CN101203759A - 使用细胞叶酸维生素受体定量法而用于癌症预后的方法 - Google Patents

使用细胞叶酸维生素受体定量法而用于癌症预后的方法 Download PDF

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Publication number
CN101203759A
CN101203759A CNA2006800192306A CN200680019230A CN101203759A CN 101203759 A CN101203759 A CN 101203759A CN A2006800192306 A CNA2006800192306 A CN A2006800192306A CN 200680019230 A CN200680019230 A CN 200680019230A CN 101203759 A CN101203759 A CN 101203759A
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China
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cancer
cancer cell
cell
antibody
kit
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Pending
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CNA2006800192306A
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English (en)
Chinese (zh)
Inventor
P·S·罗
L·C·哈特曼
C·P·利蒙
P·R·埃利斯
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Purdue Research Foundation
Endocyte Inc
Mayo Clinic in Florida
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Purdue Research Foundation
Endocyte Inc
Mayo Clinic in Florida
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Publication of CN101203759A publication Critical patent/CN101203759A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNA2006800192306A 2005-03-30 2006-03-30 使用细胞叶酸维生素受体定量法而用于癌症预后的方法 Pending CN101203759A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66643005P 2005-03-30 2005-03-30
US60/666,430 2005-03-30

Publications (1)

Publication Number Publication Date
CN101203759A true CN101203759A (zh) 2008-06-18

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CNA2006800192306A Pending CN101203759A (zh) 2005-03-30 2006-03-30 使用细胞叶酸维生素受体定量法而用于癌症预后的方法

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US (1) US20090081710A1 (https=)
EP (2) EP1864133B1 (https=)
JP (1) JP2008537778A (https=)
CN (1) CN101203759A (https=)
AT (1) ATE460668T1 (https=)
AU (1) AU2006230219A1 (https=)
CA (1) CA2602585A1 (https=)
DE (1) DE602006012816D1 (https=)
RU (1) RU2007139912A (https=)
WO (1) WO2006105141A1 (https=)

Cited By (7)

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CN102861020A (zh) * 2012-09-25 2013-01-09 上海交通大学医学院附属仁济医院 叶酸在制备预防大肠腺瘤初发药物中的应用
CN103282777A (zh) * 2010-11-12 2013-09-04 恩多塞特公司 治疗癌症的方法
CN103747802A (zh) * 2011-04-01 2014-04-23 伊缪诺金公司 用于增加folr1癌症治疗的功效的方法
CN106164093A (zh) * 2013-10-08 2016-11-23 伊缪诺金公司 抗folr1免疫偶联物给药方案
CN106483282A (zh) * 2016-09-29 2017-03-08 北京世纪沃德生物科技有限公司 一种抗原稳定剂及其制备方法与应用
CN116615455A (zh) * 2020-09-12 2023-08-18 免疫医疗有限公司 用于抗b7h4抗体-药物缀合物疗法的评分方法
CN118914552A (zh) * 2024-02-19 2024-11-08 卡秋(江苏)生物科技有限公司 一种用于卵巢癌患者伴随诊断的叶酸受体α检测试剂盒

