RU2007139912A - Способ прогнозирования течения рака на основе количественного анализа клеточного рецептора витамина фолата - Google Patents
Способ прогнозирования течения рака на основе количественного анализа клеточного рецептора витамина фолата Download PDFInfo
- Publication number
- RU2007139912A RU2007139912A RU2007139912/15A RU2007139912A RU2007139912A RU 2007139912 A RU2007139912 A RU 2007139912A RU 2007139912/15 A RU2007139912/15 A RU 2007139912/15A RU 2007139912 A RU2007139912 A RU 2007139912A RU 2007139912 A RU2007139912 A RU 2007139912A
- Authority
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- Prior art keywords
- cancer cells
- cells
- cancer
- antibody
- vitamin
- Prior art date
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66643005P | 2005-03-30 | 2005-03-30 | |
| US60/666,430 | 2005-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007139912A true RU2007139912A (ru) | 2009-05-10 |
Family
ID=36754569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007139912/15A RU2007139912A (ru) | 2005-03-30 | 2006-03-30 | Способ прогнозирования течения рака на основе количественного анализа клеточного рецептора витамина фолата |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090081710A1 (https=) |
| EP (2) | EP2199796A1 (https=) |
| JP (1) | JP2008537778A (https=) |
| CN (1) | CN101203759A (https=) |
| AT (1) | ATE460668T1 (https=) |
| AU (1) | AU2006230219A1 (https=) |
| CA (1) | CA2602585A1 (https=) |
| DE (1) | DE602006012816D1 (https=) |
| RU (1) | RU2007139912A (https=) |
| WO (1) | WO2006105141A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE427948T1 (de) | 2001-04-24 | 2009-04-15 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
| CA2484640C (en) | 2002-05-15 | 2012-01-17 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
| WO2004069159A2 (en) | 2003-01-27 | 2004-08-19 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| EP3101034A1 (en) | 2004-02-12 | 2016-12-07 | Morphotek, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| CN101175757B (zh) | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
| CA2607444C (en) | 2005-04-22 | 2015-03-10 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
| BRPI0615354A2 (pt) | 2005-08-19 | 2011-05-17 | Endocyte, Inc. | conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso |
| US20100104626A1 (en) | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| AU2008224988A1 (en) | 2007-03-14 | 2008-09-18 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| CN101784565B (zh) | 2007-06-25 | 2014-12-10 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| CN101909441B (zh) | 2007-10-25 | 2015-05-13 | 恩多塞特公司 | 微管蛋白抑制剂及其制备方法 |
| BR112012002064A2 (pt) * | 2009-07-31 | 2017-05-09 | Endocyte Inc | método para determinar se ec145 é indicado para o tratamento de um paciente com um tumor ovariano ou um tumor de pulmão; método para prever uma resposta de um tumor ovariano ou um tumor de pulmão de um paciente a terapia com ec145; método de tratamento de câncer ovariano resistente à platina em um paciente necessitando dele; uso de ec145 em combinação com doxorrubicina lipossômica peguilada; uso de ec145 para a fabricação de um medicamento; método para obter um benefício clínico comparado a tratamento com uma quantidade terapêutica de doxorrubicina lipossômica peguilada no tratamento de câncer ovariano resistente à platina em um paciente necessitando dele; método para selecionar um paciente para tratamento; composição farmacêutica; unidade de dosagem, método para determinar se um paciente com um tumor tem receptores de folato funcionalmente ativos presentes no tumor do paciente; método de tratamento de um tumor epitelial expressando receptor de folato em um paciente necessitando dele; e; método para obter um benefício clínico no tratamento de um tumor epitelial expressando receptor de folato em um paciente necessitando dele |
| TWI622402B (zh) | 2010-02-24 | 2018-05-01 | 免疫遺傳股份有限公司 | 葉酸受體1抗體類和免疫共軛物類及彼等之用途 |
| MX343607B (es) * | 2010-11-05 | 2016-11-11 | Morphotek Inc | Receptor alfa de folato como marcador de diagnóstico y pronóstico para cánceres que expresan receptor alfa de folato. |
| KR20130140032A (ko) * | 2010-11-12 | 2013-12-23 | 엔도사이트, 인코포레이티드 | 암을 치료하는 방법들 |
