RU2005134908A - Новые соединения с 14- и 15-членными кольцами - Google Patents
Новые соединения с 14- и 15-членными кольцами Download PDFInfo
- Publication number
- RU2005134908A RU2005134908A RU2005134908/04A RU2005134908A RU2005134908A RU 2005134908 A RU2005134908 A RU 2005134908A RU 2005134908/04 A RU2005134908/04 A RU 2005134908/04A RU 2005134908 A RU2005134908 A RU 2005134908A RU 2005134908 A RU2005134908 A RU 2005134908A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- optionally substituted
- represents hydrogen
- group
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 26
- 125000000217 alkyl group Chemical group 0.000 claims 59
- 229910052739 hydrogen Inorganic materials 0.000 claims 39
- 239000001257 hydrogen Substances 0.000 claims 39
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 22
- 125000000623 heterocyclic group Chemical group 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 19
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 150000002431 hydrogen Chemical class 0.000 claims 17
- -1 2 - {[2- (3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinolin-7-ylamino) ethyl] methylamino} ethyl Chemical group 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 6
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 5
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 5
- 238000006243 chemical reaction Methods 0.000 claims 5
- 229960002626 clarithromycin Drugs 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 5
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 4
- 229960004099 azithromycin Drugs 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 3
- 230000000813 microbial effect Effects 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 125000003302 alkenyloxy group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 229960003276 erythromycin Drugs 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 125000004001 thioalkyl group Chemical group 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0310986.5A GB0310986D0 (en) | 2003-05-13 | 2003-05-13 | Novel compounds |
| GB0310986.5 | 2003-05-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2005134908A true RU2005134908A (ru) | 2006-06-27 |
Family
ID=9957984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005134908/04A RU2005134908A (ru) | 2003-05-13 | 2004-05-11 | Новые соединения с 14- и 15-членными кольцами |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7569550B2 (enExample) |
| EP (1) | EP1628988B1 (enExample) |
| JP (1) | JP2007502313A (enExample) |
| KR (1) | KR20060026407A (enExample) |
| CN (1) | CN1849328A (enExample) |
| AR (1) | AR044309A1 (enExample) |
| AT (1) | ATE341560T1 (enExample) |
| AU (1) | AU2004238528A1 (enExample) |
| BR (1) | BRPI0410246A (enExample) |
| CA (1) | CA2525452A1 (enExample) |
| CL (1) | CL2004001010A1 (enExample) |
| DE (1) | DE602004002696T2 (enExample) |
| DK (1) | DK1628988T3 (enExample) |
| ES (1) | ES2273255T3 (enExample) |
| GB (1) | GB0310986D0 (enExample) |
| HR (1) | HRP20060448T3 (enExample) |
| MX (1) | MXPA05012163A (enExample) |
| PL (1) | PL1628988T3 (enExample) |
| PT (1) | PT1628988E (enExample) |
| RU (1) | RU2005134908A (enExample) |
| WO (1) | WO2004101586A1 (enExample) |
| ZA (1) | ZA200509079B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0424961D0 (en) * | 2004-11-11 | 2004-12-15 | Glaxo Group Ltd | Novel compounds |
| GB0424958D0 (en) * | 2004-11-11 | 2004-12-15 | Glaxo Group Ltd | Novel compounds |
| EP1851236B1 (en) * | 2005-01-13 | 2010-08-04 | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. | Macrolides with anti-inflammatory activity |
| WO2006120541A1 (en) * | 2005-05-10 | 2006-11-16 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Ether linked macrolides useful for the treatment of microbial infections |