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EP1389209B1 (en) 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
WO2003097647A1 (en) 2002-05-15 2003-11-27 Endocyte, Inc. Vitamin-mitomycin conjugates
DK1592457T3 (da) 2003-01-27 2012-10-22 Endocyte Inc Folat-vinblastin-konjugat som lægemiddel
CA2556027C (en) 2004-02-12 2015-11-24 Morphotek, Inc. Monoclonal antibodies that specifically block biological activity of a tumor antigen
JP5149620B2 (ja) 2004-07-23 2013-02-20 エンドサイト，インコーポレイテッド ２価リンカーおよびその結合体
EP1863816B1 (en) 2005-03-16 2014-06-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
EP2172487A1 (en) 2005-04-22 2010-04-07 Morphotek Inc. Antibodies with Immune Effector Activity that Internalize in Folate Receptor Alpha-Positive Cells
AU2006279304A1 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Multi-drug ligand conjugates
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
CN104127878A (zh) 2007-03-14 2014-11-05 恩多塞特公司 结合配体连接的微管溶素递药缀合物
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
BRPI0812970A2 (pt) 2007-06-25 2019-09-24 Endocyte Inc conjugados contendo espaçadores hidrofílicos
US9187521B2 (en) 2007-10-25 2015-11-17 Endocyte, Inc. Tubulysins and processes for preparing
EP2460013A4 (en) * 2009-07-31 2013-04-03 Endocyte Inc ON FOLLOWING DIAGNOSIS AND TREATMENT
CN103037900B (zh) 2010-02-24 2016-04-06 伊缪诺金公司 叶酸受体1抗体与免疫缀合物以及其用途
AU2011323124C1 (en) * 2010-11-05 2016-09-22 Eisai Inc. Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
PL2731972T3 (pl) 2011-07-15 2018-06-29 Eisai R&D Management Co., Ltd. Przeciwciała skierowane przeciwko receptorowi folianowemu alfa i ich zastosowania
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
HUE049693T2 (hu) 2012-08-31 2020-10-28 Immunogen Inc Diagnosztikai ASSAY-k és készletek a folát receptor 1 kimutatására
EP2908818A4 (en) 2012-10-16 2016-07-13 Endocyte Inc CONJUGATES OF DRUG DELIVERY CONTAINING ARTIFICIAL AMINO ACIDS AND METHODS OF USE
US20140154702A1 (en) * 2012-11-30 2014-06-05 Endocyte, Inc. Methods For Treating Cancer Using Combination Therapies
AU2014312086B2 (en) 2013-08-30 2020-03-12 Immunogen, Inc. Antibodies and assays for detection of folate receptor 1
WO2015077303A1 (en) 2013-11-19 2015-05-28 Purdue Research Foundation Patient selection method for inflammation
JP6246030B2 (ja) * 2014-03-12 2017-12-13 東芝メディカルシステムズ株式会社 病理染色装置及び病理染色方法
AU2016323968B2 (en) 2015-09-17 2023-07-06 Immunogen, Inc. Therapeutic combinations comprising anti-FOLR1 immunoconjugates
US11313868B2 (en) * 2016-06-14 2022-04-26 Board Of Regents, The University Of Texas System Methods of detecting anti-folic acid antibodies and uses thereof
US10822410B2 (en) 2016-11-23 2020-11-03 Eisai R&D Management Co., Ltd. Anti-folate receptor alpha antibodies and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989838A (en) * 1992-03-11 1999-11-23 Institute Of Virology, Slovak Academy Of Sciences Immunological methods of detecting MN proteins and MN polypeptides
US6218529B1 (en) * 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
US5846739A (en) 1995-12-05 1998-12-08 Wisconsin Alumni Research Foundation Immunohistochemical detection assay for carcinoma proliferative status
US6358682B1 (en) 1998-01-26 2002-03-19 Ventana Medical Systems, Inc. Method and kit for the prognostication of breast cancer
PL211872B1 (pl) 2000-03-31 2012-07-31 Purdue Research Foundation Kompozycja farmaceutyczna
KR20040053136A (ko) * 2001-09-28 2004-06-23 펄듀 리서치 파운데이션 리간드-면역원 공액체를 이용한 치료 방법
JP2005532296A (ja) * 2002-04-19 2005-10-27 エンドサイト，インコーポレイテッド アジュバントにより増強される免疫療法
WO2003097647A1 (en) 2002-05-15 2003-11-27 Endocyte, Inc. Vitamin-mitomycin conjugates
DK1592457T3 (da) * 2003-01-27 2012-10-22 Endocyte Inc Folat-vinblastin-konjugat som lægemiddel

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103282777A (zh) * 2010-11-12 2013-09-04 恩多塞特公司 治疗癌症的方法
CN103747802A (zh) * 2011-04-01 2014-04-23 伊缪诺金公司 用于增加folr1癌症治疗的功效的方法
CN108743965A (zh) * 2011-04-01 2018-11-06 伊缪诺金公司 用于增加folr1癌症治疗的功效的方法
CN114441757A (zh) * 2011-04-01 2022-05-06 伊缪诺金公司 用于增加folr1癌症治疗的功效的方法
CN102861020A (zh) * 2012-09-25 2013-01-09 上海交通大学医学院附属仁济医院 叶酸在制备预防大肠腺瘤初发药物中的应用
CN106164093A (zh) * 2013-10-08 2016-11-23 伊缪诺金公司 抗folr1免疫偶联物给药方案
CN106483282A (zh) * 2016-09-29 2017-03-08 北京世纪沃德生物科技有限公司 一种抗原稳定剂及其制备方法与应用
CN106483282B (zh) * 2016-09-29 2018-08-31 北京世纪沃德生物科技有限公司 一种抗原稳定剂及其制备方法与应用
CN116615455A (zh) * 2020-09-12 2023-08-18 免疫医疗有限公司 用于抗b7h4抗体-药物缀合物疗法的评分方法
CN118914552A (zh) * 2024-02-19 2024-11-08 卡秋(江苏)生物科技有限公司 一种用于卵巢癌患者伴随诊断的叶酸受体α检测试剂盒

Also Published As

Publication number Publication date
EP1864133A1 (en) 2007-12-12
JP2008537778A (ja) 2008-09-25
EP2199796A1 (en) 2010-06-23
DE602006012816D1 (de) 2010-04-22
WO2006105141A1 (en) 2006-10-05
AU2006230219A1 (en) 2006-10-05
ATE460668T1 (de) 2010-03-15
CA2602585A1 (en) 2006-10-05
US20090081710A1 (en) 2009-03-26
RU2007139912A (ru) 2009-05-10
EP1864133B1 (en) 2010-03-10

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