RU2011122615A - Живой аттенуированный респираторно-синцитиальный вирус - Google Patents
Живой аттенуированный респираторно-синцитиальный вирус Download PDFInfo
- Publication number
- RU2011122615A RU2011122615A RU2011122615/10A RU2011122615A RU2011122615A RU 2011122615 A RU2011122615 A RU 2011122615A RU 2011122615/10 A RU2011122615/10 A RU 2011122615/10A RU 2011122615 A RU2011122615 A RU 2011122615A RU 2011122615 A RU2011122615 A RU 2011122615A
- Authority
- RU
- Russia
- Prior art keywords
- gene
- protein encoded
- nucleotide
- amino acid
- mutation
- Prior art date
Links
- 230000002238 attenuated effect Effects 0.000 title claims abstract 39
- 241000700605 Viruses Species 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 claims abstract 146
- 235000018102 proteins Nutrition 0.000 claims abstract 91
- 102000004169 proteins and genes Human genes 0.000 claims abstract 91
- 101150082239 G gene Proteins 0.000 claims abstract 60
- 241000725643 Respiratory syncytial virus Species 0.000 claims abstract 42
- 150000001413 amino acids Chemical class 0.000 claims abstract 36
- 235000001014 amino acid Nutrition 0.000 claims abstract 30
- 230000003612 virological effect Effects 0.000 claims abstract 18
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract 17
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims abstract 16
- 235000013922 glutamic acid Nutrition 0.000 claims abstract 16
- 239000004220 glutamic acid Substances 0.000 claims abstract 16
- 239000004471 Glycine Substances 0.000 claims abstract 14
- 101150034814 F gene Proteins 0.000 claims abstract 12
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims abstract 12
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims abstract 11
- 235000004279 alanine Nutrition 0.000 claims abstract 10
- 101150062031 L gene Proteins 0.000 claims abstract 8
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims abstract 8
- 239000004472 Lysine Substances 0.000 claims abstract 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract 6
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims abstract 6
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims abstract 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract 5
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims abstract 5
- 239000002773 nucleotide Substances 0.000 claims 55
- 125000003729 nucleotide group Chemical group 0.000 claims 55
- 230000035772 mutation Effects 0.000 claims 53
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 16
- 230000002163 immunogen Effects 0.000 claims 6
- 101150033828 NS1 gene Proteins 0.000 claims 5
- 102220227441 rs899935666 Human genes 0.000 claims 5
- 229930024421 Adenine Natural products 0.000 claims 4
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 4
- 229960000643 adenine Drugs 0.000 claims 4
- 102200108568 rs1046611742 Human genes 0.000 claims 4
- 102200105394 rs1060501198 Human genes 0.000 claims 4
- 102220317346 rs145871499 Human genes 0.000 claims 4
- 102220268734 rs1555338682 Human genes 0.000 claims 4
- 102220044516 rs202197835 Human genes 0.000 claims 4
- 102220081964 rs765911841 Human genes 0.000 claims 4
- 102220597378 Cellular tumor antigen p53_E294K_mutation Human genes 0.000 claims 3
- 101150095629 NS2 gene Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 102200024306 rs35193847 Human genes 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 101150028074 2 gene Proteins 0.000 abstract 1
