RU2012101792A - Композиции и способы для лечения бокового амиотрофического склероза - Google Patents
Композиции и способы для лечения бокового амиотрофического склероза Download PDFInfo
- Publication number
- RU2012101792A RU2012101792A RU2012101792/15A RU2012101792A RU2012101792A RU 2012101792 A RU2012101792 A RU 2012101792A RU 2012101792/15 A RU2012101792/15 A RU 2012101792/15A RU 2012101792 A RU2012101792 A RU 2012101792A RU 2012101792 A RU2012101792 A RU 2012101792A
- Authority
- RU
- Russia
- Prior art keywords
- introduction
- als
- effective amount
- lateral sclerosis
- amyotrophic lateral
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 64
- 208000034189 Sclerosis Diseases 0.000 title claims 2
- 239000000203 mixture Substances 0.000 title 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims abstract 45
- FASDKYOPVNHBLU-SSDOTTSWSA-N dexpramipexole Chemical compound C1[C@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-SSDOTTSWSA-N 0.000 claims abstract 15
- 150000003839 salts Chemical class 0.000 claims abstract 15
- 208000024891 symptom Diseases 0.000 claims abstract 12
- 238000011282 treatment Methods 0.000 claims abstract 7
- 230000007659 motor function Effects 0.000 claims abstract 6
- 230000006870 function Effects 0.000 claims abstract 4
- 230000004202 respiratory function Effects 0.000 claims abstract 3
- 230000009747 swallowing Effects 0.000 claims abstract 3
- 208000000059 Dyspnea Diseases 0.000 claims abstract 2
- 206010013975 Dyspnoeas Diseases 0.000 claims abstract 2
- 206010031123 Orthopnoea Diseases 0.000 claims abstract 2
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims abstract 2
- 230000037396 body weight Effects 0.000 claims abstract 2
- 230000009194 climbing Effects 0.000 claims abstract 2
- 230000003111 delayed effect Effects 0.000 claims abstract 2
- 208000012144 orthopnea Diseases 0.000 claims abstract 2
- 201000004193 respiratory failure Diseases 0.000 claims abstract 2
- 230000029058 respiratory gaseous exchange Effects 0.000 claims abstract 2
- 238000012544 monitoring process Methods 0.000 claims 5
- 231100000673 dose–response relationship Toxicity 0.000 claims 2
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 claims 1
- 206010039424 Salivary hypersecretion Diseases 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 229960004181 riluzole Drugs 0.000 claims 1
- 208000026451 salivation Diseases 0.000 claims 1
- 238000004448 titration Methods 0.000 claims 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21865909P | 2009-06-19 | 2009-06-19 | |
| US61/218,659 | 2009-06-19 | ||
| US26794509P | 2009-12-09 | 2009-12-09 | |
| US61/267,945 | 2009-12-09 | ||
| US31711810P | 2010-03-24 | 2010-03-24 | |
| US61/317,118 | 2010-03-24 | ||
| US35643910P | 2010-06-18 | 2010-06-18 | |
| US61/356,439 | 2010-06-18 | ||
| PCT/US2010/039379 WO2010148409A1 (en) | 2009-06-19 | 2010-06-21 | Compositions and methods for treating amyotrophic lateral sclerosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012101792A true RU2012101792A (ru) | 2013-07-27 |
Family
ID=43356795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012101792/15A RU2012101792A (ru) | 2009-06-19 | 2010-06-21 | Композиции и способы для лечения бокового амиотрофического склероза |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20110009460A1 (https=) |
| EP (1) | EP2442655A4 (https=) |
| JP (1) | JP2012530723A (https=) |
| CN (1) | CN102802418A (https=) |
| AU (1) | AU2010262970A1 (https=) |
| BR (1) | BRPI1010084A2 (https=) |
| CA (1) | CA2765876A1 (https=) |
| CL (1) | CL2011003191A1 (https=) |
| CO (1) | CO6480953A2 (https=) |
| MX (1) | MX2011013577A (https=) |
| RU (1) | RU2012101792A (https=) |
