RU2009120528A - Способы гормональной терапии возрастающими дозами в режиме пролонгированного цикла - Google Patents
Способы гормональной терапии возрастающими дозами в режиме пролонгированного цикла Download PDFInfo
- Publication number
- RU2009120528A RU2009120528A RU2009120528/15A RU2009120528A RU2009120528A RU 2009120528 A RU2009120528 A RU 2009120528A RU 2009120528/15 A RU2009120528/15 A RU 2009120528/15A RU 2009120528 A RU2009120528 A RU 2009120528A RU 2009120528 A RU2009120528 A RU 2009120528A
- Authority
- RU
- Russia
- Prior art keywords
- estrogen
- phase
- daily dosage
- progestin
- dosage
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 33
- 238000001794 hormone therapy Methods 0.000 title 1
- 230000002035 prolonged effect Effects 0.000 title 1
- 229940011871 estrogen Drugs 0.000 claims abstract 56
- 239000000262 estrogen Substances 0.000 claims abstract 56
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims abstract 29
- 239000000583 progesterone congener Substances 0.000 claims abstract 27
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims abstract 11
- 229960004400 levonorgestrel Drugs 0.000 claims abstract 11
- 239000006186 oral dosage form Substances 0.000 claims 16
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 14
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims 14
- 229960002568 ethinylestradiol Drugs 0.000 claims 14
- 239000002552 dosage form Substances 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- ISHXLNHNDMZNMC-VTKCIJPMSA-N (3e,8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C\1 ISHXLNHNDMZNMC-VTKCIJPMSA-N 0.000 claims 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 claims 1
- RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 claims 1
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 229960001616 chlormadinone acetate Drugs 0.000 claims 1
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 claims 1
- 229960000978 cyproterone acetate Drugs 0.000 claims 1
- 229960004976 desogestrel Drugs 0.000 claims 1
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 claims 1
- 229960003309 dienogest Drugs 0.000 claims 1
- AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 claims 1
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 claims 1
- 229960004845 drospirenone Drugs 0.000 claims 1
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 claims 1
- 229930182833 estradiol Natural products 0.000 claims 1
- 229960005309 estradiol Drugs 0.000 claims 1
- 229960003575 estradiol acetate Drugs 0.000 claims 1
- FHXBMXJMKMWVRG-SLHNCBLASA-N estradiol acetate Chemical compound C1C[C@]2(C)[C@@H](O)CC[C@H]2[C@@H]2CCC3=CC(OC(=O)C)=CC=C3[C@H]21 FHXBMXJMKMWVRG-SLHNCBLASA-N 0.000 claims 1
- 229960004766 estradiol valerate Drugs 0.000 claims 1
- ONKUMRGIYFNPJW-KIEAKMPYSA-N ethynodiol diacetate Chemical compound C1C[C@]2(C)[C@@](C#C)(OC(C)=O)CC[C@H]2[C@@H]2CCC3=C[C@@H](OC(=O)C)CC[C@@H]3[C@H]21 ONKUMRGIYFNPJW-KIEAKMPYSA-N 0.000 claims 1
- 229960002941 etonogestrel Drugs 0.000 claims 1
- GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 claims 1
- SIGSPDASOTUPFS-XUDSTZEESA-N gestodene Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](C=C4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 SIGSPDASOTUPFS-XUDSTZEESA-N 0.000 claims 1
- 229960005352 gestodene Drugs 0.000 claims 1
- 229960004616 medroxyprogesterone Drugs 0.000 claims 1
- FRQMUZJSZHZSGN-HBNHAYAOSA-N medroxyprogesterone Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FRQMUZJSZHZSGN-HBNHAYAOSA-N 0.000 claims 1
- IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 claims 1
- 229960001390 mestranol Drugs 0.000 claims 1