- 101150090724 3 gene Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
- C07K14/135—Respiratory syncytial virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
- C12N2760/18564—Methods of inactivation or attenuation by serial passage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19832708P | 2008-11-05 | 2008-11-05 | |
| US61/198,327 | 2008-11-05 | ||
| PCT/US2009/063024 WO2010053883A1 (en) | 2008-11-05 | 2009-11-03 | Live, attentuated respiratory syncytial virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2011122615A true RU2011122615A (ru) | 2012-12-20 |
Family
ID=41527812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011122615/10A RU2011122615A (ru) | 2008-11-05 | 2009-11-03 | Живой аттенуированный респираторно-синцитиальный вирус |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9011876B2 (enExample) |
| EP (1) | EP2346990B1 (enExample) |
| JP (2) | JP5016731B2 (enExample) |
| KR (1) | KR20110063863A (enExample) |
| CN (1) | CN102272295A (enExample) |
| AU (1) | AU2009311287C1 (enExample) |
| BR (1) | BRPI0921424A2 (enExample) |
| CA (1) | CA2742086A1 (enExample) |
| CL (1) | CL2011000999A1 (enExample) |
| CO (1) | CO6362047A2 (enExample) |
| EC (1) | ECSP11011033A (enExample) |
| IL (1) | IL212437A0 (enExample) |
| MA (1) | MA32878B1 (enExample) |
| MX (1) | MX2011004719A (enExample) |
| PE (1) | PE20110394A1 (enExample) |
| RU (1) | RU2011122615A (enExample) |
| TN (1) | TN2011000182A1 (enExample) |
| WO (1) | WO2010053883A1 (enExample) |
| ZA (1) | ZA201103259B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9011876B2 (en) * | 2008-11-05 | 2015-04-21 | Merck Sharp & Dohme Corp. | Live, attenuated respiratory syncytial virus |
| US20140242669A1 (en) * | 2011-08-18 | 2014-08-28 | Ycine Llc | Production of infectious rna viruses in yeast |
| WO2013031827A1 (ja) | 2011-08-29 | 2013-03-07 | 国立大学法人徳島大学 | Rsv粘膜ワクチン |
| EP4190895A1 (en) * | 2013-02-08 | 2023-06-07 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization |
| ES2854673T3 (es) * | 2013-03-14 | 2021-09-22 | Univ Emory | VSR recombinante con mutaciones silenciosas, vacunas y métodos relacionados con ello |
| CA2927431C (en) | 2013-10-16 | 2023-10-03 | Merck Sharp & Dohme Corp. | Method of microwave vacuum drying spherical-shaped pellets of biological materials |
| CA2926696A1 (en) | 2013-10-16 | 2015-04-23 | Merck Sharp & Dohme Corp | Thermostable respiratory synctial virus (rsv) vaccine compositions |
| WO2017030997A1 (en) * | 2015-08-14 | 2017-02-23 | Research Institute At Nationwide Children's Hospital | Respiratory syncytial virus having altered ns1 protein function and related materials and methods |
| EP3368547A4 (en) | 2015-10-29 | 2019-06-05 | Emory University | CHIMERIC RSV, IMMUNOGENIC COMPOSITIONS AND METHOD FOR USE THEREOF |
| AU2017332789B2 (en) | 2016-09-23 | 2021-05-27 | Codagenix, Inc. | Vaccine candidates for human respiratory syncytial virus (RSV) having attenuated phenotypes |
| TWI761453B (zh) | 2017-03-01 | 2022-04-21 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
| CA3075990A1 (en) * | 2017-09-15 | 2019-03-21 | Ohio State Innovation Foundation | Vaccines and methods of making and using vaccines for prevention of respiratory syncytial virus (rsv) infections |