| WO (1) | WO2010148409A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| ES2379117T3 (es) | 2006-05-16 | 2012-04-20 | Knopp Neurosciences, Inc. | Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas |
| US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| CA2681110A1 (en) | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
| KR20110071064A (ko) * | 2008-08-19 | 2011-06-28 | 크놉 뉴로사이언시스 인코포레이티드 | (r)-프라미펙솔을 사용하는 조성물 및 방법 |
| KR101951220B1 (ko) | 2011-07-13 | 2019-02-22 | 싸이토키네틱스, 인코포레이티드 | 조합 als 치료법 |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| WO2013096870A1 (en) * | 2011-12-22 | 2013-06-27 | Knopp Neurosciences Inc | Compositions and methods for treating amyotrophic lateral sclerosis |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| WO2014134569A1 (en) * | 2013-02-28 | 2014-09-04 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| EP3838271B1 (en) * | 2013-07-12 | 2025-09-03 | Areteia Therapeutics, Inc. | Treating elevated levels of eosinophils and/or basophils |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| CA2921381A1 (en) * | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
| ES2813674T3 (es) | 2013-08-13 | 2021-03-24 | Knopp Biosciences Llc | Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b |
| EP3071199A2 (en) * | 2013-11-22 | 2016-09-28 | Genzyme Corporation | Novel methods for treating neurodegenerative diseases |
| US20170248579A1 (en) * | 2014-09-10 | 2017-08-31 | The Uab Research Foundation | Amyotrophic lateral sclerosis (als) biomarkers and uses thereof |
| WO2016207924A1 (en) * | 2015-06-25 | 2016-12-29 | Chiarugi Alberto | Dexpramipexole for the treatment of pain |
| WO2017103224A1 (en) * | 2015-12-16 | 2017-06-22 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method of treatment of amyotrophic lateral sclerosis |
| CN115916164A (zh) * | 2020-03-05 | 2023-04-04 | 拜奥海芬治疗学有限公司 | 用髓过氧化物酶抑制剂治疗肌萎缩侧索硬化症的方法 |
Family Cites Families (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3598122A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3731683A (en) * | 1971-06-04 | 1973-05-08 | Alza Corp | Bandage for the controlled metering of topical drugs to the skin |
| US4144317A (en) * | 1975-05-30 | 1979-03-13 | Alza Corporation | Device consisting of copolymer having acetoxy groups for delivering drugs |
| US4031894A (en) * | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
| US4201211A (en) * | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
| US4286592A (en) * | 1980-02-04 | 1981-09-01 | Alza Corporation | Therapeutic system for administering drugs to the skin |
| US4314557A (en) * | 1980-05-19 | 1982-02-09 | Alza Corporation | Dissolution controlled active agent dispenser |
| US4327725A (en) * | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| US4379454A (en) * | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
| US4849226A (en) * | 1981-06-29 | 1989-07-18 | Alza Corporation | Method for increasing oxygen supply by administering vasodilator |
| US4725272A (en) * | 1981-06-29 | 1988-02-16 | Alza Corporation | Novel bandage for administering beneficial drug |
| US4435180A (en) * | 1982-05-25 | 1984-03-06 | Alza Corporation | Elastomeric active agent delivery system and method of use |
| US4559222A (en) * | 1983-05-04 | 1985-12-17 | Alza Corporation | Matrix composition for transdermal therapeutic system |
| US4783337A (en) * | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US4612008A (en) * | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US5082668A (en) * | 1983-05-11 | 1992-01-21 | Alza Corporation | Controlled-release system with constant pushing source |
| US4704282A (en) * | 1984-06-29 | 1987-11-03 | Alza Corporation | Transdermal therapeutic system having improved delivery characteristics |