- 229960002667 norelgestromin Drugs 0.000 claims 1
- 229940053934 norethindrone Drugs 0.000 claims 1
- 229960001652 norethindrone acetate Drugs 0.000 claims 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims 1
- 229960000417 norgestimate Drugs 0.000 claims 1
- KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 claims 1
- 229960003387 progesterone Drugs 0.000 claims 1
- 239000000186 progesterone Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/554,571 US20070111975A1 (en) | 2004-10-07 | 2006-10-30 | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
| US11/554,571 | 2006-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009120528A true RU2009120528A (ru) | 2010-12-10 |
Family
ID=39864644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009120528/15A RU2009120528A (ru) | 2006-10-30 | 2007-10-30 | Способы гормональной терапии возрастающими дозами в режиме пролонгированного цикла |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20070111975A1 (enExample) |
| EP (1) | EP2079461A4 (enExample) |
| JP (1) | JP2010508275A (enExample) |
| KR (1) | KR20090094437A (enExample) |
| CN (1) | CN101626760A (enExample) |
| BR (1) | BRPI0716291A2 (enExample) |
| CA (1) | CA2668211A1 (enExample) |
| IL (1) | IL198441A (enExample) |
| MX (1) | MX2009004616A (enExample) |
| RU (1) | RU2009120528A (enExample) |
| TW (1) | TW200831107A (enExample) |
| WO (1) | WO2008127303A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2468748C (en) * | 2001-12-05 | 2010-01-26 | Barr Laboratories, Inc. | Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology |
| AU2004257772B2 (en) * | 2003-07-16 | 2009-12-17 | Teva Women's Health, Inc. | Methods of hormonal treatment utilizing contraceptive regimens with continuous estrogen administration |
| US20070111975A1 (en) * | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
| EP2392333A1 (en) * | 2004-10-07 | 2011-12-07 | Teva Women's Health, Inc. | Methods of hormonal treatment utilizing ascending-dose extended cycle regimens |
| CA2740004A1 (en) | 2008-10-08 | 2010-04-15 | Agile Therapeutics, Inc. | Transdermal delivery |
| WO2010042612A1 (en) * | 2008-10-08 | 2010-04-15 | Agile Therapeutics, Inc. | Transdermal delivery |
| CA2740002C (en) * | 2008-10-08 | 2016-11-01 | Agile Therapeutics, Inc. | Transdermal delivery |
| US9198920B2 (en) | 2009-03-27 | 2015-12-01 | Agile Therapeutics, Inc. | Contraceptive transdermal delivery of hormones |
| FI20095563L (fi) * | 2009-05-20 | 2010-11-21 | Bayer Schering Pharma Oy | Vaginaalinen antojärjestelmä |
| WO2013112947A1 (en) * | 2012-01-26 | 2013-08-01 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| CA2856520C (en) | 2011-11-23 | 2021-04-06 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| WO2013090117A1 (en) | 2011-12-13 | 2013-06-20 | Arstat, Inc. | A multiphasic contraceptive regimen for oral combination drug formulation of progestin and estrogen |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| AR100562A1 (es) | 2014-05-22 | 2016-10-12 | Therapeuticsmd Inc | Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| AU2017239645A1 (en) | 2016-04-01 | 2018-10-18 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| GB201614179D0 (en) * | 2016-08-19 | 2016-10-05 | Mereo Biopharma 2 Ltd | Dosage regimen for the treatment of endometriosis |
| CN111035763A (zh) * | 2018-10-13 | 2020-04-21 | 合肥医工医药有限公司 | 一种治疗妇女更年期综合症的药物组合物 |
| US11478503B2 (en) * | 2019-11-21 | 2022-10-25 | Lupin, Inc. | Vitamin B12 compound supplementation methods and compositions |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| US12138270B2 (en) | 2021-09-07 | 2024-11-12 | Millicent Pharma Limited | Contraceptive regimen including reduced level of estrogen |