| BR112013025415B1 (pt) * | 2011-04-01 | 2021-03-16 | Immunogen, Inc | uso de um imunoconjugado antirreceptor de folato 1 (folr1) |
| SI2731972T1 (en) | 2011-07-15 | 2018-04-30 | Eisai R&D Management Co., Ltd. | Anti-folate receptor alpha antibodies and uses thereof |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| US9200073B2 (en) | 2012-08-31 | 2015-12-01 | Immunogen, Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
| CN102861020A (zh) * | 2012-09-25 | 2013-01-09 | 上海交通大学医学院附属仁济医院 | 叶酸在制备预防大肠腺瘤初发药物中的应用 |
| BR112015008365A2 (pt) | 2012-10-16 | 2017-07-04 | Endocyte Inc | composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente |
| US20140154702A1 (en) * | 2012-11-30 | 2014-06-05 | Endocyte, Inc. | Methods For Treating Cancer Using Combination Therapies |
| CN113150145B (zh) | 2013-08-30 | 2025-02-14 | 伊缪诺金公司 | 用于检测叶酸受体1的抗体和测定 |
| PL3055332T3 (pl) * | 2013-10-08 | 2020-02-28 | Immunogen, Inc. | Schematy dawkowania immunokoniugatu anty-FOLR1 |
| WO2015077303A1 (en) | 2013-11-19 | 2015-05-28 | Purdue Research Foundation | Patient selection method for inflammation |
| JP6246030B2 (ja) * | 2014-03-12 | 2017-12-13 | 東芝メディカルシステムズ株式会社 | 病理染色装置及び病理染色方法 |
| CN116440279B (zh) | 2015-09-17 | 2026-02-24 | 伊缪诺金公司 | 包含抗folr1免疫缀合物的治疗组合 |
| US11313868B2 (en) * | 2016-06-14 | 2022-04-26 | Board Of Regents, The University Of Texas System | Methods of detecting anti-folic acid antibodies and uses thereof |
| CN106483282B (zh) * | 2016-09-29 | 2018-08-31 | 北京世纪沃德生物科技有限公司 | 一种抗原稳定剂及其制备方法与应用 |
| EP3544999A1 (en) | 2016-11-23 | 2019-10-02 | Eisai R&D Management Co., Ltd. | Anti-folate receptor alpha antibodies and uses thereof |
| CN116615455A (zh) * | 2020-09-12 | 2023-08-18 | 免疫医疗有限公司 | 用于抗b7h4抗体-药物缀合物疗法的评分方法 |
| CN117741149A (zh) * | 2024-02-19 | 2024-03-22 | 卡秋(江苏)生物科技有限公司 | 一种用于卵巢癌细胞叶酸受体α的检测试剂盒及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5989838A (en) | 1992-03-11 | 1999-11-23 | Institute Of Virology, Slovak Academy Of Sciences | Immunological methods of detecting MN proteins and MN polypeptides |
| US6218529B1 (en) | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| US5846739A (en) * | 1995-12-05 | 1998-12-08 | Wisconsin Alumni Research Foundation | Immunohistochemical detection assay for carcinoma proliferative status |
| US6358682B1 (en) | 1998-01-26 | 2002-03-19 | Ventana Medical Systems, Inc. | Method and kit for the prognostication of breast cancer |
| CN1441676B (zh) * | 2000-03-31 | 2012-08-22 | 普渡研究基金会 | 用配体-免疫原缀合物治疗的方法 |
| EP2168598A1 (en) * | 2001-09-28 | 2010-03-31 | Purdue Research Foundation | Method of Treatment Using Ligand-Immunogen Conjugates |
| WO2003089593A2 (en) * | 2002-04-19 | 2003-10-30 | Endocyte, Inc. | Adjuvant enhanced immunotherapy |
| CA2484640C (en) | 2002-05-15 | 2012-01-17 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
| WO2004069159A2 (en) | 2003-01-27 | 2004-08-19 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
-
2006
- 2006-03-30 AT AT06739883T patent/ATE460668T1/de not_active IP Right Cessation
- 2006-03-30 CN CNA2006800192306A patent/CN101203759A/zh active Pending
- 2006-03-30 CA CA002602585A patent/CA2602585A1/en not_active Abandoned
- 2006-03-30 AU AU2006230219A patent/AU2006230219A1/en not_active Abandoned
- 2006-03-30 US US11/887,438 patent/US20090081710A1/en not_active Abandoned
- 2006-03-30 JP JP2008504275A patent/JP2008537778A/ja not_active Withdrawn
- 2006-03-30 RU RU2007139912/15A patent/RU2007139912A/ru unknown
- 2006-03-30 WO PCT/US2006/011376 patent/WO2006105141A1/en not_active Ceased
- 2006-03-30 EP EP10155913A patent/EP2199796A1/en not_active Withdrawn
- 2006-03-30 EP EP06739883A patent/EP1864133B1/en not_active Expired - Lifetime
- 2006-03-30 DE DE602006012816T patent/DE602006012816D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP2199796A1 (en) | 2010-06-23 |
| EP1864133A1 (en) | 2007-12-12 |
| AU2006230219A1 (en) | 2006-10-05 |
| EP1864133B1 (en) | 2010-03-10 |
| WO2006105141A1 (en) | 2006-10-05 |
| ATE460668T1 (de) | 2010-03-15 |
| US20090081710A1 (en) | 2009-03-26 |
| CN101203759A (zh) | 2008-06-18 |
| CA2602585A1 (en) | 2006-10-05 |
| JP2008537778A (ja) | 2008-09-25 |
| DE602006012816D1 (de) | 2010-04-22 |
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