RU2006136361A - Терапевтическая комбинация для лечения болезни альцгеймера - Google Patents
Терапевтическая комбинация для лечения болезни альцгеймера Download PDFInfo
- Publication number
- RU2006136361A RU2006136361A RU2006136361/15A RU2006136361A RU2006136361A RU 2006136361 A RU2006136361 A RU 2006136361A RU 2006136361/15 A RU2006136361/15 A RU 2006136361/15A RU 2006136361 A RU2006136361 A RU 2006136361A RU 2006136361 A RU2006136361 A RU 2006136361A
- Authority
- RU
- Russia
- Prior art keywords
- active ingredient
- pharmaceutically acceptable
- pharmaceutical composition
- alzheimer
- acetylcholinesterase inhibitor
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title claims 10
- 238000011282 treatment Methods 0.000 title claims 4
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000004480 active ingredient Substances 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims 12
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 12
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 10
- 239000013543 active substance Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 6
- 239000003085 diluting agent Substances 0.000 claims 5
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 4
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 229960005370 atorvastatin Drugs 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 229960003530 donepezil Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000000051 modifying effect Effects 0.000 claims 2
- 230000006641 stabilisation Effects 0.000 claims 2
- 238000011105 stabilization Methods 0.000 claims 2
- OJRHUICOVVSGSY-RXMQYKEDSA-N (2s)-2-chloro-3-methylbutan-1-ol Chemical compound CC(C)[C@H](Cl)CO OJRHUICOVVSGSY-RXMQYKEDSA-N 0.000 claims 1
- 229960001770 atorvastatin calcium Drugs 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56214104P | 2004-04-14 | 2004-04-14 | |
| US60/562,141 | 2004-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006136361A true RU2006136361A (ru) | 2008-04-20 |
Family
ID=34963723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006136361/15A RU2006136361A (ru) | 2004-04-14 | 2005-04-04 | Терапевтическая комбинация для лечения болезни альцгеймера |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1737539A1 (enExample) |
| JP (1) | JP2007532624A (enExample) |
| KR (1) | KR20060133008A (enExample) |
| CN (1) | CN1960781A (enExample) |
| AU (1) | AU2005232447A1 (enExample) |
| BR (1) | BRPI0509881A (enExample) |
| CA (1) | CA2562069A1 (enExample) |
| IL (1) | IL178120A0 (enExample) |
| MX (1) | MXPA06011969A (enExample) |
| NO (1) | NO20065196L (enExample) |
| RU (1) | RU2006136361A (enExample) |
| TW (1) | TW200533341A (enExample) |
| WO (1) | WO2005099823A1 (enExample) |
| ZA (1) | ZA200608239B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI432195B (zh) * | 2007-10-03 | 2014-04-01 | Kowa Co | 神經細胞死亡抑制劑 |
| JP7059192B2 (ja) * | 2016-02-11 | 2022-04-25 | シグマテラ・ソシエテ・パ・アクシオンス・シンプリフィエ | 神経変性疾患の治療に使用するためのイグメシン |
| WO2020252475A1 (en) * | 2019-06-14 | 2020-12-17 | Atiba Joshua O | Triple pharmaceutical composition for proteinaceous infection |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020028826A1 (en) * | 2000-06-15 | 2002-03-07 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
| ATE331523T1 (de) * | 2002-04-02 | 2006-07-15 | Janssen Pharmaceutica Nv | Statin-therapie zur verbesserung der aufrechterhaltung der kognitiven funktion |
| AU2003298514A1 (en) * | 2002-05-17 | 2004-05-04 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
| EA012325B1 (ru) * | 2002-12-24 | 2009-08-28 | Беллус Хелс (Интернэшнл) Лимитед | Терапевтические составы для лечения болезней, связанных с наличием бета-амилоида |
| EP1603548A4 (en) * | 2003-02-05 | 2007-10-10 | Myriad Genetics Inc | METHOD AND COMPOSITION FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES |
| CA2516990A1 (en) * | 2003-03-19 | 2004-09-30 | Ares Trading S.A. | Treatment of alzheimer's disease |
| US20050090449A1 (en) * | 2003-05-13 | 2005-04-28 | Boehringer Ingelheim International Gmbh | Novel statine derivatives for the treatment of Alzheimer's disease |
-
2005
- 2005-04-04 MX MXPA06011969A patent/MXPA06011969A/es unknown
- 2005-04-04 AU AU2005232447A patent/AU2005232447A1/en not_active Abandoned
- 2005-04-04 CA CA002562069A patent/CA2562069A1/en not_active Abandoned
- 2005-04-04 KR KR1020067021174A patent/KR20060133008A/ko not_active Ceased
- 2005-04-04 RU RU2006136361/15A patent/RU2006136361A/ru not_active Application Discontinuation
- 2005-04-04 BR BRPI0509881-5A patent/BRPI0509881A/pt not_active IP Right Cessation
- 2005-04-04 EP EP05718393A patent/EP1737539A1/en not_active Withdrawn
- 2005-04-04 WO PCT/IB2005/000923 patent/WO2005099823A1/en not_active Ceased
- 2005-04-04 JP JP2007507862A patent/JP2007532624A/ja not_active Withdrawn
- 2005-04-04 CN CNA2005800173902A patent/CN1960781A/zh active Pending
- 2005-04-13 TW TW094111657A patent/TW200533341A/zh unknown
-
2006
- 2006-09-14 IL IL178120A patent/IL178120A0/en unknown
- 2006-10-03 ZA ZA200608239A patent/ZA200608239B/en unknown
- 2006-11-13 NO NO20065196A patent/NO20065196L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20065196L (no) | 2007-01-03 |
| CN1960781A (zh) | 2007-05-09 |
| IL178120A0 (en) | 2006-12-31 |
| CA2562069A1 (en) | 2005-10-27 |
| AU2005232447A1 (en) | 2005-10-27 |
| TW200533341A (en) | 2005-10-16 |
| KR20060133008A (ko) | 2006-12-22 |
| JP2007532624A (ja) | 2007-11-15 |
| EP1737539A1 (en) | 2007-01-03 |
| MXPA06011969A (es) | 2006-12-15 |
| ZA200608239B (en) | 2008-06-25 |
| WO2005099823A1 (en) | 2005-10-27 |
| BRPI0509881A (pt) | 2007-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20080507 |