Family Cites Families (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3414119A (en) | 1966-08-29 | 1968-12-03 | Container Corp | Pill carrying and dispencing device |
| US3568828A (en) * | 1967-03-01 | 1971-03-09 | Squibb & Sons Inc | Modified sequential oral contraceptive |
| US4171358A (en) | 1974-04-19 | 1979-10-16 | Eli Lilly And Company | Novel contraceptive method |
| US4145416A (en) * | 1976-06-23 | 1979-03-20 | Schering, A.G. | Novel agents and novel methods for treatment of climacteric disturbances |
| US4292315A (en) * | 1977-12-30 | 1981-09-29 | Nichols Vorys | Follicular phase estrogen or progestin with physiologic estrogen/progestin luteal phase replacement drug delivery system |
| US4215691A (en) * | 1978-10-11 | 1980-08-05 | Alza Corporation | Vaginal contraceptive system made from block copolymer |
| US4291014A (en) * | 1979-01-11 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing estradiol diacetate |
| US4438139A (en) * | 1979-08-14 | 1984-03-20 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing estrogens |
| US4390531A (en) * | 1981-08-10 | 1983-06-28 | Syntex Pharmaceuticals International Ltd. | Method of contraception using peak progestogen dosage |
| USRE35724E (en) * | 1982-04-28 | 1998-02-03 | Bio-Technology General Corp. | Contraception system and method |
| US4826831A (en) * | 1983-08-05 | 1989-05-02 | Pre Jay Holdings Limited | Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens |
| US4628051A (en) | 1983-09-26 | 1986-12-09 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
| US4530839A (en) * | 1983-09-26 | 1985-07-23 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
| US4616006A (en) | 1983-09-26 | 1986-10-07 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
| US4544554A (en) | 1983-09-26 | 1985-10-01 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
| US4736849A (en) * | 1983-12-19 | 1988-04-12 | Leonard Walter G | Calendar-oriented pill dispenser |
| US4534468A (en) * | 1983-12-19 | 1985-08-13 | Nuckols Walter S | Calendar-oriented pill dispenser |
| JPS60174716A (ja) * | 1984-02-21 | 1985-09-09 | Yamanouchi Pharmaceut Co Ltd | パツチ剤 |
| US4962098A (en) | 1987-06-15 | 1990-10-09 | Warner-Lambert Company | Graduated estrogen contraceptive |
| US5010070A (en) * | 1987-06-15 | 1991-04-23 | Warner-Lambert Company | Graduated estrogen contraceptive |
| US4752478A (en) * | 1984-12-17 | 1988-06-21 | Merck & Co., Inc. | Transdermal system for timolol |
| US5296230A (en) * | 1985-02-25 | 1994-03-22 | Rutgers, The State University Of New Jersey | Transdermal fertility control system and process |
| GB8524276D0 (en) * | 1985-10-02 | 1985-11-06 | Efamol Ltd | Pharmaceutical & dietary compositions |
| US5208225A (en) * | 1986-02-27 | 1993-05-04 | Warner-Lambert Company | Compositions containing fixed combinations |
| US4762717A (en) * | 1986-03-21 | 1988-08-09 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive |
| DK174724B1 (da) | 1986-07-15 | 2003-10-06 | Wyeth Corp | Anvendelse af et præparat omfattende et østrogen og et progestogen til fremstilling af en dosisform til tilvejebringelse af hormonerstatningsterapi og kontraception til kvinder i præmenopausen samt pakning til tilvejebringelse af præparatet |
| US5256421A (en) | 1987-09-24 | 1993-10-26 | Jencap Research Ltd. | Hormone preparation and method |
| US5108995A (en) * | 1987-09-24 | 1992-04-28 | Jencap Research Ltd. | Hormone preparation and method |
| US5276022A (en) * | 1987-09-24 | 1994-01-04 | Jencap Research Ltd. | Hormone preparation and method |