| US4588580B2 (en) * | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
| US4626539A (en) * | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
| US4568343A (en) * | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
| US4573995A (en) * | 1984-10-09 | 1986-03-04 | Alza Corporation | Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine |
| ATE45735T1 (de) * | 1984-12-22 | 1989-09-15 | Thomae Gmbh Dr K | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel. |
| US4806341A (en) * | 1985-02-25 | 1989-02-21 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration |
| US4645502A (en) * | 1985-05-03 | 1987-02-24 | Alza Corporation | Transdermal delivery of highly ionized fat insoluble drugs |
| US4904475A (en) * | 1985-05-03 | 1990-02-27 | Alza Corporation | Transdermal delivery of drugs from an aqueous reservoir |
| US4698062A (en) * | 1985-10-30 | 1987-10-06 | Alza Corporation | Medical device for pulsatile transdermal delivery of biologically active agents |
| DE3775830D1 (de) * | 1986-06-13 | 1992-02-20 | Alza Corp | Aktivierung eines transdermalen drogenabgabesystems durch feuchtigkeit. |
| US4938759A (en) * | 1986-09-02 | 1990-07-03 | Alza Corporation | Transdermal delivery device having a rate controlling adhesive |
| US5344656A (en) * | 1986-09-12 | 1994-09-06 | Alza Corporation | Subsaturated transdermal therapeutic system having improved release characteristics |
| US4908027A (en) * | 1986-09-12 | 1990-03-13 | Alza Corporation | Subsaturated transdermal therapeutic system having improved release characteristics |
| US4816258A (en) * | 1987-02-26 | 1989-03-28 | Alza Corporation | Transdermal contraceptive formulations |
| US4788062A (en) * | 1987-02-26 | 1988-11-29 | Alza Corporation | Transdermal administration of progesterone, estradiol esters, and mixtures thereof |
| US4943435A (en) * | 1987-10-05 | 1990-07-24 | Pharmetrix Corporation | Prolonged activity nicotine patch |
| US4917895A (en) * | 1987-11-02 | 1990-04-17 | Alza Corporation | Transdermal drug delivery device |
| US4781924A (en) * | 1987-11-09 | 1988-11-01 | Alza Corporation | Transdermal drug delivery device |
| US5004610A (en) * | 1988-06-14 | 1991-04-02 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
| DE69009540T2 (de) * | 1989-03-15 | 1994-09-29 | Nitto Denko Corp | Arzneimittel enthaltendes Heftpflaster. |
| US5024843A (en) * | 1989-09-05 | 1991-06-18 | Alza Corporation | Oral hypoglycemic glipizide granulation |
| US5591454A (en) * | 1989-09-05 | 1997-01-07 | Alza Corporation | Method for lowering blood glucose |
| US5091190A (en) * | 1989-09-05 | 1992-02-25 | Alza Corporation | Delivery system for administration blood-glucose lowering drug |
| DE3937271A1 (de) * | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol |
| US5314694A (en) * | 1990-10-29 | 1994-05-24 | Alza Corporation | Transdermal formulations, methods and devices |
| US5122382A (en) * | 1990-10-29 | 1992-06-16 | Alza Corporation | Transdermal contraceptive formulations, methods and devices |
| FR2688138B1 (fr) * | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
| DE69326848T2 (de) * | 1992-05-13 | 2000-01-27 | Alza Corp | Oxybutynin zur transdermalen Verabreichung |
| US5442117A (en) * | 1993-12-13 | 1995-08-15 | Albemarle Corporation | Enantiomeric resolution |
| US5635203A (en) * | 1994-09-29 | 1997-06-03 | Alza Corporation | Transdermal device having decreased delamination |
| US5650420A (en) * | 1994-12-15 | 1997-07-22 | Pharmacia & Upjohn Company | Pramipexole as a neuroprotective agent |
| US5912268A (en) * | 1995-05-22 | 1999-06-15 | Alza Corporation | Dosage form and method for treating incontinence |
| US6262115B1 (en) * | 1995-05-22 | 2001-07-17 | Alza Coporation | Method for the management of incontinence |
