RU2011147219A - Способ и устройство для изолирования искомой биочастицы из биологического образца - Google Patents
Способ и устройство для изолирования искомой биочастицы из биологического образца Download PDFInfo
- Publication number
- RU2011147219A RU2011147219A RU2011147219/15A RU2011147219A RU2011147219A RU 2011147219 A RU2011147219 A RU 2011147219A RU 2011147219/15 A RU2011147219/15 A RU 2011147219/15A RU 2011147219 A RU2011147219 A RU 2011147219A RU 2011147219 A RU2011147219 A RU 2011147219A
- Authority
- RU
- Russia
- Prior art keywords
- bioparticle
- biological sample
- channel
- module
- magnetic field
- Prior art date
Links
- 239000012472 biological sample Substances 0.000 title claims abstract 34
- 238000000034 method Methods 0.000 title claims abstract 28
- 239000003446 ligand Substances 0.000 claims abstract 34
- 238000000926 separation method Methods 0.000 claims abstract 31
- 239000012530 fluid Substances 0.000 claims abstract 22
- 239000000523 sample Substances 0.000 claims abstract 16
- 230000015572 biosynthetic process Effects 0.000 claims abstract 2
- 239000007788 liquid Substances 0.000 claims 14
- 238000005406 washing Methods 0.000 claims 8
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 239000006249 magnetic particle Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 108091005461 Nucleic proteins Proteins 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108091023037 Aptamer Proteins 0.000 claims 1
- 230000000781 anti-lymphocytic effect Effects 0.000 claims 1
- 238000011001 backwashing Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 229920002457 flexible plastic Polymers 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000002386 leaching Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 229910052761 rare earth metal Inorganic materials 0.000 claims 1
- 150000002910 rare earth metals Chemical class 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/005—Pretreatment specially adapted for magnetic separation
- B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17153209P | 2009-04-22 | 2009-04-22 | |
| US61/171,532 | 2009-04-22 | ||
| US18266109P | 2009-05-29 | 2009-05-29 | |
| US61/182,661 | 2009-05-29 | ||
| US28528609P | 2009-12-10 | 2009-12-10 | |
| US61/285,286 | 2009-12-10 | ||
| PCT/AU2010/000459 WO2010121315A1 (en) | 2009-04-22 | 2010-04-22 | Method and apparatus for isolating a target bioentity from a biological sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2011147219A true RU2011147219A (ru) | 2013-05-27 |
Family
ID=43010599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011147219/15A RU2011147219A (ru) | 2009-04-22 | 2010-04-22 | Способ и устройство для изолирования искомой биочастицы из биологического образца |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20120115167A1 (enExample) |
| EP (1) | EP2421654A1 (enExample) |
| JP (1) | JP2012524885A (enExample) |
| CN (1) | CN102458665A (enExample) |
| AU (1) | AU2010239154A1 (enExample) |
| IL (1) | IL215807A0 (enExample) |
| NZ (1) | NZ595982A (enExample) |
| RU (1) | RU2011147219A (enExample) |
| WO (1) | WO2010121315A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103261439B (zh) | 2010-11-09 | 2015-04-15 | 阿塞迪生物技术有限公司 | 母体血液中的胎儿细胞的富集和识别及这类用途的配体 |
| WO2012113028A1 (en) * | 2011-02-23 | 2012-08-30 | Clinical Genomics Pty. Ltd. | Isolation of a target bioentity from a biological sample |
