RU2009122456A - Способы стимуляции восстановления сердца с использованием факторов роста, слитых с гепарин-связывающими последовательностями - Google Patents
Способы стимуляции восстановления сердца с использованием факторов роста, слитых с гепарин-связывающими последовательностями Download PDFInfo
- Publication number
- RU2009122456A RU2009122456A RU2009122456/15A RU2009122456A RU2009122456A RU 2009122456 A RU2009122456 A RU 2009122456A RU 2009122456/15 A RU2009122456/15 A RU 2009122456/15A RU 2009122456 A RU2009122456 A RU 2009122456A RU 2009122456 A RU2009122456 A RU 2009122456A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- fusion protein
- growth factor
- specified
- cardiomyocytes
- Prior art date
Links
- 239000003102 growth factor Substances 0.000 title 1
- 238000011084 recovery Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 25
- 150000001875 compounds Chemical class 0.000 claims abstract 18
- 108020001507 fusion proteins Proteins 0.000 claims abstract 14
- 102000037865 fusion proteins Human genes 0.000 claims abstract 14
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims abstract 12
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims abstract 12
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims abstract 12
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims abstract 12
- 102000004169 proteins and genes Human genes 0.000 claims abstract 11
- 108090000623 proteins and genes Proteins 0.000 claims abstract 11
- 210000004413 cardiac myocyte Anatomy 0.000 claims abstract 9
- 229930182852 proteinogenic amino acid Natural products 0.000 claims abstract 8
- 238000002513 implantation Methods 0.000 claims abstract 4
- 238000011534 incubation Methods 0.000 claims abstract 4
- 238000002347 injection Methods 0.000 claims abstract 4
- 239000007924 injection Substances 0.000 claims abstract 4
- 210000001519 tissue Anatomy 0.000 claims abstract 3
- OVXIMRGEBNSORH-UHFFFAOYSA-N 2-[[2-[2-[[2-[[1-[1-[5-amino-2-[[2-amino-3-(1h-indol-3-yl)propanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoylamino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylp Chemical compound CCC(C)C(C(O)=O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C1N(C(=O)C(CCC(N)=O)NC(=O)C(N)CC=2C3=CC=CC=C3NC=2)CCC1 OVXIMRGEBNSORH-UHFFFAOYSA-N 0.000 claims abstract 2
- 108020004414 DNA Proteins 0.000 claims abstract 2
- 102000053602 DNA Human genes 0.000 claims abstract 2
- 210000005003 heart tissue Anatomy 0.000 claims abstract 2
- 239000002773 nucleotide Substances 0.000 claims abstract 2
- 125000003729 nucleotide group Chemical group 0.000 claims abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 2
- 230000004083 survival effect Effects 0.000 claims abstract 2
- 210000000944 nerve tissue Anatomy 0.000 claims 4
- 210000002569 neuron Anatomy 0.000 claims 4
- 210000001612 chondrocyte Anatomy 0.000 claims 3
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 230000002594 corticospinal effect Effects 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 210000002161 motor neuron Anatomy 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Developmental Biology & Embryology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85840606P | 2006-11-13 | 2006-11-13 | |
| US60/858,406 | 2006-11-13 | ||
| US11/979,708 | 2007-11-07 | ||
| US11/979,708 US9187517B2 (en) | 2006-11-13 | 2007-11-07 | Methods of promoting cardiac repair using growth factors fused to heparin binding sequences |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009122456A true RU2009122456A (ru) | 2010-12-20 |
Family
ID=39430287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009122456/15A RU2009122456A (ru) | 2006-11-13 | 2007-11-08 | Способы стимуляции восстановления сердца с использованием факторов роста, слитых с гепарин-связывающими последовательностями |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9187517B2 (enExample) |
