RU2014106509A - Получение и применение бактериального гистамина - Google Patents
Получение и применение бактериального гистамина Download PDFInfo
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- RU2014106509A RU2014106509A RU2014106509/15A RU2014106509A RU2014106509A RU 2014106509 A RU2014106509 A RU 2014106509A RU 2014106509/15 A RU2014106509/15 A RU 2014106509/15A RU 2014106509 A RU2014106509 A RU 2014106509A RU 2014106509 A RU2014106509 A RU 2014106509A
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- Prior art keywords
- product
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- histamine
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- histidine
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- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 title claims abstract 32
- 229960001340 histamine Drugs 0.000 title claims abstract 16
- 230000001580 bacterial effect Effects 0.000 title claims abstract 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract 12
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims abstract 11
- 241000124008 Mammalia Species 0.000 claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 8
- 241000186604 Lactobacillus reuteri Species 0.000 claims abstract 6
- 235000014655 lactic acid Nutrition 0.000 claims abstract 6
- 239000004310 lactic acid Substances 0.000 claims abstract 6
- 229940001882 lactobacillus reuteri Drugs 0.000 claims abstract 6
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract 4
- 230000004968 inflammatory condition Effects 0.000 claims abstract 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims abstract 4
- 238000010187 selection method Methods 0.000 claims abstract 3
- 241000894006 Bacteria Species 0.000 claims abstract 2
- 206010013554 Diverticulum Diseases 0.000 claims abstract 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims abstract 2
- 206010046914 Vaginal infection Diseases 0.000 claims abstract 2
- 201000008100 Vaginitis Diseases 0.000 claims abstract 2
- 206010009887 colitis Diseases 0.000 claims abstract 2
- 208000007565 gingivitis Diseases 0.000 claims abstract 2
- 210000004072 lung Anatomy 0.000 claims abstract 2
- 210000000214 mouth Anatomy 0.000 claims abstract 2
- 238000011321 prophylaxis Methods 0.000 claims abstract 2
- 238000012216 screening Methods 0.000 claims abstract 2
- 238000011282 treatment Methods 0.000 claims abstract 2
- 239000000047 product Substances 0.000 claims 10
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 7
- 150000002411 histidines Chemical class 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23V2400/173—Reuteri
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Abstract
1. Способ отбора молочнокислого бактериального штамма для применения в локальном продуцировании гистамина в млекопитающем, где указанный способ предусматривает скрининг бактерий на присутствие активного оперона гистидина и отбор штамма, который имеет активный оперон гистидина и способен продуцировать гистамин.2. Способ по п. 1, где указанный штамм отбирают на его способность продуцировать гистамин на уровне, большем, чем 250 пг/мл.3. Способ по п. 1 или 2, где указанный штамм является Lactobacillus reuteri.4. Продукт, содержащий клетки молочнокислого бактериального штамма, получаемый способом отбора по любому из пп. 1-3, где указанный бактериальный штамм имеет активный оперон гистидина и способен продуцировать гистамин для применения в локальном продуцировании гистамина в млекопитающем.5. Продукт для применения по п. 4, где указанным млекопитающим является человек.6. Продукт для применения по п. 4 или 5, где локальное продуцирование гистамина происходит в желудочно-кишечном тракте (GI-тракте), мочеполовых путях (GU-тракте), полости рта, легких, дыхательных путях или на коже указанного млекопитающего.7. Продукт для применения по п. 4 или 5, где указанное применение является лечением и/или профилактикой воспалительных состояний.8. Продукт для применения по п. 7, где это воспалительное состояние выбрано из группы, состоящей из Колита, Воспалительной Болезни кишечника, Синдрома Раздраженной Толстой Кишки (слизистого колита), дивертикулеза, гингивита и вагинита.9. Продукт для применения по п. 4 или 5, где указанным штаммом является Lactobacillus reuteri.10. Продукт для применения по п. 9, где указанным штаммом является Lactobacillus reuteri 6475.11. Продукт для примене
Claims (14)
1. Способ отбора молочнокислого бактериального штамма для применения в локальном продуцировании гистамина в млекопитающем, где указанный способ предусматривает скрининг бактерий на присутствие активного оперона гистидина и отбор штамма, который имеет активный оперон гистидина и способен продуцировать гистамин.