| US20140295420A1 (en) * | 2011-06-15 | 2014-10-02 | Koninklijke Philips N.V. | Processing of biological sample components |
| WO2013003898A1 (en) * | 2011-07-07 | 2013-01-10 | Clinical Genomics Pty. Ltd | Method for detection of cancer in a patient |
| DE102011088741B4 (de) | 2011-12-15 | 2013-07-25 | Institut für Bioprozess- und Analysenmesstechnik e.V. | Verfahren und Anordnung zum Markieren und Separieren von Zellen aus einer Zellsuspension |
| US9637775B2 (en) | 2012-02-13 | 2017-05-02 | Neumodx Molecular, Inc. | System and method for processing biological samples |
| US11931740B2 (en) | 2012-02-13 | 2024-03-19 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
| US9604213B2 (en) | 2012-02-13 | 2017-03-28 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
| CN104254595A (zh) | 2012-02-13 | 2014-12-31 | 纽莫德克斯莫勒库拉尔公司 | 用于处理和检测核酸的微流体盒 |
| US20140024136A1 (en) * | 2012-07-19 | 2014-01-23 | Derek L. Chappell | Magnetic particle separator |
| CN102911864B (zh) * | 2012-10-15 | 2014-08-06 | 宁波美晶医疗技术有限公司 | 一种血液中稀有细胞的分离仪 |
| US20140120544A1 (en) | 2012-10-25 | 2014-05-01 | Neumodx Molecular, Inc. | Method and materials for isolation of nucleic acid materials |
| CN103131634B (zh) * | 2013-02-25 | 2014-09-03 | 宁波美晶医疗技术有限公司 | 一种基于微磁场的免疫肿瘤细胞筛选系统 |
| CN103131693B (zh) * | 2013-02-25 | 2014-12-24 | 宁波美晶医疗技术有限公司 | 一种血液中稀有细胞的分离方法 |
| US10202577B2 (en) | 2013-10-18 | 2019-02-12 | The General Hospital Corporation | Microfluidic sorting using high gradient magnetic fields |
| CN103940997B (zh) * | 2014-03-21 | 2017-01-04 | 上海柏慧康生物科技有限公司 | 一种乳腺癌循环肿瘤细胞检测系统及试剂盒 |
| WO2016084102A1 (en) * | 2014-11-28 | 2016-06-02 | Indian Institute Of Technology Delhi | Magnetic capturing of rare cells |
| EP3061529A1 (en) * | 2015-02-24 | 2016-08-31 | AdnaGen GmbH | Apparatus and method for the analysis, isolation and/or enrichment of target structures in a fluid sample |
| EP3998335A3 (en) | 2015-05-08 | 2022-07-27 | Biomagnetic Solutions LLC | Apparatus and method for immunomagnetic cell separation |
| EP4252898A3 (en) * | 2015-09-18 | 2023-11-29 | Redbud Labs, Inc. | Flow cells utilizing surface-attached structures, and related systems and methods |
| JP2018534588A (ja) * | 2015-09-22 | 2018-11-22 | パーデュー・リサーチ・ファウンデーションPurdue Research Foundation | 稀少細胞の遠心分離なしの単離および検出 |
| CA3086405A1 (en) | 2018-01-05 | 2019-07-11 | Path Ex, Inc. | Device for the capture and removal of disease material from fluids |
| JP7396777B2 (ja) * | 2018-09-28 | 2023-12-12 | オクタン バイオテック インコーポレーテッド | 磁気分離 |
| WO2020086761A1 (en) * | 2018-10-24 | 2020-04-30 | Path Ex, Inc. | Method for the capture and isolation of disease material from flowing matter |
| AU2020289708C1 (en) | 2019-06-07 | 2024-12-12 | Arcedi Biotech Aps | Isolation of fetal cells using FACS |
| CA3152196A1 (en) * | 2019-08-30 | 2021-03-04 | Flodesign Sonics, Inc. | Acoustic affinity cell selection for multiple target receptors |
| CN113125707A (zh) * | 2020-01-10 | 2021-07-16 | 陈琪 | 一种分离磁微粒的方法、装置及设备 |
| AU2023375445A1 (en) * | 2022-11-08 | 2025-05-15 | Zhong Li | Methods for detecting target compounds and uses thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1575805A (en) * | 1976-03-12 | 1980-10-01 | Technicon Instr | Automatic diagnostic apparatus |
