RU2007124546A - Бензоил-тетрагидропиридины в качестве ингибиторов glyt-1 - Google Patents
Бензоил-тетрагидропиридины в качестве ингибиторов glyt-1 Download PDFInfo
- Publication number
- RU2007124546A RU2007124546A RU2007124546/04A RU2007124546A RU2007124546A RU 2007124546 A RU2007124546 A RU 2007124546A RU 2007124546/04 A RU2007124546/04 A RU 2007124546/04A RU 2007124546 A RU2007124546 A RU 2007124546A RU 2007124546 A RU2007124546 A RU 2007124546A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- dihydro
- compounds
- lower alkyl
- methanone
- Prior art date
Links
- BECCUPAXNMKZJU-UHFFFAOYSA-N 3,4-dihydro-2h-pyridin-1-yl(phenyl)methanone Chemical class C=1C=CC=CC=1C(=O)N1CCCC=C1 BECCUPAXNMKZJU-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- MYCHXFUKRGVKPT-UHFFFAOYSA-N (2-cyclopentyloxy-5-methylsulfonylphenyl)-[4-(4-methylsulfonylphenyl)-3,6-dihydro-2h-pyridin-1-yl]methanone Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CCN(C(=O)C=2C(=CC=C(C=2)S(C)(=O)=O)OC2CCCC2)CC1 MYCHXFUKRGVKPT-UHFFFAOYSA-N 0.000 claims 1
- PTJSAEACQULKRO-UHFFFAOYSA-N (5-methylsulfonyl-2-morpholin-4-ylphenyl)-[4-[4-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridin-1-yl]methanone Chemical compound C1CC(C=2C=CC(=CC=2)C(F)(F)F)=CCN1C(=O)C1=CC(S(=O)(=O)C)=CC=C1N1CCOCC1 PTJSAEACQULKRO-UHFFFAOYSA-N 0.000 claims 1
- FTYKSPKXEKIUAO-UHFFFAOYSA-N 3-[4-(4-chlorophenyl)-3,6-dihydro-2h-pyridine-1-carbonyl]-4-propan-2-yloxybenzonitrile Chemical compound CC(C)OC1=CC=C(C#N)C=C1C(=O)N1CC=C(C=2C=CC(Cl)=CC=2)CC1 FTYKSPKXEKIUAO-UHFFFAOYSA-N 0.000 claims 1
- KBEIKSMRJBGGNQ-UHFFFAOYSA-N 4-[1-(2-morpholin-4-yl-5-nitrobenzoyl)-3,6-dihydro-2h-pyridin-4-yl]benzonitrile Chemical compound C1CC(C=2C=CC(=CC=2)C#N)=CCN1C(=O)C1=CC([N+](=O)[O-])=CC=C1N1CCOCC1 KBEIKSMRJBGGNQ-UHFFFAOYSA-N 0.000 claims 1
- RIEKYGGNHLHYOG-UHFFFAOYSA-N [4-(4-chlorophenyl)-3,6-dihydro-2h-pyridin-1-yl]-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]methanone Chemical compound C1CC(C=2C=CC(Cl)=CC=2)=CCN1C(=O)C1=CC(S(=O)(=O)C)=CC=C1OCC1CC1 RIEKYGGNHLHYOG-UHFFFAOYSA-N 0.000 claims 1
- VHUUBINVOHBZNS-UHFFFAOYSA-N [4-(4-methylsulfonylphenyl)-3,6-dihydro-2h-pyridin-1-yl]-(2-morpholin-4-yl-5-nitrophenyl)methanone Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CCN(C(=O)C=2C(=CC=C(C=2)[N+]([O-])=O)N2CCOCC2)CC1 VHUUBINVOHBZNS-UHFFFAOYSA-N 0.000 claims 1
- LTCLXSUCHUIKND-UHFFFAOYSA-N [5-methylsulfonyl-2-(2,2,2-trifluoroethoxy)phenyl]-[4-[4-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridin-1-yl]methanone Chemical compound CS(=O)(=O)C1=CC=C(OCC(F)(F)F)C(C(=O)N2CC=C(CC2)C=2C=CC(=CC=2)C(F)(F)F)=C1 LTCLXSUCHUIKND-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Claims (12)
1. Соединения общей формулы
где R1 представляет собой неароматический гетероцикл или OR';
R' представляет собой низший алкил, низший алкил, замещенный галогеном, или представляет собой -(CH2)n-циклоалкил;
R2 представляет собой NO2, CN или SO2R”;
R” представляет собой низший алкил;
Ar представляет собой фенил, возможно замещенный галогеном, цианогруппой, низшим алкилом, который замещен галогеном, или SO2R”;
n представляет собой 0, 1 или 2;
и их фармацевтически активные соли присоединения кислоты.
