RU2006132741A - С10 циклопентил сложноэфирные таксаны - Google Patents
С10 циклопентил сложноэфирные таксаны Download PDFInfo
- Publication number
- RU2006132741A RU2006132741A RU2006132741/04A RU2006132741A RU2006132741A RU 2006132741 A RU2006132741 A RU 2006132741A RU 2006132741/04 A RU2006132741/04 A RU 2006132741/04A RU 2006132741 A RU2006132741 A RU 2006132741A RU 2006132741 A RU2006132741 A RU 2006132741A
- Authority
- RU
- Russia
- Prior art keywords
- composition according
- taxane
- dosage form
- composition
- tumor
- Prior art date
Links
- 239000000203 mixture Substances 0.000 claims 21
- 238000000034 method Methods 0.000 claims 11
- 229940123237 Taxane Drugs 0.000 claims 10
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 10
- 239000002552 dosage form Substances 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- 208000029742 colonic neoplasm Diseases 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000008389 polyethoxylated castor oil Substances 0.000 claims 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 3
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 3
- 229920000053 polysorbate 80 Polymers 0.000 claims 3
- 229940068968 polysorbate 80 Drugs 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000002960 lipid emulsion Substances 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- -1 cyclopentylcarbonyloxy substituent Chemical group 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 1
- 229960000520 diphenhydramine Drugs 0.000 claims 1
- 239000012153 distilled water Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 230000009931 harmful effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 229940100688 oral solution Drugs 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 201000001514 prostate carcinoma Diseases 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54475504P | 2004-02-13 | 2004-02-13 | |
| US60/544,755 | 2004-02-13 | ||
| US61350304P | 2004-09-27 | 2004-09-27 | |
| US60/613,503 | 2004-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006132741A true RU2006132741A (ru) | 2008-03-20 |
Family
ID=34890477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006132741/04A RU2006132741A (ru) | 2004-02-13 | 2005-02-14 | С10 циклопентил сложноэфирные таксаны |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7589111B2 (https=) |
| EP (1) | EP1713798B1 (https=) |
| JP (1) | JP4879757B2 (https=) |
| KR (1) | KR101169818B1 (https=) |
| AR (1) | AR047704A1 (https=) |
| AT (1) | ATE486596T1 (https=) |
| AU (1) | AU2005214065B2 (https=) |
| BR (1) | BRPI0507671A (https=) |
| CA (1) | CA2556200C (https=) |
| CR (1) | CR8554A (https=) |
| DE (1) | DE602005024518D1 (https=) |
| EC (1) | ECSP066765A (https=) |
| HN (1) | HN2005000054A (https=) |
| IL (1) | IL177372A (https=) |
| NO (1) | NO20064090L (https=) |
| NZ (1) | NZ548769A (https=) |
| PE (1) | PE20050693A1 (https=) |
| RU (1) | RU2006132741A (https=) |
| SV (1) | SV2006002010A (https=) |
| TW (1) | TWI353354B (https=) |
| WO (1) | WO2005079319A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1303077C (zh) * | 2004-01-16 | 2007-03-07 | 桂林晖昂生化药业有限责任公司 | 合成紫杉烷的制备工艺 |
| JP4833126B2 (ja) * | 2007-03-26 | 2011-12-07 | Ｎｔｎ株式会社 | 潤滑剤劣化検出装置および検出装置付き軸受 |
| CN113209287B (zh) * | 2021-02-04 | 2022-07-08 | 中国农业科学院农业环境与可持续发展研究所 | 油包水型纳米疫苗佐剂、制备方法及其应用 |
Family Cites Families (71)
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|---|---|---|---|---|
| FR2601675B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| US5714512A (en) | 1991-07-08 | 1998-02-03 | Rhone-Poulenc Rorer, S.A. | Compositions containing taxane derivatives |
| US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
| ATE258171T1 (de) | 1991-09-23 | 2004-02-15 | Univ Florida State | Metallalkoxide |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5710287A (en) | 1991-09-23 | 1998-01-20 | Florida State University | Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them |
| US5739362A (en) | 1991-09-23 | 1998-04-14 | Florida State University | Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5250683A (en) | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
| US5274124A (en) | 1991-09-23 | 1993-12-28 | Florida State University | Metal alkoxides |
| US5445908A (en) | 1991-10-17 | 1995-08-29 | Matsushita Electric Industrial Co., Ltd. | Alkaline dry cell |
| DK0552041T3 (da) | 1992-01-15 | 2000-10-09 | Squibb & Sons Inc | Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
| FR2691460B1 (fr) | 1992-05-21 | 1994-07-22 | Rhone Poulenc Rorer Sa | Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent. |
| US5254580A (en) | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
| CA2100808A1 (en) | 1992-10-01 | 1994-04-02 | Vittorio Farina | Deoxy paclitaxels |
| FR2696461B1 (fr) | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent. |
| CA2109861C (en) * | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| IL107950A (en) | 1992-12-15 | 2001-04-30 | Upjohn Co | 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| MX9308012A (es) | 1992-12-24 | 1994-08-31 | Bristol Myers Squibb Co | Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen. |