2. Способ по п. 1, где указанный штамм отбирают на его способность продуцировать гистамин на уровне, большем, чем 250 пг/мл.
3. Способ по п. 1 или 2, где указанный штамм является Lactobacillus reuteri.
4. Продукт, содержащий клетки молочнокислого бактериального штамма, получаемый способом отбора по любому из пп. 1-3, где указанный бактериальный штамм имеет активный оперон гистидина и способен продуцировать гистамин для применения в локальном продуцировании гистамина в млекопитающем.
5. Продукт для применения по п. 4, где указанным млекопитающим является человек.
6. Продукт для применения по п. 4 или 5, где локальное продуцирование гистамина происходит в желудочно-кишечном тракте (GI-тракте), мочеполовых путях (GU-тракте), полости рта, легких, дыхательных путях или на коже указанного млекопитающего.
7. Продукт для применения по п. 4 или 5, где указанное применение является лечением и/или профилактикой воспалительных состояний.
8. Продукт для применения по п. 7, где это воспалительное состояние выбрано из группы, состоящей из Колита, Воспалительной Болезни кишечника, Синдрома Раздраженной Толстой Кишки (слизистого колита), дивертикулеза, гингивита и вагинита.
9. Продукт для применения по п. 4 или 5, где указанным штаммом является Lactobacillus reuteri.
10. Продукт для применения по п. 9, где указанным штаммом является Lactobacillus reuteri 6475.
11. Продукт для применения по п. 4 или 5, где указанное применение дополнительно предусматривает введение по меньшей мере одного дополнительного терапевтического или пищевого агента.
12. Продукт для применения по п. 11, где указанный дополнительный агент содержит гистидин или аналог гистидина, подходящий источник углерода, который поддерживает продуцирование гистамина указанным штаммом, или их комбинацию.
13. Композиция, содержащая:
(i) молочнокислый бактериальный штамм, получаемый способом отбора по любому из пп. 1-3, где указанный молочнокислый бактериальный штамм имеет активный оперон гистидина и способен продуцировать гистамин; и
(ii) по меньшей мере один дополнительный компонент, выбранный из группы, состоящей из подходящего источника углерода, который поддерживает продуцирование гистамина указанным штаммом, источника гистидина или аналога гистидина, и их комбинации.
14. Продукт для применения по п. 12 или композиция по п. 13,
где указанный гистидин или аналог гистидина находится в форме содержащего гистидин или аналог гистидина пищевого продукта или пищевой добавки, или где указанный источник углерода содержит глюкозу.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161572742P | 2011-07-21 | 2011-07-21 | |
| US61/572,742 | 2011-07-21 | ||
| US13/552,686 | 2012-07-19 | ||
| US13/552,686 US20130022586A1 (en) | 2011-07-21 | 2012-07-19 | Production and use of bacterial histamine |
| PCT/EP2012/064351 WO2013011137A1 (en) | 2011-07-21 | 2012-07-20 | Production and use of bacterial histamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014106509A true RU2014106509A (ru) | 2015-08-27 |
| RU2628536C2 RU2628536C2 (ru) | 2017-08-18 |
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| US20130022586A1 (en) | 2011-07-21 | 2013-01-24 | James Versalovic | Production and use of bacterial histamine |
| CN103907940B (zh) * | 2014-03-14 | 2016-04-13 | 西南民族大学 | 复合菌变温发酵降低肉制品生物胺的发酵剂及发酵方法 |
| WO2016113365A1 (en) * | 2015-01-16 | 2016-07-21 | Biogaia Ab | Lactic acid bacteria and their use for the treatment of mastitis |
| MX2017012359A (es) * | 2015-03-26 | 2018-07-06 | Biogaia Ab | Cepas bacterianas productoras de histamina y su uso en cancer. |
