RU2005113692A - Вакцина против hcv - Google Patents
Вакцина против hcv Download PDFInfo
- Publication number
- RU2005113692A RU2005113692A RU2005113692/13A RU2005113692A RU2005113692A RU 2005113692 A RU2005113692 A RU 2005113692A RU 2005113692/13 A RU2005113692/13 A RU 2005113692/13A RU 2005113692 A RU2005113692 A RU 2005113692A RU 2005113692 A RU2005113692 A RU 2005113692A
- Authority
- RU
- Russia
- Prior art keywords
- hcv
- vaccine according
- protein
- hcv vaccine
- polynucleotide
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims 23
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 101710132601 Capsid protein Proteins 0.000 claims 6
- 101710144111 Non-structural protein 3 Proteins 0.000 claims 4
- 101800001554 RNA-directed RNA polymerase Proteins 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 101800001019 Non-structural protein 4B Proteins 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 108060004795 Methyltransferase Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 2
- 239000010931 gold Substances 0.000 claims 2
- 229910052737 gold Inorganic materials 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000004897 n-terminal region Anatomy 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 238000004904 shortening Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/18—Togaviridae; Flaviviridae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
- C12N15/895—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (23)
1. Вакцина против HCV (вирус гепатита С), содержащая полинуклеотид, кодирующий полипептидные последовательности белков HCV: core, NS3, NS4B и NS5B, для применения в медицине, где данный полинуклеотид не кодирует другой белок HCV.
2. Вакцина против HCV по п.1, где полинуклеотид кодирует core-белок, который укорочен с карбоксильного конца в количестве, достаточном для уменьшения ингибиторного эффекта core на экспрессию других белков HCV.
3. Вакцина против HCV по п.2, где укороченный core-белок имеет делецию по меньшей мере 10 С-концевых аминокислот.
4. Вакцина против HCV по п.3, где укороченный core-белок состоит из последовательности Core1-151.
5. Вакцина против HCV по п.3, где укороченный core-белок состоит из последовательности Core1-165.
6. Вакцина против HCV по п.1, где белки HCV присутствуют в форме слитого белка, содержащего один или более чем один белок HCV.
7. Вакцина против HCV по п.6, где слитый белок представляет собой двойное слияние, состоящее из полипептидных последовательностей NS4B и NS5B.
8. Вакцина против HCV по п.6, где слитый белок представляет собой двойное слияние, состоящее из полипептидных последовательностей NS3 и Core.
9. Вакцина против HCV по п.1, где белки HCV кодируются полинуклеотидом в более чем одной экспрессионной кассете.
10. Вакцина против HCV по п.9, где экспрессионная кассета, кодирующая core-белок, находится в цис-положении в прямом направлении относительно экспрессионной кассеты, кодирующей по меньшей мере один из других белков HCV.
11. Вакцина против HCV по п.10, где экспрессионная кассета, кодирующая core-белок, находится в прямом направлении относительно экспрессионной кассеты, кодирующей белок NS5B.
12. Вакцина против HCV по п.1, где по меньшей мере один из присутствующих белков HCV инактивирован посредством мутации.
13. Вакцина против HCV по п.12, где полинуклеотид кодирует белок NS5B, содержащий мутацию в мотиве А.
14. Вакцина против HCV по п.12, где полинуклеотид кодирует белок NS3, в котором протеазная активность аннулирована посредством мутации в любой из аминокислот каталитической триады.
15. Вакцина против HCV по п.12, где полинуклеотид кодирует белок NS3, в котором геликазная активность аннулирована посредством мутации в одном или более чем одном геликазном мотиве I, II, III или IV.
16. Вакцина против HCV по п.12, где полинуклеотид кодирует белок NS4B, содержащий укорочение с целью удаления высоковариабельного N-концевого участка.
17. Вакцина против HCV по любому из пп.1-16, кодирующая любую из комбинаций HCV от 1 до 19.
18. Вакцина против HCV по п.1, где полинуклеотид представляет собой последовательность ДНК.
19. Вакцина против HCV по п.18, где последовательность ДНК находится в форме плазмиды.
20. Вакцина по п.1, где олигонуклеотиды кодон-оптимизированы для экспрессии в клетках млекопитающих.
21. Способ предупреждения или лечения HCV-инфекции у млекопитающего, включающий введение млекопитающему вакцины по любому из пп.1-17.
22. Способ вакцинации индивидуума, при котором берут полинуклеотидную вакцину по любому из пп.1-17, наносят данный полинуклеотид на золотые гранулы и эти золотые гранулы доставляют в кожу.
