RU2007139912A - Способ прогнозирования течения рака на основе количественного анализа клеточного рецептора витамина фолата - Google Patents
Способ прогнозирования течения рака на основе количественного анализа клеточного рецептора витамина фолата Download PDFInfo
- Publication number
- RU2007139912A RU2007139912A RU2007139912/15A RU2007139912A RU2007139912A RU 2007139912 A RU2007139912 A RU 2007139912A RU 2007139912/15 A RU2007139912/15 A RU 2007139912/15A RU 2007139912 A RU2007139912 A RU 2007139912A RU 2007139912 A RU2007139912 A RU 2007139912A
- Authority
- RU
- Russia
- Prior art keywords
- cancer cells
- cells
- cancer
- antibody
- vitamin
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 31
- 201000011510 cancer Diseases 0.000 title claims abstract 31
- 238000000034 method Methods 0.000 title claims abstract 24
- 238000004445 quantitative analysis Methods 0.000 title claims 7
- 229940014144 folate Drugs 0.000 title 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title 1
- 235000019152 folic acid Nutrition 0.000 title 1
- 239000011724 folic acid Substances 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 238000004393 prognosis Methods 0.000 claims abstract 7
- 102000006815 folate receptor Human genes 0.000 claims abstract 6
- 108020005243 folate receptor Proteins 0.000 claims abstract 6
- 102000035029 vitamin receptors Human genes 0.000 claims 19
- 108091005463 vitamin receptors Proteins 0.000 claims 19
- 206010006187 Breast cancer Diseases 0.000 claims 8
- 208000026310 Breast neoplasm Diseases 0.000 claims 8
- 238000001000 micrograph Methods 0.000 claims 7
- 238000012151 immunohistochemical method Methods 0.000 claims 6
- 208000003174 Brain Neoplasms Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 206010014733 Endometrial cancer Diseases 0.000 claims 4
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 206010025323 Lymphomas Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 4
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 210000001072 colon Anatomy 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 201000010982 kidney cancer Diseases 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 206010046766 uterine cancer Diseases 0.000 claims 4
- 208000034578 Multiple myelomas Diseases 0.000 claims 3
- 238000011532 immunohistochemical staining Methods 0.000 claims 3
- 238000011269 treatment regimen Methods 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000010186 staining Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66643005P | 2005-03-30 | 2005-03-30 | |
| US60/666,430 | 2005-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007139912A true RU2007139912A (ru) | 2009-05-10 |
Family
ID=36754569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007139912/15A RU2007139912A (ru) | 2005-03-30 | 2006-03-30 | Способ прогнозирования течения рака на основе количественного анализа клеточного рецептора витамина фолата |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090081710A1 (enExample) |
| EP (2) | EP2199796A1 (enExample) |
| JP (1) | JP2008537778A (enExample) |
| CN (1) | CN101203759A (enExample) |
| AT (1) | ATE460668T1 (enExample) |
| AU (1) | AU2006230219A1 (enExample) |
| CA (1) | CA2602585A1 (enExample) |
| DE (1) | DE602006012816D1 (enExample) |
| RU (1) | RU2007139912A (enExample) |
| WO (1) | WO2006105141A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1389209B1 (en) | 2001-04-24 | 2009-04-08 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
| DE60326833D1 (de) | 2002-05-15 | 2009-05-07 | Endocyte Inc | Vitamin-mitomycin-konjugate |
| EP2517729A3 (en) | 2003-01-27 | 2013-01-02 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| US20050232919A1 (en) | 2004-02-12 | 2005-10-20 | Morphotek, Inc. | Monoclonal antibodies that specifically block biological activity of a tumor antigen |
| EP1789391B1 (en) | 2004-07-23 | 2017-06-28 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| CN101175757B (zh) | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
| EP2172487A1 (en) | 2005-04-22 | 2010-04-07 | Morphotek Inc. | Antibodies with Immune Effector Activity that Internalize in Folate Receptor Alpha-Positive Cells |
| US8465724B2 (en) | 2005-08-19 | 2013-06-18 | Endocyte, Inc. | Multi-drug ligand conjugates |
| US20100104626A1 (en) | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| CA2680535C (en) | 2007-03-14 | 2016-09-20 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| CA2690943A1 (en) | 2007-06-25 | 2008-12-31 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| WO2009055562A1 (en) | 2007-10-25 | 2009-04-30 | Endocyte, Inc. | Tubulysins and processes for preparing |
