RU2004122622A - Производные авермектина в1, содержащие аминосульфонилоксизаместитель в4"-положении - Google Patents
Производные авермектина в1, содержащие аминосульфонилоксизаместитель в4"-положении Download PDFInfo
- Publication number
- RU2004122622A RU2004122622A RU2004122622/04A RU2004122622A RU2004122622A RU 2004122622 A RU2004122622 A RU 2004122622A RU 2004122622/04 A RU2004122622/04 A RU 2004122622/04A RU 2004122622 A RU2004122622 A RU 2004122622A RU 2004122622 A RU2004122622 A RU 2004122622A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- group
- alkoxy
- phenyl
- unsubstituted
- Prior art date
Links
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical class O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 27
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- 125000004641 (C1-C12) haloalkyl group Chemical group 0.000 claims 4
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 4
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 4
- 125000003302 alkenyloxy group Chemical group 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 125000004643 (C1-C12) haloalkoxy group Chemical group 0.000 claims 3
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 3
- 241000607479 Yersinia pestis Species 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000005133 alkynyloxy group Chemical group 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- -1 methylenedioxy Chemical group 0.000 claims 3
- 244000045947 parasite Species 0.000 claims 3
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000004749 (C1-C6) haloalkylsulfinyl group Chemical group 0.000 claims 1
- 125000004741 (C1-C6) haloalkylsulfonyl group Chemical group 0.000 claims 1
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000005149 cycloalkylsulfinyl group Chemical group 0.000 claims 1
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims 1
- 125000005366 cycloalkylthio group Chemical group 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 claims 1
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims 1
- 125000005347 halocycloalkyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 230000000361 pesticidal effect Effects 0.000 claims 1
- 150000003839 salts Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH23632001 | 2001-12-21 | ||
| CH2363/01 | 2001-12-21 | ||
| CH1190/02 | 2002-07-05 | ||
| CH11902002 | 2002-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004122622A true RU2004122622A (ru) | 2006-01-20 |
Family
ID=25738950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004122622/04A RU2004122622A (ru) | 2001-12-21 | 2002-12-20 | Производные авермектина в1, содержащие аминосульфонилоксизаместитель в4"-положении |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6933260B2 (https=) |
| EP (1) | EP1456218B1 (https=) |
| JP (1) | JP2005513137A (https=) |
| KR (1) | KR20040068335A (https=) |
| CN (1) | CN1608075A (https=) |
| AR (1) | AR037938A1 (https=) |
| AT (1) | ATE397007T1 (https=) |
| AU (1) | AU2002361197A1 (https=) |
| BR (1) | BR0215170A (https=) |
| CA (1) | CA2469905A1 (https=) |
| CO (1) | CO5590963A2 (https=) |
| CY (1) | CY1108269T1 (https=) |
| DE (1) | DE60226895D1 (https=) |
| DK (1) | DK1456218T3 (https=) |
| ES (1) | ES2307823T3 (https=) |
| HU (1) | HUP0402290A2 (https=) |
| IL (1) | IL162452A0 (https=) |
| MA (1) | MA26300A1 (https=) |
| MX (1) | MXPA04006121A (https=) |
| NZ (1) | NZ533584A (https=) |
| PL (1) | PL370835A1 (https=) |
| PT (1) | PT1456218E (https=) |
| RU (1) | RU2004122622A (https=) |
| SI (1) | SI1456218T1 (https=) |
| TW (1) | TW200301079A (https=) |
| WO (1) | WO2003053988A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EG23124A (en) * | 2001-02-27 | 2004-04-28 | Syngenta Participations Ag | Avermectins substituted in the 4-position having pesticidal properties |
| CR6574A (es) * | 2001-02-27 | 2004-10-28 | Syngenta Participations Ag | Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas |
| AR036486A1 (es) | 2001-08-28 | 2004-09-15 | Syngenta Participations Ag | Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion |
| TW200407330A (en) * | 2002-05-07 | 2004-05-16 | Syngenta Participations Ag | 4"-Deoxy-4"-(S)-amido avermectin derivatives |
| GB0302309D0 (en) * | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin monosaccharide derivatives substituted in the 4 -position having pesticidal properties |
| GB0302308D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties |
| GB0302310D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties |
| GB0302547D0 (en) * | 2003-02-04 | 2003-03-12 | Syngenta Participations Ag | Avermectins and avermectin monosaccharide substituted in the 4'- and 4" position having pesticidal properties |
