RU2006105011A - Полутвердые системы, содержащие производные азетидина - Google Patents
Полутвердые системы, содержащие производные азетидина Download PDFInfo
- Publication number
- RU2006105011A RU2006105011A RU2006105011/15A RU2006105011A RU2006105011A RU 2006105011 A RU2006105011 A RU 2006105011A RU 2006105011/15 A RU2006105011/15 A RU 2006105011/15A RU 2006105011 A RU2006105011 A RU 2006105011A RU 2006105011 A RU2006105011 A RU 2006105011A
- Authority
- RU
- Russia
- Prior art keywords
- azetidine
- composition according
- active ingredient
- derivative
- enhancing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (9)
1. Стабильная фармацевтическая композиция, содержащая, по меньшей мере, одно производное азетидина общей формулы
в котором Ar - это ароматическая или гетероароматическая группа, необязательно замещенная одним или более (C1-C4)алкилом, галогеном, NO2, CN, (C1-C4)алкокси или OH группами, необязательно в комбинации с другим активным ингредиентом, способным усиливать действия производного азетидина общей формулы (Ia) или (Ib), в системе, содержащей полимерный полутвердый материал, которым является Витамин E TPGS®.
2. Фармацевтическая композиция по п.1, в которой, по меньшей мере, одним производным азетидина является соединение
3. Фармацевтическая композиция по п.1, в которой препаративная форма содержит до 200 мг производного азетидина на грамм.
4. Препаративная композиция согласно одному из пп.1-3, который кроме того содержит дополнительную добавку, выбранную из стабилизаторов, консервантов, средств, регулирующих вязкость, или средств, которые могут, например, модифицировать органолептические свойства.
5. Фармацевтическая композиция согласно п.1, в котором активный ингредиент получен из азетидина присутствует в количестве от 0,01 до 70% от общего веса композиции.
6. Способ получения композиций согласно одному из пп.1-5, в котором получают, когда это приемлемо, смесь основных наполнителей, если необходимо, после нагревания в случае твердых или полутвердых наполнителей, и затем, если необходимо, смешивают с дополнительными добавками, и затем добавляют производные азетидина, согласно п.1, и, когда это приемлемо, добавляют активный ингредиент, способный усиливать действия производного азетидина общей формулы (Ia) или (Ib), определенного в п.1, и осуществляют перемешивание для получения гомогенной смеси.
7. Набор, содержащий композицию согласно п.1 или 2 и композицию, содержащую активный ингредиент, способный усиливать действия производного азетидина, определенного в п.1.
8. Набор по п.7, в котором активным ингредиентом, способным усиливать действия производного азетидина, является сибутрамин.
9. Набор, содержащий композицию согласно п.1 или 2 и композицию, содержащую средство, которое активирует дофаминергическую нейропередачу в мозге.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291796A EP1498122A1 (en) | 2003-07-18 | 2003-07-18 | Semi-solid systems containing azetidine derivatives |
| EP03291796.5 | 2003-07-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006105011A true RU2006105011A (ru) | 2006-06-10 |
| RU2343915C2 RU2343915C2 (ru) | 2009-01-20 |
Family
ID=33462259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006105011/15A RU2343915C2 (ru) | 2003-07-18 | 2004-07-08 | Полутвердые системы, содержащие производные азетидина |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US20050026898A1 (ru) |
| EP (2) | EP1498122A1 (ru) |
| JP (1) | JP2009513560A (ru) |
| KR (1) | KR20060040691A (ru) |
| CN (1) | CN1822831A (ru) |
| AR (1) | AR045997A1 (ru) |
| AU (1) | AU2004262498B2 (ru) |
| BR (1) | BRPI0412737A (ru) |
| CA (1) | CA2532669A1 (ru) |
| CR (1) | CR8179A (ru) |
| EC (1) | ECSP066292A (ru) |
| GT (1) | GT200400135A (ru) |
| HR (1) | HRP20060022A2 (ru) |
| IL (1) | IL173111A0 (ru) |
| MA (1) | MA27922A1 (ru) |
| MX (1) | MXPA06000483A (ru) |
| MY (1) | MY142077A (ru) |
| NO (1) | NO20060509L (ru) |
| OA (1) | OA13191A (ru) |
| PA (1) | PA8606701A1 (ru) |
| PE (1) | PE20050287A1 (ru) |
| RS (1) | RS20060016A (ru) |
| RU (1) | RU2343915C2 (ru) |
| SG (1) | SG144141A1 (ru) |
| TN (1) | TNSN06013A1 (ru) |
| TW (1) | TW200522945A (ru) |
