RU2009133446A - Стабилизированная дозированная форма пикоплатина для перорального применения - Google Patents
Стабилизированная дозированная форма пикоплатина для перорального применения Download PDFInfo
- Publication number
- RU2009133446A RU2009133446A RU2009133446/15A RU2009133446A RU2009133446A RU 2009133446 A RU2009133446 A RU 2009133446A RU 2009133446/15 A RU2009133446/15 A RU 2009133446/15A RU 2009133446 A RU2009133446 A RU 2009133446A RU 2009133446 A RU2009133446 A RU 2009133446A
- Authority
- RU
- Russia
- Prior art keywords
- oral dosage
- dosage form
- picoplatin
- core
- form according
- Prior art date
Links
- IIMIOEBMYPRQGU-UHFFFAOYSA-L picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 title claims abstract 48
- 229950005566 picoplatin Drugs 0.000 title claims abstract 48
- 239000002552 dosage form Substances 0.000 title 1
- 239000006186 oral dosage form Substances 0.000 claims abstract 59
- 239000011248 coating agent Substances 0.000 claims abstract 35
- 238000000576 coating method Methods 0.000 claims abstract 35
- 239000000843 powder Substances 0.000 claims abstract 33
- 239000002245 particle Substances 0.000 claims abstract 17
- 239000004215 Carbon black (E152) Substances 0.000 claims abstract 15
- 229930195733 hydrocarbon Natural products 0.000 claims abstract 15
- 150000002430 hydrocarbons Chemical class 0.000 claims abstract 15
- 239000000945 filler Substances 0.000 claims abstract 13
- 239000002270 dispersing agent Substances 0.000 claims abstract 11
- 239000008187 granular material Substances 0.000 claims abstract 11
- 239000000203 mixture Substances 0.000 claims abstract 9
- 150000003839 salts Chemical class 0.000 claims abstract 9
- 229910052751 metal Inorganic materials 0.000 claims abstract 8
- 239000002184 metal Substances 0.000 claims abstract 8
- 108010010803 Gelatin Proteins 0.000 claims abstract 7
- 239000008273 gelatin Substances 0.000 claims abstract 7
- 229920000159 gelatin Polymers 0.000 claims abstract 7
- 235000019322 gelatine Nutrition 0.000 claims abstract 7
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract 7
- 239000007787 solid Substances 0.000 claims abstract 7
- 239000000126 substance Substances 0.000 claims abstract 7
- 239000006187 pill Substances 0.000 claims abstract 5
- 238000000465 moulding Methods 0.000 claims abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000002775 capsule Substances 0.000 claims abstract 2
- 239000007931 coated granule Substances 0.000 claims abstract 2
- 238000000926 separation method Methods 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 25
- 235000010980 cellulose Nutrition 0.000 claims 13
- 229920002678 cellulose Polymers 0.000 claims 13
- 239000001913 cellulose Substances 0.000 claims 13
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 4
- -1 alkaline earth metal salt Chemical class 0.000 claims 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 4
- 229920003086 cellulose ether Polymers 0.000 claims 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- 229930195729 fatty acid Natural products 0.000 claims 4
- 150000004665 fatty acids Chemical class 0.000 claims 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 4
- 239000008108 microcrystalline cellulose Substances 0.000 claims 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 4
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 4
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 3
- 229930006000 Sucrose Natural products 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
- 229920000609 methyl cellulose Polymers 0.000 claims 3
- 239000001923 methylcellulose Substances 0.000 claims 3
- 235000010981 methylcellulose Nutrition 0.000 claims 3
- 239000005720 sucrose Substances 0.000 claims 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- 239000001856 Ethyl cellulose Substances 0.000 claims 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 2
- 150000002016 disaccharides Chemical class 0.000 claims 2
- 229920001249 ethyl cellulose Polymers 0.000 claims 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 235000019359 magnesium stearate Nutrition 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- 150000002772 monosaccharides Chemical class 0.000 claims 2
- 239000004014 plasticizer Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 235000010356 sorbitol Nutrition 0.000 claims 2
- 150000005846 sugar alcohols Chemical class 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229910010413 TiO 2 Inorganic materials 0.000 claims 1
- 150000001342 alkaline earth metals Chemical class 0.000 claims 1
