RU2003134629A - Соединения цефема - Google Patents

Соединения цефема Download PDF

Info

Publication number
RU2003134629A
RU2003134629A RU2003134629/04A RU2003134629A RU2003134629A RU 2003134629 A RU2003134629 A RU 2003134629A RU 2003134629/04 A RU2003134629/04 A RU 2003134629/04A RU 2003134629 A RU2003134629 A RU 2003134629A RU 2003134629 A RU2003134629 A RU 2003134629A
Authority
RU
Russia
Prior art keywords
alkyl
amino
formula
compound
carboxy
Prior art date
Application number
RU2003134629/04A
Other languages
English (en)
Russian (ru)
Inventor
Хиденори ОХКИ (JP) ОХКИ Хиденори (JP)
Хиденори ОХКИ
Синь ОКУДА (JP) ОКУДА Синь (JP)
Синья ОКУДА
Тосио ЯМАНАКА (JP) ЯМАНАКА Тосио (JP)
Тосио ЯМАНАКА
Такаси ОГИНО (умер) ОГИНО Такаси (умер)
Такаси ОГИНО (умер)
Кохдзи КАВАБАТА (JP) КАВАБАТА Кохдзи (JP)
Кохдзи КАВАБАТА
Сатоси ИНОУЕ (JP) ИНОУЕ Сатоси (JP)
Сатоси ИНОУЕ
Кейдзи МИСУМИ (JP) МИСУМИ Кейдзи (JP)
Кейдзи МИСУМИ
Кендзи ИТОХ (JP) ИТОХ Кендзи (JP)
Кендзи ИТОХ
Хисаси АКАМАЦУ (JP) АКАМАЦУ Хисаси (JP)
Хисаси АКАМАЦУ
Кендзи САТОХ (JP) САТОХ Кендзи (JP)
Кендзи САТОХ
Original Assignee
Фудзисава Фармасьютикал Ко., Лтд. (Jp) Фудзисава Фармасьютикал Ко., Лтд. (Jp)
Фудзисава Фармасьютикал Ко., Лтд.
Вакунага Фармасьютикал Ко., Лтд. (Jp) Вакунага Фармасьютикал Ко., Лтд. (Jp)
Вакунага Фармасьютикал КО., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPR4690A external-priority patent/AUPR469001A0/en
Priority claimed from AUPR5834A external-priority patent/AUPR583401A0/en
Application filed by Фудзисава Фармасьютикал Ко., Лтд. (Jp) Фудзисава Фармасьютикал Ко., Лтд. (Jp), Фудзисава Фармасьютикал Ко., Лтд., Вакунага Фармасьютикал Ко., Лтд. (Jp) Вакунага Фармасьютикал Ко., Лтд. (Jp), Вакунага Фармасьютикал КО., Лтд. filed Critical Фудзисава Фармасьютикал Ко., Лтд. (Jp) Фудзисава Фармасьютикал Ко., Лтд. (Jp)
Publication of RU2003134629A publication Critical patent/RU2003134629A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
RU2003134629/04A 2001-05-01 2002-04-24 Соединения цефема RU2003134629A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPR4690A AUPR469001A0 (en) 2001-05-01 2001-05-01 Cephem compounds
AUPR4690 2001-05-01
AUPR5834A AUPR583401A0 (en) 2001-06-20 2001-06-20 Cephem compounds
AUPR5834 2001-06-20

Publications (1)

Publication Number Publication Date
RU2003134629A true RU2003134629A (ru) 2005-06-10

Family

ID=25646666

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003134629/04A RU2003134629A (ru) 2001-05-01 2002-04-24 Соединения цефема

Country Status (19)

Country Link
US (1) US7179801B2 (enExample)
EP (1) EP1392704B1 (enExample)
JP (1) JP4251873B2 (enExample)
KR (1) KR20030090794A (enExample)
CN (1) CN1522259A (enExample)
AR (1) AR033300A1 (enExample)
AT (1) ATE318269T1 (enExample)
BR (1) BR0209452A (enExample)
CA (1) CA2446099A1 (enExample)
DE (1) DE60209341T2 (enExample)
ES (1) ES2254671T3 (enExample)
HU (1) HUP0304042A2 (enExample)
MX (1) MXPA03010002A (enExample)
NO (1) NO20034824L (enExample)
NZ (1) NZ529887A (enExample)
PL (1) PL366507A1 (enExample)
RU (1) RU2003134629A (enExample)
TW (1) TWI224599B (enExample)
WO (1) WO2002090364A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4448821B2 (ja) * 2002-10-30 2010-04-14 アステラス製薬株式会社 セフェム化合物
AU2003902380A0 (en) * 2003-05-16 2003-06-05 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE602004026451D1 (de) * 2003-09-18 2010-05-20 Astellas Pharma Inc Cephem-verbindungen
WO2005044819A1 (en) * 2003-10-28 2005-05-19 Schering Corporation Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines
EP1721906A4 (en) * 2004-03-05 2008-02-27 Shionogi & Co METHYLCEPHEM COMPOUND 3-PYRIDINIUM
JP2009530228A (ja) * 2006-03-16 2009-08-27 アステラス製薬株式会社 セフェム化合物および抗菌薬としての利用
HK1200096A1 (en) 2011-09-09 2015-07-31 Merck Sharp & Dohme Corp. Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20140274994A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Stabilizing ceftolozane
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274993A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane-tazobactam pharmaceutical compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
CN104140427A (zh) * 2014-07-05 2014-11-12 湖南华腾制药有限公司 一种四氢吡唑并[1,5-a]嘧啶的制备方法
CN107922435B (zh) * 2015-09-08 2022-05-17 桑多斯股份公司 由7-氨基头孢烷酸(7-aca)制备头孢洛扎的方法
CN107586305A (zh) * 2017-06-23 2018-01-16 浙江惠迪森药业有限公司 一种β‑内酰胺类化合物羧基及羟基保护基脱除方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194432A (en) * 1985-11-22 1993-03-16 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
CA1293719C (en) * 1986-09-22 1991-12-31 Takao Takaya Cephem compounds and processes for preparation thereof
US5210080A (en) * 1987-09-07 1993-05-11 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US5663163A (en) * 1987-09-07 1997-09-02 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
IE63094B1 (en) * 1987-09-14 1995-03-22 Fujisawa Pharmaceutical Co Cephem compound and a process for preparation thereof
US5173485A (en) * 1988-03-09 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Cephem compounds
GB8905301D0 (en) * 1989-03-08 1989-04-19 Fujisawa Pharmaceutical Co New cephem compound and a process for preparation thereof
US5215982A (en) * 1989-11-10 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
KR910015587A (ko) * 1990-02-27 1991-09-30 후지사와 토모키치로 세펨 화합물
JPH09110877A (ja) 1995-10-17 1997-04-28 Katayama Seiyakushiyo:Kk セフェム化合物、その製造法及びそれを含有する抗菌剤
AUPN955596A0 (en) * 1996-04-30 1996-05-23 Fujisawa Pharmaceutical Co., Ltd. New compound
JP4448821B2 (ja) * 2002-10-30 2010-04-14 アステラス製薬株式会社 セフェム化合物
AU2003902380A0 (en) * 2003-05-16 2003-06-05 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE602004026451D1 (de) * 2003-09-18 2010-05-20 Astellas Pharma Inc Cephem-verbindungen