| JP2938463B2 (ja) | 1987-10-22 | 1999-08-23 | マサチユセツツ・インスチチユート・オブ・テクノロジー | 月経前又は後期黄体期症候群の処置 |
| US4971998A (en) | 1987-10-22 | 1990-11-20 | Massachusetts Institute Of Technology | Methods for treating the premenstrual or late luteal phase syndrome |
| CA1336328C (en) * | 1988-04-11 | 1995-07-18 | Walter G. Leonard | Method of increasing bone density in humans |
| US4848585A (en) * | 1988-09-20 | 1989-07-18 | Etna Products Co. Inc. | Jewelry storage case |
| US5043331A (en) * | 1989-06-15 | 1991-08-27 | Orion-Yhtyma Oy | Treatment of postmenopausal disorders |
| US5098714A (en) * | 1989-11-16 | 1992-03-24 | Alza Corporation | Osmotic, oral dosage form for fertility control |
| US4998623A (en) * | 1990-04-27 | 1991-03-12 | Omni Medical Systems Inc. | Medication dispensing package |
| US5105949A (en) * | 1990-10-17 | 1992-04-21 | Blair Paul A | Medicine and record holder |
| IE71203B1 (en) | 1990-12-13 | 1997-02-12 | Akzo Nv | Low estrogen oral contraceptives |
| DE4104385C1 (enExample) * | 1991-02-09 | 1992-08-13 | Marika Dr.Med. 6509 Framersheim De Ehrlich | |
| US5211952A (en) * | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
| ZA924811B (en) * | 1991-06-28 | 1993-12-29 | Endorecherche Inc | Controlled release systems and low dose androgens |
| USD340860S (en) | 1991-12-04 | 1993-11-02 | Alnamar Corporation | Pill dispenser |
| US5348158A (en) * | 1991-12-19 | 1994-09-20 | G. D. Searle & Co. | Dispenser pack for the successive dispensing of a drug |
| MX9301121A (es) | 1992-03-02 | 1993-09-01 | Schering Ag | Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina. |
| DE4224534A1 (de) | 1992-07-24 | 1994-01-27 | Marika Dr Med Ehrlich | Ovulationshemmendes Mittel zur hormonalen Kontrazeption |
| USD339742S (en) * | 1992-08-07 | 1993-09-28 | American Home Products Corporation | Trifold pharmaceutical tablet dispenser |
| US5351818A (en) | 1992-08-20 | 1994-10-04 | Yousef Daneshvar | Medicine box |
| US5372258A (en) | 1992-08-20 | 1994-12-13 | Daneshvar; Yousef | Pill sample illustrator, and weekly medicine box |
| US5368187A (en) | 1993-01-19 | 1994-11-29 | Poncetta; Stanley | Method and apparatus for dispensing materials from blister packages |
| NL9301562A (nl) | 1993-09-09 | 1995-04-03 | Saturnus Ag | Preparaat voor substitutietherapie. |
| USD358762S (en) * | 1993-10-20 | 1995-05-30 | American Home Products Corporation | Trifold pharmaceutical tablet dispenser |
| USD358546S (en) * | 1993-10-20 | 1995-05-23 | American Home Products Corporation | Trifold pharmaceutical tablet dispenser |
| DE4344462C2 (de) * | 1993-12-22 | 1996-02-01 | Schering Ag | Zusammensetzung für die Empfängnisverhütung |
| DE4344405C2 (de) * | 1993-12-24 | 1995-12-07 | Marika Dr Med Ehrlich | Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption |
| DE4411585A1 (de) * | 1994-03-30 | 1995-10-05 | Schering Ag | Pharmazeutisches Kombinationspräparat zur hormonalen Kontrazeption |
| US5552394A (en) * | 1994-07-22 | 1996-09-03 | The Medical College Of Hampton Roads | Low dose oral contraceptives with less breakthrough bleeding and sustained efficacy |
| US6039208A (en) * | 1994-07-29 | 2000-03-21 | Ortho Pharmaceutical Corporation | Variable day start tablet dispenser |
| DE4429374C1 (de) * | 1994-08-12 | 1996-02-01 | Jenapharm Gmbh | Pharmazeutische Präparate zur Kontrazeption/Hormonsubstitution mit biogener Estrogenkomponente |
| DE19513662A1 (de) | 1995-04-08 | 1996-10-10 | Schering Ag | Pharmazeutisches Kombinationspräparat zur hormonalen Kontrazeption |
| DE19525017A1 (de) | 1995-06-28 | 1997-01-02 | Schering Ag | Pharmazeutisches Kombinatonspräparat, Kit und Methode zur hormonalen Kontrazeption |
