CN102458665A - 用于从生物学样品中分离靶生物实体的方法和仪器 - Google Patents

用于从生物学样品中分离靶生物实体的方法和仪器 Download PDF

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Publication number
CN102458665A
CN102458665A CN2010800262983A CN201080026298A CN102458665A CN 102458665 A CN102458665 A CN 102458665A CN 2010800262983 A CN2010800262983 A CN 2010800262983A CN 201080026298 A CN201080026298 A CN 201080026298A CN 102458665 A CN102458665 A CN 102458665A
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China
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magnetic
flow path
fluid flow
module
separation module
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CN2010800262983A
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English (en)
Chinese (zh)
Inventor
H·M·钱德勒
M·B·钱德勒
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Clinical Genomics Pty Ltd
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Clinical Genomics Pty Ltd
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Publication of CN102458665A publication Critical patent/CN102458665A/zh
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/28Magnetic plugs and dipsticks
    • B03C1/288Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/005Pretreatment specially adapted for magnetic separation
    • B03C1/01Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/18Magnetic separation whereby the particles are suspended in a liquid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/26Details of magnetic or electrostatic separation for use in medical or biological applications

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2010800262983A 2009-04-22 2010-04-22 用于从生物学样品中分离靶生物实体的方法和仪器 Pending CN102458665A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17153209P 2009-04-22 2009-04-22
US61/171,532 2009-04-22
US18266109P 2009-05-29 2009-05-29
US61/182,661 2009-05-29
US28528609P 2009-12-10 2009-12-10
US61/285,286 2009-12-10
PCT/AU2010/000459 WO2010121315A1 (en) 2009-04-22 2010-04-22 Method and apparatus for isolating a target bioentity from a biological sample

Publications (1)

Publication Number Publication Date
CN102458665A true CN102458665A (zh) 2012-05-16

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CN2010800262983A Pending CN102458665A (zh) 2009-04-22 2010-04-22 用于从生物学样品中分离靶生物实体的方法和仪器

Country Status (9)

Country Link
US (1) US20120115167A1 (enExample)
EP (1) EP2421654A1 (enExample)
JP (1) JP2012524885A (enExample)
CN (1) CN102458665A (enExample)
AU (1) AU2010239154A1 (enExample)
IL (1) IL215807A0 (enExample)
NZ (1) NZ595982A (enExample)
RU (1) RU2011147219A (enExample)
WO (1) WO2010121315A1 (enExample)

Cited By (5)

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CN102911864A (zh) * 2012-10-15 2013-02-06 宁波美晶医疗技术有限公司 一种血液中稀有细胞的分离仪
CN103131693A (zh) * 2013-02-25 2013-06-05 宁波美晶医疗技术有限公司 一种血液中稀有细胞的分离方法
CN103131634A (zh) * 2013-02-25 2013-06-05 宁波美晶医疗技术有限公司 一种基于微磁场的免疫肿瘤细胞筛选系统
CN103940997A (zh) * 2014-03-21 2014-07-23 上海柏慧康生物科技有限公司 一种乳腺癌循环肿瘤细胞检测系统及试剂盒
CN115655825A (zh) * 2015-09-18 2023-01-31 紫荆实验室股份有限公司 利用表面附着结构的流动池,以及相关的系统和方法