- 239000002518 antifoaming agent Substances 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000003605 opacifier Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000193 polymethacrylate Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 239000004408 titanium dioxide Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/28—Mercury; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88917107P | 2007-02-09 | 2007-02-09 | |
| US60/889,171 | 2007-02-09 | ||
| US88968107P | 2007-02-13 | 2007-02-13 | |
| US60/889,681 | 2007-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009133446A true RU2009133446A (ru) | 2011-03-20 |
Family
ID=39682046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009133446/15A RU2009133446A (ru) | 2007-02-09 | 2008-02-08 | Стабилизированная дозированная форма пикоплатина для перорального применения |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2114418A4 (https=) |
| JP (1) | JP2010518089A (https=) |
| KR (1) | KR20090109129A (https=) |
| CN (2) | CN101678046A (https=) |
| AU (1) | AU2008214202A1 (https=) |
| BR (1) | BRPI0806418A2 (https=) |
| CA (1) | CA2677640A1 (https=) |
| HK (1) | HK1206267A1 (https=) |
| IL (1) | IL200262A0 (https=) |
| MX (1) | MX2009008488A (https=) |
| RU (1) | RU2009133446A (https=) |
| WO (1) | WO2008097661A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168661B2 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8178564B2 (en) | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| EP2418955A4 (en) * | 2009-04-15 | 2012-11-21 | Poniard Pharmaceuticals Inc | ORAL PICOPLATIN ANTITUMOR THERAPY WITH HIGH BIOAVAILABILITY |
| KR102451223B1 (ko) * | 2014-05-23 | 2022-10-05 | 밍사이트 파마슈티칼스, 인크. | 자가면역 질환의 치료 |
| CN107778331B (zh) * | 2016-08-27 | 2020-06-30 | 鲁南制药集团股份有限公司 | 一种甲啶铂的提纯方法 |
| CN108864177B (zh) * | 2018-04-20 | 2020-07-28 | 公安部物证鉴定中心 | [2h3]-1-甲氨基-2-苯基丙烷的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9502799D0 (en) * | 1995-02-14 | 1995-04-05 | Johnson Matthey Plc | Improvements in platinum complexes |
| ATE348617T1 (de) * | 2000-02-16 | 2007-01-15 | Astellas Pharma Inc | Heilmittel gegen durch endothelin verursachte erkrankungen |
| US6989156B2 (en) * | 2001-04-23 | 2006-01-24 | Nucryst Pharmaceuticals Corp. | Therapeutic treatments using the direct application of antimicrobial metal compositions |
| DE10141528B4 (de) * | 2001-08-24 | 2006-08-10 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Platin(II)- und Platin(IV)-Komplexe und ihre Verwendung |
| US20050119238A1 (en) * | 2002-03-01 | 2005-06-02 | Baron John A. | Compositions and methods for preventing sporadic neoplasia in colon |
| WO2004006859A2 (en) * | 2002-07-16 | 2004-01-22 | Sonus Pharmaceuticals, Inc. | Platinum compound |
| JP2006502233A (ja) * | 2002-08-02 | 2006-01-19 | トランセーブ，インク． | 白金凝集物およびその製造方法 |
| WO2005089448A2 (en) * | 2004-03-18 | 2005-09-29 | Transave, Inc. | Administration of cisplatin by inhalation |
| US20060205810A1 (en) * | 2004-11-24 | 2006-09-14 | Schering Corporation | Platinum therapeutic combinations |
-
2008
- 2008-02-08 EP EP08725393A patent/EP2114418A4/en not_active Withdrawn
- 2008-02-08 CA CA002677640A patent/CA2677640A1/en not_active Abandoned
- 2008-02-08 MX MX2009008488A patent/MX2009008488A/es not_active Application Discontinuation
- 2008-02-08 JP JP2009549128A patent/JP2010518089A/ja active Pending
- 2008-02-08 CN CN200880011357A patent/CN101678046A/zh active Pending
- 2008-02-08 KR KR1020097018780A patent/KR20090109129A/ko not_active Withdrawn
- 2008-02-08 WO PCT/US2008/001752 patent/WO2008097661A1/en not_active Ceased
- 2008-02-08 CN CN201410283507.2A patent/CN104288119A/zh active Pending
- 2008-02-08 AU AU2008214202A patent/AU2008214202A1/en not_active Abandoned
- 2008-02-08 BR BRPI0806418-0A patent/BRPI0806418A2/pt not_active IP Right Cessation
- 2008-02-08 RU RU2009133446/15A patent/RU2009133446A/ru not_active Application Discontinuation
-
2009
- 2009-08-06 IL IL200262A patent/IL200262A0/en unknown
-
2015
- 2015-07-21 HK HK15106959.9A patent/HK1206267A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN104288119A (zh) | 2015-01-21 |
| AU2008214202A1 (en) | 2008-08-14 |
| CN101678046A (zh) | 2010-03-24 |
| MX2009008488A (es) | 2010-01-15 |
| BRPI0806418A2 (pt) | 2011-09-06 |
| CA2677640A1 (en) | 2008-08-14 |
| IL200262A0 (en) | 2010-04-29 |
| JP2010518089A (ja) | 2010-05-27 |
| EP2114418A1 (en) | 2009-11-11 |
| WO2008097661A1 (en) | 2008-08-14 |
| KR20090109129A (ko) | 2009-10-19 |
| HK1206267A1 (en) | 2016-01-08 |
| EP2114418A4 (en) | 2013-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20120315 |