JP2010508845A - ヘパリン結合配列に融合した増殖因子を使用して心臓修復を促進する方法 - Google Patents
ヘパリン結合配列に融合した増殖因子を使用して心臓修復を促進する方法 Download PDFInfo
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- C12N5/0655—Chondrocytes; Cartilage
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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| PCT/US2007/023527 WO2008063424A2 (en) | 2006-11-13 | 2007-11-08 | Methods of promoting cardiac repair using growth factors fused to heparin binding sequences |
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| JP2010508845A true JP2010508845A (ja) | 2010-03-25 |
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| EP (1) | EP2091550B1 (enExample) |
| JP (1) | JP2010508845A (enExample) |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012093290A (ja) * | 2010-10-28 | 2012-05-17 | Sumitomo Bakelite Co Ltd | 医療用粒子および生理活性物質の捕捉方法 |
| JP2013530146A (ja) * | 2010-05-21 | 2013-07-25 | メリマック ファーマシューティカルズ インコーポレーティッド | 二重特異的融合タンパク質 |
| JP2015522590A (ja) * | 2012-06-25 | 2015-08-06 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 標的化治療薬 |
| US9790264B2 (en) | 2012-06-25 | 2017-10-17 | The Brigham And Women's Hospital, Inc. | Compounds and methods for modulating pharmacokinetics |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9187517B2 (en) * | 2006-11-13 | 2015-11-17 | The Brigham And Women's Hospital, Inc. | Methods of promoting cardiac repair using growth factors fused to heparin binding sequences |
| US9637531B2 (en) | 2012-06-25 | 2017-05-02 | The Brigham And Women's Hospital, Inc | Selective cartilage therapy |
| EP3355907B1 (en) | 2015-10-02 | 2021-01-20 | Silver Creek Pharmaceuticals, Inc. | Bi-specific therapeutic proteins for tissue repair |
| EA037848B1 (ru) * | 2016-07-14 | 2021-05-27 | Общество С Ограниченной Ответственностью "Биохимический Агент" | Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты) |
| JP2021516966A (ja) | 2018-03-09 | 2021-07-15 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 組織への生物学的薬物の送達 |
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| US5723331A (en) * | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
| CA2261292C (en) * | 1996-07-25 | 2008-09-30 | Genzyme Corporation | Chondrocyte media formulations and culture procedures |
| AU2001288392A1 (en) * | 2000-08-30 | 2002-03-13 | University Of Delaware | Delivery system for heparin-binding growth factors |
| US7598224B2 (en) | 2002-08-20 | 2009-10-06 | Biosurface Engineering Technologies, Inc. | Dual chain synthetic heparin-binding growth factor analogs |
| CA2496732A1 (en) | 2002-08-20 | 2004-03-04 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
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| WO2005014619A2 (en) | 2003-03-28 | 2005-02-17 | Thomas Jefferson University | Heparin-binding peptides and uses thereof |
| US20080227696A1 (en) * | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
| US7399831B2 (en) | 2004-10-25 | 2008-07-15 | The Brigham And Women's Hospital, Inc. | Targeted delivery of biological factors using self-assembling peptide nanofibers |
| US7429567B2 (en) | 2005-01-04 | 2008-09-30 | The Brigham And Women's Hospital, Inc. | Sustained delivery of PDGF using self-assembling peptide nanofibers |
| US9187517B2 (en) * | 2006-11-13 | 2015-11-17 | The Brigham And Women's Hospital, Inc. | Methods of promoting cardiac repair using growth factors fused to heparin binding sequences |
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| JP2002512018A (ja) * | 1998-04-17 | 2002-04-23 | グロペップ・リミテッド | マトリックス結合因子 |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013530146A (ja) * | 2010-05-21 | 2013-07-25 | メリマック ファーマシューティカルズ インコーポレーティッド | 二重特異的融合タンパク質 |
| JP2017000143A (ja) * | 2010-05-21 | 2017-01-05 | メリマック ファーマシューティカルズ インコーポレーティッド | 二重特異的融合タンパク質 |
| JP2017225442A (ja) * | 2010-05-21 | 2017-12-28 | メリマック ファーマシューティカルズ インコーポレーティッド | 二重特異的融合タンパク質 |
| JP2019196365A (ja) * | 2010-05-21 | 2019-11-14 | シルバー・クリーク・ファーマシューティカルズ・インコーポレイテッドＳｉｌｖｅｒ Ｃｒｅｅｋ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 二重特異的融合タンパク質 |
| JP2012093290A (ja) * | 2010-10-28 | 2012-05-17 | Sumitomo Bakelite Co Ltd | 医療用粒子および生理活性物質の捕捉方法 |
| JP2015522590A (ja) * | 2012-06-25 | 2015-08-06 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 標的化治療薬 |
| US9421245B2 (en) | 2012-06-25 | 2016-08-23 | The Brigham And Women's Hospital, Inc. | Targeted therapeutics |
| US9790264B2 (en) | 2012-06-25 | 2017-10-17 | The Brigham And Women's Hospital, Inc. | Compounds and methods for modulating pharmacokinetics |
Also Published As
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| CA2670830A1 (en) | 2008-05-29 |
| KR20090087061A (ko) | 2009-08-14 |
| EP2091550A2 (en) | 2009-08-26 |
| WO2008063424A3 (en) | 2008-09-12 |
| US9187517B2 (en) | 2015-11-17 |
| RU2009122456A (ru) | 2010-12-20 |
| IL198708A0 (en) | 2011-08-01 |
| US9969788B2 (en) | 2018-05-15 |
| EP2091550A4 (en) | 2009-12-09 |
| US20080138323A1 (en) | 2008-06-12 |
| AU2007322217A1 (en) | 2008-05-29 |
| US20160024170A1 (en) | 2016-01-28 |
| EP2091550B1 (en) | 2013-01-02 |
| WO2008063424A2 (en) | 2008-05-29 |
| NZ577235A (en) | 2011-12-22 |
| MX2009005090A (es) | 2009-07-24 |
| NO20092261L (no) | 2009-08-06 |
| BRPI0718679A2 (pt) | 2014-02-04 |
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