RU2011131532A - Способ лечения бессонницы - Google Patents
Способ лечения бессонницы Download PDFInfo
- Publication number
- RU2011131532A RU2011131532A RU2011131532/15A RU2011131532A RU2011131532A RU 2011131532 A RU2011131532 A RU 2011131532A RU 2011131532/15 A RU2011131532/15 A RU 2011131532/15A RU 2011131532 A RU2011131532 A RU 2011131532A RU 2011131532 A RU2011131532 A RU 2011131532A
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- RU
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- Prior art keywords
- melatonin
- drug
- medicament
- release composition
- sustained release
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
1. Применение мелатонина, перорально в композиции с замедленным высвобождением, в производстве лекарственного средства для лечения субъективно оцененного нересторативного сна у пациентов, страдающих первичной бессонницей, по определению DSM-IV, в котором указанное лекарственное средство включает также, по меньшей мере, один фармацевтически приемлемый разбавитель, консервант, антиоксидант, растворитель, эмульгатор, адъювант или носитель, в котором указанный мелатонин присутствует в указанном лекарственном средстве при эффективном количестве в пределах от 0,0025 до 50 мг.2. Использование по п.1, при котором лекарственное средство представлено в единичной дозированной форме, а каждая единичная доза содержит мелатонин в пределах 0,025-10 мг.3. Использование по п.2, при котором указанная композиция с замедленным высвобождением включает акриловую резину.4. Лекарственное средство для лечения субъективно оцененного нересторативного сна у пациентов, страдающих первичной бессонницей, по определению DSM-IV, содержащее мелатонин, в эффективных количествах в пределах от 0,0025 до 50 мг, перорально в композиции с замедленным высвобождением, и, по меньшей мере, один фармацевтически приемлемый разбавитель, консервант, антиоксидант, растворитель, эмульгатор, адъювант или носитель.5. Лекарственное средство по п.4, в котором каждая единичная доза содержит мелатонин в пределах от 0,0025 до 10 мг.6. Лекарственное средство по п.5, в котором указанная композиция с замедленным высвобождением включает акриловую резину.
Claims (6)
1. Применение мелатонина, перорально в композиции с замедленным высвобождением, в производстве лекарственного средства для лечения субъективно оцененного нересторативного сна у пациентов, страдающих первичной бессонницей, по определению DSM-IV, в котором указанное лекарственное средство включает также, по меньшей мере, один фармацевтически приемлемый разбавитель, консервант, антиоксидант, растворитель, эмульгатор, адъювант или носитель, в котором указанный мелатонин присутствует в указанном лекарственном средстве при эффективном количестве в пределах от 0,0025 до 50 мг.
2. Использование по п.1, при котором лекарственное средство представлено в единичной дозированной форме, а каждая единичная доза содержит мелатонин в пределах 0,025-10 мг.
3. Использование по п.2, при котором указанная композиция с замедленным высвобождением включает акриловую резину.
4. Лекарственное средство для лечения субъективно оцененного нересторативного сна у пациентов, страдающих первичной бессонницей, по определению DSM-IV, содержащее мелатонин, в эффективных количествах в пределах от 0,0025 до 50 мг, перорально в композиции с замедленным высвобождением, и, по меньшей мере, один фармацевтически приемлемый разбавитель, консервант, антиоксидант, растворитель, эмульгатор, адъювант или носитель.
5. Лекарственное средство по п.4, в котором каждая единичная доза содержит мелатонин в пределах от 0,0025 до 10 мг.