23. Применение вакцины против HCV по любому из пп.1-17 в изготовлении лекарства для лечения HCV.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0226722.7 | 2002-11-15 | ||
| GBGB0226722.7A GB0226722D0 (en) | 2002-11-15 | 2002-11-15 | Vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005113692A true RU2005113692A (ru) | 2006-01-27 |
| RU2323744C2 RU2323744C2 (ru) | 2008-05-10 |
Family
ID=9947928
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005113692/13A RU2323744C2 (ru) | 2002-11-15 | 2003-11-13 | Вакцина против hcv |
| RU2005113691/13A RU2363492C2 (ru) | 2002-11-15 | 2003-11-13 | Вакцина |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005113691/13A RU2363492C2 (ru) | 2002-11-15 | 2003-11-13 | Вакцина |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US20060135451A1 (ru) |
| EP (2) | EP1560844A1 (ru) |
| JP (2) | JP2006524181A (ru) |
| KR (2) | KR20050085009A (ru) |
| CN (2) | CN1738834A (ru) |
| AR (1) | AR041964A1 (ru) |
| AU (2) | AU2003288084A1 (ru) |
| BR (2) | BR0316244A (ru) |
| CA (2) | CA2504715A1 (ru) |
| CO (1) | CO5700833A2 (ru) |
| GB (1) | GB0226722D0 (ru) |
| IS (2) | IS7831A (ru) |
| MA (2) | MA27700A1 (ru) |
| MX (2) | MXPA05005203A (ru) |
| NO (2) | NO20052149L (ru) |
| NZ (2) | NZ539999A (ru) |
| PL (2) | PL376967A1 (ru) |
| RU (2) | RU2323744C2 (ru) |
| TW (1) | TW200502246A (ru) |
| WO (2) | WO2004046176A1 (ru) |
| ZA (2) | ZA200503803B (ru) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| GB0226722D0 (en) * | 2002-11-15 | 2002-12-24 | Glaxo Group Ltd | Vaccine |
| US7439042B2 (en) | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| BRPI0516356A (pt) * | 2004-10-18 | 2008-09-02 | Globeimmune Inc | terapia à base de levedura para infecções crÈnicas da hepatite c |
| ES2551113T3 (es) * | 2006-01-04 | 2015-11-16 | Glaxosmithkline Biologicals S.A. | Proteína E1E2 del VHC adyuvantada con MF59 más vector de alfavirus que codifica E1E2 del VHC para provocar linfocitos T específicos del VHC |
| KR20080113358A (ko) * | 2006-03-09 | 2008-12-30 | 트랜스진 에스.에이. | Ｃ형 간염 바이러스 비구조 융합 단백질 |
| JP2009544322A (ja) * | 2006-07-27 | 2009-12-17 | リゴサイト ファーマシューティカルズ インコーポレイテッド | キメラウイルス様粒子 |
| WO2008094197A2 (en) | 2006-07-27 | 2008-08-07 | Ligocyte Pharmaceuticals, Inc. | Chimeric influenza virus-like particles |
| KR100759106B1 (ko) * | 2007-02-14 | 2007-09-19 | 이화여자대학교 산학협력단 | 초미세 전기기계 시스템 미러에서 미러 판을 정전 구동부와 결합하는 방법 |
| EP2185195A2 (en) | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen platform |
| CA2722423A1 (en) * | 2008-04-22 | 2009-10-29 | Rutgers, The State University | Hcv e2 construct compositions and methods |
| US9758794B2 (en) | 2008-04-22 | 2017-09-12 | Rutgers, The State University Of New Jersey | HCV E2 construct compositions and methods |
| JP2011529077A (ja) * | 2008-07-24 | 2011-12-01 | アデュロ バイオテック | Ｃ型肝炎の治療のための組成物および方法 |
| WO2010033841A1 (en) | 2008-09-19 | 2010-03-25 | Globeimmune, Inc. | Immunotherapy for chronic hepatitis c virus infection |
| CN101748151B (zh) * | 2008-12-19 | 2012-10-17 | 深圳市源兴生物医药科技有限公司 | 一种重组人丙肝病毒抗原腺病毒载体及其应用 |
| JP2010168288A (ja) * | 2009-01-20 | 2010-08-05 | Yokohama City Univ | 最適化した抗原遺伝子の使用によるウイルスワクチンの免疫原性の増強 |
| JP5917402B2 (ja) | 2009-11-03 | 2016-05-11 | タケダ ヴァクシーンズ， インコーポレイテッド | キメラＲＳＶ−Ｆポリペプチド、およびレンチウイルスＧａｇまたはアルファレトロウイルスＧａｇに基づくＶＬＰ |
| CN102233137B (zh) * | 2010-04-30 | 2013-02-20 | 北京凯因科技股份有限公司 | 一种用于治疗乙型肝炎的重组质粒dna疫苗组合物 |
| CN105658790A (zh) | 2013-02-21 | 2016-06-08 | 东安大略研究所儿童医院有限公司 | 疫苗组合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297048B1 (en) * | 1992-02-04 | 2001-10-02 | Chiron Corporation | Hepatitis therapeutics |
| WO1996010997A1 (en) * | 1994-10-05 | 1996-04-18 | Apollon, Inc. | Hepatitis virus vaccines |
| IL118364A0 (en) * | 1995-05-22 | 1996-09-12 | Bionova Corp | A hepatitis C virus-derived composition methods for the preparation thereof and assays for the detection of hepatitis C virus |
| JP2002500502A (ja) * | 1996-06-11 | 2002-01-08 | メルク エンド カンパニー インコーポレーテッド | 合成ｃ型肝炎遺伝子 |
| US7052696B2 (en) * | 1998-07-10 | 2006-05-30 | The United States Of America As Represented By The Department Of Health And Human Services | Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins |
| EP1200465A1 (en) * | 1999-07-09 | 2002-05-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by The Secretary, Department of Health and Human Services | Antigenic epitopes and mosaic polypeptides of hepatitis c virus proteins |
| US6562346B1 (en) * | 1999-10-27 | 2003-05-13 | Chiron Corporation | Activation of HCV-specific T cells |
| ATE376558T1 (de) * | 1999-11-24 | 2007-11-15 | Novartis Vaccines & Diagnostic | Neues nichtstrukturelles hcv polypeptid |
| FI116851B (fi) * | 2001-05-03 | 2006-03-15 | Fit Biotech Oyj Plc | Ilmentämisvektori, sen käyttöjä ja menetelmä sen valmistamiseksi sekä sitä sisältäviä tuotteita |
| GB0226722D0 (en) * | 2002-11-15 | 2002-12-24 | Glaxo Group Ltd | Vaccine |
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2002
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