RU2014101763A - Композиции комбинаций амикацина и фосфомицина, способы и системы для лечения вентилятор-ассоциированной пневмонии и вентилятор-ассоциированного трахеоброхита - Google Patents

Композиции комбинаций амикацина и фосфомицина, способы и системы для лечения вентилятор-ассоциированной пневмонии и вентилятор-ассоциированного трахеоброхита Download PDF

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Publication number
RU2014101763A
RU2014101763A RU2014101763/15A RU2014101763A RU2014101763A RU 2014101763 A RU2014101763 A RU 2014101763A RU 2014101763/15 A RU2014101763/15 A RU 2014101763/15A RU 2014101763 A RU2014101763 A RU 2014101763A RU 2014101763 A RU2014101763 A RU 2014101763A
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RU
Russia
Prior art keywords
concentration
composition
fosfomycin
amikacin
aerosol
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Application number
RU2014101763/15A
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English (en)
Russian (ru)
Inventor
Алан Брюс МОНТГОМЕРИ
Original Assignee
Кардис Фарма Корпорейшн
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Application filed by Кардис Фарма Корпорейшн filed Critical Кардис Фарма Корпорейшн
Publication of RU2014101763A publication Critical patent/RU2014101763A/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A61M16/16—Devices to humidify the respiration air

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2014101763/15A 2011-07-12 2012-07-12 Композиции комбинаций амикацина и фосфомицина, способы и системы для лечения вентилятор-ассоциированной пневмонии и вентилятор-ассоциированного трахеоброхита RU2014101763A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161572225P 2011-07-12 2011-07-12
US61/572,225 2011-07-12
PCT/US2012/046559 WO2013010041A1 (en) 2011-07-12 2012-07-12 Formulations of amikacin and fosfomycin combinations and methods and systems for treatment of ventilator associated pneumonia (vap) and ventilator associated tracheal (vat) bronchitis

Publications (1)

Publication Number Publication Date
RU2014101763A true RU2014101763A (ru) 2015-08-20

Family

ID=46545929

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014101763/15A RU2014101763A (ru) 2011-07-12 2012-07-12 Композиции комбинаций амикацина и фосфомицина, способы и системы для лечения вентилятор-ассоциированной пневмонии и вентилятор-ассоциированного трахеоброхита

Country Status (12)

Country Link
US (2) US10471083B2 (pt)
EP (1) EP2731586B1 (pt)
JP (2) JP2014523909A (pt)
KR (1) KR20140025534A (pt)
CN (1) CN103702663A (pt)
AU (2) AU2012281068A1 (pt)
BR (1) BR112014000275A2 (pt)
CA (1) CA2841272C (pt)
MX (1) MX2014000540A (pt)
RU (1) RU2014101763A (pt)
WO (1) WO2013010041A1 (pt)
ZA (2) ZA201309028B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101424518B1 (ko) * 2005-09-29 2014-08-06 노바르티스 아게 항생제 제형, 단위 투여체, 키트 및 방법
US9861616B2 (en) * 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
TWI571259B (zh) * 2013-03-15 2017-02-21 卡帝俄斯製藥公司 胺基糖苷及磷黴素組合之改良調配物及用於治療呼吸器相關性肺炎（ｖａｐ）與呼吸器相關性氣管（ｖａｔ）支氣管炎之方法及系統
RU2691658C2 (ru) 2013-08-26 2019-06-17 Кардис Фарма Корпорейшн Комбинированные препараты аминогликозидов и фосфомицина, обладающие улучшенными химическими свойствами
JP6741887B1 (ja) 2017-06-28 2020-08-19 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 患者に供給される呼吸可能なガスの加圧流の加湿のためのシステム

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508269A (en) 1994-10-19 1996-04-16 Pathogenesis Corporation Aminoglycoside formulation for aerosolization
SI20959A (sl) 1998-12-17 2003-02-28 Pathogenesis Corporation Metoda za zdravljenje hudega kroničnega bronhitisa (bronhiektazije) z aerosoliziranimi antibiotiki
US6968840B2 (en) 2000-05-05 2005-11-29 Aerogen, Inc. Methods and systems for operating an aerosol generator
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
MXPA02010884A (es) 2000-05-05 2003-03-27 Aerogen Ireland Ltd Aparato y metodo para el suministro de medicamentos al sistema respiratorio.
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US7100600B2 (en) 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
CA2447600C (en) 2001-05-18 2015-10-20 Chiron Corporation Methods and unit dose formulations for the inhalation administration of aminoglycoside antibiotics
US7607436B2 (en) 2002-05-06 2009-10-27 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
ITMI20021881A1 (it) 2002-09-04 2004-03-05 Zambon Spa Composizioni farmaceutiche per il trattamento di infezioni da patogeni dell'apparato urinario.
EP1684720B1 (en) 2003-11-17 2009-05-27 Nektar Therapeutics Introducing aerosol into a ventilator circuit
BRPI0509026A (pt) * 2004-05-17 2007-09-18 Corus Pharma Inc formulação de aerossol, método para a prevenção e tratamento de infecção causada por bactéria do trato respiratório, e, solução
JP2008503500A (ja) 2004-06-18 2008-02-07 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド 気管支感染症の治療法
KR101424518B1 (ko) 2005-09-29 2014-08-06 노바르티스 아게 항생제 제형, 단위 투여체, 키트 및 방법
US20090032427A1 (en) 2005-09-29 2009-02-05 Nektar Therapeutics Receptacles and Kits, Such as for Dry Powder Packaging
JP2010512350A (ja) 2006-12-11 2010-04-22 ダラグレキュル・アンパルトセルスカブ ホスホマイシンの肺投与により細菌感染を伴う嚢胞性線維症または肺炎を処置するための方法
JP2010540526A (ja) 2007-09-25 2010-12-24 ノバルティス アーゲー エアロゾル化されたバンコマイシンのような薬剤での肺障害の処置
GB0813211D0 (en) 2008-07-18 2008-08-27 E Therapeutics Plc Antibacterial combination therapy for the treatment of gram positive bacterial infections
AU2010229721A1 (en) 2009-03-26 2011-10-06 Pulmatrix, Inc. Methods for treating and preventing pneumonia and ventilator-associated tracheobronchitis
JP2013512193A (ja) 2009-11-24 2013-04-11 ギリアード サイエンシーズ， インコーポレイテッド 慢性閉塞性肺疾患の処置のための吸入型ホスホマイシン／トブラマイシン
PL2567691T3 (pl) 2011-09-12 2015-05-29 Meiji Seika Pharma Co Ltd Kompozycje wodne obejmujące arbekacynę

Also Published As

Publication number Publication date
ZA201309028B (en) 2015-08-26
JP2014523909A (ja) 2014-09-18
US20130014759A1 (en) 2013-01-17
WO2013010041A1 (en) 2013-01-17
EP2731586A1 (en) 2014-05-21
US8603439B2 (en) 2013-12-10
AU2016202244A1 (en) 2016-05-05
ZA201409204B (en) 2016-10-26
EP2731586B1 (en) 2019-09-25
CN103702663A (zh) 2014-04-02
JP2015232026A (ja) 2015-12-24
CA2841272A1 (en) 2013-01-17
AU2012281068A1 (en) 2013-12-19
US20140221302A1 (en) 2014-08-07
CA2841272C (en) 2019-01-15
KR20140025534A (ko) 2014-03-04
BR112014000275A2 (pt) 2017-04-18
MX2014000540A (es) 2014-05-01
US10471083B2 (en) 2019-11-12

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Effective date: 20160819