| TW202535439A (zh) * | 2023-11-17 | 2025-09-16 | 美商賽諾菲巴斯德公司 | 海藻糖疫苗調配物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2438597A (en) | 1996-04-04 | 1997-10-29 | Regents Of The University Of Michigan, The | Attenuated respiratory syncytial virus |
| IL138681A0 (en) | 1998-03-26 | 2001-10-31 | American Cyanamid Co | Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup b |
| KR100905450B1 (ko) | 1999-07-09 | 2009-07-02 | 더 가버먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 리프리젠티드 바이 더 디파트먼트 오브 헬스 앤 휴먼 서비씨즈 | 약독화된 인간-소 키메릭 호흡기 신시티움 바이러스백신의 제조 방법 |
| AU2003295339B2 (en) | 2002-09-27 | 2009-03-26 | Medimmune, Llc | Functional mutations in respiratory syncytial virus |
| ATE469170T1 (de) * | 2003-03-28 | 2010-06-15 | Medimmune Llc | Zusammensetzungen und verfahren mit dem respiratory syncytial virus untergruppe b stamm 9320 |
| CN101646768A (zh) * | 2007-02-07 | 2010-02-10 | 生物载体株式会社 | 减毒负链rna病毒 |
| US9011876B2 (en) * | 2008-11-05 | 2015-04-21 | Merck Sharp & Dohme Corp. | Live, attenuated respiratory syncytial virus |
-
2009
- 2009-11-03 US US13/127,647 patent/US9011876B2/en active Active
- 2009-11-03 MX MX2011004719A patent/MX2011004719A/es unknown
- 2009-11-03 AU AU2009311287A patent/AU2009311287C1/en not_active Ceased
- 2009-11-03 KR KR1020117010304A patent/KR20110063863A/ko not_active Ceased
- 2009-11-03 CN CN2009801537266A patent/CN102272295A/zh active Pending
- 2009-11-03 BR BRPI0921424A patent/BRPI0921424A2/pt not_active IP Right Cessation
- 2009-11-03 RU RU2011122615/10A patent/RU2011122615A/ru not_active Application Discontinuation
- 2009-11-03 WO PCT/US2009/063024 patent/WO2010053883A1/en not_active Ceased
- 2009-11-03 CA CA2742086A patent/CA2742086A1/en not_active Abandoned
- 2009-11-03 EP EP09748199.8A patent/EP2346990B1/en active Active
- 2009-11-03 JP JP2011534864A patent/JP5016731B2/ja not_active Expired - Fee Related
- 2009-11-03 PE PE2011000971A patent/PE20110394A1/es not_active Application Discontinuation
-
2011
- 2011-04-17 IL IL212437A patent/IL212437A0/en unknown
- 2011-04-19 TN TN2011000182A patent/TN2011000182A1/fr unknown
- 2011-05-04 CL CL2011000999A patent/CL2011000999A1/es unknown
- 2011-05-05 ZA ZA2011/03259A patent/ZA201103259B/en unknown
- 2011-05-05 EC EC2011011033A patent/ECSP11011033A/es unknown
- 2011-05-12 CO CO11058596A patent/CO6362047A2/es not_active Application Discontinuation
- 2011-06-03 MA MA33913A patent/MA32878B1/fr unknown
- 2011-08-05 JP JP2011171459A patent/JP5743794B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2742086A1 (en) | 2010-05-14 |
| BRPI0921424A2 (pt) | 2016-01-05 |
| MA32878B1 (fr) | 2011-12-01 |
| CL2011000999A1 (es) | 2012-07-20 |
| AU2009311287A1 (en) | 2010-05-14 |
| PE20110394A1 (es) | 2011-06-22 |
| ECSP11011033A (es) | 2011-12-30 |
| ZA201103259B (en) | 2012-01-25 |
| JP5743794B2 (ja) | 2015-07-01 |
| AU2009311287B2 (en) | 2013-02-07 |
| CO6362047A2 (es) | 2012-01-20 |
| AU2009311287C1 (en) | 2015-02-19 |
| MX2011004719A (es) | 2011-05-31 |
| TN2011000182A1 (en) | 2012-12-17 |
| US20110212130A1 (en) | 2011-09-01 |
| IL212437A0 (en) | 2011-06-30 |
| EP2346990B1 (en) | 2016-01-06 |
| KR20110063863A (ko) | 2011-06-14 |
| CN102272295A (zh) | 2011-12-07 |
| JP2012507302A (ja) | 2012-03-29 |
| EP2346990A1 (en) | 2011-07-27 |
| JP5016731B2 (ja) | 2012-09-05 |
| WO2010053883A1 (en) | 2010-05-14 |
| US9011876B2 (en) | 2015-04-21 |
| JP2011250798A (ja) | 2011-12-15 |
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