| FR2737411B1 (fr) * | 1995-08-01 | 1997-10-17 | Theramex | Nouveaux medicaments hormonaux et leur utilisation pour la correction des carences estrogeniques |
| DE19531936A1 (de) * | 1995-08-17 | 1997-02-20 | Schering Ag | Kombinationspräparat zur Kontrazeption, Kits diese enthaltend und eine Methode diese verwendend |
| NZ299724A (en) | 1995-11-15 | 1997-03-24 | Nihon Mediphysics Co Ltd | Analysis of liquid using diminished intensity of a reflected beam, use in analysing trace samples and apparatus therefor |
| US5747480A (en) | 1996-05-08 | 1998-05-05 | American Home Products Corporation | Oral contraceptive |
| AU2558297A (en) | 1996-05-16 | 1997-12-05 | Gynetics Inc. | Emergency contraceptive kit |
| SE515129C2 (sv) * | 1996-07-01 | 2001-06-11 | Astrazeneca Ab | Blisterförpackning, apparat och förfarande för tillverkning av en blisterförpackning samt användning av en blisterförpackning |
| US6139873A (en) | 1996-07-10 | 2000-10-31 | Cedars-Sinai Medical Center | Combined pharmaceutical estrogen-androgen-progestin |
| US5858405A (en) * | 1996-07-26 | 1999-01-12 | American Home Products Corporation | Oral contraceptive |
| AU3888597A (en) | 1996-07-26 | 1998-02-20 | American Home Products Corporation | Oral contraceptive |
| WO1998004267A1 (en) | 1996-07-26 | 1998-02-05 | American Home Products Corporation | Progestin/estrogen oral contraceptive |
| US6479475B1 (en) | 1996-07-26 | 2002-11-12 | Wyeth | Oral contraceptive |
| AU3961697A (en) | 1996-07-26 | 1998-02-20 | American Home Products Corporation | Oral contraceptive |
| US6765002B2 (en) * | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
| US6511970B1 (en) * | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
| US6028064A (en) | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| DE19705229C2 (de) * | 1997-02-12 | 1999-04-15 | Hesch Rolf Dieter Prof Dr Med | Verwendung von drei Hormonkomponenten zur hormonalen Kontrazeption zur Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen |
| US5898032A (en) * | 1997-06-23 | 1999-04-27 | Medical College Of Hampton Roads | Ultra low dose oral contraceptives with less menstrual bleeding and sustained efficacy |
| USD411445S (en) * | 1997-06-30 | 1999-06-22 | Glaxo Group Limited | Holder for blister packs |
| USD414106S (en) * | 1997-06-30 | 1999-09-21 | Glaxo Group Limited | Holder for blister packs |
| GB9713876D0 (en) * | 1997-06-30 | 1997-09-03 | Glaxo Group Ltd | Device for holding blister pack |
| US6251956B1 (en) * | 1998-08-20 | 2001-06-26 | Ortho Pharmaceutical Corporation | Combination progestin oral contraceptive regimen |
| DE19739916C2 (de) | 1997-09-11 | 2001-09-13 | Hesch Rolf Dieter | Verwendung einer Kombination aus einem Gestagen und einem Estrogen zur kontinuierlichen Ovulationshemmung und ggf. gleichzeitigen Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen |
| CA2301162A1 (en) | 1997-09-12 | 1999-03-25 | Michael Jay Gast | Oral contraceptive preparation having a first phase comprising progestin/estrogen and a second phase comprising progestin |
| US6306914B1 (en) | 1997-10-21 | 2001-10-23 | Columbia Laboratories, Inc. | Progestin therapy for maintaining amenorrhea |
| USD423111S (en) * | 1998-06-01 | 2000-04-18 | Ortho Pharmaceutical Corp. | Drug dosage container |
| TW412499B (en) * | 1998-06-29 | 2000-11-21 | Sony Corp | Cartridge holder |
| US6265393B1 (en) * | 1998-08-07 | 2001-07-24 | Heinrichs William Leroy | Prevention of endometriosis signs or symptons |