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CN103261439B (zh) 2010-11-09 2015-04-15 阿塞迪生物技术有限公司 母体血液中的胎儿细胞的富集和识别及这类用途的配体
WO2012113028A1 (en) * 2011-02-23 2012-08-30 Clinical Genomics Pty. Ltd. Isolation of a target bioentity from a biological sample
US20140295420A1 (en) * 2011-06-15 2014-10-02 Koninklijke Philips N.V. Processing of biological sample components
WO2013003898A1 (en) * 2011-07-07 2013-01-10 Clinical Genomics Pty. Ltd Method for detection of cancer in a patient
DE102011088741B4 (de) 2011-12-15 2013-07-25 Institut für Bioprozess- und Analysenmesstechnik e.V. Verfahren und Anordnung zum Markieren und Separieren von Zellen aus einer Zellsuspension
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
US11931740B2 (en) 2012-02-13 2024-03-19 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
CN104254595A (zh) 2012-02-13 2014-12-31 纽莫德克斯莫勒库拉尔公司 用于处理和检测核酸的微流体盒
US20140024136A1 (en) * 2012-07-19 2014-01-23 Derek L. Chappell Magnetic particle separator
US20140120544A1 (en) 2012-10-25 2014-05-01 Neumodx Molecular, Inc. Method and materials for isolation of nucleic acid materials
US10202577B2 (en) 2013-10-18 2019-02-12 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
WO2016084102A1 (en) * 2014-11-28 2016-06-02 Indian Institute Of Technology Delhi Magnetic capturing of rare cells
EP3061529A1 (en) * 2015-02-24 2016-08-31 AdnaGen GmbH Apparatus and method for the analysis, isolation and/or enrichment of target structures in a fluid sample
EP3998335A3 (en) 2015-05-08 2022-07-27 Biomagnetic Solutions LLC Apparatus and method for immunomagnetic cell separation
JP2018534588A (ja) * 2015-09-22 2018-11-22 パーデュー・リサーチ・ファウンデーションPurdue Research Foundation 稀少細胞の遠心分離なしの単離および検出
CA3086405A1 (en) 2018-01-05 2019-07-11 Path Ex, Inc. Device for the capture and removal of disease material from fluids
JP7396777B2 (ja) * 2018-09-28 2023-12-12 オクタン バイオテック インコーポレーテッド 磁気分離
WO2020086761A1 (en) * 2018-10-24 2020-04-30 Path Ex, Inc. Method for the capture and isolation of disease material from flowing matter
AU2020289708C1 (en) 2019-06-07 2024-12-12 Arcedi Biotech Aps Isolation of fetal cells using FACS
CA3152196A1 (en) * 2019-08-30 2021-03-04 Flodesign Sonics, Inc. Acoustic affinity cell selection for multiple target receptors
CN113125707A (zh) * 2020-01-10 2021-07-16 陈琪 一种分离磁微粒的方法、装置及设备
AU2023375445A1 (en) * 2022-11-08 2025-05-15 Zhong Li Methods for detecting target compounds and uses thereof

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CN1899698A (zh) * 2006-06-30 2007-01-24 上海师范大学 磁性分离柱及其在生物样品分离中的应用
WO2009026566A1 (en) * 2007-08-23 2009-02-26 Cynvenio Biosystems, Llc Trapping magnetic sorting system for target species

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US5795470A (en) * 1991-03-25 1998-08-18 Immunivest Corporation Magnetic separation apparatus
CN1506460A (zh) * 2002-12-09 2004-06-23 �廪��ѧ 从样品中分离细胞粒子的方法及其试剂盒
CN1899698A (zh) * 2006-06-30 2007-01-24 上海师范大学 磁性分离柱及其在生物样品分离中的应用
WO2009026566A1 (en) * 2007-08-23 2009-02-26 Cynvenio Biosystems, Llc Trapping magnetic sorting system for target species

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102911864A (zh) * 2012-10-15 2013-02-06 宁波美晶医疗技术有限公司 一种血液中稀有细胞的分离仪
CN103131693A (zh) * 2013-02-25 2013-06-05 宁波美晶医疗技术有限公司 一种血液中稀有细胞的分离方法
CN103131634A (zh) * 2013-02-25 2013-06-05 宁波美晶医疗技术有限公司 一种基于微磁场的免疫肿瘤细胞筛选系统
CN103940997A (zh) * 2014-03-21 2014-07-23 上海柏慧康生物科技有限公司 一种乳腺癌循环肿瘤细胞检测系统及试剂盒
CN115655825A (zh) * 2015-09-18 2023-01-31 紫荆实验室股份有限公司 利用表面附着结构的流动池,以及相关的系统和方法

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Publication number Publication date
RU2011147219A (ru) 2013-05-27
AU2010239154A1 (en) 2011-11-10
WO2010121315A1 (en) 2010-10-28
JP2012524885A (ja) 2012-10-18
NZ595982A (en) 2013-10-25
IL215807A0 (en) 2012-01-31
EP2421654A1 (en) 2012-02-29
US20120115167A1 (en) 2012-05-10

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Application publication date: 20120516