RU2007139912A - Способ прогнозирования течения рака на основе количественного анализа клеточного рецептора витамина фолата - Google Patents

Способ прогнозирования течения рака на основе количественного анализа клеточного рецептора витамина фолата Download PDF

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Publication number
RU2007139912A
RU2007139912A RU2007139912/15A RU2007139912A RU2007139912A RU 2007139912 A RU2007139912 A RU 2007139912A RU 2007139912/15 A RU2007139912/15 A RU 2007139912/15A RU 2007139912 A RU2007139912 A RU 2007139912A RU 2007139912 A RU2007139912 A RU 2007139912A
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Russia
Prior art keywords
cancer cells
cells
cancer
antibody
vitamin
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RU2007139912/15A
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English (en)
Russian (ru)
Inventor
Филип Стюарт ЛОУ (US)
Филип Стюарт ЛОУ
Линн К. ХАРТМАНН (US)
Линн К. ХАРТМАНН
Кристофер Пол ЛИМОН (US)
Кристофер Пол Лимон
Фил Роналд ЭЛЛИС (US)
Фил Роналд ЭЛЛИС
Original Assignee
Пердью Рисерч Фаундейшн (Us)
Пердью Рисерч Фаундейшн
Эндосайт, Инк. (Us)
Эндосайт, Инк.
Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Ричерч (Us)
Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Ричерч
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Application filed by Пердью Рисерч Фаундейшн (Us), Пердью Рисерч Фаундейшн, Эндосайт, Инк. (Us), Эндосайт, Инк., Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Ричерч (Us), Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Ричерч filed Critical Пердью Рисерч Фаундейшн (Us)
Publication of RU2007139912A publication Critical patent/RU2007139912A/ru

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2007139912/15A 2005-03-30 2006-03-30 Способ прогнозирования течения рака на основе количественного анализа клеточного рецептора витамина фолата RU2007139912A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66643005P 2005-03-30 2005-03-30
US60/666,430 2005-03-30

Publications (1)

Publication Number Publication Date
RU2007139912A true RU2007139912A (ru) 2009-05-10

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Application Number Title Priority Date Filing Date
RU2007139912/15A RU2007139912A (ru) 2005-03-30 2006-03-30 Способ прогнозирования течения рака на основе количественного анализа клеточного рецептора витамина фолата

Country Status (10)