| US20020169205A1 (en) | 1998-09-29 | 2002-11-14 | Krzysztof Chwalisz | Implantation rates after in vitro fertilization, and treatment of infertility and early pregnancy loss with a nitric oxide donor or substrate alone or in combination with progesterone, and a method for contraception with nitric oxide inhibitors in combination with antiprogestins or other agents |
| US6214815B1 (en) * | 1998-12-23 | 2001-04-10 | Ortho-Mcneil Pharmaceuticals, Inc. | Triphasic oral contraceptive |
| US20050038006A1 (en) * | 1998-12-23 | 2005-02-17 | Shangold Gary A. | Triphasic oral contraceptive |
| US6667050B1 (en) * | 1999-04-06 | 2003-12-23 | Galen (Chemicals) Limited | Chewable oral contraceptive |
| US6569857B1 (en) * | 1999-05-03 | 2003-05-27 | Drugtech Corporation | Dietary supplement |
| US6036018A (en) * | 1999-05-19 | 2000-03-14 | Valley Design Inc. | Multi-drawer child resistant blister pack container |
| US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| US6173838B1 (en) * | 2000-01-31 | 2001-01-16 | Owens Illinois Closure Inc. | Child-resistant medication compact |
| US20010044431A1 (en) | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| US6540082B2 (en) * | 2000-05-11 | 2003-04-01 | Meds Made Easy | Medicine dispensing apparatus |
| US7297688B2 (en) * | 2000-06-08 | 2007-11-20 | Wyeth | Starter kit for low dose oral contraceptives |
| HK1052877A1 (zh) | 2000-07-06 | 2003-10-03 | Wyeth | Ssri与雌激素剂之组合 |
| CN1159161C (zh) | 2001-02-06 | 2004-07-28 | 王怀珍 | 免擦环转黑板 |
| WO2002092102A2 (en) * | 2001-05-16 | 2002-11-21 | Endeavor Pharmaceuticals | Treatment of conditions relating to hormone deficiencies by administration of progestins |
| US20020193356A1 (en) * | 2001-05-23 | 2002-12-19 | Van Beek Agatha Antonia Magdalena | Means and method for hormonal contraception |
| US20030018018A1 (en) * | 2001-07-10 | 2003-01-23 | Medical College Of Hampton Roads | Ultra low dose oral contraceptives with sustained efficacy and induced amenorrhea |
| USD460254S1 (en) * | 2001-09-25 | 2002-07-16 | Robert J. Rufo | Pill caddy |
| US6789677B2 (en) * | 2001-11-30 | 2004-09-14 | West Pharmaceutical Services, Inc. | Child-resistant container |
| CA2468748C (en) | 2001-12-05 | 2010-01-26 | Barr Laboratories, Inc. | Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology |
| US7070048B2 (en) * | 2001-12-11 | 2006-07-04 | Meadwestvaco Corporation | Packaging for multiple media discs and methods for making same |
| EP1324411A3 (en) * | 2001-12-26 | 2004-12-22 | Mitsubishi Chemical Corporation | Composite material for fuel cell separator molding and production method thereof, and fuel cell separator which uses the composite material and production method thereof |
| US20030219471A1 (en) | 2002-03-11 | 2003-11-27 | Caubel Patrick Michel | Extended cycle estrogen and sulfatase inhibiting progestogen contraceptive regimens |
| US20040142914A1 (en) * | 2002-03-11 | 2004-07-22 | Friedman Andrew Joseph | Extended transdermal contraceptive regimens |
| JP2005519961A (ja) | 2002-03-11 | 2005-07-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 継続的スルファターゼ阻害プロゲストゲンホルモン補充療法 |
| EP1494679A4 (en) | 2002-04-03 | 2009-10-28 | Barr Lab Inc | STEP-BY-STEP ESTROGENTHERAPY |
| USD508164S1 (en) * | 2003-02-07 | 2005-08-09 | Pharma Design Inc | Container for storing pills |
| US20090163454A1 (en) | 2003-05-02 | 2009-06-25 | Duramed Pharmaceuticals, Inc. | Methods of Step-Down Hormone Treatment |
| WO2004098517A2 (en) | 2003-05-02 | 2004-11-18 | Duramed Pharmaceuticals, Inc. | Methods of hormonal treatment utilizing extended cycle contraceptive regimens |
| US20040251301A1 (en) | 2003-05-05 | 2004-12-16 | Niemann Amy C. | Device for calculating anticipated days for menstruation |