| FI903345A7 (fi) * | 1988-01-04 | 1990-07-03 | Du Pont | Monivaiheinen affiniteettimenetelmä spesifisten solujen eristämiseksi soluseoksesta |
| US5795470A (en) * | 1991-03-25 | 1998-08-18 | Immunivest Corporation | Magnetic separation apparatus |
| WO1996026011A1 (en) * | 1995-02-21 | 1996-08-29 | Siddiqi Iqbal W | Apparatus and method for mixing and separation employing magnetic particles |
| US5705059A (en) * | 1995-02-27 | 1998-01-06 | Miltenyi; Stefan | Magnetic separation apparatus |
| FR2748569B1 (fr) * | 1996-05-07 | 1998-08-07 | Biocom Sa | Procede et installation de separation de particules magnetiques dans un fluide pour l'analyse biologique, et application dudit procede |
| US20030095897A1 (en) * | 2001-08-31 | 2003-05-22 | Grate Jay W. | Flow-controlled magnetic particle manipulation |
| CN1230531C (zh) * | 2002-12-09 | 2005-12-07 | 清华大学 | 从样品中分离细胞粒子的方法 |
| US7553625B2 (en) * | 2003-12-22 | 2009-06-30 | John Wayne Cancer Institute | Method and apparatus for in vivo collection of circulating biological components |
| JP2006010529A (ja) * | 2004-06-25 | 2006-01-12 | Canon Inc | 磁性粒子分離装置および分離方法 |
| JP2006051850A (ja) * | 2004-08-10 | 2006-02-23 | Matsushita Electric Ind Co Ltd | 運転支援装置及び運転支援方法 |
| US20090305236A1 (en) * | 2005-05-11 | 2009-12-10 | Genetic Technologies Limited | Methods of enriching fetal cells |
| JP2007010500A (ja) * | 2005-06-30 | 2007-01-18 | Canon Inc | サンプル検出装置とそれを含む検体分析装置 |
| WO2007092713A2 (en) * | 2006-02-02 | 2007-08-16 | Trustees Of The University Of Pennsylvania | Microfluidic system and method for analysis of gene expression in cell-containing samples and detection of disease |
| JP2009530606A (ja) * | 2006-03-13 | 2009-08-27 | ギロス パテント アーべー | 増強型磁気粒子ステアリング |
| CN100546724C (zh) * | 2006-06-30 | 2009-10-07 | 上海师范大学 | 磁性分离柱及其在生物样品分离中的应用 |
| CN101842161A (zh) * | 2007-08-23 | 2010-09-22 | 辛温尼奥生物系统公司 | 用于目标物质的俘获磁性拣选系统 |
| WO2009117611A2 (en) * | 2008-03-19 | 2009-09-24 | Cynvenio Biosystems, Llc | Trapping magnetic cell sorting system |
| US20110137018A1 (en) * | 2008-04-16 | 2011-06-09 | Cynvenio Biosystems, Inc. | Magnetic separation system with pre and post processing modules |
| US8377669B2 (en) * | 2009-11-17 | 2013-02-19 | Abbott Point Of Care Inc. | Reducing leukocyte interference in non-competitive immunoassays |
-
2010
- 2010-04-22 CN CN2010800262983A patent/CN102458665A/zh active Pending
- 2010-04-22 JP JP2012506281A patent/JP2012524885A/ja not_active Ceased
- 2010-04-22 WO PCT/AU2010/000459 patent/WO2010121315A1/en not_active Ceased
- 2010-04-22 AU AU2010239154A patent/AU2010239154A1/en not_active Abandoned
- 2010-04-22 RU RU2011147219/15A patent/RU2011147219A/ru not_active Application Discontinuation
- 2010-04-22 US US13/265,674 patent/US20120115167A1/en not_active Abandoned
- 2010-04-22 NZ NZ595982A patent/NZ595982A/xx not_active IP Right Cessation
- 2010-04-22 EP EP10766508A patent/EP2421654A1/en not_active Withdrawn
-
2011
- 2011-10-23 IL IL215807A patent/IL215807A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010239154A1 (en) | 2011-11-10 |
| WO2010121315A1 (en) | 2010-10-28 |
| JP2012524885A (ja) | 2012-10-18 |
| NZ595982A (en) | 2013-10-25 |
| IL215807A0 (en) | 2012-01-31 |
| CN102458665A (zh) | 2012-05-16 |
| EP2421654A1 (en) | 2012-02-29 |
| US20120115167A1 (en) | 2012-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20130423 |