2. Соединения формулы I по п.1, где R1 представляет собой морфолин.
3. Соединения формулы I по п.2, представляющие собой
4-[1-(2-морфолин-4-ил-5-нитробензоил)-1,2,3,6-тетрагидропиридин-4-ил]-бензонитрил,
(5-метансульфонил-2-морфолин-4-ил-фенил)-[4-(4-трифторметилфенил)-3,6дигидро-2Н-пиридин-1-ил]-метанон или
[4-(4-метансульфонилфенил)-3,6-дигидро-2Н-пиридин-1-ил]-(2-морфолин-4-ил-5-нитрофенил)-метанон.
4. Соединения формулы I по п.1, где R1 представляет собой -O-низший алкил, замещенный галогеном.
5. Соединение формулы I по п.4, представляющее собой [5-метансульфонил-2-(2,2,2-трифторэтокси)-фенил]-[4-(4-трифторметилфенил)-3,6-дигидро-2Н-пиридин-1-ил]-метанон.
6. Соединения формулы I по п.1, где R1 представляет собой -O-низший алкил.
7. Соединение формулы I по п.6, представляющее собой 3-[4-(4-хлорфенил)-3,6-дигидро-2Н-пиридин-1-карбонил]-4-изопропоксибензонитрил.
8. Соединения формулы I no п.1, где R1 представляет собой -O-(СН2)n-циклоалкил.
9. Соединение формулы I по п.8, представляющее собой (2-циклопентилокси-5-метансульфонилфенил)-[4-(4-метансульфонилфенил)-3,6-дигидро-2Н-пиридин-1-ил]-метанон или [4-(4-хлорфенил)-3,6-дигидро-2Н-пиридин-1-ил]-(2-циклопропилметокси-5-метансульфонилфенил)-метанон.
10. Лекарство, содержащее одно или более чем одно соединение по любому из пп.1-9, и фармацевтически приемлемые эксципиенты.
11. Лекарство по п.10 для лечения болезни Альцгеймера.
12. Применение соединения по любому из пп.1-9 для изготовления лекарств для лечения болезни Альцгеймера.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05100027.1 | 2005-01-04 | ||
EP05100027 | 2005-01-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2007124546A true RU2007124546A (ru) | 2009-02-20 |
Family
ID=36118130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2007124546/04A RU2007124546A (ru) | 2005-01-04 | 2005-12-27 | Бензоил-тетрагидропиридины в качестве ингибиторов glyt-1 |
Country Status (19)
Country | Link |
---|---|
US (1) | US7485637B2 (ru) |
EP (1) | EP1836168B1 (ru) |
JP (1) | JP4738421B2 (ru) |
KR (1) | KR100957280B1 (ru) |
CN (1) | CN101111477B (ru) |
AR (1) | AR052553A1 (ru) |
AT (1) | ATE423770T1 (ru) |
AU (1) | AU2005324109B2 (ru) |
BR (1) | BRPI0519746A2 (ru) |
CA (1) | CA2594260A1 (ru) |
DE (1) | DE602005012997D1 (ru) |
ES (1) | ES2319220T3 (ru) |
IL (1) | IL184206A (ru) |
MX (1) | MX2007008043A (ru) |
NO (1) | NO20073275L (ru) |
RU (1) | RU2007124546A (ru) |
TW (1) | TW200635898A (ru) |
WO (1) | WO2006072432A1 (ru) |
ZA (1) | ZA200705383B (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2406085T3 (es) * | 2006-06-22 | 2013-06-05 | F. Hoffmann-La Roche Ag | Derivados de fenil-metanona sustituida y su empleo como inhibidores de receptores de GlyT1 y GlyT2 |
JP6034215B2 (ja) * | 2013-02-19 | 2016-11-30 | 株式会社東芝 | 紙葉類処理装置 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2423847A1 (de) | 1973-05-28 | 1975-01-02 | Ciba Geigy Ag | Neue sulfamoylbenzoesaeureamide |
DE2533604A1 (de) | 1975-07-26 | 1977-02-10 | Bayer Ag | 2-substituierte 5-trifluormethyl1,3,4-thiadiazole, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide und insektizide |