| US20040222123A1 (en) | 2003-05-06 | 2004-11-11 | Barr Laboratories, Inc. | Kit for pharmaceuticals |
| AU2004257772B2 (en) | 2003-07-16 | 2009-12-17 | Teva Women's Health, Inc. | Methods of hormonal treatment utilizing contraceptive regimens with continuous estrogen administration |
| JP4989969B2 (ja) * | 2003-09-04 | 2012-08-01 | ファーマデザイン インコーポレイテッド. | 錠剤の受容と小出しのための錠剤受けスリーブを備えるケース |
| RU2006114791A (ru) | 2003-10-01 | 2007-11-27 | Янссен Фармацевтика Н.В. (Be) | Продленные режимы трехфазных контрацептивов |
| US20050113350A1 (en) * | 2003-11-26 | 2005-05-26 | Bernd Duesterberg | Extended use combination comprising estrogens and progestins |
| EP1535618A1 (en) * | 2003-11-26 | 2005-06-01 | Schering Aktiengesellschaft | Pharmaceutical preparation for continuous hormonal treatment over a period of longer than 21-28 days comprising two estrogen and/or progestin compositions |
| CN1933873A (zh) * | 2004-03-19 | 2007-03-21 | 沃纳奇尔科特公司 | 延长周期的多相口服避孕方法 |
| CN1672685A (zh) * | 2004-03-26 | 2005-09-28 | 董可娟 | 一种新的避孕药物 |
| MY151322A (en) * | 2004-04-30 | 2014-05-15 | Bayer Ip Gmbh | Management of breakthrough bleeding in extended hormonal contraceptive regimens |
| CN1972692A (zh) * | 2004-05-26 | 2007-05-30 | 惠氏公司 | 治疗经前焦虑障碍的组合物和方法 |
| EP2392333A1 (en) | 2004-10-07 | 2011-12-07 | Teva Women's Health, Inc. | Methods of hormonal treatment utilizing ascending-dose extended cycle regimens |
| US20070111975A1 (en) * | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
| CA2640432A1 (en) | 2006-01-27 | 2007-08-09 | Duramed Pharmaceuticals, Inc. | Regimens for treatment of conditions related to estrogen deficiency |
| CA2640520C (en) * | 2006-03-02 | 2014-04-22 | Warner Chilcott Company, Inc. | Extended cycle multiphasic oral contraceptive method |
-
2006
- 2006-10-30 US US11/554,571 patent/US20070111975A1/en not_active Abandoned
-
2007
- 2007-08-17 US US11/892,026 patent/US8415332B2/en active Active
- 2007-10-30 JP JP2009534693A patent/JP2010508275A/ja not_active Withdrawn
- 2007-10-30 EP EP07873464A patent/EP2079461A4/en not_active Withdrawn
- 2007-10-30 MX MX2009004616A patent/MX2009004616A/es not_active Application Discontinuation
- 2007-10-30 RU RU2009120528/15A patent/RU2009120528A/ru not_active Application Discontinuation
- 2007-10-30 KR KR1020097011178A patent/KR20090094437A/ko not_active Withdrawn
- 2007-10-30 CA CA002668211A patent/CA2668211A1/en not_active Abandoned
- 2007-10-30 CN CN200780046391A patent/CN101626760A/zh active Pending
- 2007-10-30 BR BRPI0716291-0A2A patent/BRPI0716291A2/pt not_active IP Right Cessation
- 2007-10-30 TW TW096140829A patent/TW200831107A/zh unknown
- 2007-10-30 WO PCT/US2007/022832 patent/WO2008127303A1/en not_active Ceased
-
2009
- 2009-04-28 IL IL198441A patent/IL198441A/en not_active IP Right Cessation
-
2012
- 2012-06-08 US US13/492,138 patent/US8450299B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN101626760A (zh) | 2010-01-13 |
| KR20090094437A (ko) | 2009-09-07 |
| MX2009004616A (es) | 2009-05-22 |
| TW200831107A (en) | 2008-08-01 |
| US20070111975A1 (en) | 2007-05-17 |
| EP2079461A1 (en) | 2009-07-22 |
| WO2008127303A1 (en) | 2008-10-23 |
| EP2079461A4 (en) | 2011-07-20 |
| CA2668211A1 (en) | 2008-10-23 |
| US20120252767A1 (en) | 2012-10-04 |
| US20080125402A1 (en) | 2008-05-29 |
| BRPI0716291A2 (pt) | 2013-12-24 |
| US8415332B2 (en) | 2013-04-09 |
| IL198441A0 (en) | 2010-02-17 |
| IL198441A (en) | 2014-07-31 |
| JP2010508275A (ja) | 2010-03-18 |
| US8450299B2 (en) | 2013-05-28 |
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Legal Events
| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20120514 |