| EP (1) | EP2091550B1 (enExample) |
| JP (1) | JP2010508845A (enExample) |
| KR (1) | KR20090087061A (enExample) |
| AU (1) | AU2007322217A1 (enExample) |
| BR (1) | BRPI0718679A2 (enExample) |
| CA (1) | CA2670830A1 (enExample) |
| IL (1) | IL198708A0 (enExample) |
| MX (1) | MX2009005090A (enExample) |
| NO (1) | NO20092261L (enExample) |
| NZ (1) | NZ577235A (enExample) |
| RU (1) | RU2009122456A (enExample) |
| WO (1) | WO2008063424A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9187517B2 (en) * | 2006-11-13 | 2015-11-17 | The Brigham And Women's Hospital, Inc. | Methods of promoting cardiac repair using growth factors fused to heparin binding sequences |
| US8691771B2 (en) * | 2010-05-21 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins for tissue repair |
| JP2012093290A (ja) * | 2010-10-28 | 2012-05-17 | Sumitomo Bakelite Co Ltd | 医療用粒子および生理活性物質の捕捉方法 |
| US9421245B2 (en) * | 2012-06-25 | 2016-08-23 | The Brigham And Women's Hospital, Inc. | Targeted therapeutics |
| US9790264B2 (en) | 2012-06-25 | 2017-10-17 | The Brigham And Women's Hospital, Inc. | Compounds and methods for modulating pharmacokinetics |
| WO2014004467A1 (en) * | 2012-06-25 | 2014-01-03 | The Brigham And Women's Hospital, Inc. | Selective cartilage therapy |
| CA3000742A1 (en) | 2015-10-02 | 2017-04-06 | Silver Creek Pharmaceuticals, Inc. | Bi-specific therapeutic proteins for tissue repair |
| EA037848B1 (ru) * | 2016-07-14 | 2021-05-27 | Общество С Ограниченной Ответственностью "Биохимический Агент" | Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты) |
| JP2021516966A (ja) | 2018-03-09 | 2021-07-15 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 組織への生物学的薬物の送達 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670483A (en) * | 1992-12-28 | 1997-09-23 | Massachusetts Insititute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
| US6037329A (en) * | 1994-03-15 | 2000-03-14 | Selective Genetics, Inc. | Compositions containing nucleic acids and ligands for therapeutic treatment |
| US5723331A (en) * | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
| EP0920490A2 (en) * | 1996-07-25 | 1999-06-09 | Genzyme Corporation | Chondrocyte media formulations and culture procedures |
| AUPP298498A0 (en) * | 1998-04-17 | 1998-05-07 | Gropep Pty Ltd | Matrix binding factor |
| AU2001288392A1 (en) * | 2000-08-30 | 2002-03-13 | University Of Delaware | Delivery system for heparin-binding growth factors |
| CA2496732A1 (en) | 2002-08-20 | 2004-03-04 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
| US7166574B2 (en) * | 2002-08-20 | 2007-01-23 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
| US7598224B2 (en) * | 2002-08-20 | 2009-10-06 | Biosurface Engineering Technologies, Inc. | Dual chain synthetic heparin-binding growth factor analogs |
| WO2005014619A2 (en) * | 2003-03-28 | 2005-02-17 | Thomas Jefferson University | Heparin-binding peptides and uses thereof |
| US20080227696A1 (en) * | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
| US7399831B2 (en) * | 2004-10-25 | 2008-07-15 | The Brigham And Women's Hospital, Inc. | Targeted delivery of biological factors using self-assembling peptide nanofibers |
| AU2005323062A1 (en) * | 2005-01-04 | 2006-07-13 | The Brigham And Women's Hospital, Inc. | Sustained delivery of PDGF using self-assembling peptide nanofibers |
| US9187517B2 (en) * | 2006-11-13 | 2015-11-17 | The Brigham And Women's Hospital, Inc. | Methods of promoting cardiac repair using growth factors fused to heparin binding sequences |
-
2007
- 2007-11-07 US US11/979,708 patent/US9187517B2/en active Active
- 2007-11-08 MX MX2009005090A patent/MX2009005090A/es active IP Right Grant
