RU2007118726A - Фармацевтическая композиция, включающая диклофенак - Google Patents
Фармацевтическая композиция, включающая диклофенак Download PDFInfo
- Publication number
- RU2007118726A RU2007118726A RU2007118726/15A RU2007118726A RU2007118726A RU 2007118726 A RU2007118726 A RU 2007118726A RU 2007118726/15 A RU2007118726/15 A RU 2007118726/15A RU 2007118726 A RU2007118726 A RU 2007118726A RU 2007118726 A RU2007118726 A RU 2007118726A
- Authority
- RU
- Russia
- Prior art keywords
- food film
- film according
- food
- diclofenac
- flavoring
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Claims (17)
1. Фармацевтическая композиция, предназначенная для перорального введения, в форме пищевой пленки, включающей диклофенак, которая быстро и полностью разлагается в ротовой полости пациента в течение менее 60 с.
2. Пищевая пленка по п.1 толщиной 250 мкм или менее.
3. Пищевая пленка по п.1, включающая диклофенак в форме свободной кислоты.
4. Пищевая пленка по п.2, включающая диклофенак в форме свободной кислоты.
5. Пищевая пленка по п.4, включающая диклофенак в форме свободной кислоты со средним размером частиц 2 мкм или менее.
6. Пищевая пленка по любому из пп.1-5, включающая (А) по крайней мере один пленкообразующий полимер и (В) по крайней мере один пластификатор.
7. Пищевая пленка по п.6, включающая от 10 до 50 мас.% диклофенака, от 10 до 80 мас.% по крайней мере одного пленкообразующего полимера (А) и от 1 до 10 мас.% по крайней мере одного пластификатора (В) в расчете на массу конечной пищевой пленки (сухая масса).
8. Пищевая пленка по п.7, в которой по крайней мере один пленкообразующий полимер (А) выбирают из группы, включающей гидроксипропилметилцеллюлозу, гидроксиэтилцеллюлозу, гидроксипропилцеллюлозу, фталат целлюлозы или их смесь.
9. Пищевая пленка по п.7, в которой пленкообразующий полимер (А) означает гидроксипропилметилцеллюлозу.
10. Пищевая пленка по любому из пп.1-5 или 7-9, в которой по крайней мере один пластификатор (В) выбирают из группы, включающей глицерин, полиэтиленгликоль, этиленгликоль, пропиленгликоль или их смеси.
11. Пищевая пленка по п.10, в которой пластификатор (В) означает глицерин.
12. Пищевая пленка по любому из пп.1-5, 7-9 или 11, включающая по крайней мере один антиоксидант (С).
13. Пищевая пленка по п.12, в которой по крайней мере один антиоксидант (С) выбирают из группы, включающей альфа-токоферол, аскорбиновую кислоту, лимонную кислоту или их смеси.
14. Пищевая пленка по любому из пп.1-5, 7-9, 11 или 13, включающая по крайней мере один ароматизатор (D), выбранный из группы, включающей грейпфрутовый, мятный ароматизаторы и маскирующий вкус ароматизатор.
15. Пищевая пленка по п.14, включающая маскирующий вкус ароматизатор, грейпфрутовый ароматизатор и хлорид натрия.
16. Пищевая пленка по п.14, включающая маскирующий вкус ароматизатор, мятный ароматизатор, хлорид натрия и ментол.