DE2611705A1 (de) | 1976-03-18 | 1977-09-22 | Josef Dipl Chem Dr Rer N Klosa | N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel |
US4122083A (en) | 1978-01-16 | 1978-10-24 | E. R. Squibb & Sons, Inc. | 1,2,3,4-Tetrahydropyrido[4',3':4.5]thiazolo-[3,2-a]benzimidazoles |
US4436002A (en) | 1981-12-11 | 1984-03-13 | Hughes Tool Company | Reversal mechanism for power tong |
IT1176613B (it) | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
RU2124511C1 (ru) | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
TW498067B (en) * | 1996-07-19 | 2002-08-11 | Hoffmann La Roche | 4-hydroxy-piperidine derivatives |
AU3254499A (en) | 1998-03-06 | 1999-09-20 | Janssen Pharmaceutica N.V. | Glycine transport inhibitors |
JP2002505277A (ja) | 1998-03-06 | 2002-02-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | グリシン輸送阻害剤 |
US20030216385A1 (en) * | 2000-05-19 | 2003-11-20 | Takahiko Tobe | Triazole derivatives |
GB0021419D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
GB0106661D0 (en) | 2001-03-16 | 2001-05-09 | Pfizer Ltd | Pharmaceutically active compounds |
WO2003004480A2 (en) | 2001-07-02 | 2003-01-16 | Novo Nordisk A/S | Substituted piperazine and diazepanes as histamine h3 receptor agonists |
WO2003035602A1 (fr) | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Modulateurs lipidiques |
HUP0402320A2 (hu) * | 2001-12-20 | 2005-03-29 | H. Lundbeck A/S | Ariloxifenil- és arilszulfanilfenil-piperazin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
WO2004037800A1 (en) | 2002-10-22 | 2004-05-06 | Glaxo Group Limited | Aryloxyalkylamine derivates as h3 receptor ligands |
BRPI0407543A (pt) | 2003-02-17 | 2006-02-14 | Hoffmann La Roche | derivados de piperidina-benzenossulfonamida |
DK1656361T3 (da) | 2003-08-11 | 2008-05-05 | Hoffmann La Roche | Piperazin med OR-substitueret phenylgruppe og anvendelse deraf som GLYT1-inhibitorer |
DK1663232T3 (da) | 2003-09-09 | 2008-02-04 | Hoffmann La Roche | Benzimidazolderivater som human chymase-inhibitorer |
DK1703909T3 (da) | 2003-09-09 | 2009-06-22 | Hoffmann La Roche | 1-benzoyl-piperazinderivater som glycinoptagelsesinhibitorer til behandling af psykoser |
DE602005014274D1 (de) * | 2004-12-09 | 2009-06-10 | Hoffmann La Roche | Phenylpiperazin-methanon-derivate |
RU2007121768A (ru) * | 2004-12-15 | 2009-01-27 | Ф. Хоффманн-Ля Рош Аг (Ch) | Би- и трициклически замещенные фенилметаноны в качестве ингибиторов переносчика глицина 1 (glyt-1) для лечения болезни альцгеймера |
US20090137601A1 (en) * | 2005-11-23 | 2009-05-28 | Astrazeneca Ab | L-Phenylalanine Derivatives |
-
2005
- 2005-12-13 US US11/302,403 patent/US7485637B2/en not_active Expired - Fee Related
- 2005-12-27 AT AT05820269T patent/ATE423770T1/de active
- 2005-12-27 CN CN2005800476568A patent/CN101111477B/zh not_active Expired - Fee Related
- 2005-12-27 KR KR1020077017900A patent/KR100957280B1/ko not_active IP Right Cessation
- 2005-12-27 WO PCT/EP2005/014052 patent/WO2006072432A1/en active Application Filing
- 2005-12-27 BR BRPI0519746-5A patent/BRPI0519746A2/pt not_active IP Right Cessation
- 2005-12-27 AU AU2005324109A patent/AU2005324109B2/en not_active Ceased