| US5674895A (en) * | 1995-05-22 | 1997-10-07 | Alza Corporation | Dosage form comprising oxybutynin |
| US6929801B2 (en) * | 1996-02-19 | 2005-08-16 | Acrux Dds Pty Ltd | Transdermal delivery of antiparkinson agents |
| US6919373B1 (en) * | 1996-11-12 | 2005-07-19 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
| GB9705428D0 (en) * | 1997-03-15 | 1997-04-30 | Knoll Ag | Therapeutic agents |
| US5804215A (en) * | 1997-03-21 | 1998-09-08 | L. Perrigo Company | Transdermal patch disposal system and method |
| US20010055613A1 (en) * | 1998-10-21 | 2001-12-27 | Beth A. Burnside | Oral pulsed dose drug delivery system |
| US6541486B1 (en) * | 1999-06-04 | 2003-04-01 | Elan Pharma International Ltd. | Bis-benzimidazole compounds and analogs thereof for inhibiting cell death |
| US6480820B1 (en) * | 1999-09-20 | 2002-11-12 | Advanced Cochlear Systems, Inc. | Method of processing auditory data |
| US6750235B1 (en) * | 1999-09-30 | 2004-06-15 | The General Hospital Corporation | Pramipexole as a treatment for cocaine craving |
| US6443976B1 (en) * | 1999-11-30 | 2002-09-03 | Akorn, Inc. | Methods for treating conditions and illnesses associated with abnormal vasculature |
| JP2003523741A (ja) * | 2000-02-01 | 2003-08-12 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | Bcl−2様ポリヌクレオチド、ポリペプチドおよび抗体 |
| US6955821B2 (en) * | 2000-04-28 | 2005-10-18 | Adams Laboratories, Inc. | Sustained release formulations of guaifenesin and additional drug ingredients |
| US6598123B1 (en) * | 2000-06-28 | 2003-07-22 | Intel Corporation | Snoop filter line replacement for reduction of back invalidates in multi-node architectures |
| ES2187249B1 (es) * | 2000-09-18 | 2004-09-16 | Synthon Bv | Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles. |
| US20020177626A1 (en) * | 2001-01-19 | 2002-11-28 | Cook Graham D. | Treatment of sleep disturbances |
| MXPA03009185A (es) * | 2001-04-09 | 2004-02-17 | Neurosearch As | Antagonistas de receptor a2a de adenosina combinados con compuestos de actividad neurotrofica en el tratamiento de la enfermedad de parkinson. |
| GB0117618D0 (en) * | 2001-07-19 | 2001-09-12 | Phoqus Ltd | Pharmaceutical dosage form |
| US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
| ES2432527T3 (es) * | 2001-12-11 | 2013-12-04 | University Of Virginia Patent Foundation | Uso de pramipexol para tratar la esclerosis lateral amiotrófica |
| CN101352421A (zh) * | 2002-01-16 | 2009-01-28 | 贝林格尔英格海姆法玛两合公司 | 一种制备基本上非结晶形式的替米沙坦的方法 |
| US20050226926A1 (en) * | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
| US20050074865A1 (en) * | 2002-08-27 | 2005-04-07 | Compound Therapeutics, Inc. | Adzymes and uses thereof |
| GB0221513D0 (en) * | 2002-09-17 | 2002-10-23 | Generics Uk Ltd | Novel compounds and processes |
| SI1610791T1 (sl) * | 2003-03-31 | 2011-05-31 | Titan Pharmaceuticals Inc | Implantibilna polimerna naprava za zadržano sproščanje dopaminskega agonista |
| US7365086B2 (en) * | 2003-07-25 | 2008-04-29 | Synthon Ip Inc. | Pramipexole acid addition salts |
| US20080020028A1 (en) * | 2003-08-20 | 2008-01-24 | Euro-Celtique S.A. | Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent |
| US20050053649A1 (en) * | 2003-09-08 | 2005-03-10 | Anne-Marie Chalmers | Medication delivery device |
| US20050220877A1 (en) * | 2004-03-31 | 2005-10-06 | Patel Ashish A | Bilayer tablet comprising an antihistamine and a decongestant |
| WO2006003471A2 (en) * | 2004-07-03 | 2006-01-12 | Generics [Uk] Limited | Process for the preparation of pramipexole by chiral chromatography |
| EA200700388A1 (ru) * | 2004-08-13 | 2007-08-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Композиция пеллеты пролонгированного высвобождения, содержащая прамипексол или его фармацевтически приемлемую соль, способ её изготовления и её применение |
