JP2007504222A5 - - Google Patents
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- Publication number
- JP2007504222A5 JP2007504222A5 JP2006525304A JP2006525304A JP2007504222A5 JP 2007504222 A5 JP2007504222 A5 JP 2007504222A5 JP 2006525304 A JP2006525304 A JP 2006525304A JP 2006525304 A JP2006525304 A JP 2006525304A JP 2007504222 A5 JP2007504222 A5 JP 2007504222A5
- Authority
- JP
- Japan
- Prior art keywords
- ammonium salt
- omeprazole
- esomeprazole
- salt
- adamantane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims 11
- QHKGZGABGGEUOC-UHFFFAOYSA-N adamantane;azane Chemical compound N.C1C(C2)CC3CC1CC2C3 QHKGZGABGGEUOC-UHFFFAOYSA-N 0.000 claims 11
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 claims 10
- 229960000381 omeprazole Drugs 0.000 claims 10
- 229960004770 esomeprazole Drugs 0.000 claims 9
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 210000004211 gastric acid Anatomy 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 1
- XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical compound N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- -1 methoxy-3,5-dimethyl-2-pyridinyl Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302381A SE0302381D0 (sv) | 2003-09-04 | 2003-09-04 | New salts I |
| PCT/SE2004/001258 WO2005023796A1 (en) | 2003-09-04 | 2004-09-01 | New salts of omeprazole and esomeprazole i |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007504222A JP2007504222A (ja) | 2007-03-01 |
| JP2007504222A5 true JP2007504222A5 (enExample) | 2007-09-27 |
Family
ID=28787270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006525304A Pending JP2007504222A (ja) | 2003-09-04 | 2004-09-01 | オメプラゾール及びエソメプラゾールｉの新規な塩 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7326724B2 (enExample) |
| EP (1) | EP1664019A1 (enExample) |
| JP (1) | JP2007504222A (enExample) |
| CA (1) | CA2549465A1 (enExample) |
| SE (1) | SE0302381D0 (enExample) |
| WO (1) | WO2005023796A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302382D0 (sv) | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts II |
| US7576219B2 (en) | 2005-10-26 | 2009-08-18 | Hanmi Pharm. Co., Ltd | Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same |
| EP1801110A1 (en) | 2005-12-22 | 2007-06-27 | KRKA, tovarna zdravil, d.d., Novo mesto | Esomeprazole arginine salt |
| JP2009539830A (ja) * | 2006-06-07 | 2009-11-19 | アストラゼネカ・アクチエボラーグ | エソメプラゾールのアンモニウム塩の新規な製造方法 |
| EA200900985A1 (ru) | 2007-01-31 | 2009-12-30 | Крка, Товарна Здравил, Д. Д., Ново Место | Способ получения оптически чистого омепразола |
| WO2011058569A1 (en) | 2009-11-12 | 2011-05-19 | Hetero Research Foundation | Process for the resolution of omeprazole |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4316905A (en) * | 1980-07-01 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of various 4-substituted prolines |
| SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
| SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| SE504459C2 (sv) | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
| SE508669C2 (sv) | 1996-04-26 | 1998-10-26 | Astra Ab | Nytt förfarande |
| SE510650C2 (sv) | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
| WO2003074514A1 (en) | 2002-03-05 | 2003-09-12 | Astrazeneca Ab | Alkylammonium salts of omeprazole and esomeprazole |
| SE0302382D0 (sv) | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts II |
-
2003
- 2003-09-04 SE SE0302381A patent/SE0302381D0/xx unknown
-
2004
- 2004-09-01 WO PCT/SE2004/001258 patent/WO2005023796A1/en not_active Ceased
- 2004-09-01 US US10/569,819 patent/US7326724B2/en not_active Expired - Fee Related
- 2004-09-01 EP EP04775364A patent/EP1664019A1/en not_active Ceased
- 2004-09-01 CA CA002549465A patent/CA2549465A1/en not_active Abandoned
- 2004-09-01 JP JP2006525304A patent/JP2007504222A/ja active Pending
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