BRPI0519746A2 - benzoil tetraidro piridina como inibidores de glyt-1 - Google Patents

benzoil tetraidro piridina como inibidores de glyt-1

Info

Publication number
BRPI0519746A2
BRPI0519746A2 BRPI0519746-5A BRPI0519746A BRPI0519746A2 BR PI0519746 A2 BRPI0519746 A2 BR PI0519746A2 BR PI0519746 A BRPI0519746 A BR PI0519746A BR PI0519746 A2 BRPI0519746 A2 BR PI0519746A2
Authority
BR
Brazil
Prior art keywords
lower alkyl
glyt
inhibitors
halogen
substituted
Prior art date
Application number
BRPI0519746-5A
Other languages
English (en)
Inventor
Synese Jolidon
Roger David Norcross
Emmanuel Pinard
Robert Narquizian
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0519746A2 publication Critical patent/BRPI0519746A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

BENZOIL TETRAIDRO PIRIDINA COMO INIBIDORES DE GLYT-1. A presente invenção refere-se a compostos da fórmula geral (I) onde R¹ um heterociclo não-aromático ou OR'; R' é alquila inferior, alquila inferior substituído com halogênio ou é -(CH~ 2~)~ n~-cicIo alquila; R² é NO~ 2~, CN ou SO~ 2~R"; R" é alquila inferior; Ar é fenila, opcionalmente substituído com halogênio, dano, alquila inferior substituído com halogênio ou SO~ 2~R"; n é 0,1 ou2; e a sais de adição ácida farmaceuticamente ativos e a seu uso no tratamento de distúrbios neurológicos e neuropsiquiátricos.
BRPI0519746-5A 2005-01-04 2005-12-27 benzoil tetraidro piridina como inibidores de glyt-1 BRPI0519746A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05100027 2005-01-04
PCT/EP2005/014052 WO2006072432A1 (en) 2005-01-04 2005-12-27 Benzoyl-tetrahydropyridine as glyt-1 inhibitors

Publications (1)

Publication Number Publication Date
BRPI0519746A2 true BRPI0519746A2 (pt) 2009-03-10

Family

ID=36118130

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519746-5A BRPI0519746A2 (pt) 2005-01-04 2005-12-27 benzoil tetraidro piridina como inibidores de glyt-1

Country Status (19)

Country Link
US (1) US7485637B2 (pt)
EP (1) EP1836168B1 (pt)
JP (1) JP4738421B2 (pt)
KR (1) KR100957280B1 (pt)
CN (1) CN101111477B (pt)
AR (1) AR052553A1 (pt)
AT (1) ATE423770T1 (pt)
AU (1) AU2005324109B2 (pt)
BR (1) BRPI0519746A2 (pt)
CA (1) CA2594260A1 (pt)
DE (1) DE602005012997D1 (pt)
ES (1) ES2319220T3 (pt)
IL (1) IL184206A (pt)
MX (1) MX2007008043A (pt)
NO (1) NO20073275L (pt)
RU (1) RU2007124546A (pt)
TW (1) TW200635898A (pt)
WO (1) WO2006072432A1 (pt)
ZA (1) ZA200705383B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2437872C2 (ru) * 2006-06-22 2011-12-27 Ф. Хоффманн-Ля Рош Аг Замещенные производные фенилметанона
JP6034215B2 (ja) * 2013-02-19 2016-11-30 株式会社東芝 紙葉類処理装置

