RU2014150071A - Способы кристаллизации для очистки моноклональных антител - Google Patents

Способы кристаллизации для очистки моноклональных антител Download PDF

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Publication number
RU2014150071A
RU2014150071A RU2014150071A RU2014150071A RU2014150071A RU 2014150071 A RU2014150071 A RU 2014150071A RU 2014150071 A RU2014150071 A RU 2014150071A RU 2014150071 A RU2014150071 A RU 2014150071A RU 2014150071 A RU2014150071 A RU 2014150071A
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RU
Russia
Prior art keywords
buffer
paragraphs
composition
supernatant
ionic strength
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RU2014150071A
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English (en)
Russian (ru)
Inventor
Дариуш ХЕКМАТ
Бернхард НЕЛЬК
Хенк Конрад ШУЛЬЦ
Бенджамин СМЕЙКАЛЬ
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Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2014150071A publication Critical patent/RU2014150071A/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Botany (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2014150071A 2012-05-11 2013-05-10 Способы кристаллизации для очистки моноклональных антител RU2014150071A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261645855P 2012-05-11 2012-05-11
US61/645,855 2012-05-11
PCT/EP2013/059696 WO2013167720A1 (en) 2012-05-11 2013-05-10 Crystallization methods for purification of monoclonal antibodies

Publications (1)

Publication Number Publication Date
RU2014150071A true RU2014150071A (ru) 2016-07-10

Family

ID=48326319

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014150071A RU2014150071A (ru) 2012-05-11 2013-05-10 Способы кристаллизации для очистки моноклональных антител

Country Status (14)

Country Link
US (2) US20150133642A1 (https=)
EP (1) EP2846830A1 (https=)
JP (1) JP2015517306A (https=)
KR (1) KR20150016503A (https=)
CN (1) CN104284676B (https=)
AU (1) AU2013258006B2 (https=)
BR (1) BR112014027994A2 (https=)
CA (1) CA2872145A1 (https=)
IL (1) IL235483A0 (https=)
IN (1) IN2014DN09097A (https=)
MX (1) MX2014013754A (https=)
RU (1) RU2014150071A (https=)
SG (1) SG11201406664SA (https=)
WO (1) WO2013167720A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3015542A1 (de) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
WO2018115520A1 (en) * 2016-12-23 2018-06-28 Arla Foods Amba Production of novel beta-lactoglobulin preparations and related methods, uses, and food products
DK3596101T3 (da) * 2017-03-14 2022-03-14 Amgen Inc Fremgangsmåder rettet mod krystallinske biomolekyler
WO2020002426A1 (en) 2018-06-27 2020-01-02 Arla Foods Amba Process for producing beta-lactoglobulin isolates and related methods and uses
WO2020081408A1 (en) 2018-10-18 2020-04-23 Merck Sharp & Dohme Corp. Formulations of anti-rsv antibodies and methods of use thereof
MX2021004928A (es) 2018-10-31 2021-06-08 Merck Sharp & Dohme Llc Cristales de anticuerpo anti-pd-1 humano y metodos de uso de los mismos.
IT202100004496A1 (it) 2021-02-25 2022-08-25 Univ Della Calabria Recupero di farmaci biologici o loro frammenti da soluzioni impure mediante cristallizzazione o precipitazione con membrane
CN116949036B (zh) * 2023-09-11 2023-12-15 成都斯马特科技有限公司 一种快速从腹水中提取核酸的试剂盒及提取方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030074693A (ko) * 2000-12-28 2003-09-19 알투스 바이올로직스 인코포레이티드 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법
EP1450847B1 (en) * 2001-11-13 2010-09-29 Genentech, Inc. APO2 ligand/ TRAIL formulations and uses thereof
US7087719B2 (en) * 2002-11-19 2006-08-08 Gtc Biotherapeutics, Inc. Method for the crystallization of human serum albumin
RU2010130467A (ru) * 2007-12-21 2012-01-27 Дженентек, Инк. (Us) Кристаллизация анти-cd20-антител
CN101320006B (zh) * 2008-07-17 2010-12-01 西北工业大学 蛋白质结晶条件的筛选方法

Also Published As

Publication number Publication date
BR112014027994A2 (pt) 2017-06-27
WO2013167720A1 (en) 2013-11-14
MX2014013754A (es) 2015-02-12
CN104284676A (zh) 2015-01-14
SG11201406664SA (en) 2014-11-27
JP2015517306A (ja) 2015-06-22
AU2013258006B2 (en) 2016-04-28
AU2013258006A1 (en) 2014-11-06
US20170198028A1 (en) 2017-07-13
IN2014DN09097A (https=) 2015-05-22
IL235483A0 (en) 2014-12-31
US20150133642A1 (en) 2015-05-14
KR20150016503A (ko) 2015-02-12
EP2846830A1 (en) 2015-03-18
CA2872145A1 (en) 2013-11-14
CN104284676B (zh) 2018-11-27

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FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20190403