RU2006133260A - Соединения замещенного пиразолина, их получение и применение в качестве лекарственных средств - Google Patents
Соединения замещенного пиразолина, их получение и применение в качестве лекарственных средств Download PDFInfo
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- RU2006133260A RU2006133260A RU2006133260/04A RU2006133260A RU2006133260A RU 2006133260 A RU2006133260 A RU 2006133260A RU 2006133260/04 A RU2006133260/04 A RU 2006133260/04A RU 2006133260 A RU2006133260 A RU 2006133260A RU 2006133260 A RU2006133260 A RU 2006133260A
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
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- Anesthesiology (AREA)
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Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200400378 | 2004-02-17 | ||
ES200400378 | 2004-02-17 | ||
US80453404A | 2004-03-19 | 2004-03-19 | |
US10/804,534 | 2004-03-19 | ||
EP04021974.3 | 2004-09-16 | ||
EP04021974A EP1637522A1 (de) | 2004-09-16 | 2004-09-16 | Substituierte Pyrazoline zur Senkung von Triglyceriden im Blut |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2006133260A true RU2006133260A (ru) | 2008-04-10 |
Family
ID=34864786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006133260/04A RU2006133260A (ru) | 2004-02-17 | 2005-02-14 | Соединения замещенного пиразолина, их получение и применение в качестве лекарственных средств |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1718619A1 (de) |
JP (1) | JP2007522252A (de) |
KR (1) | KR20060135815A (de) |
AU (1) | AU2005212817A1 (de) |
BR (1) | BRPI0507790A (de) |
CA (1) | CA2556568A1 (de) |
IL (1) | IL177454A0 (de) |
NO (1) | NO20064186L (de) |
RU (1) | RU2006133260A (de) |
WO (1) | WO2005077909A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007510647A (ja) | 2003-10-30 | 2007-04-26 | メルク エンド カムパニー インコーポレーテッド | カンナビノイド受容体調節剤としてのアラルキルアミン類 |
TW200533657A (en) * | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
WO2007009704A2 (en) * | 2005-07-15 | 2007-01-25 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes |
ES2330993B1 (es) * | 2005-07-15 | 2010-07-06 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de antagonista del receptor de cannabinoides de tipo pirazolina y estatina. |
EP1746090A1 (de) * | 2005-07-15 | 2007-01-24 | Laboratorios del Dr. Esteve S.A. | Substituierte Pyrazoline mit vorbestimmter Stereochemie zur Senkung von Triglyceriden im Blut |
WO2007009683A2 (en) * | 2005-07-15 | 2007-01-25 | Laboratorios Del Dr.Esteve, S.A. | Pharmaceutical formulations of substituted pyrazoline compounds |
EP1749527A1 (de) * | 2005-07-15 | 2007-02-07 | Laboratorios Del Dr. Esteve, S.A. | Verwendung substituierter Pyrazolinderivate zur Behandlung des metabolischen Syndroms |
EP1743637A1 (de) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Verwendung substituierter Pyrazolinderivate und Kombinationen davon zur Behandlung des metabolischen Syndroms |
WO2007009700A2 (en) * | 2005-07-15 | 2007-01-25 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazoline compounds for the treatment of the lipid parameters of the metabolic syndrome |
ES2336883B1 (es) * | 2005-07-15 | 2011-03-22 | Laboratorios Del Dr. Esteve, S.A. | Compuestos de pirazolina sustituidos, con una estereoquimica predeterminada, para la reduccion de trigliceridos en sangre. |
WO2007009707A2 (en) * | 2005-07-15 | 2007-01-25 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazoline compounds for the treatment of coagulation related diseases |
EP1743889A1 (de) * | 2005-07-15 | 2007-01-17 | Laboratorios del Dr. Esteve S.A. | Substituierte Pyrazoline mit vorbestimmter Stereochemie zur Senkung von Triglyceriden im Blut |
EP1749526A1 (de) * | 2005-07-15 | 2007-02-07 | Laboratorios Del Dr. Esteve, S.A. | Verwendung substituierter Pyrazolinderivate zur Behandlung von Nahrungsmittel bedingten Störungen, wie Obesitas oder des metabolischen Syndroms in Patienten mit fortgeschrittener Diabetis |
