
- RU
- Russia
- Prior art keywords
- lachinimod
- pharmaceutically acceptable
- acceptable salt
- effective amount
- therapeutically effective
- Prior art date
Links
- 208000027866 inflammatory disease Diseases 0.000 title claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 37
- 206010046851 Uveitis Diseases 0.000 claims abstract 14
- 208000030533 eye disease Diseases 0.000 claims abstract 13
- 230000002757 inflammatory effect Effects 0.000 claims abstract 13
- 208000024891 symptom Diseases 0.000 claims abstract 8
- 206010061218 Inflammation Diseases 0.000 claims abstract 7
- 230000004054 inflammatory process Effects 0.000 claims abstract 7
- 210000001519 tissue Anatomy 0.000 claims abstract 6
- 208000023275 Autoimmune disease Diseases 0.000 claims abstract 5
- 206010015943 Eye inflammation Diseases 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims abstract 5
- 206010010741 Conjunctivitis Diseases 0.000 claims abstract 4
- 210000004087 cornea Anatomy 0.000 claims abstract 4
- 210000000744 eyelid Anatomy 0.000 claims abstract 4
- 210000004561 lacrimal apparatus Anatomy 0.000 claims abstract 4
- 210000001525 retina Anatomy 0.000 claims abstract 4
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 210000005112 optic tract Anatomy 0.000 claims abstract 3
- 230000004421 optic tracts Effects 0.000 claims abstract 3
- 208000002691 Choroiditis Diseases 0.000 claims abstract 2
- 206010010755 Conjunctivitis viral Diseases 0.000 claims abstract 2
- 206010061818 Disease progression Diseases 0.000 claims abstract 2
- 206010022941 Iridocyclitis Diseases 0.000 claims abstract 2
- 208000003971 Posterior uveitis Diseases 0.000 claims abstract 2
- 208000005914 Viral Conjunctivitis Diseases 0.000 claims abstract 2
- 201000004612 anterior uveitis Diseases 0.000 claims abstract 2
- 201000007032 bacterial conjunctivitis Diseases 0.000 claims abstract 2
- 230000006378 damage Effects 0.000 claims abstract 2
- 230000005750 disease progression Effects 0.000 claims abstract 2
- 201000007407 panuveitis Diseases 0.000 claims abstract 2
- 230000002207 retinal effect Effects 0.000 claims abstract 2
- 210000003979 eosinophil Anatomy 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 5
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 4
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 4
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 210000000795 conjunctiva Anatomy 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000008595 infiltration Effects 0.000 claims 2
- 238000001764 infiltration Methods 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000003186 pharmaceutical solution Substances 0.000 claims 2
- 206010002198 Anaphylactic reaction Diseases 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 208000003455 anaphylaxis Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 206010067671 Disease complication Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261655526P | 2012-06-05 | 2012-06-05 | |
| US61/655,526 | 2012-06-05 | ||
| PCT/US2013/044058 WO2013184650A2 (en) | 2012-06-05 | 2013-06-04 | Treatment of ocular inflammatory diseases using laquinimod |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014151992A true RU2014151992A (ru) | 2016-07-27 |
Family
ID=49671002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014151992A RU2014151992A (ru) | 2012-06-05 | 2013-06-04 | Лечение воспалительных заболеваний глаз с применением лахинимода |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US20130324574A1 (https=) |
| EP (1) | EP2854767A4 (https=) |