17. Пищевая пленка по любому из пп.1-5, 7-9, 11,13 или 15 и 16, включающая по крайней мере один подсластитель (Е), выбранный из группы, включающей сукралозу, ацесульфам К, аспартам и любую их смесь.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62070604P | 2004-10-21 | 2004-10-21 | |
| US60/620,706 | 2004-10-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007118726A true RU2007118726A (ru) | 2008-11-27 |
| RU2424793C2 RU2424793C2 (ru) | 2011-07-27 |
Family
ID=35840581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007118726/15A RU2424793C2 (ru) | 2004-10-21 | 2005-10-20 | Фармацевтическая композиция, включающая диклофенак |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8911769B2 (ru) |
| EP (1) | EP1804777B1 (ru) |
| JP (1) | JP5213446B2 (ru) |
| KR (1) | KR101288162B1 (ru) |
| CN (1) | CN101043880B (ru) |
| AR (1) | AR051397A1 (ru) |
| AU (1) | AU2005299741B2 (ru) |
| BR (1) | BRPI0516238A (ru) |
| CA (1) | CA2577862C (ru) |
| IL (1) | IL182020A0 (ru) |
| MX (1) | MX2007004736A (ru) |
| NO (1) | NO20072262L (ru) |
| NZ (1) | NZ553475A (ru) |
| PE (1) | PE20060935A1 (ru) |
| PL (1) | PL1804777T3 (ru) |
| RU (1) | RU2424793C2 (ru) |
| TW (1) | TWI406680B (ru) |
| WO (1) | WO2006047365A1 (ru) |
| ZA (1) | ZA200701557B (ru) |
Families Citing this family (31)
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| US20090110715A1 (en) * | 2006-05-10 | 2009-04-30 | Kureha Corporation | Edible film Package Having Product for Oral Intake Enclosed Therein |
| JP4916894B2 (ja) * | 2007-01-11 | 2012-04-18 | 株式会社ツキオカ | フィルム状製剤及びフィルム状製剤の製造方法 |
| KR20100020008A (ko) * | 2007-05-18 | 2010-02-19 | 티티아이 엘뷰 가부시키가이샤 | 생물학적 인터페이스를 통한 활성 성분의 방출을 개선한 경피 전달 장치 |
| JP5624472B2 (ja) * | 2008-08-25 | 2014-11-12 | 救急薬品工業株式会社 | ロペラミド塩酸塩含有フィルム製剤 |
| WO2010086989A1 (ja) | 2009-01-29 | 2010-08-05 | 日東電工株式会社 | 口腔内フィルム状基剤及び製剤 |
| US20120328675A1 (en) * | 2010-03-03 | 2012-12-27 | Kowa Co., Ltd. | Film preparation containing medicament with unpleasant taste |
| AU2011232408B2 (en) | 2010-03-24 | 2015-07-30 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
| JP5751868B2 (ja) | 2010-03-30 | 2015-07-22 | 日東電工株式会社 | フィルム状製剤及びその製造方法 |
| JP2011207847A (ja) * | 2010-03-30 | 2011-10-20 | Nitto Denko Corp | フィルム状製剤及びその製造方法 |
| JP5555148B2 (ja) * | 2010-12-10 | 2014-07-23 | 日東電工株式会社 | シート状製剤及びシート状製剤の製造方法 |
| US9597287B2 (en) | 2011-06-08 | 2017-03-21 | LTS Lohmann Therapic-Systeme AG | Edible oral strip or wafer dosage form containing ion exchange resin for taste masking |
| JP5841433B2 (ja) | 2012-01-11 | 2016-01-13 | 日東電工株式会社 | 口腔内フィルム状基剤及び製剤 |
| US11116769B2 (en) | 2013-04-11 | 2021-09-14 | Ctc Bio, Inc. | Tadalafil free base-containing film dosage form containing polyethylene glycol-based polymer and/or vinyl pyrrolidone-based polymer as dispersion stabilizer |
| AU2014251532B2 (en) * | 2013-04-11 | 2019-05-23 | Ctc Bio, Inc. | Tadalafil free base-containing film dosage form containing polyethylene glycol-based polymer and/or vinyl pyrrolidone-based polymer as dispersion stabilizer |
| BR112015028291A2 (pt) * | 2013-05-10 | 2017-07-25 | Ctc Bio Inc | filme contendo base livre de donepezil e método para a preparação do mesmo. |
| JP6580305B2 (ja) * | 2014-03-30 | 2019-09-25 | 小林製薬株式会社 | 外用医薬組成物 |