| US6593482B2 (en) * | 1993-02-01 | 2003-07-15 | Aventis Pharma S.A. | Methods for preparing new taxoids and pharmaceutical compositions containing them |
| FR2702212B1 (fr) | 1993-03-02 | 1995-04-07 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US5703247A (en) | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| US5475011A (en) | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| IT1261667B (it) | 1993-05-20 | 1996-05-29 | Tassano ad attivita' antitumorale. | |
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| MA23823A1 (fr) | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
| FR2732342B1 (fr) | 1995-04-03 | 1997-04-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2732968B1 (fr) | 1995-04-14 | 1997-05-16 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
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| WO1997009979A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| US5767297A (en) | 1997-02-05 | 1998-06-16 | Ensuiko Sugar Refining Co., Ltd. | Taxoid derivative and method of producing thereof |
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| US6576636B2 (en) | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
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| AU710156B2 (en) | 1996-07-15 | 1999-09-16 | Kabushiki Kaisha Yakult Honsha | Taxane derivatives and drugs containing the same |
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| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
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| JPH1192468A (ja) | 1997-09-17 | 1999-04-06 | Yakult Honsha Co Ltd | 新規なタキサン誘導体 |
| WO1999032473A1 (en) | 1997-12-19 | 1999-07-01 | Kabushiki Kaisha Yakult Honsha | Taxane derivatives |
| US6156789A (en) | 1998-03-17 | 2000-12-05 | Rhone-Poulenc Rorer S.A. | Method for treating abnormal cell proliferation in the brain |
| JP2003026673A (ja) | 1999-03-05 | 2003-01-29 | Asahi Kasei Corp | 骨形成促進剤 |
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| US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| JP2003522171A (ja) | 2000-02-02 | 2003-07-22 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 抗腫瘍剤としてのｃ１０カーボネート置換タキサン |
| HUP0600302A2 (en) | 2000-02-02 | 2006-07-28 | Univ Florida State Res Found | C10 ester substituted taxanes as antitumor agents |
| KR20010111580A (ko) | 2000-02-02 | 2001-12-19 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 개선된 용해도를 갖는 탁산 제형물 |
| CA2367661A1 (en) | 2000-02-02 | 2001-08-09 | Robert A. Holton | Taxane formulations having improved solubility |
| IT1319168B1 (it) | 2000-03-17 | 2003-09-26 | Indena Spa | Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono. |
| JP4717252B2 (ja) * | 2001-04-25 | 2011-07-06 | 株式会社小松製作所 | プレスのスライド駆動装置 |
| CA2354471A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 ester substituted taxanes |
| JP2008530122A (ja) | 2005-02-14 | 2008-08-07 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | Ｃ１０シクロプロピルエステル置換タキサン組成物 |
| CA2808297C (en) * | 2010-08-13 | 2018-09-18 | Roilblue Corporation | Oil containment assembly and method of using same |
-
2005
- 2005-02-11 HN HN2005000054A patent/HN2005000054A/es unknown
- 2005-02-11 PE PE2005000166A patent/PE20050693A1/es not_active Application Discontinuation
- 2005-02-11 SV SV2005002010A patent/SV2006002010A/es not_active Application Discontinuation
- 2005-02-14 US US11/057,703 patent/US7589111B2/en not_active Expired - Fee Related
- 2005-02-14 AU AU2005214065A patent/AU2005214065B2/en not_active Ceased
- 2005-02-14 BR BRPI0507671-4A patent/BRPI0507671A/pt not_active IP Right Cessation
- 2005-02-14 CA CA2556200A patent/CA2556200C/en not_active Expired - Fee Related
- 2005-02-14 AR ARP050100515A patent/AR047704A1/es unknown
- 2005-02-14 DE DE602005024518T patent/DE602005024518D1/de not_active Expired - Lifetime
- 2005-02-14 WO PCT/US2005/004442 patent/WO2005079319A2/en not_active Ceased
- 2005-02-14 AT AT05713407T patent/ATE486596T1/de not_active IP Right Cessation
- 2005-02-14 KR KR1020067016219A patent/KR101169818B1/ko not_active Expired - Fee Related
- 2005-02-14 JP JP2006553281A patent/JP4879757B2/ja not_active Expired - Fee Related
- 2005-02-14 TW TW094104216A patent/TWI353354B/zh not_active IP Right Cessation
- 2005-02-14 NZ NZ548769A patent/NZ548769A/en not_active IP Right Cessation
- 2005-02-14 EP EP05713407A patent/EP1713798B1/en not_active Expired - Lifetime
- 2005-02-14 RU RU2006132741/04A patent/RU2006132741A/ru not_active Application Discontinuation
-
2006
- 2006-08-08 IL IL177372A patent/IL177372A/en not_active IP Right Cessation
- 2006-08-09 CR CR8554A patent/CR8554A/es unknown
- 2006-08-10 EC EC2006006765A patent/ECSP066765A/es unknown
- 2006-09-12 NO NO20064090A patent/NO20064090L/no not_active Application Discontinuation
-
2009
- 2009-08-10 US US12/538,409 patent/US8003812B2/en not_active Expired - Fee Related
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