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2423847A1 (de) * 1973-05-28 1975-01-02 Ciba Geigy Ag Neue sulfamoylbenzoesaeureamide
DE2533605A1 (de) 1975-07-26 1977-02-03 Bayer Ag Antiparasitenmittel
DE2611705A1 (de) * 1976-03-18 1977-09-22 Josef Dipl Chem Dr Rer N Klosa N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel
US4122083A (en) * 1978-01-16 1978-10-24 E. R. Squibb & Sons, Inc. 1,2,3,4-Tetrahydropyrido[4',3':4.5]thiazolo-[3,2-a]benzimidazoles
US4436002A (en) 1981-12-11 1984-03-13 Hughes Tool Company Reversal mechanism for power tong
IT1176613B (it) 1984-08-14 1987-08-18 Ravizza Spa Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione
RU2124511C1 (ru) 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
TW498067B (en) * 1996-07-19 2002-08-11 Hoffmann La Roche 4-hydroxy-piperidine derivatives
CA2322136A1 (en) 1998-03-06 1999-09-10 Ludo Edmond Josephine Kennis Glycine transport inhibitors
CA2322164A1 (en) 1998-03-06 1999-09-10 Ludo Edmond Josephine Kennis Glycine transport inhibitors
US20030216385A1 (en) * 2000-05-19 2003-11-20 Takahiko Tobe Triazole derivatives
GB0021419D0 (en) 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
GB0106661D0 (en) 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
DE60234453D1 (de) 2001-07-02 2009-12-31 High Point Pharmaceuticals Llc Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
WO2003035602A1 (fr) 2001-10-25 2003-05-01 Sankyo Company, Limited Modulateurs lipidiques
CN100457738C (zh) * 2001-12-20 2009-02-04 H·隆德贝克有限公司 芳氧基苯基和芳硫基苯基衍生物
JP2006512404A (ja) 2002-10-22 2006-04-13 グラクソ　グループ　リミテッド Ｈ３受容体リガンドとしてのアリールオキシアルキルアミン誘導体
RU2330842C2 (ru) 2003-02-17 2008-08-10 Ф.Хоффманн-Ля Рош Аг Производные пиперидинбензолсульфамида
EA009986B1 (ru) * 2003-08-11 2008-04-28 Ф. Хоффманн-Ля Рош Аг Пиперазин с or-замещенной фенильной группой и его применение в качестве ингибиторов glyt1
NZ545613A (en) * 2003-09-09 2009-11-27 Hoffmann La Roche 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses
NZ545454A (en) * 2003-09-09 2009-11-27 Hoffmann La Roche 1-(2-amino-benzoyl)-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses
ATE430142T1 (de) * 2004-12-09 2009-05-15 Hoffmann La Roche Phenylpiperazin-methanon-derivate
NZ555476A (en) * 2004-12-15 2009-09-25 Hoffmann La Roche Bi- and tricyclic substituted phenyl methanones as glycine transporter I (GLYT-1) inhibitors for the treatment of alzheimerÆs disease
EP2091916A2 (en) * 2005-11-23 2009-08-26 AstraZeneca AB L-phenylalanine derivatives and their use as integrin antagonists

Also Published As

Publication number Publication date
IL184206A0 (en) 2007-10-31
EP1836168B1 (en) 2009-02-25
NO20073275L (no) 2007-07-31
IL184206A (en) 2011-09-27
KR20070094953A (ko) 2007-09-27
JP2008526794A (ja) 2008-07-24
KR100957280B1 (ko) 2010-05-12
JP4738421B2 (ja) 2011-08-03
US20060148797A1 (en) 2006-07-06
AU2005324109B2 (en) 2011-01-20
WO2006072432A1 (en) 2006-07-13
MX2007008043A (es) 2007-07-16
ES2319220T3 (es) 2009-05-05
ZA200705383B (en) 2008-09-25
CA2594260A1 (en) 2006-07-13
TW200635898A (en) 2006-10-16
US7485637B2 (en) 2009-02-03
RU2007124546A (ru) 2009-02-20
EP1836168A1 (en) 2007-09-26
AR052553A1 (es) 2007-03-21
DE602005012997D1 (de) 2009-04-09
AU2005324109A1 (en) 2006-07-13
ATE423770T1 (de) 2009-03-15
CN101111477B (zh) 2010-05-26
CN101111477A (zh) 2008-01-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.