- 2005-12-27 MX MX2007008043A patent/MX2007008043A/es active IP Right Grant
- 2005-12-27 JP JP2007549822A patent/JP4738421B2/ja not_active Expired - Fee Related
- 2005-12-27 RU RU2007124546/04A patent/RU2007124546A/ru not_active Application Discontinuation
- 2005-12-27 DE DE602005012997T patent/DE602005012997D1/de active Active
- 2005-12-27 EP EP05820269A patent/EP1836168B1/en not_active Not-in-force
- 2005-12-27 CA CA002594260A patent/CA2594260A1/en not_active Abandoned
- 2005-12-27 ES ES05820269T patent/ES2319220T3/es active Active
-
2006
- 2006-01-02 TW TW095100092A patent/TW200635898A/zh unknown
- 2006-01-03 AR ARP060100011A patent/AR052553A1/es unknown
-
2007
- 2007-06-25 IL IL184206A patent/IL184206A/en active IP Right Grant
- 2007-06-27 NO NO20073275A patent/NO20073275L/no not_active Application Discontinuation
- 2007-07-02 ZA ZA200705383A patent/ZA200705383B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP2008526794A (ja) | 2008-07-24 |
DE602005012997D1 (de) | 2009-04-09 |
JP4738421B2 (ja) | 2011-08-03 |
US20060148797A1 (en) | 2006-07-06 |
NO20073275L (no) | 2007-07-31 |
ATE423770T1 (de) | 2009-03-15 |
EP1836168B1 (en) | 2009-02-25 |
TW200635898A (en) | 2006-10-16 |
ZA200705383B (en) | 2008-09-25 |
AR052553A1 (es) | 2007-03-21 |
CA2594260A1 (en) | 2006-07-13 |
ES2319220T3 (es) | 2009-05-05 |
CN101111477A (zh) | 2008-01-23 |
EP1836168A1 (en) | 2007-09-26 |
AU2005324109A1 (en) | 2006-07-13 |
MX2007008043A (es) | 2007-07-16 |
IL184206A0 (en) | 2007-10-31 |
WO2006072432A1 (en) | 2006-07-13 |
BRPI0519746A2 (pt) | 2009-03-10 |
AU2005324109B2 (en) | 2011-01-20 |
US7485637B2 (en) | 2009-02-03 |
KR100957280B1 (ko) | 2010-05-12 |
CN101111477B (zh) | 2010-05-26 |
IL184206A (en) | 2011-09-27 |
KR20070094953A (ko) | 2007-09-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2007120209A (ru) | Производные фенил-пиперазин метанона | |
RU2475478C2 (ru) | Соединения для лечения пролиферативных расстройств | |
RU2361860C2 (ru) | Новые замещенные 3-сера-индолы | |
JP2017502940A5 (ru) | ||
JP2005539088A5 (ru) | ||
RU2008126391A (ru) | Производные 1,5-замещенного индол-2-иламида | |
JP2007505922A5 (ru) | ||
RU2004104625A (ru) | Аналоги простагландинов в качестве агонистов рецептора ep4 | |
RU2008120850A (ru) | Соединения и композиции в качестве ингибиторов протеинкиназ | |
RU2007124545A (ru) | Производные [4-(гетероарил)пиперазин-1-ил]-(2,5-замещенный фенил)метанона в качестве ингибиторов переносчика глицина-1 (glyt-1) для лечения неврологических и психоневрологических заболеваний | |
JP2009501745A5 (ru) | ||
JP2018502906A5 (ru) | ||
JP2013509392A5 (ru) | ||
RU2002123350A (ru) | Дипептиднитрильные ингибиторы катепсина К | |
RU2420522C2 (ru) | Новый класс ингибиторов гистондеацетилаз | |
JP2018527295A5 (ru) | ||
RU2007130532A (ru) | Дизамещенные мочевины в качестве ингибиторов киназы | |
RU2002127781A (ru) | Производные карбоновых кислот в качестве антагонистов ip | |
JP2007507494A5 (ru) | ||
RU2011105151A (ru) | Азольные соединения | |
JP2006501201A5 (ru) | ||
JP2005508923A5 (ru) | ||
JP2013506674A5 (ru) | ||
JP2010155827A5 (ru) | ||
JP2017500321A5 (ru) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20100217 |