6. Лекарственное средство по п.5, в котором указанная композиция с замедленным высвобождением включает акриловую резину.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL144900 | 2001-08-14 | ||
| IL144900A IL144900A (en) | 2001-08-14 | 2001-08-14 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
| PCT/IL2002/000662 WO2003015690A2 (en) | 2001-08-14 | 2002-08-12 | Method for treating primary insomnia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2011131532A true RU2011131532A (ru) | 2013-03-27 |
| RU2560840C2 RU2560840C2 (ru) | 2015-08-20 |
Family
ID=11075696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011131532/15A RU2560840C2 (ru) | 2001-08-14 | 2002-08-12 | Способ лечения бессонницы |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US8962024B2 (ru) |
| EP (2) | EP1441702B1 (ru) |
| JP (1) | JP2005501095A (ru) |
| KR (1) | KR20040032917A (ru) |
| CN (1) | CN100453078C (ru) |
| AR (1) | AR034975A1 (ru) |
| AU (1) | AU2002326114C1 (ru) |
| BR (1) | BR0211855A (ru) |
| CA (1) | CA2454699C (ru) |
| CL (1) | CL2002001701A1 (ru) |
| CR (1) | CR7271A (ru) |
| CY (2) | CY1118924T1 (ru) |
| DK (2) | DK3103443T3 (ru) |
| EA (1) | EA200400302A1 (ru) |
| ES (2) | ES2626591T3 (ru) |
| GT (1) | GT200200164A (ru) |
| HK (1) | HK1066161A1 (ru) |
| HU (1) | HU230786B1 (ru) |
| IL (1) | IL144900A (ru) |
| IS (1) | IS3004B (ru) |
| JO (1) | JO3446B1 (ru) |
| LT (1) | LT1441702T (ru) |
| MX (1) | MXPA04001372A (ru) |
| NO (1) | NO334788B2 (ru) |
| NZ (1) | NZ531318A (ru) |
| PA (1) | PA8552301A1 (ru) |
| PE (1) | PE20030331A1 (ru) |
| PL (1) | PL367872A1 (ru) |
| PT (2) | PT1441702T (ru) |
| RU (1) | RU2560840C2 (ru) |
| SI (1) | SI1441702T1 (ru) |
| UA (1) | UA87262C2 (ru) |
| UY (1) | UY27401A1 (ru) |
| WO (1) | WO2003015690A2 (ru) |
| ZA (1) | ZA200402005B (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL144900A (en) | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
| IL149377A (en) * | 2002-04-28 | 2012-10-31 | Neurim Pharma 1991 | Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds |
| US20070088079A1 (en) * | 2005-09-20 | 2007-04-19 | Takeda Pharmaceutical Company Limited | Prophylactic or therapeutic agent for sleep disorder |
| AR056076A1 (es) * | 2005-09-20 | 2007-09-19 | Takeda Pharmaceutical | Agente profilactico o terapeutico para el desorden de sueno |
| MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
| US8940326B2 (en) | 2007-03-19 | 2015-01-27 | Vita Sciences Llc | Transdermal patch and method for delivery of vitamin B12 |
| WO2008122102A1 (en) * | 2007-04-05 | 2008-10-16 | Iomedix Development International Srl | Melatonin-based composition for improved sleep |
| US20080248106A1 (en) | 2007-04-05 | 2008-10-09 | Marvin Heuer | Melatonin-based composition for improved sleep |
| US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
| WO2012103411A2 (en) * | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
| US10849856B2 (en) | 2016-10-31 | 2020-12-01 | Neurim Pharmaceuticals Ltd. | Melatonin mini-tablets and method of manufacturing the same |
| AU2016426598C1 (en) | 2016-10-31 | 2024-02-08 | Neurim Pharmaceuticals Ltd. | Melatonin mini-tablets and method of manufacturing the same |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3126375A (en) | 1964-03-24 | Chioacyl | ||
| US2789118A (en) | 1956-03-30 | 1957-04-16 | American Cyanamid Co | 16-alpha oxy-belta1, 4-pregnadienes |
| US2990401A (en) | 1958-06-18 | 1961-06-27 | American Cyanamid Co | 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids |
| US3048581A (en) | 1960-04-25 | 1962-08-07 | Olin Mathieson | Acetals and ketals of 16, 17-dihydroxy steroids |
| US3749712A (en) | 1970-09-25 | 1973-07-31 | Sigma Tau Ind Farmaceuti | Triamcinolone acetonide esters and process for their preparation |
| SE378109B (ru) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| SE378110B (ru) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| US3996359A (en) | 1972-05-19 | 1976-12-07 | Ab Bofors | Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith |
| EP0126630B1 (en) | 1983-05-18 | 1987-09-16 | Monash University | The use of melatonin for the manufacture of a medicament |
| JPS6045513A (ja) * | 1983-05-18 | 1985-03-12 | モナシユ ユニバ−シテイ | 身体行動および機能の日周期の不調を軽減する薬剤 |
| US4600723A (en) * | 1983-05-18 | 1986-07-15 | Monash University | Method for minimizing disturbances in circadian rhythms of bodily performance and function |
| US5151446A (en) | 1989-09-25 | 1992-09-29 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
| FR2658818B1 (fr) | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5707652A (en) | 1990-12-04 | 1998-01-13 | State Of Oregon | Methods of treating circadian rhythm phase disorders |
| US5591768A (en) * | 1990-12-04 | 1997-01-07 | State Of Oregan, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Methods for treating circadian rhythm phase disturbances |
| DE122007000073I1 (de) * | 1991-05-09 | 2008-01-31 | Neurim Pharma 1991 | Melatonin enthaltene Arzneimittel |
