BRPI0507671A - taxanos substituìdos com éster de ciclopentila em c10 - Google Patents

taxanos substituìdos com éster de ciclopentila em c10

Info

Publication number
BRPI0507671A
BRPI0507671A BRPI0507671-4A BRPI0507671A BRPI0507671A BR PI0507671 A BRPI0507671 A BR PI0507671A BR PI0507671 A BRPI0507671 A BR PI0507671A BR PI0507671 A BRPI0507671 A BR PI0507671A
Authority
BR
Brazil
Prior art keywords
substituent
cyclopentyl ester
ester substituted
substituted taxanes
taxanes
Prior art date
Application number
BRPI0507671-4A
Other languages
English (en)
Inventor
Robert A Holton
Phong Vu
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of BRPI0507671A publication Critical patent/BRPI0507671A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)

Abstract

TAXANOS SUBSTITUìDOS COM éSTER DE CICLOPENTILA EM C10. A presente invenção se refere-se a um taxano tendo um substituinte de éster de ciclopentila em C10, um substituinte e ceto em C9, um substituinte de hidróxi em C2, um substituinte de 2- tienila em C3' e um substituinte de isopropoxicarbamento em C3.
BRPI0507671-4A 2004-02-13 2005-02-14 taxanos substituìdos com éster de ciclopentila em c10 BRPI0507671A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54475504P 2004-02-13 2004-02-13
US61350304P 2004-09-27 2004-09-27
PCT/US2005/004442 WO2005079319A2 (en) 2004-02-13 2005-02-14 C10 cyclopentyl ester substituted taxanes

Publications (1)

Publication Number Publication Date
BRPI0507671A true BRPI0507671A (pt) 2007-07-17

Family

ID=34890477

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507671-4A BRPI0507671A (pt) 2004-02-13 2005-02-14 taxanos substituìdos com éster de ciclopentila em c10

Country Status (22)

Country Link
US (2) US7589111B2 (pt)
EP (1) EP1713798B1 (pt)
JP (1) JP4879757B2 (pt)
KR (1) KR101169818B1 (pt)
AR (1) AR047704A1 (pt)
AT (1) ATE486596T1 (pt)
AU (1) AU2005214065B2 (pt)
BR (1) BRPI0507671A (pt)
CA (1) CA2556200C (pt)
CR (1) CR8554A (pt)
DE (1) DE602005024518D1 (pt)
EC (1) ECSP066765A (pt)
HK (1) HK1097534A1 (pt)
HN (1) HN2005000054A (pt)
IL (1) IL177372A (pt)
NO (1) NO20064090L (pt)
NZ (1) NZ548769A (pt)
PE (1) PE20050693A1 (pt)
RU (1) RU2006132741A (pt)
SV (1) SV2006002010A (pt)
TW (1) TWI353354B (pt)
WO (1) WO2005079319A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1303077C (zh) * 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 合成紫杉烷的制备工艺
JP4833126B2 (ja) * 2007-03-26 2011-12-07 Ｎｔｎ株式会社 潤滑剤劣化検出装置および検出装置付き軸受
CN113209287B (zh) * 2021-02-04 2022-07-08 中国农业科学院农业环境与可持续发展研究所 油包水型纳米疫苗佐剂、制备方法及其应用