WO2007009701A2 (en) * | 2005-07-15 | 2007-01-25 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazole compounds and combinations thereof for the treatment of the metabolic syndrome |
EP1745781A1 (de) * | 2005-07-15 | 2007-01-24 | Laboratorios Del Dr. Esteve, S.A. | Kombination von Cannabinoid Rezeptor Antagonist des Pyrazolin-Typs und Statin |
WO2007009706A2 (en) * | 2005-07-15 | 2007-01-25 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood |
EP1743639A1 (de) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Verwendung substituierter Pyrazolinderivate zur Behandlung von Krankheiten im Zusammenhang mit Blutgerinnung |
EP1944296A1 (de) * | 2007-01-15 | 2008-07-16 | Laboratorios del Dr. Esteve S.A. | Amorphe Phase eines substituierten Pyrazolins, seine Herstellung und Verwendung als Medikament |
EP1944295A1 (de) * | 2007-01-15 | 2008-07-16 | Laboratorios del Dr. Esteve S.A. | Nicht racemische Verbindungen von (R)-N-piperidinyl-5-(4-chlorophenyl)1-1(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-carboxamid und (S)-N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-carboxamid |
EP1946779A1 (de) * | 2007-01-16 | 2008-07-23 | Laboratorios del Dr. Esteve S.A. | Zusammensetzung enthaltend substituierte Pyrazoline und gegen Dyslipämie wirksame Mittel |
EP2114892A1 (de) * | 2007-01-17 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | Substituierte pyrazolinverbindungen mit acat-hemmungsaktivität sowie deren herstellung und medizinische verwendung |
US20100099712A1 (en) * | 2007-01-17 | 2010-04-22 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds with acat inhibition activity |
EP1950203A1 (de) * | 2007-01-24 | 2008-07-30 | Laboratorios del Dr. Esteve S.A. | Substitutierte Pyrazolinverbindungen mit ACAT, ihre Herstellung und Verwendung als Medikamente |
EP1947088A1 (de) * | 2007-01-17 | 2008-07-23 | Laboratorios del Dr. Esteve S.A. | Substitutierte Pyrazolinverbindungen, ihre Herstellung und Verwendung als Medikamente |
KR101395658B1 (ko) | 2012-09-20 | 2014-05-16 | 서울대학교산학협력단 | 4-(5-(2-메톡시페닐)-3-(p-톨릴)-4,5-디하이드로-1H-피라졸-1-일)-4-옥소부탄산을 포함하는 골대사성 질환의 예방 및 치료용 조성물 |
KR101466377B1 (ko) * | 2012-10-22 | 2014-12-01 | 건국대학교 산학협력단 | 디메톡시페닐디히드로피라졸릴나프탈레놀 유도체 및 그 제법 및 항암제로서의 용도 |
US9604964B2 (en) * | 2012-11-16 | 2017-03-28 | Bristol-Myers Squibb Company | Dihydropyrazole GPR40 modulators |
CN104812748B (zh) * | 2012-11-16 | 2017-10-24 | 百时美施贵宝公司 | 二氢吡唑gpr40调节剂 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1053661B (it) * | 1966-09-27 | 1981-10-10 | Farmacosmici S P A | Ammidi dell acido 3 5 metil 5 3 pirazol carbossilico |
ATE57690T1 (de) * | 1987-01-05 | 1990-11-15 | Du Pont | Pyrazolin mit insektizidischer aktivitaet. |
ES2174757B1 (es) * | 2001-04-06 | 2003-11-01 | Esteve Labor Dr | Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares. |
-
2005
- 2005-02-14 EP EP05715327A patent/EP1718619A1/de not_active Withdrawn
- 2005-02-14 KR KR1020067018876A patent/KR20060135815A/ko not_active Application Discontinuation
- 2005-02-14 CA CA002556568A patent/CA2556568A1/en not_active Abandoned
- 2005-02-14 BR BRPI0507790-7A patent/BRPI0507790A/pt not_active IP Right Cessation
- 2005-02-14 RU RU2006133260/04A patent/RU2006133260A/ru not_active Application Discontinuation
- 2005-02-14 AU AU2005212817A patent/AU2005212817A1/en not_active Abandoned
- 2005-02-14 JP JP2006553505A patent/JP2007522252A/ja active Pending
- 2005-02-14 WO PCT/EP2005/001465 patent/WO2005077909A1/en active Application Filing
-
2006
- 2006-08-10 IL IL177454A patent/IL177454A0/en unknown
- 2006-09-15 NO NO20064186A patent/NO20064186L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2005077909A1 (en) | 2005-08-25 |
NO20064186L (no) | 2006-11-14 |
IL177454A0 (en) | 2006-12-10 |
KR20060135815A (ko) | 2006-12-29 |
BRPI0507790A (pt) | 2007-07-17 |
JP2007522252A (ja) | 2007-08-09 |
CA2556568A1 (en) | 2005-08-25 |
AU2005212817A1 (en) | 2005-08-25 |
EP1718619A1 (de) | 2006-11-08 |
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