RU2012101792A - Композиции и способы для лечения бокового амиотрофического склероза - Google Patents
Композиции и способы для лечения бокового амиотрофического склероза Download PDFInfo
- Publication number
- RU2012101792A RU2012101792A RU2012101792/15A RU2012101792A RU2012101792A RU 2012101792 A RU2012101792 A RU 2012101792A RU 2012101792/15 A RU2012101792/15 A RU 2012101792/15A RU 2012101792 A RU2012101792 A RU 2012101792A RU 2012101792 A RU2012101792 A RU 2012101792A
- Authority
- RU
- Russia
- Prior art keywords
- introduction
- als
- effective amount
- lateral sclerosis
- amyotrophic lateral
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 64
- 208000034189 Sclerosis Diseases 0.000 title claims 2
- 239000000203 mixture Substances 0.000 title 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims abstract 45
- FASDKYOPVNHBLU-SSDOTTSWSA-N dexpramipexole Chemical compound C1[C@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-SSDOTTSWSA-N 0.000 claims abstract 15
- 150000003839 salts Chemical class 0.000 claims abstract 15
- 208000024891 symptom Diseases 0.000 claims abstract 12
- 238000011282 treatment Methods 0.000 claims abstract 7
- 230000007659 motor function Effects 0.000 claims abstract 6
- 230000006870 function Effects 0.000 claims abstract 4
- 230000004202 respiratory function Effects 0.000 claims abstract 3
- 230000009747 swallowing Effects 0.000 claims abstract 3
- 208000000059 Dyspnea Diseases 0.000 claims abstract 2
- 206010013975 Dyspnoeas Diseases 0.000 claims abstract 2
- 206010031123 Orthopnoea Diseases 0.000 claims abstract 2
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims abstract 2
- 230000037396 body weight Effects 0.000 claims abstract 2
- 230000009194 climbing Effects 0.000 claims abstract 2
- 230000003111 delayed effect Effects 0.000 claims abstract 2
- 208000012144 orthopnea Diseases 0.000 claims abstract 2
- 201000004193 respiratory failure Diseases 0.000 claims abstract 2
- 230000029058 respiratory gaseous exchange Effects 0.000 claims abstract 2
- 238000012544 monitoring process Methods 0.000 claims 5
- 231100000673 dose–response relationship Toxicity 0.000 claims 2
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 claims 1
- 206010039424 Salivary hypersecretion Diseases 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 229960004181 riluzole Drugs 0.000 claims 1
- 208000026451 salivation Diseases 0.000 claims 1
- 238000004448 titration Methods 0.000 claims 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21865909P | 2009-06-19 | 2009-06-19 | |
| US61/218,659 | 2009-06-19 | ||
| US26794509P | 2009-12-09 | 2009-12-09 | |
| US61/267,945 | 2009-12-09 | ||
| US31711810P | 2010-03-24 | 2010-03-24 | |
| US61/317,118 | 2010-03-24 | ||
| US35643910P | 2010-06-18 | 2010-06-18 | |
| US61/356,439 | 2010-06-18 | ||
| PCT/US2010/039379 WO2010148409A1 (en) | 2009-06-19 | 2010-06-21 | Compositions and methods for treating amyotrophic lateral sclerosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012101792A true RU2012101792A (ru) | 2013-07-27 |
Family
ID=43356795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012101792/15A RU2012101792A (ru) | 2009-06-19 | 2010-06-21 | Композиции и способы для лечения бокового амиотрофического склероза |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20110009460A1 (enExample) |
| EP (1) | EP2442655A4 (enExample) |
| JP (1) | JP2012530723A (enExample) |
| CN (1) | CN102802418A (enExample) |
| AU (1) | AU2010262970A1 (enExample) |
| BR (1) | BRPI1010084A2 (enExample) |
| CA (1) | CA2765876A1 (enExample) |
| CL (1) | CL2011003191A1 (enExample) |
| CO (1) | CO6480953A2 (enExample) |
| MX (1) | MX2011013577A (enExample) |