| IN2012DN01708A (enExample) * | 2009-07-31 | 2015-06-05 | Endocyte Inc | |
| RS55738B1 (sr) | 2010-02-24 | 2017-07-31 | Immunogen Inc | Imunokonjugati protiv folatnog receptora 1 i njihove upotrebe |
| ES2780192T3 (es) * | 2010-11-05 | 2020-08-24 | Eisai Inc | Folato receptor alfa como marcador diagnóstico y de pronóstico para cánceres que expresan folato receptor alfa |
| EP2638395A4 (en) * | 2010-11-12 | 2016-06-01 | Endocyte Inc | METHOD FOR TREATING CARCINOMA |
| BR112013025415B1 (pt) * | 2011-04-01 | 2021-03-16 | Immunogen, Inc | uso de um imunoconjugado antirreceptor de folato 1 (folr1) |
| SI2731972T1 (en) | 2011-07-15 | 2018-04-30 | Eisai R&D Management Co., Ltd. | Anti-folate receptor alpha antibodies and uses thereof |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| MX362514B (es) | 2012-08-31 | 2019-01-22 | Immunogen Inc | Kits y ensayos de diagnostico para la deteccion del receptor 1 de folato. |
| CN102861020A (zh) * | 2012-09-25 | 2013-01-09 | 上海交通大学医学院附属仁济医院 | 叶酸在制备预防大肠腺瘤初发药物中的应用 |
| IN2015DN04147A (enExample) | 2012-10-16 | 2015-10-16 | Endocyte Inc | |
| US20140154702A1 (en) * | 2012-11-30 | 2014-06-05 | Endocyte, Inc. | Methods For Treating Cancer Using Combination Therapies |
| PL3038650T3 (pl) | 2013-08-30 | 2021-11-22 | Immunogen, Inc. | Przeciwciała i testy do wykrywania receptora folianu 1 |
| IL298044B2 (en) * | 2013-10-08 | 2024-11-01 | Immunogen Inc | Dosing regimens of anti-FOLR1 immunoconjugate |
| EP3071971B1 (en) | 2013-11-19 | 2019-04-24 | Purdue Research Foundation | Patient selection method for inflammation |
| JP6246030B2 (ja) * | 2014-03-12 | 2017-12-13 | 東芝メディカルシステムズ株式会社 | 病理染色装置及び病理染色方法 |
| KR102700777B1 (ko) | 2015-09-17 | 2024-08-29 | 이뮤노젠 아이엔씨 | 항-folr1 면역접합체를 포함하는 치료제 조합 |
| US11313868B2 (en) | 2016-06-14 | 2022-04-26 | Board Of Regents, The University Of Texas System | Methods of detecting anti-folic acid antibodies and uses thereof |
| CN106483282B (zh) * | 2016-09-29 | 2018-08-31 | 北京世纪沃德生物科技有限公司 | 一种抗原稳定剂及其制备方法与应用 |
| JP7072571B2 (ja) | 2016-11-23 | 2022-05-20 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗葉酸受容体アルファ抗体およびその使用 |
| CN117741149A (zh) * | 2024-02-19 | 2024-03-22 | 卡秋(江苏)生物科技有限公司 | 一种用于卵巢癌细胞叶酸受体α的检测试剂盒及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5989838A (en) | 1992-03-11 | 1999-11-23 | Institute Of Virology, Slovak Academy Of Sciences | Immunological methods of detecting MN proteins and MN polypeptides |
| US6218529B1 (en) * | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| US5846739A (en) | 1995-12-05 | 1998-12-08 | Wisconsin Alumni Research Foundation | Immunohistochemical detection assay for carcinoma proliferative status |
| US6358682B1 (en) * | 1998-01-26 | 2002-03-19 | Ventana Medical Systems, Inc. | Method and kit for the prognostication of breast cancer |
| PL211872B1 (pl) * | 2000-03-31 | 2012-07-31 | Purdue Research Foundation | Kompozycja farmaceutyczna |
| DE60234782D1 (de) * | 2001-09-28 | 2010-01-28 | Purdue Research Foundation | Behandlungsverfahren mit liganden-immunogenkonjugaten |
| EP1496934A4 (en) * | 2002-04-19 | 2006-08-02 | Endocyte Inc | IMPROVED IMMUNOTHERAPY BY ADJUVANT |
| DE60326833D1 (de) | 2002-05-15 | 2009-05-07 | Endocyte Inc | Vitamin-mitomycin-konjugate |
| EP2517729A3 (en) | 2003-01-27 | 2013-01-02 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
-
2006
- 2006-03-30 DE DE602006012816T patent/DE602006012816D1/de active Active
- 2006-03-30 EP EP10155913A patent/EP2199796A1/en not_active Withdrawn
- 2006-03-30 JP JP2008504275A patent/JP2008537778A/ja not_active Withdrawn
- 2006-03-30 CA CA002602585A patent/CA2602585A1/en not_active Abandoned
- 2006-03-30 CN CNA2006800192306A patent/CN101203759A/zh active Pending
- 2006-03-30 RU RU2007139912/15A patent/RU2007139912A/ru unknown
- 2006-03-30 WO PCT/US2006/011376 patent/WO2006105141A1/en not_active Ceased
- 2006-03-30 AU AU2006230219A patent/AU2006230219A1/en not_active Abandoned
- 2006-03-30 AT AT06739883T patent/ATE460668T1/de not_active IP Right Cessation
- 2006-03-30 EP EP06739883A patent/EP1864133B1/en not_active Not-in-force
- 2006-03-30 US US11/887,438 patent/US20090081710A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1864133B1 (en) | 2010-03-10 |
| CN101203759A (zh) | 2008-06-18 |
| EP1864133A1 (en) | 2007-12-12 |
| CA2602585A1 (en) | 2006-10-05 |
| DE602006012816D1 (de) | 2010-04-22 |
| WO2006105141A1 (en) | 2006-10-05 |
| EP2199796A1 (en) | 2010-06-23 |
| ATE460668T1 (de) | 2010-03-15 |
| AU2006230219A1 (en) | 2006-10-05 |
| JP2008537778A (ja) | 2008-09-25 |
| US20090081710A1 (en) | 2009-03-26 |
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