| IT1251544B (it) * | 1991-05-13 | 1995-05-17 | Gabriele Biella | Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico |
| FR2680507B1 (fr) | 1991-08-23 | 1993-10-08 | Adir Cie | Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| ATE141051T1 (de) * | 1992-04-07 | 1996-08-15 | Neurim Pharma 1991 | Verwendung von melatonin zur herstellung eines arzneimittels zur behandlung der gutartigen prostatahyperplasie |
| US5449683A (en) | 1992-10-01 | 1995-09-12 | Massachussetts Institute Of Technology | Methods of inducing sleep using melatonin |
| IL103411A (en) | 1992-10-11 | 1996-11-14 | Neurim Pharma 1991 | Melatonin Controlled Pharmacy Preparation for the Correction of Melatonin Deficiency or Distortion in Melatonin in Human Plasma |
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| TW336932B (en) | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
| TW444018B (en) | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
| KR100190730B1 (ko) | 1992-12-17 | 1999-06-01 | 디. 제이. 우드, 스피겔 알렌 제이 | 부신피질 호르몬 유리인자(crf) 길항물질로서 치환된 피라졸 |
| AU7550994A (en) | 1993-07-26 | 1995-02-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Sustained release oral compositions containing melatonin |
| US5654325A (en) | 1993-11-18 | 1997-08-05 | Eli Lilly And Company | Melatonin derivatives for use in treating sleep disorders |
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| US6469044B1 (en) | 1995-02-01 | 2002-10-22 | Neurim Pharmaceuticals (1991) Ltd. | Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies |
| US5688520A (en) * | 1995-03-29 | 1997-11-18 | Minnesota Mining And Manufacturing Company | Transmucosal delivery of melatonin for prevention of migraine |
| EP0748627A3 (en) | 1995-06-14 | 1997-05-21 | Lilly Co Eli | Melatonin agonists for the treatment of benign forms of hyperplasia of the prostate |
| NO981489L (no) * | 1995-10-03 | 1998-05-22 | Interneuron Pharma | Blandinger av melatonin og analgetika samt anvendelser derav |
| ATE265209T1 (de) * | 1996-07-17 | 2004-05-15 | Merck & Co Inc | Änderung des zirkadischen rhythmus mit nicht- peptidischen neurokinin-1 rezeptor antagonisten |
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| PL201219B1 (pl) * | 2000-01-05 | 2009-03-31 | Neurim Pharma 1991 | Zastosowanie melatoniny do wytwarzania leku |
| IL144900A (en) | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
| US6703412B1 (en) | 2002-09-27 | 2004-03-09 | Holly A. Rosenthal | Method of treating sleeplessness with melatonin on an acute basis |
| JP2014533981A (ja) | 2011-09-27 | 2014-12-18 | アイビス・メディカル・インコーポレーテッド | 胃内インプラントデバイス |
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2001
- 2001-08-14 IL IL144900A patent/IL144900A/en active IP Right Grant
-
2002
- 2002-07-29 UY UY27401A patent/UY27401A1/es not_active Application Discontinuation
- 2002-07-31 CL CL2002001701A patent/CL2002001701A1/es unknown
- 2002-08-05 AR ARP020102964A patent/AR034975A1/es not_active Application Discontinuation
- 2002-08-08 JO JOP/2002/0086A patent/JO3446B1/ar active
- 2002-08-09 PA PA20028552301A patent/PA8552301A1/es unknown
- 2002-08-12 MX MXPA04001372A patent/MXPA04001372A/es unknown
- 2002-08-12 DK DK16172415.8T patent/DK3103443T3/da active
- 2002-08-12 SI SI200231087T patent/SI1441702T1/sl unknown
- 2002-08-12 EP EP02760523.7A patent/EP1441702B1/en not_active Revoked
- 2002-08-12 KR KR10-2004-7002245A patent/KR20040032917A/ko active Search and Examination
- 2002-08-12 RU RU2011131532/15A patent/RU2560840C2/ru active
- 2002-08-12 ES ES02760523.7T patent/ES2626591T3/es not_active Expired - Lifetime
- 2002-08-12 PT PT2760523T patent/PT1441702T/pt unknown
- 2002-08-12 CA CA2454699A patent/CA2454699C/en not_active Expired - Lifetime
- 2002-08-12 ES ES16172415T patent/ES2882584T3/es not_active Expired - Lifetime
- 2002-08-12 PT PT161724158T patent/PT3103443T/pt unknown
- 2002-08-12 EP EP16172415.8A patent/EP3103443B1/en not_active Expired - Lifetime
- 2002-08-12 HU HU0401042A patent/HU230786B1/hu unknown
- 2002-08-12 WO PCT/IL2002/000662 patent/WO2003015690A2/en active Application Filing
- 2002-08-12 BR BR0211855-6A patent/BR0211855A/pt not_active Application Discontinuation
- 2002-08-12 AU AU2002326114A patent/AU2002326114C1/en not_active Expired
- 2002-08-12 CN CNB028158326A patent/CN100453078C/zh not_active Ceased
- 2002-08-12 LT LTEP02760523.7T patent/LT1441702T/lt unknown
- 2002-08-12 NZ NZ531318A patent/NZ531318A/en not_active IP Right Cessation
- 2002-08-12 PL PL02367872A patent/PL367872A1/xx not_active Application Discontinuation
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- 2002-08-12 US US10/486,688 patent/US8962024B2/en active Active
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- 2002-08-12 DK DK02760523.7T patent/DK1441702T3/en active
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2004
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2017
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2021
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