| RU (1) | RU2012101792A (enExample) |
| WO (1) | WO2010148409A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| ES2379117T3 (es) | 2006-05-16 | 2012-04-20 | Knopp Neurosciences, Inc. | Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas |
| US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| WO2008113056A2 (en) | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
| CN102186350A (zh) * | 2008-08-19 | 2011-09-14 | 诺普神经科学股份有限公司 | 使用(r)-普拉克索的组合物与方法 |
| EP2731611B1 (en) * | 2011-07-13 | 2019-09-18 | Cytokinetics, Inc. | Combination therapie for als |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| WO2013096870A1 (en) * | 2011-12-22 | 2013-06-27 | Knopp Neurosciences Inc | Compositions and methods for treating amyotrophic lateral sclerosis |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| WO2014134569A1 (en) * | 2013-02-28 | 2014-09-04 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| SMT202100119T1 (it) | 2013-07-12 | 2021-05-07 | Knopp Biosciences Llc | Trattamento dei livelli elevati di eosinofili e/o basofili |
| EP3038467B1 (en) | 2013-08-13 | 2020-07-29 | Knopp Biosciences LLC | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
| AU2014306597B2 (en) * | 2013-08-13 | 2018-05-17 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
| TN2016000197A1 (en) * | 2013-11-22 | 2017-10-06 | Genzyme Corp | Novel methods for treating neurodegenerative diseases. |
| WO2016040643A1 (en) * | 2014-09-10 | 2016-03-17 | The Uab Research Foundation | Amyotrophic lateral sclerosis (als) biomarkers and uses thereof |
| WO2016207924A1 (en) * | 2015-06-25 | 2016-12-29 | Chiarugi Alberto | Dexpramipexole for the treatment of pain |
| WO2017103224A1 (en) * | 2015-12-16 | 2017-06-22 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method of treatment of amyotrophic lateral sclerosis |
| KR20220149709A (ko) * | 2020-03-05 | 2022-11-08 | 바이오하벤 테라퓨틱스 리미티드 | 골수 세포형과산화효소 저해제를 사용한 근위축성 측삭 경화증의 치료 방법 |
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| US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
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-
2010
- 2010-06-21 US US12/819,990 patent/US20110009460A1/en not_active Abandoned
- 2010-06-21 JP JP2012516375A patent/JP2012530723A/ja active Pending
- 2010-06-21 AU AU2010262970A patent/AU2010262970A1/en not_active Abandoned
- 2010-06-21 CA CA2765876A patent/CA2765876A1/en not_active Abandoned
- 2010-06-21 RU RU2012101792/15A patent/RU2012101792A/ru unknown
- 2010-06-21 WO PCT/US2010/039379 patent/WO2010148409A1/en not_active Ceased
- 2010-06-21 EP EP10790329A patent/EP2442655A4/en not_active Withdrawn
- 2010-06-21 MX MX2011013577A patent/MX2011013577A/es not_active Application Discontinuation
- 2010-06-21 CN CN2010800366747A patent/CN102802418A/zh active Pending
- 2010-06-21 BR BRPI1010084-9A patent/BRPI1010084A2/pt not_active IP Right Cessation
-
2011
- 2011-12-16 CL CL2011003191A patent/CL2011003191A1/es unknown
- 2011-12-26 CO CO11178793A patent/CO6480953A2/es not_active Application Discontinuation
-
2012
- 2012-12-20 US US13/722,150 patent/US20130245081A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110009460A1 (en) | 2011-01-13 |
| CL2011003191A1 (es) | 2012-07-20 |
| CA2765876A1 (en) | 2010-12-23 |
| EP2442655A1 (en) | 2012-04-25 |
| AU2010262970A1 (en) | 2012-01-12 |
| US20130245081A1 (en) | 2013-09-19 |
| JP2012530723A (ja) | 2012-12-06 |
| MX2011013577A (es) | 2012-04-10 |
| CN102802418A (zh) | 2012-11-28 |
| EP2442655A4 (en) | 2013-04-03 |
| WO2010148409A1 (en) | 2010-12-23 |
| BRPI1010084A2 (pt) | 2015-08-25 |
| CO6480953A2 (es) | 2012-07-16 |
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