| JP (2) | JP2015523986A (https=) |
| AR (1) | AR092842A1 (https=) |
| CA (1) | CA2874767A1 (https=) |
| IL (1) | IL235874A0 (https=) |
| RU (1) | RU2014151992A (https=) |
| TW (1) | TW201400117A (https=) |
| UY (1) | UY34843A (https=) |
| WO (1) | WO2013184650A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106063787A (zh) | 2012-02-03 | 2016-11-02 | 泰华制药工业有限公司 | 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| CN105960238A (zh) * | 2013-11-15 | 2016-09-21 | 梯瓦制药工业有限公司 | 使用拉喹莫德治疗青光眼 |
| EA201692180A1 (ru) | 2014-04-29 | 2017-08-31 | Тева Фармасьютикал Индастриз Лтд. | Лахинимод для лечения пациентов с рецидивирующе-ремиттирующим рассеянным склерозом (рррс) с высоким статусом инвалидизации |
| PL3886858T3 (pl) * | 2019-12-19 | 2022-08-29 | Active Biotech Ab | Związki do leczenia chorób oka związanych z nadmiernym unaczynieniem |
| WO2022207773A1 (en) * | 2021-04-01 | 2022-10-06 | Active Biotech Ab | Laquinimod formulation for ocular use |
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| CN106063787A (zh) | 2012-02-03 | 2016-11-02 | 泰华制药工业有限公司 | 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 |
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| TW201410243A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療大麻素受體型１（ｃｂ１）媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| US20140107154A1 (en) | 2012-10-12 | 2014-04-17 | Teva Pharmaceutical Industries, Ltd. | Laquinimod for reducing thalamic damage in multiple sclerosis |
| JP2015535287A (ja) | 2012-11-07 | 2015-12-10 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドのアミン塩 |
-
2013
- 2013-05-31 TW TW102119465A patent/TW201400117A/zh unknown
- 2013-06-03 AR ARP130101957A patent/AR092842A1/es unknown
- 2013-06-03 UY UY0001034843A patent/UY34843A/es not_active Application Discontinuation
- 2013-06-04 RU RU2014151992A patent/RU2014151992A/ru not_active Application Discontinuation
- 2013-06-04 JP JP2015516113A patent/JP2015523986A/ja active Pending
- 2013-06-04 US US13/909,403 patent/US20130324574A1/en not_active Abandoned
- 2013-06-04 EP EP13800213.4A patent/EP2854767A4/en not_active Withdrawn
- 2013-06-04 CA CA2874767A patent/CA2874767A1/en not_active Abandoned
- 2013-06-04 WO PCT/US2013/044058 patent/WO2013184650A2/en not_active Ceased
-
2014
- 2014-11-24 IL IL235874A patent/IL235874A0/en unknown
-
2017
- 2017-04-28 US US15/582,162 patent/US20170231971A1/en not_active Abandoned
- 2017-08-07 US US15/670,684 patent/US20170333420A1/en not_active Abandoned
- 2017-08-21 JP JP2017158674A patent/JP2018024677A/ja not_active Withdrawn
- 2017-11-17 US US15/816,402 patent/US11654140B2/en active Active
-
2021
- 2021-08-27 US US17/459,971 patent/US20210386731A1/en not_active Abandoned
-
2024
- 2024-07-16 US US18/774,728 patent/US20250134881A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018024677A (ja) | 2018-02-15 |
| IL235874A0 (en) | 2015-01-29 |
| EP2854767A2 (en) | 2015-04-08 |
| JP2015523986A (ja) | 2015-08-20 |
| US20170333420A1 (en) | 2017-11-23 |
| US20250134881A1 (en) | 2025-05-01 |
| AR092842A1 (es) | 2015-05-06 |
| WO2013184650A3 (en) | 2015-07-02 |
| US20170231971A1 (en) | 2017-08-17 |
| CA2874767A1 (en) | 2013-12-12 |
| US20180071275A1 (en) | 2018-03-15 |
| EP2854767A4 (en) | 2016-04-27 |
| UY34843A (es) | 2013-12-31 |
| TW201400117A (zh) | 2014-01-01 |
| US20130324574A1 (en) | 2013-12-05 |
| WO2013184650A2 (en) | 2013-12-12 |
| US11654140B2 (en) | 2023-05-23 |
| US20210386731A1 (en) | 2021-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20180510 |