Also Published As

Publication number Publication date
AR033300A1 (es) 2003-12-10
NZ529887A (en) 2005-05-27
JP2004529172A (ja) 2004-09-24
ES2254671T3 (es) 2006-06-16
CN1522259A (zh) 2004-08-18
CA2446099A1 (en) 2002-11-14
NO20034824D0 (no) 2003-10-29
KR20030090794A (ko) 2003-11-28
WO2002090364A1 (en) 2002-11-14
TWI224599B (en) 2004-12-01
ATE318269T1 (de) 2006-03-15
EP1392704A1 (en) 2004-03-03
JP4251873B2 (ja) 2009-04-08
DE60209341T2 (de) 2006-08-03
US7179801B2 (en) 2007-02-20
PL366507A1 (en) 2005-02-07
HUP0304042A2 (hu) 2004-04-28
MXPA03010002A (es) 2004-06-30
NO20034824L (no) 2003-12-29
DE60209341D1 (de) 2006-04-27
EP1392704B1 (en) 2006-02-22
US20040248875A1 (en) 2004-12-09
BR0209452A (pt) 2004-12-14

Similar Documents

Publication Publication Date Title
RU2003134629A (ru) Соединения цефема
CA2504730A1 (en) Cephem compounds
BR9916790A (pt) Uso de um composto, composto, processo para amanufatura do mesmo, composição farmacêtica, e,método para produzir um efeito de dano vascularem um animal de sangue quente
EP1862458A3 (en) Therapeutic agents useful for treating pain
AU2003225617A1 (en) Thiadiazolylpiperazine derivatives useful for treating or preventing pain
RU2008119842A (ru) Производные триазола в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы-1
RU2005105576A (ru) Производные плевромутилина в качестве противомикроюных средств
KR940005534A (ko) 아릴글리신아미드 유도체, 이의 제조방법 및 활성성분으로서 이를 함유하는 배뇨 장해 치료제
KR910009712A (ko) 세펨 화합물 및 이의 제조방법
CA2380414A1 (en) Method of cancer treatment
JP2004529172A5 (enExample)
RU2002123641A (ru) С-4 карбонатсодержащие таксаны
RU94037246A (ru) Применение 2-фенил-3-ароилбензотиофенов для ингибирования разрушения хряща
FR2903107B1 (fr) Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique
RU2000125889A (ru) Замещенные бисиндолималеимиды, предназначенные для ингибирования пролиферации клеток
SG145570A1 (en) 4-æ7-halo-2-quino(xa-)linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents
KR950703941A (ko) 일산화질소 합성 억제제(nitrogen monoxide synthesis inhibitor)
RU2007138582A (ru) Пероральные дозированные формы производных гемцитабина
CA2438509A1 (en) Use of cyclohexenone derivatives for the manufacture of a medicament in the treatment of dysuria
CA2441309A1 (en) Biguanide derivatives
RU2001104454A (ru) Производные имидазола с бифенилсульфонильным замещением, способ их получения, их применение в качестве лекарственного средства или средства для диагностики, а также содержащее их лекарственное средство
KR970705999A (ko) 타목시펜 및 타목시펜 유사체의 자궁향성 효과를 최소화시키는 방법 (a method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs)
RU94032285A (ru) Цефалоспориновые соединения, способ их получения, фармацевтическая композиция
RU2002125463A (ru) Полипептидное соединение, способы его получения, фармацевтическая композиция и способ профилактики или лечения грибковых заболеваний
KR890014561A (ko) 세펨 화합물 및 이의 제조방법

Legal Events

Date Code Title Description
FA93 Acknowledgement of application withdrawn (no request for examination)

Effective date: 20050601