- 2007-11-08 RU RU2009122456/15A patent/RU2009122456A/ru not_active Application Discontinuation
- 2007-11-08 KR KR1020097012163A patent/KR20090087061A/ko not_active Withdrawn
- 2007-11-08 BR BRPI0718679-7A2A patent/BRPI0718679A2/pt not_active IP Right Cessation
- 2007-11-08 JP JP2009536294A patent/JP2010508845A/ja active Pending
- 2007-11-08 NZ NZ577235A patent/NZ577235A/en not_active IP Right Cessation
- 2007-11-08 WO PCT/US2007/023527 patent/WO2008063424A2/en not_active Ceased
- 2007-11-08 AU AU2007322217A patent/AU2007322217A1/en not_active Abandoned
- 2007-11-08 CA CA002670830A patent/CA2670830A1/en not_active Abandoned
- 2007-11-08 EP EP07867389A patent/EP2091550B1/en active Active
-
2009
- 2009-05-12 IL IL198708A patent/IL198708A0/en unknown
- 2009-06-12 NO NO20092261A patent/NO20092261L/no not_active Application Discontinuation
-
2015
- 2015-10-07 US US14/877,474 patent/US9969788B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20080138323A1 (en) | 2008-06-12 |
| IL198708A0 (en) | 2011-08-01 |
| US20160024170A1 (en) | 2016-01-28 |
| JP2010508845A (ja) | 2010-03-25 |
| MX2009005090A (es) | 2009-07-24 |
| KR20090087061A (ko) | 2009-08-14 |
| NO20092261L (no) | 2009-08-06 |
| EP2091550A4 (en) | 2009-12-09 |
| WO2008063424A3 (en) | 2008-09-12 |
| US9187517B2 (en) | 2015-11-17 |
| EP2091550B1 (en) | 2013-01-02 |
| EP2091550A2 (en) | 2009-08-26 |
| WO2008063424A2 (en) | 2008-05-29 |
| US9969788B2 (en) | 2018-05-15 |
| AU2007322217A1 (en) | 2008-05-29 |
| BRPI0718679A2 (pt) | 2014-02-04 |
| NZ577235A (en) | 2011-12-22 |
| CA2670830A1 (en) | 2008-05-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2020001328A (es) | Muteinas de interleucina 21 y metodos de tratamiento. | |
| RU2525913C1 (ru) | Новый пептид и его применение | |
| RU2014150224A (ru) | Сконструированный белок с анкириновым повтором, связывающийся с фактором роста тромбоцитов | |
| RU2011122201A (ru) | Связывающие белки, ингибирующие взаимодействия vegf-a рецептора | |
| SG11202110607WA (en) | Adeno-associated virus with engineered capsid | |
| AU2011201593A1 (en) | Self-assembling peptide amphiphiles and related methods for growth factor delivery | |
| US10898609B2 (en) | Tissue decellularization methods | |
| JPH06507304A (ja) | 合成生物接着性ポリペプチド | |
| DE23193601T1 (de) | Verfahren zur erhöhung der funktion eines aav-vektors | |
| RU2015111706A (ru) | Терапевтические пептиды | |
| RU2017116353A (ru) | Варианты рекомбинантных ааv и их применения | |
| EA201490379A1 (ru) | Варианты белков axmi205 и способы их применения | |
| BRPI0612273A2 (pt) | anticorpo de ligaÇço a il-1 beta ou fragmento de ligaÇço a il-1 beta do mesmo, Ácido nucleico, vetor, cÉlula, animal transgÊnico, hibridoma, composiÇço, e, mÉtodos de tratamento ou prevenÇço de uma doenÇa ou doenÇa relacionada a il-1 em um mamÍfero, e de preparaÇço de um polipeptÍdeo de ligaÇço a il-1 beta maturado por afinidade | |
| EA201170685A1 (ru) | Гены, кодирущие токсины нематод | |
| AR047345A1 (es) | Vacuna para mejorar el crecimiento de animales a base de epitopos neutralizantes | |
| CY1112940T1 (el) | Ειδικα εναντι ογκων μορια αναγνωρισης | |
| GEP20146050B (en) | Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors | |
| RU2017126566A (ru) | ВСТРЕЧАЮЩИЕСЯ В ПРИРОДЕ миРНК ДЛЯ КОНТРОЛИРОВАНИЯ ЭКСПРЕССИИ ГЕНОВ И ИХ ПРИМЕНЕНИЕ | |
| CN106478776A (zh) | 抗纤维化肽及其在用于治疗以纤维化为特征的疾病和病症的方法中的用途 | |
| JP2024537778A (ja) | 生物学的に活性なコラーゲンハイブリダイズペプチド | |
| NO20092261L (no) | Fremgangsmater for a fremme reparasjon av hjerte ved anvendelse av vekstfaktorer fusjonert til heparin bindingssekvenser | |
| JP2023515672A5 (enExample) | ||
| CN107073063A (zh) | 用于修复软骨损伤的方法 | |
| EA201391444A1 (ru) | Вариант инсектицидного гена axmiи способы его применения | |
| JP2010053041A (ja) | ナマコ放卵・放精誘起剤、及びそれを用いたナマコの生産方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20120217 |