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5714512A (en) * 1991-07-08 1998-02-03 Rhone-Poulenc Rorer, S.A. Compositions containing taxane derivatives
SG46582A1 (en) * 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
WO1993006079A1 (en) 1991-09-23 1993-04-01 Florida State University PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND β-LACTAMS
US5250683A (en) 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5274124A (en) * 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5445908A (en) 1991-10-17 1995-08-29 Matsushita Electric Industrial Co., Ltd. Alkaline dry cell
ES2149800T3 (es) * 1992-01-15 2000-11-16 Squibb & Sons Inc Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermediarios en la preparacion de taxanos.
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
FR2691460B1 (fr) 1992-05-21 1994-07-22 Rhone Poulenc Rorer Sa Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent.
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
CA2100808A1 (en) 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
FR2696461B1 (fr) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent.
CA2109861C (en) * 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
MX9307777A (es) 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
MX9308012A (es) 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
US6593482B2 (en) * 1993-02-01 2003-07-15 Aventis Pharma S.A. Methods for preparing new taxoids and pharmaceutical compositions containing them
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) * 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
SI0703909T1 (en) * 1993-06-11 2000-08-31 Pharmacia & Upjohn Company Delta 6,7 -taxols antineoplastic use and pharmaceutical compositions containing them
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) * 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
WO1995004154A1 (en) 1993-07-27 1995-02-09 Nippon Steel Corporation Process for producing taxol and its analogues using microorganisms
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
HU222496B1 (hu) * 1994-07-26 2003-07-28 Indena S.P.A. Félszintetikus taxánszármazékok, eljárás ezek előállítására, valamint ezeket tartalmazó gyógyászati készítmények
WO1996013495A1 (en) 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
US6100411A (en) 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
JPH09509431A (ja) 1994-11-04 1997-09-22 フアルマシア・エツセ・ピー・アー タキサン誘導体
MA23823A1 (fr) * 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
FR2732342B1 (fr) 1995-04-03 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2732968B1 (fr) * 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5780653A (en) * 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
US5760251A (en) 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
WO1997009979A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
US5767297A (en) * 1997-02-05 1998-06-16 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
EP0927175A4 (en) 1996-05-06 2002-05-22 Univ Florida State 1-DEOXYBACCATIN III, 1-DEOXYTAXOL AND 1-DEOXYTAXOL ANALOG AND METHOD FOR THE PRODUCTION THEREOF
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
DE69703294T2 (de) 1996-05-22 2001-05-17 Protarga Inc Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten
KR100476247B1 (ko) 1996-07-15 2005-03-10 가부시키가이샤 야쿠루트 혼샤 탁산 유도체 및 그를 함유하는 의약
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
CA2206739C (en) 1997-06-03 2006-10-10 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
JPH1192468A (ja) 1997-09-17 1999-04-06 Yakult Honsha Co Ltd 新規なタキサン誘導体
CN1221539C (zh) 1997-12-19 2005-10-05 株式会社益力多本社 紫杉烷衍生物
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
JP2003026673A (ja) 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤
BR0104779A (pt) * 2000-02-02 2001-12-26 Univ Florida State Res Found Taxanos substituìdos com carbonato c10 comoagentes antitumor
MXPA01009906A (es) * 2000-02-02 2003-07-28 Univ Florida State Res Found Taxanos sustituidos con carbonato en c7 como agentes.
NZ514073A (en) 2000-02-02 2004-02-27 Univ Florida State Res Found Taxane formulations having improved solubility
CZ20013498A3 (cs) * 2000-02-02 2002-04-17 Florida State University Research Foundation, Inc. Taxanové formulace mající zlepąenou rozpustnost
AU782150B2 (en) 2000-02-02 2005-07-07 Florida State University Research Foundation, Inc. C10 ester substituted taxanes as antitumor agents
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
IT1319168B1 (it) 2000-03-17 2003-09-26 Indena Spa Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.
JP4717252B2 (ja) * 2001-04-25 2011-07-06 株式会社小松製作所 プレスのスライド駆動装置
CA2354471A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 ester substituted taxanes
US20060189679A1 (en) 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
CA2808297C (en) * 2010-08-13 2018-09-18 Roilblue Corporation Oil containment assembly and method of using same

Also Published As

Publication number Publication date
CR8554A (es) 2008-04-25
US7589111B2 (en) 2009-09-15
WO2005079319A3 (en) 2005-11-17
KR20060129018A (ko) 2006-12-14
ATE486596T1 (de) 2010-11-15
SV2006002010A (es) 2006-08-23
TWI353354B (en) 2011-12-01
TW200530209A (en) 2005-09-16
IL177372A (en) 2011-09-27
NZ548769A (en) 2009-10-30
EP1713798B1 (en) 2010-11-03
WO2005079319A2 (en) 2005-09-01
US8003812B2 (en) 2011-08-23
CA2556200A1 (en) 2005-09-01
CA2556200C (en) 2012-06-26
US20050228037A1 (en) 2005-10-13
KR101169818B1 (ko) 2012-07-30
EP1713798A4 (en) 2007-12-05
PE20050693A1 (es) 2005-09-27
RU2006132741A (ru) 2008-03-20
EP1713798A2 (en) 2006-10-25
AU2005214065B2 (en) 2009-11-12
NO20064090L (no) 2006-11-10
JP4879757B2 (ja) 2012-02-22
AU2005214065A1 (en) 2005-09-01
AR047704A1 (es) 2006-02-08
HN2005000054A (es) 2009-02-18
JP2007522236A (ja) 2007-08-09
HK1097534A1 (en) 2007-06-29
US20100056614A1 (en) 2010-03-04
DE602005024518D1 (en) 2010-12-16
AU2005214065A2 (en) 2005-09-01
ECSP066765A (es) 2006-12-29
IL177372A0 (en) 2006-12-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2308 DE 31/03/2015.