| PE20070802A1 (es) * | 2005-11-09 | 2007-10-19 | Glaxo Group Ltd | Derivados de eritromicina 4''-sustituidos como agentes antimicrobianos |
| EP1945652A1 (en) * | 2005-11-09 | 2008-07-23 | Glaxo Group Limited | Macrolones |
| EP2384333B1 (en) | 2009-01-30 | 2013-04-17 | Glaxo Group Limited | Anti-inflammatory macrolide |
| CN111574575B (zh) * | 2020-04-29 | 2022-05-17 | 北京理工大学 | 一种含有大环内酯基的喹喏酮衍生物、制备方法及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE128714T1 (de) * | 1989-03-28 | 1995-10-15 | Abbott Lab | Erythromycinderivate. |
| WO1996034007A1 (es) * | 1995-04-27 | 1996-10-31 | Laboratorios Aranda, S.A. De C.V. | Derivados de quinolonilcarboxieritromicina y composiciones farmaceuticas que los contienen |
| CA2253451A1 (en) * | 1996-05-07 | 1997-11-13 | Abbott Laboratories | 3-descladinose-2,3-anhydroerythromycin derivatives |
| GB0025688D0 (en) * | 2000-10-19 | 2000-12-06 | Glaxo Group Ltd | Macrolides |
| WO2003014136A1 (en) * | 2001-08-08 | 2003-02-20 | Taisho Pharmaceutical Co., Ltd. | 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME |
| GB0127349D0 (en) * | 2001-11-14 | 2002-01-02 | Glaxo Group Ltd | Macrolides |
-
2003
- 2003-05-13 GB GBGB0310986.5A patent/GB0310986D0/en not_active Ceased
-
2004
- 2004-05-11 RU RU2005134908/04A patent/RU2005134908A/ru not_active Application Discontinuation
- 2004-05-11 CL CL200401010A patent/CL2004001010A1/es unknown
- 2004-05-11 AT AT04732102T patent/ATE341560T1/de not_active IP Right Cessation
- 2004-05-11 HR HR20060448T patent/HRP20060448T3/xx unknown
- 2004-05-11 BR BRPI0410246-0A patent/BRPI0410246A/pt not_active IP Right Cessation
- 2004-05-11 DE DE602004002696T patent/DE602004002696T2/de not_active Expired - Lifetime
- 2004-05-11 CA CA002525452A patent/CA2525452A1/en not_active Abandoned
- 2004-05-11 US US10/556,645 patent/US7569550B2/en not_active Expired - Fee Related
- 2004-05-11 PL PL04732102T patent/PL1628988T3/pl unknown
- 2004-05-11 EP EP04732102A patent/EP1628988B1/en not_active Expired - Lifetime
- 2004-05-11 JP JP2006529794A patent/JP2007502313A/ja active Pending
- 2004-05-11 PT PT04732102T patent/PT1628988E/pt unknown
- 2004-05-11 AU AU2004238528A patent/AU2004238528A1/en not_active Abandoned
- 2004-05-11 DK DK04732102T patent/DK1628988T3/da active
- 2004-05-11 CN CNA2004800192646A patent/CN1849328A/zh active Pending
- 2004-05-11 AR ARP040101614A patent/AR044309A1/es not_active Application Discontinuation
- 2004-05-11 KR KR1020057021593A patent/KR20060026407A/ko not_active Withdrawn
- 2004-05-11 WO PCT/EP2004/005082 patent/WO2004101586A1/en not_active Ceased
- 2004-05-11 ES ES04732102T patent/ES2273255T3/es not_active Expired - Lifetime
- 2004-05-11 MX MXPA05012163A patent/MXPA05012163A/es active IP Right Grant
-
2005
- 2005-11-09 ZA ZA200509079A patent/ZA200509079B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20070185117A1 (en) | 2007-08-09 |
| ATE341560T1 (de) | 2006-10-15 |
| AR044309A1 (es) | 2005-09-07 |
| CA2525452A1 (en) | 2004-11-25 |
| HRP20060448T3 (hr) | 2007-03-31 |
| GB0310986D0 (en) | 2003-06-18 |
| EP1628988A1 (en) | 2006-03-01 |
| MXPA05012163A (es) | 2006-05-19 |
| CL2004001010A1 (es) | 2005-03-18 |
| CN1849328A (zh) | 2006-10-18 |
| DE602004002696T2 (de) | 2007-08-16 |
| PL1628988T3 (pl) | 2007-03-30 |
| ES2273255T3 (es) | 2007-05-01 |
| AU2004238528A1 (en) | 2004-11-25 |
| DK1628988T3 (da) | 2007-02-05 |
| ZA200509079B (en) | 2007-02-28 |
| DE602004002696D1 (de) | 2006-11-16 |
| WO2004101586A1 (en) | 2004-11-25 |
| EP1628988B1 (en) | 2006-10-04 |
| KR20060026407A (ko) | 2006-03-23 |
| BRPI0410246A (pt) | 2006-05-16 |
| JP2007502313A (ja) | 2007-02-08 |
| US7569550B2 (en) | 2009-08-04 |
| PT1628988E (pt) | 2007-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20090211 |