| UA (1) | UA80633C2 (ru) |
| UY (1) | UY28421A1 (ru) |
| WO (1) | WO2005013973A1 (ru) |
| ZA (1) | ZA200600490B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070084531A (ko) * | 2004-11-24 | 2007-08-24 | 머크 앤드 캄파니 인코포레이티드 | 치환된 아미드의 경구 투여용 액체 및 반고체 약제학적제형 |
| FR2923719B1 (fr) * | 2007-11-15 | 2009-11-20 | Sanofi Aventis | Compositions pharmaceutiques a base de derives d'azetidine |
| CN101926757B (zh) * | 2010-09-01 | 2013-01-02 | 北京大学 | 一种难溶性药物的液体组合物及其制备方法 |
| RU2603833C2 (ru) * | 2010-11-08 | 2016-11-27 | Кадила Фармасьютикалз Лимитед | Фармацевтическая композиция таксоидов |
| CN105848643A (zh) * | 2013-12-23 | 2016-08-10 | 强生消费者公司 | 消旋卡多曲组合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0825849A1 (en) * | 1995-05-19 | 1998-03-04 | Abbott Laboratories | Self-emulsifying formulations of lipophilic drugs |
| WO2000003753A2 (en) * | 1998-07-14 | 2000-01-27 | Em Industries, Inc. | Microdisperse drug delivery systems |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6355631B1 (en) * | 2000-03-03 | 2002-03-12 | Aventis Pharma S.A. | Pharmaceutical compositions containing azetidine derivatives, novel azetidine derivatives and their preparation |
| FR2814678B1 (fr) * | 2000-10-04 | 2002-12-20 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite |
| FR2829027A1 (fr) * | 2001-08-29 | 2003-03-07 | Aventis Pharma Sa | Association avec un antagoniste du recepteur cb1, les compositions pharmaceutiques les contenant et leur utilisation pour le traitement de la maladie de parkinson |
| FR2833842B1 (fr) * | 2001-12-21 | 2004-02-13 | Aventis Pharma Sa | Compositions pharmaceutiques a base de derives d'azetidine |
| EP1498123A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Emulsifying systems containing azetidine derivatives |
-
2003
- 2003-07-18 EP EP03291796A patent/EP1498122A1/en not_active Withdrawn
-
2004
- 2004-07-01 PE PE2004000634A patent/PE20050287A1/es not_active Application Discontinuation
- 2004-07-08 CA CA002532669A patent/CA2532669A1/en not_active Abandoned
- 2004-07-08 JP JP2006519901A patent/JP2009513560A/ja active Pending
- 2004-07-08 CN CNA2004800206441A patent/CN1822831A/zh active Pending
- 2004-07-08 AU AU2004262498A patent/AU2004262498B2/en not_active Ceased
- 2004-07-08 WO PCT/EP2004/008553 patent/WO2005013973A1/en active Application Filing
- 2004-07-08 KR KR1020067001148A patent/KR20060040691A/ko not_active Application Discontinuation
- 2004-07-08 EP EP04763639A patent/EP1648442A1/en not_active Withdrawn
- 2004-07-08 OA OA1200600018A patent/OA13191A/en unknown
- 2004-07-08 RS YUP-2006/0016A patent/RS20060016A/sr unknown
- 2004-07-08 BR BRPI0412737-4A patent/BRPI0412737A/pt not_active IP Right Cessation
- 2004-07-08 SG SG200804303-6A patent/SG144141A1/en unknown
- 2004-07-08 RU RU2006105011/15A patent/RU2343915C2/ru not_active IP Right Cessation
- 2004-07-08 MX MXPA06000483A patent/MXPA06000483A/es not_active Application Discontinuation
- 2004-07-13 US US10/889,713 patent/US20050026898A1/en not_active Abandoned
- 2004-07-14 PA PA20048606701A patent/PA8606701A1/es unknown
- 2004-07-15 AR ARP040102495A patent/AR045997A1/es not_active Application Discontinuation
- 2004-07-16 GT GT200400135A patent/GT200400135A/es unknown
- 2004-07-16 TW TW093121229A patent/TW200522945A/zh unknown
- 2004-07-16 MY MYPI20042869A patent/MY142077A/en unknown
- 2004-07-16 UY UY28421A patent/UY28421A1/es unknown
- 2004-08-07 UA UAA200601708A patent/UA80633C2/uk unknown
-
2006
- 2006-01-06 CR CR8179A patent/CR8179A/es not_active Application Discontinuation
- 2006-01-12 IL IL173111A patent/IL173111A0/en unknown
- 2006-01-16 MA MA28726A patent/MA27922A1/fr unknown
- 2006-01-17 TN TNP2006000013A patent/TNSN06013A1/en unknown
- 2006-01-17 EC EC2006006292A patent/ECSP066292A/es unknown
- 2006-01-17 HR HR20060022A patent/HRP20060022A2/hr not_active Application Discontinuation
- 2006-01-17 ZA ZA200600490A patent/ZA200600490B/en unknown
- 2006-01-31 NO NO20060509A patent/NO20060509L/no not_active Application Discontinuation
-
2008
- 2008-07-28 US US12/180,691 patent/US20080293686A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20100709 |