Country Link
US (1) US20090081710A1 (https=)
EP (2) EP1864133B1 (https=)
JP (1) JP2008537778A (https=)
CN (1) CN101203759A (https=)
AT (1) ATE460668T1 (https=)
AU (1) AU2006230219A1 (https=)
CA (1) CA2602585A1 (https=)
DE (1) DE602006012816D1 (https=)
RU (1) RU2007139912A (https=)
WO (1) WO2006105141A1 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1389209B1 (en) 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
WO2003097647A1 (en) 2002-05-15 2003-11-27 Endocyte, Inc. Vitamin-mitomycin conjugates
DK1592457T3 (da) 2003-01-27 2012-10-22 Endocyte Inc Folat-vinblastin-konjugat som lægemiddel
CA2556027C (en) 2004-02-12 2015-11-24 Morphotek, Inc. Monoclonal antibodies that specifically block biological activity of a tumor antigen
JP5149620B2 (ja) 2004-07-23 2013-02-20 エンドサイト，インコーポレイテッド ２価リンカーおよびその結合体
EP1863816B1 (en) 2005-03-16 2014-06-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
EP2172487A1 (en) 2005-04-22 2010-04-07 Morphotek Inc. Antibodies with Immune Effector Activity that Internalize in Folate Receptor Alpha-Positive Cells
AU2006279304A1 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Multi-drug ligand conjugates
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
CN104127878A (zh) 2007-03-14 2014-11-05 恩多塞特公司 结合配体连接的微管溶素递药缀合物
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
BRPI0812970A2 (pt) 2007-06-25 2019-09-24 Endocyte Inc conjugados contendo espaçadores hidrofílicos
US9187521B2 (en) 2007-10-25 2015-11-17 Endocyte, Inc. Tubulysins and processes for preparing
EP2460013A4 (en) * 2009-07-31 2013-04-03 Endocyte Inc ON FOLLOWING DIAGNOSIS AND TREATMENT
CN103037900B (zh) 2010-02-24 2016-04-06 伊缪诺金公司 叶酸受体1抗体与免疫缀合物以及其用途
AU2011323124C1 (en) * 2010-11-05 2016-09-22 Eisai Inc. Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
KR20130140033A (ko) * 2010-11-12 2013-12-23 엔도사이트, 인코포레이티드 암을 치료하는 방법들
IL281714B2 (en) * 2011-04-01 2023-11-01 Immunogen Inc Methods for increasing the effectiveness of FOLR1 cancer therapy
PL2731972T3 (pl) 2011-07-15 2018-06-29 Eisai R&D Management Co., Ltd. Przeciwciała skierowane przeciwko receptorowi folianowemu alfa i ich zastosowania
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
HUE049693T2 (hu) 2012-08-31 2020-10-28 Immunogen Inc Diagnosztikai ASSAY-k és készletek a folát receptor 1 kimutatására
CN102861020A (zh) * 2012-09-25 2013-01-09 上海交通大学医学院附属仁济医院 叶酸在制备预防大肠腺瘤初发药物中的应用
EP2908818A4 (en) 2012-10-16 2016-07-13 Endocyte Inc CONJUGATES OF DRUG DELIVERY CONTAINING ARTIFICIAL AMINO ACIDS AND METHODS OF USE
US20140154702A1 (en) * 2012-11-30 2014-06-05 Endocyte, Inc. Methods For Treating Cancer Using Combination Therapies
AU2014312086B2 (en) 2013-08-30 2020-03-12 Immunogen, Inc. Antibodies and assays for detection of folate receptor 1
IL298044B2 (en) * 2013-10-08 2024-11-01 Immunogen Inc Dosing regimens of anti-FOLR1 immunoconjugate
WO2015077303A1 (en) 2013-11-19 2015-05-28 Purdue Research Foundation Patient selection method for inflammation
JP6246030B2 (ja) * 2014-03-12 2017-12-13 東芝メディカルシステムズ株式会社 病理染色装置及び病理染色方法
AU2016323968B2 (en) 2015-09-17 2023-07-06 Immunogen, Inc. Therapeutic combinations comprising anti-FOLR1 immunoconjugates
US11313868B2 (en) * 2016-06-14 2022-04-26 Board Of Regents, The University Of Texas System Methods of detecting anti-folic acid antibodies and uses thereof
CN106483282B (zh) * 2016-09-29 2018-08-31 北京世纪沃德生物科技有限公司 一种抗原稳定剂及其制备方法与应用
US10822410B2 (en) 2016-11-23 2020-11-03 Eisai R&D Management Co., Ltd. Anti-folate receptor alpha antibodies and uses thereof
CA3194182A1 (en) * 2020-09-12 2022-03-17 Medimmune Limited A scoring method for an anti-b7h4 antibody-drug conjugate therapy
CN117741149A (zh) * 2024-02-19 2024-03-22 卡秋(江苏)生物科技有限公司 一种用于卵巢癌细胞叶酸受体α的检测试剂盒及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989838A (en) * 1992-03-11 1999-11-23 Institute Of Virology, Slovak Academy Of Sciences Immunological methods of detecting MN proteins and MN polypeptides
US6218529B1 (en) * 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
US5846739A (en) 1995-12-05 1998-12-08 Wisconsin Alumni Research Foundation Immunohistochemical detection assay for carcinoma proliferative status
US6358682B1 (en) 1998-01-26 2002-03-19 Ventana Medical Systems, Inc. Method and kit for the prognostication of breast cancer
PL211872B1 (pl) 2000-03-31 2012-07-31 Purdue Research Foundation Kompozycja farmaceutyczna
KR20040053136A (ko) * 2001-09-28 2004-06-23 펄듀 리서치 파운데이션 리간드-면역원 공액체를 이용한 치료 방법
JP2005532296A (ja) * 2002-04-19 2005-10-27 エンドサイト，インコーポレイテッド アジュバントにより増強される免疫療法
WO2003097647A1 (en) 2002-05-15 2003-11-27 Endocyte, Inc. Vitamin-mitomycin conjugates
DK1592457T3 (da) * 2003-01-27 2012-10-22 Endocyte Inc Folat-vinblastin-konjugat som lægemiddel

Also Published As

Publication number Publication date
EP1864133A1 (en) 2007-12-12
JP2008537778A (ja) 2008-09-25
EP2199796A1 (en) 2010-06-23
DE602006012816D1 (de) 2010-04-22
WO2006105141A1 (en) 2006-10-05
AU2006230219A1 (en) 2006-10-05
ATE460668T1 (de) 2010-03-15
CA2602585A1 (en) 2006-10-05
US20090081710A1 (en) 2009-03-26
EP1864133B1 (en) 2010-03-10
CN101203759A (zh) 2008-06-18

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