| JP6599083B2 (ja) * | 2014-03-30 | 2019-10-30 | 小林製薬株式会社 | 外用医薬組成物 |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| DE102017103346A1 (de) * | 2017-02-17 | 2018-08-23 | Lts Lohmann Therapie-Systeme Ag | Strukturierte orodispergierbare Filme |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| US10882945B2 (en) | 2018-03-26 | 2021-01-05 | Medtronic, Inc. | Modified polyisobutylene-based polymers, methods of making, and medical devices |
| CA3099679A1 (en) * | 2018-05-14 | 2019-11-21 | Rks Global Pte Ltd | A dosage in film package form, an film composition and a process for preparation thereof |
| WO2020106735A1 (en) | 2018-11-19 | 2020-05-28 | Jazz Pharmaceuticals Ireland Limited | Alcohol-resistant drug formulations |
| WO2020178695A1 (en) | 2019-03-01 | 2020-09-10 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
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| US4855142A (en) | 1987-02-27 | 1989-08-08 | Ciba-Geigy Corporation | Pharmaceutical plaster |
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| JP2004043450A (ja) * | 2002-05-16 | 2004-02-12 | Kyukyu Yakuhin Kogyo Kk | 速溶性フィルム状製剤 |
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-
2005
- 2005-10-19 PE PE2005001228A patent/PE20060935A1/es not_active Application Discontinuation
- 2005-10-19 AR ARP050104366A patent/AR051397A1/es unknown
- 2005-10-20 AU AU2005299741A patent/AU2005299741B2/en not_active Ceased
- 2005-10-20 NZ NZ553475A patent/NZ553475A/en unknown
- 2005-10-20 WO PCT/US2005/038090 patent/WO2006047365A1/en active Application Filing
- 2005-10-20 EP EP05816335.3A patent/EP1804777B1/en not_active Not-in-force
- 2005-10-20 BR BRPI0516238-6A patent/BRPI0516238A/pt not_active Application Discontinuation
- 2005-10-20 PL PL05816335T patent/PL1804777T3/pl unknown
- 2005-10-20 KR KR1020077008968A patent/KR101288162B1/ko not_active IP Right Cessation
- 2005-10-20 TW TW094136742A patent/TWI406680B/zh not_active IP Right Cessation
- 2005-10-20 MX MX2007004736A patent/MX2007004736A/es active IP Right Grant
- 2005-10-20 US US11/666,086 patent/US8911769B2/en not_active Expired - Fee Related
- 2005-10-20 CN CN2005800360078A patent/CN101043880B/zh not_active Expired - Fee Related
- 2005-10-20 JP JP2007538108A patent/JP5213446B2/ja not_active Expired - Fee Related
- 2005-10-20 CA CA2577862A patent/CA2577862C/en not_active Expired - Fee Related
- 2005-10-20 RU RU2007118726/15A patent/RU2424793C2/ru not_active IP Right Cessation
-
2007
- 2007-02-22 ZA ZA200701557A patent/ZA200701557B/xx unknown
- 2007-03-19 IL IL182020A patent/IL182020A0/en unknown
- 2007-05-02 NO NO20072262A patent/NO20072262L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1804777B1 (en) | 2018-05-09 |
| US20080003267A1 (en) | 2008-01-03 |
| NZ553475A (en) | 2010-10-29 |
| RU2424793C2 (ru) | 2011-07-27 |
| WO2006047365A1 (en) | 2006-05-04 |
| CN101043880A (zh) | 2007-09-26 |
| BRPI0516238A (pt) | 2008-08-26 |
| KR101288162B1 (ko) | 2013-07-18 |
| US8911769B2 (en) | 2014-12-16 |
| MX2007004736A (es) | 2007-06-18 |
| TW200621317A (en) | 2006-07-01 |
| JP5213446B2 (ja) | 2013-06-19 |
| TWI406680B (zh) | 2013-09-01 |
| CA2577862A1 (en) | 2006-05-04 |
| KR20070065890A (ko) | 2007-06-25 |
| CA2577862C (en) | 2013-06-04 |
| JP2008517935A (ja) | 2008-05-29 |
| AR051397A1 (es) | 2007-01-10 |
| NO20072262L (no) | 2007-05-14 |
| CN101043880B (zh) | 2011-08-10 |
| PL1804777T3 (pl) | 2018-09-28 |
| ZA200701557B (en) | 2008-08-27 |
| EP1804777A1 (en) | 2007-07-11 |
| PE20060935A1 (es) | 2006-10-26 |
| AU2005299741A1 (en) | 2006-05-04 |
| AU2005299741B2 (en) | 2009-03-12 |
| IL182020A0 (en) | 2007-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20171021 |