| DE102004044578A1 (de) * | 2004-09-13 | 2006-03-30 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit einer Haftschicht, Verfahren zum Silikonisieren einer Rückschicht des Systems und Verwendung der Rückschicht |
| US20060069263A1 (en) * | 2004-09-30 | 2006-03-30 | Irina Gribun | Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole |
| CN103083318A (zh) * | 2004-11-05 | 2013-05-08 | 贝林格尔.英格海姆国际有限公司 | 包含替米沙坦和氨氯地平的双层片剂 |
| WO2006070406A1 (en) * | 2004-12-29 | 2006-07-06 | J.B. Chemicals & Pharmaceuticals Ltd | Bilayer tablets of oxcarbazepine for controlled delivery and a process of preparation thereof |
| DE112005003227T5 (de) * | 2004-12-30 | 2007-11-15 | Chemagis Ltd. | Neues Verfahren zur Herstellung von Pramipexol und dem Gemisch seiner optischen Isomeren durch Reduktion mit Natriumtriacetoxyborhydrid |
| WO2007022182A1 (en) * | 2005-08-15 | 2007-02-22 | University Of Virginia Patent Foundation | Neurorestoration with r(+) pramipexole |
| EP1931632A4 (en) * | 2005-08-18 | 2011-05-11 | Microbia Inc | USEFUL INDOOR CONNECTIONS |
| CA2625341A1 (en) * | 2005-10-18 | 2007-04-26 | Ono Pharmaceutical Co., Ltd. | Pharmaceutical for protection of motor nerve in patient with amyotrophic lateral sclerosis |
| US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| WO2007121188A2 (en) * | 2006-04-10 | 2007-10-25 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
| ES2379117T3 (es) * | 2006-05-16 | 2012-04-20 | Knopp Neurosciences, Inc. | Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas |
| WO2008042611A2 (en) * | 2006-09-29 | 2008-04-10 | Centocor, Inc. | Method of using il6 antagonists with mitoxantrone for prostate cancer |
| DK2101766T3 (en) * | 2006-12-14 | 2017-01-16 | Knopp Biosciences Llc | Compositions and Methods for Using (R) -Pramipexole |
| US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| CA2681110A1 (en) * | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
| JP2010521493A (ja) * | 2007-03-14 | 2010-06-24 | ノップ ニューロサイエンシーズ、インク. | (6r)−4,5,6,7−テトラヒドロ−n6−プロピル−2,6−ベンゾチアゾール−ジアミンの放出調節製剤およびそれらの使用方法 |
-
2010
- 2010-06-21 RU RU2012101792/15A patent/RU2012101792A/ru unknown
- 2010-06-21 CA CA2765876A patent/CA2765876A1/en not_active Abandoned
- 2010-06-21 EP EP10790329A patent/EP2442655A4/en not_active Withdrawn
- 2010-06-21 US US12/819,990 patent/US20110009460A1/en not_active Abandoned
- 2010-06-21 CN CN2010800366747A patent/CN102802418A/zh active Pending
- 2010-06-21 MX MX2011013577A patent/MX2011013577A/es not_active Application Discontinuation
- 2010-06-21 BR BRPI1010084-9A patent/BRPI1010084A2/pt not_active IP Right Cessation
- 2010-06-21 WO PCT/US2010/039379 patent/WO2010148409A1/en not_active Ceased
- 2010-06-21 JP JP2012516375A patent/JP2012530723A/ja active Pending
- 2010-06-21 AU AU2010262970A patent/AU2010262970A1/en not_active Abandoned
-
2011
- 2011-12-16 CL CL2011003191A patent/CL2011003191A1/es unknown
- 2011-12-26 CO CO11178793A patent/CO6480953A2/es not_active Application Discontinuation
-
2012
- 2012-12-20 US US13/722,150 patent/US20130245081A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2011013577A (es) | 2012-04-10 |
| BRPI1010084A2 (pt) | 2015-08-25 |
| US20130245081A1 (en) | 2013-09-19 |
| CA2765876A1 (en) | 2010-12-23 |
| CL2011003191A1 (es) | 2012-07-20 |
| JP2012530723A (ja) | 2012-12-06 |
| CN102802418A (zh) | 2012-11-28 |
| AU2010262970A1 (en) | 2012-01-12 |
| EP2442655A4 (en) | 2013-04-03 |
| EP2442655A1 (en) | 2012-04-25 |
| US20110009460A1 (en) | 2011-01-13 |
| CO6480953A2 (es) | 2012-07-16 |
| WO2010148409A1 (en) | 2010-12-23 |
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