| FR2854071B1 (fr) * | 2003-04-25 | 2009-01-30 | Ethypharm Sa | Procede de dispersion de substances hydrosolubles ou hydrophiles dans un fluide a pression supercritique |
| GB0313937D0 (en) * | 2003-06-16 | 2003-07-23 | Syngenta Participations Ag | Avermectin B1 monosaccharide derivatives having an aminosulfonyloxy substituentin the 4'-position |
| GB0320176D0 (en) * | 2003-08-28 | 2003-10-01 | Syngenta Participations Ag | Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties |
| EP1849363A1 (en) * | 2006-03-09 | 2007-10-31 | Cheminova A/S | Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin |
| EP2568980B1 (en) | 2010-05-12 | 2015-11-11 | Merial, Inc. | Injectable parasiticidal formulations of levamisole and macrocyclic lactones |
| WO2012078605A1 (en) | 2010-12-07 | 2012-06-14 | Merial Limited | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
| CN103936755B (zh) * | 2014-04-08 | 2016-03-23 | 甘肃省农业科学院植物保护研究所 | 一种米尔贝霉素类似物及其制备方法和在农药中的应用 |
| RU2554074C1 (ru) * | 2014-04-18 | 2015-06-27 | Игорь Викторович Заварзин | Антипаразитарный агент |
| RU2554350C1 (ru) * | 2014-04-18 | 2015-06-27 | Игорь Викторович Заварзин | Инсектицидный агент |
| EP4067368A1 (en) | 2016-06-01 | 2022-10-05 | Athira Pharma, Inc. | Compounds |
| CN108690108B (zh) * | 2018-07-27 | 2022-03-11 | 河北威远生物化工有限公司 | 一种磺酰胺基取代的阿维菌素B2a/B2b衍生物及其制备方法与应用 |
| CA3189027A1 (en) | 2020-07-11 | 2022-01-20 | Pfizer Inc. | Antiviral heteroaryl ketone derivatives |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4427663A (en) * | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
-
2002
- 2002-12-19 AR ARP020105025A patent/AR037938A1/es not_active Application Discontinuation
- 2002-12-19 TW TW091136626A patent/TW200301079A/zh unknown
- 2002-12-20 EP EP02796710A patent/EP1456218B1/en not_active Expired - Lifetime
- 2002-12-20 JP JP2003554704A patent/JP2005513137A/ja active Pending
- 2002-12-20 AU AU2002361197A patent/AU2002361197A1/en not_active Abandoned
- 2002-12-20 SI SI200230716T patent/SI1456218T1/sl unknown
- 2002-12-20 DE DE60226895T patent/DE60226895D1/de not_active Expired - Lifetime
- 2002-12-20 AT AT02796710T patent/ATE397007T1/de active
- 2002-12-20 MX MXPA04006121A patent/MXPA04006121A/es unknown
- 2002-12-20 HU HU0402290A patent/HUP0402290A2/hu unknown
- 2002-12-20 PT PT02796710T patent/PT1456218E/pt unknown
- 2002-12-20 KR KR10-2004-7009873A patent/KR20040068335A/ko not_active Withdrawn
- 2002-12-20 WO PCT/EP2002/014671 patent/WO2003053988A2/en not_active Ceased
- 2002-12-20 CN CNA028258835A patent/CN1608075A/zh active Pending
- 2002-12-20 PL PL02370835A patent/PL370835A1/xx not_active Application Discontinuation
- 2002-12-20 NZ NZ533584A patent/NZ533584A/en unknown
- 2002-12-20 RU RU2004122622/04A patent/RU2004122622A/ru not_active Application Discontinuation
- 2002-12-20 ES ES02796710T patent/ES2307823T3/es not_active Expired - Lifetime
- 2002-12-20 US US10/498,858 patent/US6933260B2/en not_active Expired - Lifetime
- 2002-12-20 CA CA002469905A patent/CA2469905A1/en not_active Abandoned
- 2002-12-20 DK DK02796710T patent/DK1456218T3/da active
- 2002-12-20 IL IL16245202A patent/IL162452A0/xx unknown
- 2002-12-20 BR BR0215170-7A patent/BR0215170A/pt not_active Application Discontinuation
-
2004
- 2004-06-15 CO CO04055633A patent/CO5590963A2/es not_active Application Discontinuation
- 2004-07-19 MA MA27793A patent/MA26300A1/fr unknown
-
2008
- 2008-08-18 CY CY20081100877T patent/CY1108269T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL162452A0 (en) | 2005-11-20 |
| CN1608075A (zh) | 2005-04-20 |
| JP2005513137A (ja) | 2005-05-12 |
| SI1456218T1 (sl) | 2008-10-31 |
| CA2469905A1 (en) | 2003-07-03 |
| WO2003053988A3 (en) | 2003-12-11 |
| PT1456218E (pt) | 2008-08-06 |
| AR037938A1 (es) | 2004-12-22 |
| US20050032717A1 (en) | 2005-02-10 |
| CY1108269T1 (el) | 2014-02-12 |
| KR20040068335A (ko) | 2004-07-30 |
| DK1456218T3 (da) | 2008-08-04 |
| DE60226895D1 (de) | 2008-07-10 |
| CO5590963A2 (es) | 2005-12-30 |
| EP1456218B1 (en) | 2008-05-28 |
| PL370835A1 (en) | 2005-05-30 |
| WO2003053988A2 (en) | 2003-07-03 |
| AU2002361197A1 (en) | 2003-07-09 |
| ATE397007T1 (de) | 2008-06-15 |
| NZ533584A (en) | 2005-12-23 |
| ES2307823T3 (es) | 2008-12-01 |
| US6933260B2 (en) | 2005-08-23 |
| BR0215170A (pt) | 2004-10-19 |
| MA26300A1 (fr) | 2004-09-01 |
| EP1456218A2 (en) | 2004-09-15 |
| MXPA04006121A (es) | 2004-10-29 |
| HUP0402290A2 (hu) | 2005-02-28 |
| TW200301079A (en) | 2003-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20060216 |