| AU2015410635B2 (en) | 2015-09-29 | 2021-08-19 | Kimberly-Clark Worldwide, Inc. | Synergistic composition for maintenance of healthy balance of microflora |
| AU2017262408A1 (en) * | 2016-05-09 | 2018-11-15 | Biogaia Ab | Selection of bacterial strains useful in allergy treatment |
| WO2019115576A1 (en) * | 2017-12-13 | 2019-06-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of treating heart failure |
| CN111004757B (zh) * | 2019-12-31 | 2021-11-02 | 深圳市沁帆科技有限公司 | 一种罗伊氏乳杆菌、微生物菌剂及食物制品 |
| CN112168847A (zh) * | 2020-09-30 | 2021-01-05 | 浙江大学 | 罗伊氏乳杆菌在制备治疗急性肝衰竭药物中的用途 |
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| ES23106A1 (es) | 1898-09-19 | 1898-10-01 | Welch Charles Kingston | Mejoras en los aros metálicos para ruedas. |
| US5413960A (en) | 1987-05-01 | 1995-05-09 | Biogaia Ab | Antibiotic reuterin |
| US5458875A (en) | 1990-06-15 | 1995-10-17 | Biogaia Ab | In ovo method for delivering Lactobacillus reuteri to the gastrointestinal tract of poultry |
| JP3021789B2 (ja) | 1991-06-24 | 2000-03-15 | 三洋電機株式会社 | 培養装置 |
| US5534253A (en) | 1995-06-07 | 1996-07-09 | Biogaia Ab | Method of treating enteropathogenic bacterial infections in poultry |
| US5837238A (en) | 1996-06-05 | 1998-11-17 | Biogaia Biologics Ab | Treatment of diarrhea |
| IT1288119B1 (it) * | 1996-06-28 | 1998-09-10 | Renata Maria Anna Ve Cavaliere | Composizioni dietetiche da utilizzare nell'alimentazione per via enterica |
| IT1306716B1 (it) * | 1999-06-21 | 2001-10-02 | Mendes S U R L | Associazione di batteri lattici e suo uso per la prevenzione e/o iltrattamento terapeutico di infezioni e di stati infiammatori. |
| RU2178975C1 (ru) * | 2000-06-08 | 2002-02-10 | Борц Михаил Самуилович | Пищевой продукт с биологически активными добавками |
| JP2004531477A (ja) * | 2001-02-06 | 2004-10-14 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 乳酸菌及びビフィズス菌による内毒素結合 |
| US20050281756A1 (en) * | 2004-06-14 | 2005-12-22 | Eamonn Connolly | Use of lactic acid bacteria for decreasing gum bleeding and reducing oral inflammation |
| US20040208863A1 (en) * | 2003-01-30 | 2004-10-21 | James Versalovic | Anti-inflammatory activity from lactic acid bacteria |
| JP2004344004A (ja) * | 2003-04-24 | 2004-12-09 | Japan Science & Technology Agency | ヒスタミン生産菌の検出方法、及び該方法で用いるプライマー |
| US7344867B2 (en) * | 2005-04-15 | 2008-03-18 | Eamonn Connolly | Selection and use of lactic acid bacteria for reducing inflammation in mammals |
| ES2310063B1 (es) * | 2005-07-29 | 2009-11-16 | Consejo Superior Investig. Cientificas | Deteccion de bacterias del acido lactico productoras de histamina mediante reaccion en cadena de la polimerasa cuantitativa a tiempo real (qrt-pcr) y sus aplicaciones. |
| US20080254011A1 (en) * | 2007-04-11 | 2008-10-16 | Peter Rothschild | Use of selected lactic acid bacteria for reducing atherosclerosis |
| CN101328468B (zh) * | 2007-06-21 | 2012-05-23 | 东宇生物科技股份有限公司 | 抗过敏的乳酸菌 |
| CN101575582B (zh) * | 2008-05-08 | 2011-10-12 | 景岳生物科技股份有限公司 | 具有抗炎活性的乳杆菌分离株及其用途 |
| CN102115721B (zh) * | 2008-05-08 | 2012-09-26 | 景岳生物科技股份有限公司 | 具有抗炎活性的乳杆菌分离株及其用途 |
| WO2010013143A2 (en) * | 2008-08-01 | 2010-02-04 | Institut Pasteur | Methods for inhibiting mast cell activation and treating mast cell-dependent inflammatory diseases and disorders using lactobacillus |
| CN102143756A (zh) | 2008-09-04 | 2011-08-03 | Om药物公司 | 来自乳杆菌属细菌的免疫调节提取物及其制备及使用方法 |
| US20130022586A1 (en) | 2011-07-21 | 2013-01-24 | James Versalovic | Production and use of bacterial histamine |
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