RU2014104357A - Полиморфы гидрохлорида 6-(пиперидин-4-илокси)-2н-изохинолин-1-она - Google Patents
Полиморфы гидрохлорида 6-(пиперидин-4-илокси)-2н-изохинолин-1-она Download PDFInfo
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- RU2014104357A RU2014104357A RU2014104357/04A RU2014104357A RU2014104357A RU 2014104357 A RU2014104357 A RU 2014104357A RU 2014104357/04 A RU2014104357/04 A RU 2014104357/04A RU 2014104357 A RU2014104357 A RU 2014104357A RU 2014104357 A RU2014104357 A RU 2014104357A
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- polymorph
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- piperidin
- isoquinolin
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
- KMNVOGVCCZNVNU-UHFFFAOYSA-N 6-piperidin-4-yloxy-2h-isoquinolin-1-one;hydrochloride Chemical compound Cl.C=1C=C2C(=O)NC=CC2=CC=1OC1CCNCC1 KMNVOGVCCZNVNU-UHFFFAOYSA-N 0.000 claims abstract 19
- 238000000634 powder X-ray diffraction Methods 0.000 claims abstract 14
- 230000005855 radiation Effects 0.000 claims abstract 6
- 239000004480 active ingredient Substances 0.000 claims 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims 7
- 206010020772 Hypertension Diseases 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 208000017169 kidney disease Diseases 0.000 claims 4
- 230000002093 peripheral effect Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 208000031104 Arterial Occlusive disease Diseases 0.000 claims 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 2
- 208000020084 Bone disease Diseases 0.000 claims 2
- 201000006474 Brain Ischemia Diseases 0.000 claims 2
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- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims 2
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- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 claims 1
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- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims 1
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- FAIIFDPAEUKBEP-UHFFFAOYSA-N Nilvadipine Chemical compound COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC([N+]([O-])=O)=C1 FAIIFDPAEUKBEP-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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| EP11305891.1 | 2011-07-08 | ||
| EP11305891 | 2011-07-08 | ||
| EP11306034.7 | 2011-12-29 | ||
| EP11306034 | 2011-12-29 | ||
| PCT/EP2012/062444 WO2013007519A1 (en) | 2011-07-08 | 2012-06-27 | Polymorphs of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride |
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| RU2014104357A true RU2014104357A (ru) | 2015-08-20 |
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| RU2014104357/04A RU2014104357A (ru) | 2011-07-08 | 2012-06-27 | Полиморфы гидрохлорида 6-(пиперидин-4-илокси)-2н-изохинолин-1-она |
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| CN109810173B (zh) * | 2017-11-21 | 2020-11-27 | 首都医科大学 | 二氢异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用 |
| CN119630643A (zh) * | 2022-08-01 | 2025-03-14 | 瓦洛健康公司 | 用于制备6-取代的-1-(2h)-异喹啉酮的方法和中间化合物 |
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| SK9742002A3 (en) * | 2000-01-07 | 2003-02-04 | Transform Pharmaceuticals Inc | High-throughput formation, identification, and analysis of diverse solid-forms |
| NZ565668A (en) * | 2005-07-26 | 2010-09-30 | Sanofi Aventis | Piperidinyl-substituted isoquinolone derivatives as RHO-kinase inhibitors |
| TW200738682A (en) | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| KR101517154B1 (ko) * | 2006-12-27 | 2015-04-30 | 사노피 | Ｒｈｏ-키나제의 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 |
| BRPI0821837A2 (pt) * | 2007-12-26 | 2015-06-16 | Sanofi Aventis | Processo para a preparação de 6-substituídas-1-(2h)-isoquinolinonas |
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| AU2012283277A1 (en) | 2014-02-27 |
| CY1117545T1 (el) | 2017-04-26 |
| HK1192234A1 (zh) | 2014-08-15 |
| KR20140046460A (ko) | 2014-04-18 |
| SI2729461T1 (sl) | 2016-06-30 |
| JP2014518236A (ja) | 2014-07-28 |
| HRP20160358T1 (hr) | 2016-05-06 |
| ES2567317T3 (es) | 2016-04-21 |
| PL2729461T3 (pl) | 2016-06-30 |
| CA2843777C (en) | 2018-11-06 |
| EP2729461B1 (en) | 2016-01-20 |
| CN103781777A (zh) | 2014-05-07 |
| KR102013567B1 (ko) | 2019-08-23 |
| DK2729461T3 (en) | 2016-04-11 |
| CA2843777A1 (en) | 2013-01-17 |
| EP2729461A1 (en) | 2014-05-14 |
| HUE028550T2 (en) | 2016-12-28 |
| WO2013007519A1 (en) | 2013-01-17 |
| IN2014CN00834A (enExample) | 2015-04-03 |
| AU2012283277B2 (en) | 2016-07-21 |
| US20130012479A1 (en) | 2013-01-10 |
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